Netflix‘s limited series adaptation of the Julia May Jonas novel “Vladimir” is rounding out its main cast.
Nine new cast members have joined the series alongside previously announced leads Rachel Weisz and Leo Woodall. Variety has learned that John Slattery (“Mad Men,” “Spotlight,” “Nuremberg”), Jessica Henwick (“Glass Onion: A Knives Out Mystery,” “Silo”), and Ellen Robertson (“Mickey 17,” “Black Mirror,” “Too Much”) have been cast as series regulars in the roles of John, Cynthia, and Sid respectively.
The new recurring cast members are: Kayli Carter (“The Marvelous Mrs. Maisel,” “Mrs. America,” “Private Life”) as Lila, Miriam Silverman (“Your Friends and Neighbors,” “The Sign in Sidney Brustein’s Window”) as Florence, Mallori Johnson (“Is God Is,” “Steal Away”) as Edwina, Matt Walsh (“Veep,” “Ghosts,” “Novocaine”) as David, Tattiawna Jones (“Murderbot,” “Station Eleven”) as Alexis, and Louise Lambert (“Chucky,” “Doc,” “Ginny & Georgia”) as Dawn.
In addition, the Oscar-nominated and Emmy-winning team of Shari Springer Berman and Robert Pulcini (“Fleishman Is in Trouble,” “American Splendor”) are set to direct three of the show’s eight episodes, including the pilot. They will also be executive producers on the series.
The official logline for the show states, “As a woman’s (Weisz) life unravels, she becomes obsessed with her captivating new colleague (Woodall). Full of sexy secrets, dark humor and complex characters, ‘Vladimir’ is about what happens when a woman goes hell-bent to turn her fantasies into reality.”
Jonas is adapting her book for the screen and also serves as executive producer on the series. Weisz will executive produce in addition to starring. Sharon Horgan, Stacy Greenberg, and Kira Carstensen executive produce via Merman along Jason Winer & Jon Radler of Small Dog Picture Company, as well as Springer Berman and Pulcini. 20th Television is the studio.
(Pictured from top left, left to right: John Slattery, Jessica Henwick, Ellen Robertson, Kayli Carter, Matt Walsh, Tattiawna Jones, Mallori Johnson, Louise Lambert, Miriam Silverman)
WIMBLEDON — Mirra Andreeva continues to play a level of tennis far ahead of her time.
On Monday, the 18-year-old defeated No. 10 seed Emma Navarro 6-2, 6-3 to advance to the quarterfinals at the All England Club. She’s the youngest to do that since Nicole Vaidisova, some 18 years ago. Andreeva is also the first teenager to reach the elite eight since Victoria Azarenka and Sabine Lisicki in 2009.
On Wednesday, Andreeva meets Belinda Bencic, who was a 7-6 (4), 6-4 winner over No. 18 seed Ekaterina Alexandrova.
Wimbledon: Scores | Order of play | Draws
Andreeva is a startlingly complete player for one so young. On a cool, breezy day on Centre Court, she converted a cold-hearted six of seven break points against Navarro and saved four of six in a match that required only 75 minutes.
Only World No. 1 Aryna Sabalenka and No. 2 Coco Gauff (7) have beaten more Top 10 players this year than Andreeva’s six. She’s also third to those same players with 36 WTA Tour-level victories.
At 24, Navarro is six years older than Andreeva, but this is the third Wimbledon main draw for both of them. Andreeva came in this year with a 3-2 record, while Navarro was 4-2 — a small sample size, but their early returns here have been encouraging.
Andreeva hadn’t dropped a set in three matches and Navarro eliminated defending champion Barbora Krejcikova in a three set, third-round match. In terms of ranking, this was the highest-level match so far this fortnight.
Breaking Navarro in just the third game and again in the fifth, Andreeva never gave her any real hope. Serving is what separated these two; Andreeva’s first-serve average was more than 16 miles per hour more than Navarro’s.
In the last game of the first set, when Navarro managed to force a break point, here is how Andreeva responded with a:
119 mph unreturned serve.
117 mph unreturned serve.
121 mph unreturned serve.
That last one converted her third set point and held up as her fastest of the match.
Second set was more of the same as Andreeva broke Navarro’s serve four more times. She was so dialed in that when she finally won the match — at love — she didn’t realize it. It was only after she glanced at the celebration in her player box that she broke into a smile and sprinted to the net to shake hands.
Andreeva has now won seven of the nine matches she’s played at Wimbledon. She’s already mastered the subtle movements required on grass and when to pack the power into her service games. And while the second serve, which averaged only 83.9 mph against Navarro, is a work in progress, we’d remind you that she’s the age of a typical college freshman.
This is the third quarterfinal in her past six major appearances and the second in a row.
Editor’s Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians, but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case that you would like to suggest for a future Case Challenge, please email us at ccsuggestions@medscape.com with the subject line “Case Challenge Suggestion.” We look forward to hearing from you.
Background and Initial Presentation
A 35-year-old man with a history of two prior spontaneous pneumothoraxes — both managed conservatively — presents to the emergency department with new-onset chest pain and lightheadedness. The pain is described as sudden, intense, and exacerbated by deep breathing. He indicates that it is located in the center of the chest. He denies dyspnea or leg swelling and has no other complaints. When asked, he says this pain is different from his pneumothorax pain, mainly because it is in the center of his chest.
Physical Examination and Workup
Vital signs are within normal limits, except for a pulse > 120 bpm. Physical examination reveals diminished breath sounds on the left hemithorax. There are no rales or wheezes and no leg edema.
Discussion
Central pleuritic chest pain in a patient with a history of pneumothorax suggests a pulmonary etiology. A chest x-ray is the most appropriate investigation to promptly assess for recurrent pneumothorax, pleural effusion, structural abnormalities, or other intrathoracic pathology.
ECG or cardiac biomarkers such as troponins are indicated primarily if myocardial ischemia or infarction is suspected. This suspicion would be raised if the patient described his chest pain as squeezing or pressure-like sensation radiating to the neck, jaw, or left arm. The patient’s young age and lack of history of coronary artery disease also make acute coronary syndrome less likely.
A CBC may provide supplementary information about signs of infection or inflammation, especially if the chest x-ray appears normal, but a CBC alone is unlikely to determine the cause of the patient’s acute pleuritic chest pain.
On initial testing, chest x-ray, metabolic panel, and troponin level were normal. CBC showed an elevated white blood cell count (16,200/μL). An ECG was also performed (Figure 1).
Figure 1. ECG performed on patient in ED.
Despite the central location of symptoms, the patient’s young age, history of pneumothorax, and presence of pleuritic chest pain would have placed pneumothorax high on the initial differential diagnosis. After pneumothorax was ruled out with chest x-ray, PE should have become the leading consideration given the pleuritic pain and the patient’s age group, in which PE is far more common than coronary artery disease. Although anxiety is also common in this age group — as it is in others — it should remain a diagnosis of exclusion, considered only after more serious conditions have been reasonably ruled out.
While the ECG is not diagnostic of PE, it raises suspicion by demonstrating three supportive findings: tachycardia, incomplete right bundle branch block, and nonspecific ST-segment changes.[1] A subsequent D-dimer test was positive, and chest CT angiography showed extensive bilateral pulmonary emboli, more pronounced on the left side.
PE typically presents as either unilateral pleuritic chest pain or as dyspnea with or without chest pain.[1] However, PE can present without the typical symptom of chest pain, sometimes being asymptomatic or discovered incidentally during diagnostic workup for other conditions.[1,2,3] Other symptoms of large pulmonary emboli may include syncope, diaphoresis, and cardiac arrest. Other symptoms of smaller emboli may include minor hemoptysis or cough.[1,3]
Although most patients with PE have at least one identifiable risk factor, up to 20% of patients present without any known risk factor, so the absence of risk factors should not exclude the diagnosis.[1]
Pain in patients with PE is believed to result from pulmonary infarction, which typically occurs when small to medium emboli lodge distally in the peripheral pulmonary arteries — areas with limited collateral circulation — making them more susceptible to infarction. The absence of chest pain does not exclude PE and may contribute to missed diagnoses, increasing the risk of patient morbidity and mortality.
PE classically presents with pleuritic chest pain and dyspnea associated with known risk factors, tachycardia, and clear lungs both on auscultation and chest radiography. However, most patients with PE present with one or more atypical features, which may include the absence of pain or any known risk factors and/or normal or nonspecific ECG findings.[1] About 40% of patients with PE have tachycardia.[1]
Scoring systems such as the PE Rule-out Criteria (PERC) can be useful in evaluating patients with suspected PE, but clinicians must be familiar with both the inclusion and exclusion criteria and should recognize that applying PERC requires a low pretest probability based on clinical judgment and the presence of a more likely alternate diagnosis with adequate supporting evidence.
When PE cannot be excluded based on clinical assessment, diagnostic testing is warranted, typically beginning with a D-dimer assay. If the D-dimer is positive, imaging with CT pulmonary angiography or a or ventilation-perfusion scan should follow.[2,3] D-dimer should not be ordered reflexively or “just in case,” as this often leads to unnecessary imaging. As Greg Henry advises, ”In medicine and life, don’t ask questions you don’t really want to know the answer to.”
PE is typically treated with anticoagulants unless they are absolutely contraindicated, in which case a vena cava interruption filter may be used.[2,3,4] The treatment setting and choice of anticoagulant depend on various factors, including PE severity, comorbidities, and bleeding risk.[3] Most patients are admitted for treatment initiation, but some low-risk patients may be discharged with oral anticoagulants.[2] Patients with hypotension or right ventricular strain often require ICU admission for close monitoring and may be treated with thrombolytic therapy or, in some cases, surgical intervention.[1,2,3]
The absolute contraindication to thrombolytic therapy is a history of intracranial hemorrhage, due to a significantly increased risk of catastrophic bleeding.[1,2,4] Thrombolytic agents can dissolve blood clots, but they also impair hemostasis.
A history of pneumothorax episodes is not considered an absolute contraindication to thrombolytics in this patient.[1] Anemia is an important clinical factor that significantly increases the risk of bleeding during anticoagulation, but it does not preclude thrombolysis, if not caused by active bleeding or associated with a significant coagulopathy.[1,3,5]
Hemodynamic instability is not a contraindication but rather an indication for thrombolytic therapy in patients with massive PE. The benefits of restoring circulation outweigh the bleeding risk associated with thrombolysis.[1,2,4]
Hospital admission on intravenous heparin is reasonable. The patient could deteriorate if additional thrombi embolize. ICU admission is typically reserved for patients who remain unstable or require intravenous fibrinolytics. Discharge may be appropriate for stable patients who meet discharge criteria. For patients who are stable but do not qualify for discharge and have a low risk of decompensation, admission to a general medical floor may be considered.
Because this patient’s CT angiography showed extensive PE and his vital signs were concerning, thrombolytics were considered. However, after heparin was initiated, his vital signs normalized within a few hours, so he was able to be admitted to a telemetry bed.
Although most patients with PE meet criteria for outpatient treatment,[3,4] a minority of eligible patients are actually discharged from the emergency department despite having an estimated mortality risk of less than 3%.[1,2] Risk stratification tools such as the Pulmonary Embolism Severity Index and the Hestia criteria can help identify candidates for outpatient treatment. Clinicians should also consider using an online calculator (eg, MDcalc.com). In addition to PE severity, clinicians should evaluate the patient’s bleeding risk on anticoagulation when making disposition decisions.[1,2,3,4]
Editor’s Note: This article was created using several editorial tools, including generative AI models, as part of the process. Human review and editing of this content were performed prior to publication.
A 19-year-old newlywed was admitted to Civil Hospital Karachi in critical condition after allegedly enduring “brutal sexual violence” at the hands of her husband, who has since been arrested, officials said on Monday.
Police surgeon Dr Summaiya Syed told Dawn.com, “As per the family and the police record, the 19-year-old girl married in Lyari on June 15. She is now in a coma. Her physical examination findings are consistent with sexual violence.”
According to the contents of the first information report (FIR) registered at the Baghdadi Police Station on July 5 under Sections 324 (attempt to commit qatl-i-amd) and 376-B (punishment for gang-rape) of the Pakistan Penal Code, the complainant, the brother of the victim, said that he was a resident of Shah Beg Lane in Baghdadi, Lyari.
“On the third day of her marriage, my sister was subjected to brutal sexual violence allegedly by her husband. She remained admitted at a private hospital in the city and was later taken to Shaheed Mohtarma Benazir Bhutto Trauma Centre of Civil Hospital Karachi in a critical condition the other day,” the FIR read.
The complainant said his 19-year-old sister married the suspect on June 15. Her health condition deteriorated on June 30, compelling the family to bring her back home. She informed the parents that on July 17, her husband subjected her to an “unnatural sexual act”, per the FIR.
It added that the husband also sexually assaulted her with a foreign object. Subsequently, the husband subjected her to sexual violence, leading to bleeding. As per the FIR, the suspect threatened his wife with “dire consequences” if she disclosed anything to anyone.
The complainant said the family took his sister to a private hospital on Garden Road when her condition deteriorated, but no improvement was seen. The in-laws again took the victim to their home. Later on, she was brought to the trauma centre on July 4, where she was admitted to the intensive care unit (ICU), the FIR said, adding that the complainant was seeking legal proceedings against the suspect.
South Deputy Inspector General of Police Syed Asad Raza told Dawn.com that the suspect had been arrested and an investigation has been launched.
Despite the presence of anti-rape laws — with punishment for rape either resulting in the death penalty or imprisonment of between 10 and 25 years — cases continue to prevail in the country.
Last week, police had said that they had arrested the primary suspect allegedly involved in the gang-rape of a girl in Ittehad Town.
In May, two sisters were subjected to a sexual assault in their home in North Karachi, police and doctors had said.
In April, in a rare verdict, an additional district and sessions judge in Gujranwala handed down 10-year rigorous imprisonment to a man for subjecting his wife to an unnatural sexual offence.
Louis Vuitton reentered the novelty bag space with the release of its Lifebuoy bag.
Designed with the French luxury fashion house‘s signature craft, the bag was teased by guests at the Louis Vuitton men’s spring 2026 show in Paris in June. Featuring its iconic logo on the leather canvas material, the bag is now listed on the brand’s website as “Notify Me” with a retail price of $10,000.
A guest wears a dark brown Louis Vuitton lifebuoy canvas bag.
Getty Images
Despite the unique circular design, the bag is functional, featuring three separate zipped compartments and an adjustable leather strap for shoulder or cross-body carry. The accessory is already catching the attention of social media.
This is not the first time the French house has had a novelty purse making waves online. In 2021, Louis Vuitton debuted a viral airplane bag, created by the late Virgil Abloh, which retailed for roughly $39,000. Other entries into the brand’s novelty bag list include the LV Fan bag, from the spring 2025 runway, the LV Monogram LV Paint Can Bag and the LV x Yayoi Kusama Pumpkin Shoulder Bag.
Louis Vuitton’s Lifebuoy bag.
Louis Vuitton
Over the course of the last several seasons, luxury brands have released a selection of novelty bags that stand out for their playful and unconventional designs. Notable examples include Moschino’s Teddy Bear purse, Balenciaga’s trash bag and Loewe’s tomato clutch.
“There’s been always a pendulum on what rises and falls and swings and sways,” said Susan Korn, designer of accessories label Susan Alexandra, about the trend in an interview with WWD in August 2024. “In the past couple of years we’ve seen there’s been this return to a very serious suit dressing — like neutral suit dressing, the vest as a shirt and the return to the traditional black bag. On the other end of the spectrum, you have a really fun, ridiculous, outrageous, not so serious bag. When you go too far in one direction, you always want to go to the other.”
A guest holds the Louis Vuitton Lifebuoy bag.
Getty Images
Prior to the 2024 resurgence of novelty bags, signs of the trend’s rise were evident in 2020, amid the COVID-19 pandemic. In February 2020, novelty handbags were spotted at the Fame and Moda trade shows in New York City. Heather London, a sales rep for Mary Frances Accessories, noted how the trend was making a comeback at the time.
“You’re seeing it on the runway; you’re seeing it with the major designers,” London told WWD in February 2020. “It trickles down and it just keeps getting more and more popular.”
Tony Hawk’s Pro Skater is one of the most popular skating simulation titles which have ever graced the gaming world. Now to carry forward that legacy, the upcoming installment, Tony Hawk’s Pro Skater 3+4 is releasing very soon.This is going to be a combined remastered collection of two of the most sold titles of the franchise, THPS 3 and THPS 4. THPS 3+4 will also serve as a follow-up installment of the 2020 title, THPS 1+2, which is in turn, another remastered combo of the first two games of the series. As we are nearing the launch of the upcoming installment, the release date and times for every region is now here.
Tony Hawk’s Pro Skater 3+4: Release dates and timings for every region
Tony Hawk’s Pro Skater 3+4 is releasing on July 11, 2025. | Image via Iron Galaxy.
The developer of Tony Hawk’s Pro Skater 3+4, Iron Galaxy, has confirmed that there will be two editions of this game – Standard and Digital Deluxe on PS4, PS5, Xbox One/X/S, Nintendo Switch 1, Switch 2, and PC (Steam, Battle.net, Game Pass). The standard edition is going to be released on July 11, 2025.But just like any other premium version, the Digital Deluxe Edition owners will be able to play the game three days earlier than the Standard Edition release, which is on July 8, 2025. As THPS 3+4 is going to have a concurrent release, here are all the release dates and timings of the game for different regions:
Region
Timezone
Release Date and Time
Los Angeles, USA
PDT (UTC‑7)
July 10, 2025 – 10:00 PM
New York City, USA
EDT (UTC‑4)
July 11, 2025 – 1:00 AM
London, UK
BST (UTC+1)
July 11, 2025 – 6:00 AM
Paris, France
CEST (UTC+2)
July 11, 2025 – 7:00 AM
Berlin, Germany
CEST (UTC+2)
July 11, 2025 – 7:00 AM
Mumbai, India
IST (UTC+5:30)
July 11, 2025 – 10:30 AM
Beijing, China
CST (UTC+8)
July 11, 2025 – 1:00 PM
Tokyo, Japan
JST (UTC+9)
July 11, 2025 – 2:00 PM
Sydney, Australia
AEST (UTC+10)
July 11, 2025 – 3:00 PM
São Paulo, Brazil
BRT (UTC‑3)
July 11, 2025 – 2:00 AM
As earlier mentioned, those who have pre-ordered the Digital Deluxe Edition will grant themselves a 72-hour early access period. So, they can easily calculate the time from when they can jump into the game by looking at this table. For example: the early access of THPS 3+4 will begin from 9 PM PDT on July 7, 2025 in Los Angeles. Players from different locations can convert these timings to their native timezones to get the respective release dates and timings. Besides a 3-day early access, the Digital Deluxe Edition owners will get a free cosmetic reward as well. Read More: New Upcoming games releasing in July 2025
The US is set to take the Syrian Islamist group Hayat Tahrir al-Sham (HTS) off its list of foreign terrorist organisations on Tuesday, according to a state department memo.
The group led a rebel offensive in December that toppled the Assad regime, which had ruled Syria for 54 years. Its leader Ahmed al-Sharaa is now the country’s interim president.
HTS, also known as al-Nusra Front, was previously al-Qaeda’s affiliate in Syria until al-Sharaa severed ties in 2016.
In recent months, Western countries have sought to reset relations with Syria – which has faced heavy sanctions aimed at the old regime.
In late June, President Trump signed an executive order to formally end US sanctions against the country, with the White House saying the move was intended to support its “path to stability and peace”.
It added it would monitor the new Syrian government’s actions including “taking concrete steps toward normalising ties with Israel” as well as “addressing foreign terrorists” and “banning Palestinian terrorist groups”.
Syrian Foreign Minister Asaad al-Shibani said the move would “lift the obstacle” to economic recovery and open the country to the international community.
On Friday, Syria said it was willing to cooperate with the US to reimplement a 1974 disengagement agreement with Israel.
Over the weekend, UK Foreign Secretary David Lammy visited Syria – the first government minister to do so in 14 years.
He met with al-Sharaa and announced an additional £94.5m support package – aimed at supporting longer-term recovery and countries helping Syrian refugees.
The UK earlier lifted sanctions on Syria’s defence and interior ministries.
Ninety percent of Syria’s population were left under the poverty line when the Assad regime was ousted after 13 years of devastating civil war.
Al-Sharaa has promised a new Syria, but there are concerns within the country about how the new government is operating – with some suspicious of his radical past.
Only one female government minister has been appointed to date – and al-Sharaa has made almost every other appointment directly.
There have also been multiple violent attacks against minority groups in recent months.
In March, hundreds of civilians from the minority Alawite sect were killed during clashes between the new security forces and Assad loyalists. In April there were deadly clashes between Islamist armed factions, security forces and fighters from the Druze religious minority. And in June at least 25 people were killed in a suicide attack on a church in Damascus.
