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  • Kirkland Advises LevelBlue on Acquisition of Trustwave, Becoming Largest Pure-Play Managed Security Services Provider | News

    Kirkland & Ellis advised LevelBlue, a global leader in cloud-based, AI-driven managed security services, on a definitive agreement to acquire Trustwave, a global provider of cybersecurity and managed detection and response services from the MC2 Security Fund, a private equity fund sponsored by The Chertoff Group, an internationally recognized security and growth advisory firm. This strategic acquisition further strengthens LevelBlue’s market leadership, uniting two leading Managed Security Service Providers (MSSPs) to deliver unparalleled cybersecurity outcomes through a comprehensive and expanded suite of services designed to stay ahead of the rapidly evolving threat landscape. The acquisition will create the largest pure-play MSSP in the industry.

    Read the transaction press release

    The Kirkland team included corporate lawyers Jeremy Mandell, John Kaercher, Corey Fox, Meredith Bennett and Alex Knight; debt finance lawyers Maureen Dixon and Jacob Klapholz; and tax lawyers Adam Kool, Steven Cantor and Liv Schmertzler.

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  • Jinu’s seriously derpy tiger origin story

    Jinu’s seriously derpy tiger origin story

    Without singing a note or swinging a weapon, one character from “Kpop Demon Hunters” has entranced the audience off pure vibes alone.

    We’re talking about Derpy Tiger, an oversized blue cat with glowing yellow eyes, a snaggletooth grin and a penchant for righting overturned vessels. The breakout character is a courier, delivering messages between rival K-pop band members: Jinu, a demon seeking to drain souls from fans listening to his tunes, and Rumi, an idol by day and a hunter by night, protecting the souls of humanity.

    Co-directed by Maggie Kang and Chris Appelhans, “Kpop Demon Hunters” has quickly become a hit for Netflix, claiming the No. 1 spot on the streamer’s English-langauge Top 10 list and ranking in the Top 10 in all countries globally, with an additional 24.2 million views in its second week. Derpy Tiger has ridden this wave as well, with Netflix boasting how the character’s plushie is among its Top 5 sold items in its shop for the year already.

    We’re introduced to Derpy in a late-night scene when he emerges from a portal from the Underworld and promptly knocks over a flowerpot. Several awkward seconds pass as the stubby-legged feline attempts to set the pot back upright, but fails every time. Who knows how long the tenacious tabby would have continued with this Sisyphean task had Rumi not stepped in? And with that, he won over the hearts if not souls of the audience. Take a look:

    “When I saw the pot scene with Derpy I thought that it was genius. It’s so good,” raved story artist Radford Sechrist told Salon. “I believe the idea came from a story room and it was first storyboarded by an artist named Jessie Wong.”

    Sechrist, who happens to be married to Kang, is the veteran animator tasked with designing the cat who would be king of derps.

    “He is the creator of ‘Kipo and the Age of Wonderbeasts,’ so that whole aesthetic is his,” Kang said about Sechrist. “He started as a character designer and he storyboarded for the movie as well, and wrote a lot of the scenes. When you’re doing storyboards, you get a character that has no design so you also end up drawing it and designing it. The design of the cat is based on minhwa, which is a folk art that depicts this tiger and it’s always paired with a magpie.”

    Minhwa is a style of Korean folk art popular during the Chosun era, with the Hojak-do genre specializing in images of tigers, magpies and pine trees. And while these images were often hung up at entrances for the new year – tigers were seen as keeping evil at bay while magpies would deliver good news – the way these animals were depicted together evolved over time to become more satirical by the 17th century. The once powerful tiger, a stand-in for the ruling class of aristocrats, was painted to look foolish and yes, derpy, hence the nickname “idiot tiger” (바보호랑이). In contrast, the magpie was positioned over the cat and represented the common folk, cheekily flipping the hierarchy of the day.

    “The way the tiger is depicted in this art is so funny,” said Kang. “It’s very goofy, and that is the reason why we call him Derpy Tiger. Those drawings are very derpy. He’s always walleyed and weird looking.”

    Sechrist reveals that while he did draw on that traditional art for inspiration he also looked closer to home.

    “I would say 90% based on the minhwa artwork, which was incredible to reference and 10% is our cat,” he said. “For instance the shorter body and shorter legs feel like our cat. A bit of the neck as well, how our cat has this fluffy bump. We named our cat ‘Yumyan’ after Yumyan Hammerpaw, a cat character from a show I created called ‘Kipo and the Age of Wonderbeasts.’ But we call her ‘Fluffy’ for short because she’s a long-haired Himalayan cat.”

    Check out an early Derpy model and then swipe to check out Fluffy:

    “I was a little nervous at first to design something based in history with cultural significance, but we had an advisor who was supportive of the idea,” he added. “We wanted to include a tiger in the movie because tigers are the national animal of South Korea. Also, a lot of us on the crew are cat lovers.”

    As for Derpy’s bright blue hue, Sechrist said, “I believe that may have been [production designer] Helen Chen giving the tiger a more magical feel. I was designing it closer to the old artwork which was gray.”

    Although Derpy clearly had star potential, he didn’t initially have a defined role in the movie.

    “We were like, ‘Oh my gosh, this is such a fun character that we could have in the movie,’ but we didn’t want to just have a sidekick,” acknowledged Kang. “We didn’t want to just do that, so we put it off to the side . . . We [also] needed some way for Rumi and Jinu to communicate with each other. We wanted him to send her an invite to meet, and it felt odd for him to text her. He’s 400 years old. He doesn’t know how to use a cellphone. So at first, we were like, ‘Do we use a carrier pigeon?’

    “Our production designer, [Helen Mingjue Chen] did this really beautiful painting of a statue of a tiger turning into a real tiger, and Jinu is standing next to it and he has his shirt open for no reason. When we saw that, we were like, ‘Oh, maybe he is Jinu’s pet, and he can use this tiger to deliver messages to Rumi.’ So that’s how Derpy was integrated into the movie as a mailbox basically, and then the bird tagged along with him.”

    Check out Chen’s art that started it all:

    The bird Kang refers to is Sussy, the magpie who accompanies Derpy. (It should be noted that neither of these names are official (yet), but rather the default names given by the crew for the creatures.) Sussy has two distinguishing features. First, he has too many eyes. While most fans believe he has three eyes (which led to some conjecture of its relationship to the three-legged crows in Eastern mythology), we are only seeing one side of his head. “I can confirm it does have six eyes total, three on each side,” said Sechrist.

    Neither Kang nor Sechrist could recall who came up with the idea for the additional eyes or why he has them, but it could be similar to the decision to make Derpy blue. A six-eyed magpie is a good indicator that it’s from another realm and not your average two-eyed terrestrial bird.

    Sussy’s second defining feature is his love of hats, namely a tall, jaunty gat, similar to the ones that the Saja Boys wear in the Underworld and in their performance of “Your Idol.” Whence came this love of headgear? In the film, Jinu tells Rumi, “I made [the hat] for the tiger, but the bird keeps stealing it.”

    “We were in a brainstorm and someone asked, ‘Why does the bird have a tiny hat?’ And I just said, ‘Jinu made it for the tiger, but the bird keeps stealing it.’ It got a laugh so I suggested maybe Jinu actually says that. I always love it when everyone is just riffing ideas together, and you can actually throw some of those ideas in. The energy in a brainstorm room is really fun, especially with Maggie; she’s so funny. I still remember her pitching me corn eyes or even, ‘What if there’s a demon boy band?’”

    The success of and “Kpop Demon Hunters” has opened the audience’s eyes to how collaborative the creative process is for what we see onscreen, which especially true of animation. Fans hungry for more of the story are clamoring for a sequel, and in the meantime are finding the rich treasure trove of concept art and other story and visual elements that led up to the finished product. Secrhist has felt this love from fans of the movie as well.

    “The team elevated the tiger design and made it so cool – from Helen Chen’s color choices and [art director] Scott Watanabe’s refinements, as well as the modeling, animation and lighting,” he said. “At every step this movie was such a labor of love so I figured if we were all fans, everyone else would love it too. But I didn’t anticipate the cultural phenomenon aspect. I’ve never been part of a movie that went so viral online. It’s kind of amazing to see how much people love it.”

    In addition to dominating Netflix streaming, the film’s original soundtrack has broken through as well, entering the Billboard 200 at No. 8. This is the highest-charting soundtrack from an animated film since the OST from another Sony Animated film, “Spider-Man: Across the Spider-Verse” ranked No. 7 on the Billboard 200 in July 2023. Over on Spoitfy, the cast soundtrack is currently No. 5 on the Weekly Top Albums on Spotify globally and No. 6 in the U.S. It also boast the most spots on Spotify’s Daily Top Songs Global list, with the anthem “Golden” the highest at No. 3.

    The post “Kpop Demon Hunters”: Jinu’s seriously derpy tiger origin story appeared first on Salon.com.

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  • Beaufille Resort 2026 Ready-to-Wear Runway, Fashion Show & Collection Review

    Beaufille Resort 2026 Ready-to-Wear Runway, Fashion Show & Collection Review

    Beaufille’s sister-duo Chloé and Parris Gordon are switching things up. After years of debuting collections twice a year on the pre-season calendar, the cofounders are now releasing four carefully curated collections a year.

    “We’ve been running our own e-commerce now for about four years, and we really felt the lull between when you do two seasons a year — promoting the same collection to our audience for over six months became challenging. We started to understand ourselves why retailers want this constant newness and several drops,” Parris Gordon explained. “With running our own e-commerce, we really have the feedback of when our clients are buying the product, and what that [product is].”

    Beyond evening dressing and their popular feminine stretch lace styles, which come in a lovely burgundy hue for resort, the strategic shift also allows the duo to “take a few risks that retailers wouldn’t take,” Chloé Gordon added, noting that their initial handbag launch and higher-priced styles have performed well on their e-commerce.

    Taking this knowledge, Chloé Gordon said resort was all about offering more special, novelty styles and investment pieces designed for holiday dressing. For instance, a great selection of new leopard printed pony hair leather layers, including tailored jackets, miniskirts, jean-like pants and playfully chic handbags. The duo also started working with artisans in India to develop their new drapey silk cotton fringed layers that nicely played into their holiday mindset.

    “I think people are dressing a little less formal, and we interpreted that into a lot of looks,” Chloé Gordon said of the collection’s new takes on masculine tailoring, such as a pale pink sharp yet sexy, plunging keyhole blouse with a one-button brown suit or an intriguing shirt dress designed around the “idea of a jacket tied around your waist, but it is functional,” she added.

    For the brand’s latest jewelry, Parris Gordon said she was into designing earrings, rings and necklaces that felt easy to dress up and had a bit of a casual element to them, as seen through resort’s great beaded sterling silver or lapis lazuil chandelier tassel earrings and necklaces, oversize gemstone studs and slightly oversize hoops.

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  • Princess Kate ‘Has Good Days and Bad Days’ As She Continues to Recover From Cancer Battle: Source

    Princess Kate ‘Has Good Days and Bad Days’ As She Continues to Recover From Cancer Battle: Source

    The royals were out in force at Royal Ascot in mid June, days of world-class horse racing, with spectators in top hats and whimsical fascinators sipping on Pimm’s Cup and riding in open carriages to the course in Berkshire, England, about 25 miles west of London. Kate Middleton, the Princess of Wales, of course, was not among the well-dressed crowd.

    Minutes after Buckingham Palace’s official carriage list was released — indicating that Kate and her husband, Prince William, would arrive in a horse-drawn landau — Kensington Palace announced the 43-year-old would not attend. After initially claiming the list was sent in error, a  royal source told ABC News that Kate was “disappointed” to miss the social event, but “has to find the right balance as she fully returns to public-facing duties.”

    It’s a stark reminder that the princess, who revealed in March 2024 that she was diagnosed with an undisclosed form of cancer, is still not completely well. And once again, she is torn between her duties as the future queen and her need to take care of her health. “It’s a delicate balance whereby Kate is striving to care for herself and still carry out royal duties,” an insider tells Star. “Kate has good days and bad days, that’s just part of her recovery.”

    Finding Meaning

    The princess’ illness, which involved abdominal surgery in January 2024 as well as chemotherapy, has made her more reflective of how she spends her time. In a video last June, the mom of George, 11, Charlotte, 10, and 6-year-old Louis explained that on bad days she felt “weak” and “tired,” adding, “But on the good days, when you feel stronger, you want to make the most of feeling well.”

    MEGA

    While she skipped Ascot, Kate made sure to fulfill a less glitzy obligation, penning a June 20 letter to draw attention to the work of children’s hospices. Naming two that she is patron of, Kate wrote of the privilege of seeing them “lifting spirits through laughter, fun and play, as well as listening, holding, caring and sharing. They support children and families through life, death and beyond.”

    Her own brush with mortality has left Kate even more devoted to her young family. “As harrowing as the illness was on Kate, it did teach her a lot about priorities,” notes the insider. “Spending time with her kids, as well as William of course, is her biggest priority bar none.” She’s also determined not to worry her children. “She keeps them up to speed on her health,” adds the insider, “reassuring the kids that she’s getting better and better as time goes on.”

    Future Queen

    Kate’s health setback comes as her father-in-law, King Charles III, is also battling cancer, reportedly undergoing weekly treatments. The 76-year-old’s declining health has no doubt put pressure on Kate and future king William, 43, as they face the prospect of ascending to the throne far sooner than they expected. “Kate is acutely aware that she’ll be queen one day and is mindful that she has to prepare for that eventuality,” explains the insider.

     <span class="wp-caption-text">WireImage</span>

    WireImage

    At the same time, Charles — who attended Royal Ascot with his wife, Queen Camilla, 77 — has barely slowed his busy schedule. “Seeing King Charles carrying on with his full workload even whilst he’s so poorly is something Kate finds admirable,” says the insider. “But at the same time there’s probably a lingering worry that she may look like she’s slacking by comparison.”

    Not that the king is pointing fingers. Throughout their illnesses, Charles and Kate have grown close, reveals the insider. “They’ve bonded enormously. There’s so much mutual respect between the two, and as awful as it’s been, the one positive is that it’s brought them so much closer together.”

     <span class="wp-caption-text">MEGA</span>

    MEGA

    William, too, has discovered a new appreciation for the woman he met as an undergrad at Scotland’s University of St Andrews and wed in 2011. “He’s quick to quell any anxiety or jitters she may have,” says the source. “He often goes out of his way to reassure Kate that by taking a step back from time to time she’s by no means neglecting her royal duties.”

    As one of the most popular royals in the family, Kate is still learning how to put herself first. “The people love her, the royal family appreciate her,” says the insider. “ Still, she’s a perfectionist at heart, always striving to contribute and fulfill her role to the best of her abilities.

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  • FDA Grants Accelerated Approval to Sunvozertinib for Metastatic NSCLC With EGFR Exon 20 Insertion Mutations

    FDA Grants Accelerated Approval to Sunvozertinib for Metastatic NSCLC With EGFR Exon 20 Insertion Mutations

    The FDA has granted accelerated approval to sunvozertinib (Zegfrovy) for the treatment of adult patients with locally advanced or metastatic non–small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or following platinum-based chemotherapy.1

    The efficacy of the agent was examined in the multinational, open-label WU-KONG1b trial (NCT03974022). Data showed that sunvozertinib elicited an objective response rate of 46% (95% CI, 35%-57%), with a duration of response of 11.1 months (95% CI, 8.2-not evaluable).

    About the Trial

    WU-KONG1 Part B enrolled patients with locally advanced or metastatic NSCLC with EGFR exon 20 insertion mutations confirmed in tumor tissue.2 Patients needed to have an ECOG performance status of 0 or 1 and have received prior treatment with platinum-based chemotherapy.

    Patients were randomly assigned 1:1 to receive sunvozertinib at 200 mg daily or 300 mg daily. At the interim analysis, 111 patients went on to receive continuous dosing of the agent at 300 mg daily until trial discontinuation criteria were met.

    Independent review committee (IRC)–assessed ORR served as the trial’s primary end point. IRC-assessed duration of response (DOR) was a key secondary end point. Other secondary end points included investigator-assessed ORR and DOR.

    Safety Spotlight

    The most common grade 3 or higher treatment-related adverse effects (TRAEs) observed with the agent at the 300-mg dose included diarrhea (17.1%), increased blood creatinine phosphokinase levels (10.8%), anemia (3.6%), rash (3.6%), increased lipase levels (3.6%), decreased neutrophil counts (2.7%), hypokalemia (2.7%), decreased appetite (2.7%), and asthenia (2.7%). TRAEs led to dose reduction and treatment discontinuation in 36.0% and 6.3% of patients, respectively. Investigators noted that most of the common TRAEs were grade 1 or 2 in severity and clinically manageable. No TRAEs led to fatal outcomes.

    What Came Before

    Previously, in April 2024, the FDA granted breakthrough therapy designation to sunvozertinib for patients with treatment-naive NSCLC harboring an EGFR exon 20 insertion mutation.3

    References

    1. FDA grants accelerated approval to sunvozertinib for metastatic non-small cell lung cancer with EGFR exon 20 insertion mutations. FDA. July 2, 2025. Accessed July 2, 2025. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-sunvozertinib-metastatic-non-small-cell-lung-cancer-egfr-exon-20
    2. Yang J CH, Doucet L, Wang M, et al. A multinational pivotal study of sunvozertinib in platinum pretreated non-small cell lung cancer with EGFR exon 20 insertion mutations: primary analysis of WU-KONG1 study. J Clin Oncol. 2024;42(suppl 16)8513. doi:10.1200/JCO.2024.42.16_suppl.8513
    3. FDA grants breakthrough therapy designation to sunvozertinib for the first-line treatment of patients with advanced non-small cell lung cancer harboring EGFR exon 20 insertion mutations. News Release. Dizal Pharma. April 7, 2024. Accessed July 2, 2025. https://www.dizalpharma.com/news/detail?id=70&search=&currentPage=1

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  • Fitch Affirms Bunge at 'BBB+'/Stable; Upgrades and Withdraws Viterra's IDR – Fitch Ratings

    1. Fitch Affirms Bunge at ‘BBB+’/Stable; Upgrades and Withdraws Viterra’s IDR  Fitch Ratings
    2. Bunge Global upgraded to A- by S&P following Viterra merger  Investing.com
    3. Glencore announces $1 billion share buyback  Global Banking | Finance | Review
    4. Bunge and Viterra Complete Merger to Create Premier Global Agribusiness Solutions Company  Yahoo Finance
    5. Bunge completes $8.2B Viterra acquisition, creating global agriculture powerhouse  The Business Journals

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  • Blizzard is winding down support for its Warcraft mobile game

    Blizzard is winding down support for its Warcraft mobile game

    Microsoft’s layoff of roughly 9,000 employees is continuing to have downstream effects at the company’s subsidiaries. Aftermath reports that as many as 100 developers at Blizzard have been impacted, and as a result the studio is winding down development on its mobile tower defense game Warcraft Rumble.

    In an announcement, Blizzard wrote that while the game will not be abandoned entirely, the company will cease development on any new content. “Moving forward, we’ll continue supporting Rumble with updates focused on regular, systemic in-game events and bug fixes, but no new content. ”

    Blizzard continued, saying Rumble, “struggled to find its footing relative to our ambition for its long-term success.” And while its developers worked to respond to player feedback that, “ultimately wasn’t enough to put the game on a path to sustainability.”

    Warcraft Rumble was the first mobile focused game in the Warcraft Universe. It launched in 2023 after nine years in development and was originally one of two mobile games Blizzard was working on, the other being Blizzard’s take on Pokémon Go. That game was never officially announced by Blizzard and cancelled sometime in 2022. Warcraft Rumble joins a handful of other Blizzard games in development stasis along with Starcraft II and Heroes of the Storm.

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  • Webb and Chandra Image of Bullet Cluster Maps Invisible Dark Matter

    Webb and Chandra Image of Bullet Cluster Maps Invisible Dark Matter

    ‘This is the central region of the Bullet Cluster, which is made up of two massive galaxy clusters. The vast number of galaxies and foreground stars in the image were captured by NASA’s James Webb Space Telescope in near-infrared light. Glowing, hot X-rays captured by NASA’s Chandra X-ray Observatory appear in pink. The blue represents the dark matter, which was precisely mapped by researchers with Webb’s detailed imaging. Normally, gas, dust, stars, and dark matter are combined into galaxies, even when they are gravitationally bound within larger groups known as galaxy clusters. The Bullet Cluster is unusual in that the intracluster gas and dark matter are separated, offering further evidence in support of dark matter. (See the defined galaxy clusters within the dashed circle.’ | Credit: NASA, ESA, CSA, STScI, CXC; Science: James Jee (Yonsei University/UC Davis), Sangjun Cha (Yonsei University), Kyle Finner (IPAC at Caltech)

    NASA’s James Webb Space Telescope (JWST) and Chandra X-ray Observatory combined their efforts to look at the Bullet Cluster in a new way, enabling scientists to precisely map the cluster’s dark matter.

    Webb’s near-infrared imaging capabilities enabled astronomers to capture the highest detailed images yet of the Bullet Cluster, which comprises a pair of massive galaxy clusters. With Webb’s highly sensitive cameras, researchers can see fainter, more distant galaxies in the Bullet Cluster than ever before.

    “With Webb’s observations, we carefully measured the mass of the Bullet Cluster with the largest lensing dataset to date, from the galaxy clusters’ cores all the way out to their outskirts,” says Sangjun Cha, the lead author on a new research paper published this week in The Astrophysical Journal Letters. Cha is a PhD student at Yonsei University in Seoul, South Korea.

    “Webb’s images dramatically improve what we can measure in this scene — including pinpointing the position of invisible particles known as dark matter,” adds Kyle Finner, a co-author of the new research paper and an assistant scientist at IPAC at Caltech in Pasadena, California.

    As NASA explains, “all galaxies are made up of stars, gas, dust, and dark matter, which are bound together by gravity.” The Bullet Cluster is not just a galaxy, but a grouping of two “very massive collections of galaxies.”

    The galaxy clusters, which are massive and therefore have powerful gravitational forces, can act as gravitational lenses that significantly magnify the light of background galaxies. The amount of gravitational lensing, when compared against the amount of visible mass in a cluster, enables scientists to infer the distribution of invisible dark matter.

    A deep space image showing countless distant galaxies of various shapes and sizes, scattered against a dark background with several bright stars featuring diffraction spikes.
    Bullet Cluster — NIRCam image

    “Gravitational lensing allows us to infer the distribution of dark matter,” says co-author James Jee, professor at Yonsei University and research associate at UC Davis in California.

    It is helpful to think about gravitational lensing and dark matter using a metaphor of a pond filled with crystal-clear water and pebbles, Jee says.

    “You cannot see the water unless there is wind, which causes ripples,” the scientist explains. “Those ripples distort the shapes of the pebbles below, causing the water to act like a lens.” This same phenomenon occurs in space, where the water represents dark matter, and the pebbles in the example represent background galaxies.

    With Webb’s imaging capabilities, it is much easier to see and measure the galaxies, including the background ones, meaning it is possible to weigh both visible and invisible matter (dark matter) in the galaxy clusters. The researchers also mapped and measured the collective light emitted by intracluster stars. These are stars that are no longer bound to an individual galaxy.

    “We confirmed that the intracluster light can be a reliable tracer of dark matter, even in a highly dynamic environment like the Bullet Cluster,” Cha says. If intracluster stars are not bound to galaxies, and instead are bound to dark matter, scientists could learn much more about dark matter and its distribution.


    Image credits: NASA, ESA, CSA, STScI, CXC; Science: James Jee (Yonsei University/UC Davis), Sangjun Cha (Yonsei University), Kyle Finner (IPAC at Caltech). Video credits: NASA, ESA, CSA, Joseph DePasquale (STScI)

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  • Over Decades, A Healthy Lifestyle Outperforms Metformin in Preventing Onset of Type 2 Diabetes

    Over Decades, A Healthy Lifestyle Outperforms Metformin in Preventing Onset of Type 2 Diabetes

    In the early 2000s the U.S. Diabetes Prevention Program (DPP), a large randomized clinical trial, showed that intensive lifestyle modification was better than a medication called metformin at preventing at-risk patients from developing Type 2 diabetes.

    In a newly completed follow-up study, a team of researchers including Vallabh “Raj” Shah, professor emeritus in The University of New Mexico Departments of Internal Medicine and Biochemistry & Molecular Biology at the School of Medicine, found that the health benefits from the lifestyle intervention persisted more than 20 years later.

     

    Within three years, they had to stop the study because lifestyle was better than metformin. That means lifestyle, which everybody is banking on, is more effective — that is the news.

     

    -Vallabh “Raj” Shah, PhD, Professor Emeritus, The University of New Mexico Departments of Internal Medicine and Biochemistry & Molecular Biology at the School of Medicine

    In a paper published in The Lancet Diabetes & Endocrinology, they reported that the greatest results from both interventions were seen in the first few years of the study, and they were durable, Shah said. “The data suggests that those people who didn’t get diabetes also didn’t get diabetes after 22 years,” he said.

    The DPP was launched in 1996 to compare the benefits of metformin – then newly approved by the FDA to treat Type 2 diabetes – and a lifestyle modification regimen that included exercise and a healthy diet. The study enrolled 3,234 patients with prediabetes at 30 institutions in 22 states.

    2025_06_11_Raj_Shah-4

    Vallabh “Raj” Shah, PhD. Photo Credit: Jett Loe

    The intensive lifestyle intervention reduced the development of diabetes by 24%, and metformin reduced diabetes development by 17%, according to the new study. The DPP had previously found that after the first three years of study, the lifestyle intervention of moderate weight loss and increased physical activity reduced the onset of Type 2 diabetes by 58% compared with a placebo medicine, while metformin reduced development of diabetes by 31%.

    Compared with the original placebo group, the median time without diabetes was extended by three-and-a-half years in the lifestyle group and two-and-a-half years in the metformin group.

    “Within three years, they had to stop the study because lifestyle was better than metformin,” Shah said. “That means lifestyle, which everybody is banking on, is more effective – that is the news.”

    But because a wealth of health and biological data had already been collected for patients participating in the project, the DPP was repurposed into the DPP Outcomes Study (DPPOS), enabling researchers to follow their health outcomes in multiple domains over a period of decades, he said.

    2025_06_11_Raj_Shah-3

    Vallabh “Raj” Shah, PhD. Photo Credit: Jett Loe

    Shah has contributed to kidney disease research for more than three decades, conducting multiple studies at Zuni Pueblo and other American Indian communities in western New Mexico. He has also overseen the participation of the American Indian cohort enrolled in the DPPOS. Meanwhile, David Schade, MD, chief of the Division of Endocrinology in the UNM School of Medicine, recruited New Mexico participants in the study.

    More recently, he said, DPPOS researchers have taken advantage of their large, well-documented cohort to repurpose the study to focus on diseases associated with aging, such as cancer and dementia, Shah said.

    Banner Photo: Vallabh “Raj” Shah, PhD. Photo Credit: Jett Loe

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  • Gaza: Access to key water facility in Khan Younis disrupted, UN reports

    Gaza: Access to key water facility in Khan Younis disrupted, UN reports

    According to the UN Office for the Coordination of Humanitarian Affairs (OCHA), Israeli authorities issued displacement orders overnight for two neighbourhoods in Khan Younis, where up to 80,000 people had been living.

    The Al Satar reservoir – a critical hub for distributing piped water from Israel – has become inaccessible as a result.

    Grave warnings

    “Any damage to the reservoir could lead to a collapse of the city’s main distribution of the water system, with grave humanitarian consequences,” UN spokesperson Stéphane Dujarric told reporters at a daily news briefing in New York.

    Al Satar’s disruption comes as Gaza’s infrastructure buckles under relentless displacement, strained services and critical shortages of fuel and supplies.

    Approximately 85 per cent of Gaza’s territory is currently either under displacement orders or located within military zones – severely hampering people’s access to essential aid and the ability of humanitarians to reach those in need, OCHA reported.

    Displacement continues

    Since the collapse of a temporary ceasefire in March, nearly 714,000 Palestinians have been displaced again, including 29,000 in the 24 hours between Sunday and Monday. Existing shelters are overwhelmed, and aid partners report deteriorating health conditions driven by insufficient water, sanitation and hygiene services.

    Health teams report that rates of acute watery diarrhoea have reached 39 per cent among patients receiving health consultations. Khan Younis and Gaza governorates are hardest hit, with densely overcrowded shelters and little access to clean water exacerbating the spread of disease.

    Adding to the crisis, no shelter materials have entered Gaza in over four months, despite the hundreds of thousands of newly displaced people. UN partners reported that in 97 per cent of surveyed sites, displaced families are sleeping in the open, exposed to heat, disease and trauma.

    Fuel shortages

    Meanwhile, fuel shortages are jeopardising the humanitarian response. A shipment of diesel intended for northern Gaza was denied on Wednesday by Israeli authorities, just a day after a successful but limited delivery to Al Shifa Hospital in Gaza City.

    If the fuel crisis is not urgently addressed, Mr. Dujarric warned that relief efforts could grind to a halt.

    “If the fuel crisis isn’t addressed soon, humanitarian responders could be left without the systems and the tools that are necessary to operate safely, manage logistics and distribute humanitarian assistance,” he said.

    “This would obviously endanger aid workers and escalate an already dire humanitarian crisis.”

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