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  • Hormone Tx Safe for Menopausal Symptoms in Younger Women – Medscape

    1. Hormone Tx Safe for Menopausal Symptoms in Younger Women  Medscape
    2. Long a subject of fear, menopause hormone therapy can be a lifesaver  The Boston Globe
    3. Lisi Tesher: My sweet aunt lost two kids. Her husband suffered a terrible injury. Now she’s having terrible hot flashes. Will HRT help? Ask Lisi  Toronto Star
    4. Hormone Therapy Found Safe for the Hearts of Women Below Age 60 Experiencing Symptoms of Menopause  Mass General Brigham
    5. Wellness Wednesday: Treating symptoms of menopause  WLNS 6 News

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  • PM lauds forces for successful counter-terrorism operation in Balochistan – RADIO PAKISTAN

    1. PM lauds forces for successful counter-terrorism operation in Balochistan  RADIO PAKISTAN
    2. 4 ‘India-sponsored’ terrorists killed in Balochistan’s Khuzdar during IBO: ISPR  Dawn
    3. Pakistani army says clashes near the Afghan border killed 19 soldiers and 45 militants  AP News
    4. Bannu, Lakki Marwat Operations Kill Dozens of Terrorists  Daily Times
    5. Security forces kill five Indian-sponsored terrorists in Khuzdar  Dunya News

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  • Caliber launches as a holding company for The News Movement, The Recount, Capsule, and The Caliber Collective with a view toward global expansion

    Caliber launches as a holding company for The News Movement, The Recount, Capsule, and The Caliber Collective with a view toward global expansion

    Caliber to debut creator-driven platform, SaySo, in 2026

    NEW YORK, Sept. 18, 2025 /PRNewswire/ — Caliber, the newly launched multi-platform parent company of The News Movement (TNM), The Recount, Capsule, and The Caliber Collective, today announced its formation, set to define a new era of journalism in a digital-first culture.

    Under the guidance of Ramin Beheshti, co-founder and CEO, Caliber reaches more than 100 million users each month through its growing family of socially native, creator-led, and social-first brands. These include TNM, Gen Z-catered news; The Recount, U.S. political news; Capsule, lifestyle and trends; and The Caliber Collective, a creative studio delivering digital campaigns for more than 25 clients, including Amazon, KFC, Planned Parenthood, and Snap.

    Later this year, Caliber will continue its expansion with the launch of its owned platform, SaySo. The news and information app will give journalistic-minded creators a new way to reach consumers, create revenue opportunities around their original content, and provide ongoing tools and support to help them thrive long-term.

    “Caliber’s long-term vision is to set a new precedent to deliver journalism that moves at the speed of culture,” said Ramin Beheshti, co-founder and CEO of Caliber. “In a world that moves fast, we are committed to telling stories that are grounded in our depth of craft. As we enter this new phase, we’re building a model that keeps pace with how people consume information today – social, short-form, and fast – but grounded in truth and responsibility. We remain as energized as ever about the role journalism plays in society and are excited to platform a multitude of storytellers across news and culture in the formats consumers seek today.”

    Founded in 2022, the company expanded in 2023 through the acquisition of The Recount and Capsule and the launch of The Collective.

    The launch of Caliber also ushers in a new generation of creator-journalists. Leading this is the appointment of Senior Correspondent Dan Ming at TNM, an Emmy-nominated correspondent and Peabody-winning producer (formerly of Vice, Netflix, and Al Jazeera), who will deliver a steady stream of high-impact, consequential and original journalism. Dan joins TNM’s expanding U.S. newsroom and creator studio, now based in the company’s new Flatiron location in New York.

    This momentum is further fuelled by The Recount, which is cultivating emerging talent such as Grace Weinstein. With a following of more than 100,000, Grace just last week launched “Who Broke It?” – a new newsletter examining the creator economy across the political spectrum.

    About Caliber
    Caliber is a media company built to define a new era for journalism. All the brands in the Caliber family are shaped to reimagine how stories are created, shared and valued. We believe that modern audiences need to be met on their terms, in their tone and on their time and we do that by supporting storytellers with the tools, training and rigor to shape the world with integrity.

    With newsrooms in New York and London, we are supported by a global network of creators who are trained in the rigor and craft of journalism, vetted by senior editorial talent and supported by a leading production team – all working together to cut through with purpose, context and credibility. From breaking news to emerging trends, we deliver stories that matter, shaped by robust measurement and a deep understanding of digital platforms.

    SOURCE Caliber

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  • Concentrix Launches Agentic Operating Framework™ to Help Enterprises Solve Key Issues Behind Failed AI Deployments

    Concentrix Launches Agentic Operating Framework™ to Help Enterprises Solve Key Issues Behind Failed AI Deployments

    NEWARK, Calif., Sept. 18, 2025 (GLOBE NEWSWIRE) — Concentrix Corporation (NASDAQ: CNXC), a global technology and services leader, today announced the launch of its Agentic Operating Framework, optimized to help enterprises overcome the common problems behind the widespread AI pilot failures in businesses today.

    Building on decades of expertise earned by helping the world’s best brands create differentiated customer experiences, the Agentic Operating Framework combines cutting-edge technologies with deep consulting capabilities to move AI from failed pilots to real operational impact.

    The Framework delivers a full ecosystem of agentic AI services—from readiness and strategy to brand-aligned language models, agentic engineering, data management, and monitoring— integrating Concentrix’ technology-agnostic approach with strategic partners and proprietary iX suite of products. Agentic Value Maps™ pinpoint and prioritize the highest-value opportunities for human and AI collaboration to help clients scale AI with confidence, aligned for growth and performance.

    Unlike typical AI solutions that stop at bots or tools, Concentrix’ Framework opens up new end-to-end planning capabilities that address the big picture, intelligently transforming overall business processes with AI integrations at the core. With expert guidance and agentic AI that can work independently or alongside humans, the Framework helps clients break down data silos, set clear outcomes, build the right processes, and equip teams with the skills and trust they need to succeed.

    Concentrix has worked with early adopter clients to turn AI potential into measurable outcomes, including a leading North American airline where a customer experience (CX) strategy assessment led to an agentic AI transformation roadmap that maintained the airline’s human-touch approach while unlocking $150M in potential new revenue and $45.8M in cost-saving ROI through automation and CX redesign.

    “Concentrix is among the few organizations to successfully use AI and automation at scale, both across our own global operations, and for many of our clients. While many enterprises are struggling to get pilot projects off the ground, Concentrix is helping clients shift from just implementing technology to fully operational AI,” said Ryan Peterson, EVP and Chief Product Officer at Concentrix. “Businesses want repeatable, scalable paths to outcomes and through the technology and services in our agentic framework, our experts design, build and run a playbook that delivers.”

    Learn more about the Agentic Operating Framework, available globally, today.

    About us: Powering a World That Works
    Concentrix Corporation (NASDAQ: CNXC), a Fortune 500® company, is the global technology and services leader that powers the world’s best brands, today and into the future. We’re solution-focused, tech-powered, intelligence-fueled. Every day, we design, build, and run fully integrated, end-to-end solutions at speed and scale across the entire enterprise, helping over 2,000 clients solve their toughest business challenges. With unique data and insights, deep industry expertise, and advanced technology solutions, we’re the intelligent transformation partner that powers a world that works, helping companies become refreshingly simple to work, interact, and transact with. Delivering outcomes unimagined across every major vertical in 70+ markets. Virtually everywhere. Visit concentrix.com to learn more. 

    Media Contact:
    Marketing & Communications
    Concentrix Corporation
    [email protected]

    From Fortune. ©2025 Fortune Media (USA) Corporation. All rights reserved. Used under license. Fortune and Fortune 500 are registered trademarks of Fortune Media (USA) Corporation and are used under license. Fortune and Fortune Media (USA) Corporation are not affiliated with, and do not endorse products or services of, Concentrix.

    Safe Harbor Statement
    This news release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements include, but are not limited to, statements regarding the company’s capabilities and positioning to deliver business outcomes and solve challenges for its clients, including AI deployment successes, operational impacts, revenue growth, and return on investment, and statements that include words such as believe, expect, may, will, provide, could and should and other similar expressions. These forward-looking statements are inherently uncertain and involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, risks related to the company’s ability to successfully execute its strategy, competitive conditions in the company’s industry, and other factors contained in the Company’s Annual Report on Form 10-K for the fiscal year ended November 30, 2024 filed with the Securities and Exchange Commission and subsequent SEC filings. We do not undertake a duty to update forward-looking statements, which speak only as of the date on which they are made.

    Copyright © 2025 Concentrix Corporation and its subsidiaries. All rights reserved. Concentrix, the Concentrix logo, and all other Concentrix company, product and services word and design marks and slogans are trademarks or registered trademarks of Concentrix Corporation and its subsidiaries. Other names and marks are the property of their respective owners. All rights reserved.

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  • World Athletics Championships 2025: Sydney McLaughlin-Levrone scorches to women’s 400m gold; just misses world record

    World Athletics Championships 2025: Sydney McLaughlin-Levrone scorches to women’s 400m gold; just misses world record

    Sydney McLaughlin-Levrone has won the women’s 400m gold in the falling rain at the World Athletics Championships in Tokyo on Thursday 18 September.

    Having claimed two Olympic golds and a world title in the 400m hurdles, the 26-year-old has secured her first global title in the flat event, crossing the line in a time of 47.78 seconds, just outside the 40-year-old world record of Marita Koch (47.60).

    While she may have missed out on that bit of history, her run did break the world championships record from 1983, and was the second-fastest time in history.

    Olympic champion Marileidy Paulino of Dominican Republic won silver in 47.98, while Salwa Eid Naser of Bahrain claimed bronze in 48.19.

    McLaughlin-Levrone only confirmed she would compete in the 400m flat in the weeks leading up to these championships. However, having broken the U.S. record and set a world lead in the semi-finals, her gold medal this evening will go down as one of the most remarkable achievements in recent athletics history.

    More to follow…

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  • Benford’s Law Spotlighted as a Practical Early Warning Tool to Help Identify Fraud at PayrollOrg’s Annual Leaders Conference

    Payroll fraud remains a persistent risk for employers—and analytics is increasingly central to the response. According to the Association of Certified Fraud Examiners (ACFE), payroll fraud is among the most common forms of occupational fraud, and 64% of organizations expand their use of data monitoring and analytics after experiencing an incident. That backdrop shaped discussions during one of the programs at the 2025 PayrollOrg Leaders Conference, where attendees examined how statistical techniques can enhance payroll oversight without disrupting operations.

    In a session on foundational payroll analytics, Candace White, CPP, Director of Payroll Administration and Training, highlighted Benford’s Law as a practical early-warning tool for identifying potential fraud. Long used by forensic accountants and cited in IRS analytics, the technique helps payroll teams flag anomalies in transactional data for deeper review. White emphasized that Benford’s Law is a screening method—not a conclusion—designed to guide attention toward areas that may warrant further investigation.

    What Benford’s Law Shows—and Why It Matters

    Benford’s Law observes that in many naturally occurring datasets spanning several orders of magnitude, smaller leading digits appear more frequently. For example, the digit 1 appears as the first digit about 30% of the time, while 9 leads fewer than 5% of values. This logarithmic distribution often holds in transactional data not bounded by fixed price points or policies.

    • Payroll relevance: Categories such as overtime, manual checks, adjustments, and reimbursements can meet Benford’s conditions, especially when values vary widely across employees, pay periods, and locations. If leading-digit frequencies in these categories diverge significantly from the expected pattern—or from an organization’s historical baselines—that discrepancy can justify targeted follow-up.
    • IRS application: The IRS has publicly discussed using Benford-type tests in its risk models, including on Schedule C expenses for sole proprietors. Unusual clustering of high leading digits (such as 8s and 9s) may indicate fabricated or inflated amounts and can prompt additional scrutiny. White noted that payroll teams can apply similar logic to internal datasets—such as scanning overtime or adjustment amounts at the department level—then reviewing outliers in context, including policy changes, seasonality, or staffing shifts.

    A Documented Pattern in Payroll Investigations

    Forensic accounting literature, including Benford’s Law: Applications for Forensic Accounting, Auditing, and Fraud Detection by Mark J. Nigrini, documents cases where an overrepresentation of high leading digits in payment amounts signaled potential manipulation. In one example, repeated amounts such as 9,500 or 9,800 drove an abnormal share of 9-leading transactions, ultimately helping investigators focus on a small subset of suspicious payments and uncover a scheme involving fictitious payees.

    The takeaway for payroll practitioners: Benford’s Law can compress a large review into a manageable set of transactions that merit closer inspection.

    Limits—and How to Use It Responsibly

    • Best-fit datasets: Benford’s Law performs best on large, heterogeneous datasets that are not artificially constrained. Small samples or narrow ranges—such as fixed stipends or standardized allowances—may be poor candidates and can produce misleading signals.
    • Context is critical: Legitimate business events—mergers, wage-scale changes, retro pay, or bonus programs—can shift digit patterns. Analysts should corroborate anomalies with policy documentation, timekeeping logs, and approvals.
    • Not a standalone test: Treat Benford’s results as triage. Pair them with trend analysis, peer-group comparisons, user access reviews, segregation-of-duties checks, and follow-up inquiries.

    How Payroll Teams Can Put It to Work

    • Start with the right categories: Overtime, supplemental pay, manual checks, off-cycle payments, adjustments, reimbursements, and vendor-like payees (e.g., garnishment remitters) often yield informative patterns.
    • Establish baselines: Compare current-period leading-digit distributions to both Benford’s expected frequencies and your organization’s historical distributions by business unit and pay group.
    • Investigate outliers methodically: For digits or categories that deviate materially, review source documentation, approval chains, user activity, and timing. Look for repeat amounts, round numbers near policy thresholds, and concentration by preparer or approver.
    • Automate and monitor: Build recurring reports or dashboards that compute leading-digit frequencies and flag deviations beyond defined thresholds. Include explanatory notes so operational changes don’t trigger unnecessary alerts.
    • Document decisions: Record why an anomaly was escalated or cleared to strengthen your control environment and support audit readiness.

    The Bottom Line

    As White reminded attendees, Benford’s Law is not a fraud detector—it’s a filter that helps professionals focus their attention. With the IRS and forensic practitioners using leading-digit analysis as part of broader analytics programs, payroll departments, professionals, and practitioners can adopt similar, measured approaches to improve detection, streamline audits, and reinforce controls.

    In a landscape where payroll fraud remains a top operational risk—and most organizations expand analytics only after an incident—the 2025 PayrollOrg Leaders Conference underscored that responsibly applied simple statistical screens can meaningfully strengthen payroll integrity.

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  • Liverpool late winners: Arne Slot’s team’s goals analysed with data

    Liverpool late winners: Arne Slot’s team’s goals analysed with data

    The Reds’ late wins this season have come about in a variety of circumstances.

    Against Bournemouth and Atletico they were comfortably on top and built a two-goal advantage, before throwing away cheap goals and ultimately rectifying the situation after piling on the pressure.

    At 10-man Newcastle they also threw away a two-goal lead – but their late winner came against the run of play.

    And against Arsenal and Burnley they struggled to create clear-cut opportunities against resolute defences, ultimately prevailing thanks to set-pieces.

    There is no blueprint by which Liverpool are earning these victories, then.

    But looking at the way the goals have come about perhaps gives some insight into why they’re happening.

    Liverpool’s squad has been significantly overhauled since Klopp set about revamping their midfield in the summer of 2023. Only nine members of the first-team squad that finished the 2022-23 season remain.

    The revitalised group is led by a small collection of senior players who won every trophy on offer under Klopp – Alisson, Van Dijk, Andy Robertson, and Salah.

    The last of those has generated the most goal involvements for this season’s late winners – scoring twice and assisting once.

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  • Nostalgic Olympic stars ‘inspired’ during Milano Figure Skating Qualifier 2025 practice

    Nostalgic Olympic stars ‘inspired’ during Milano Figure Skating Qualifier 2025 practice

    A full team for USA at the Olympics? Shin and Nagy want to end a 41-year-long wait

    For Audrey Shin and Balasz Nagy, the mission at the 2025 ISU Skate to Milano Figure Skating Qualifier is not only to prove that they deserve to be on the Olympic stage along with the world’s best pairs skaters, but also to recapture a milestone for Team USA.

    If they manage to obtain a quota for their National Olympic Committee at this event, it would be the first time that the United States will send a full team to the Olympic Games since Sarajevo 1984. USA already have three skaters qualified in the men’s and women’s singles, three ice dance couples and two pairs.

    It’s been a steep learning curve for Shin and Nagy who only teamed up in 2024. Before that, Shin was competing in singles skating.

    “It’s kind of hard to believe because when I was doing singles, I was still watching Beijing 2022 (and thinking) maybe I can make it there, but now I’m here in Beijing trying to get the spot in the pairs discipline,” she told Olympics.com. “It’s been lots of ups and downs, but it’s been super exciting and, all the hard work, I’m excited to show it here.”

    While USA athletes are used to being part of a large delegation at any figure skating event, the qualifier in Beijing has an entirely different feel. Here Shin and Nagy are the only USA skaters competing – an unusual circumstance that they were both quick to notice.

    “It’s so weird,” Shin said. “Even when we were doing our team meeting, it took like 30 seconds.”

    Her skating partner, on the other hand, is enjoying every minute of representing the USA flag in relative solitude.

    “I love it,” Nagy said with a laugh. “I’m getting royal treatment!”

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  • Tiny protein pairs may hold the secret to life’s origin

    Tiny protein pairs may hold the secret to life’s origin

    Genes are the building blocks of life, and the genetic code provides the instructions for the complex processes that make organisms function. But how and why did it come to be the way it is? A recent study from the University of Illinois Urbana-Champaign sheds new light on the origin and evolution of the genetic code, providing valuable insights for genetic engineering and bioinformatics.

    “We find the origin of the genetic code mysteriously linked to the dipeptide composition of a proteome, the collective of proteins in an organism,” said corresponding author Gustavo Caetano-Anollés, professor in the Department of Crop Sciences, the Carl R. Woese Institute for Genomic Biology, and Biomedical and Translation Sciences of Carle Illinois College of Medicine at U. of I.

    Caetano-Anollés’ work focuses on phylogenomics, which is the study of evolutionary relationships between the genomes of organisms. His research team previously built phylogenetic trees mapping the evolutionary timelines of protein domains (structural units in proteins) and transfer RNA (tRNA), an RNA molecule that delivers amino acids to the ribosome during protein synthesis. In this study, they explored the evolution of dipeptide sequences (basic modules of two amino acids linked by a peptide bond), finding the histories of domains, tRNA, and dipeptides all match.

    Life on Earth began 3.8 billion years ago, but genes and the genetic code did not emerge until 800,000 million years later, and there are competing theories about how it happened.

    Some scientists believe RNA-based enzymatic activity came first, while others suggest proteins first started working together. The research of Caetano-Anollés and his colleagues over the past decades supports the latter view, showing that ribosomal proteins and tRNA interactions appeared later in the evolutionary timeline.

    Life runs on two codes that work hand in hand, Caetano-Anollés explained. The genetic code stores instructions in nucleic acids (DNA and RNA), while the protein code tells enzymes and other molecules how to keep cells alive and running. Bridging the two is the ribosome, the cell’s protein factory, which assembles amino acids carried by tRNA molecules into proteins. The enzymes that load the amino acids onto the tRNAs are called aminoacyl tRNA synthetases. These synthetase enzymes serve as guardians of the genetic code, monitoring that everything works properly.

    “Why does life rely on two languages – one for genes and one for proteins?” Caetano-Anollés asked. “We still don’t know why this dual system exists or what drives the connection between the two. The drivers couldn’t be in RNA, which is functionally clumsy. Proteins, on the other hand, are experts in operating the sophisticated molecular machinery of the cell.”

    The proteome appeared to be a better fit to hold the early history of the genetic code, with dipeptides playing a particularly significant role as early structural modules of proteins. There are 400 possible dipeptide combinations whose abundances vary across different organisms.

    The research team analyzed a dataset of 4.3 billion dipeptide sequences across 1,561 proteomes representing organisms from the three superkingdoms of life: Archaea, Bacteria, and Eukarya. They used the information to construct a phylogenetic tree and a chronology of dipeptide evolution. They also mapped the dipeptides to a tree of protein structural domains to see if similar patterns arose.

    In previous work, the researchers had built a phylogeny of tRNA that helped provide a timeline of the entry of amino acids into the genetic code, categorizing amino acids into three groups based on when they appeared. The oldest were Group 1, which included tyrosine, serine, and leucine, and Group 2, with 8 additional amino acids. These two groups were associated with the origin of editing in synthetase enzymes, which corrected inaccurate loading of amino acids, and an early operational code, which established the first rules of specificity, ensuring each codon corresponds to a single amino acid. Group 3 included amino acids that came later and were linked to derived functions related to the standard genetic code.

    The team had already demonstrated the co-evolution of synthetases and tRNA in relation to the appearance of amino acids. Now, they could add dipeptides to the analysis.

    “We found the results were congruent,” Caetano-Anollés explained. “Congruence is a key concept in phylogenetic analysis. It means that a statement of evolution obtained with one type of data is confirmed by another. In this case, we examined three sources of information: protein domains, tRNAs, and dipeptide sequences. All three reveal the same progression of amino acids being added to the genetic code in a specific order.”

    Another novel finding was duality in the appearance of dipeptide pairs. Each dipeptide combines two amino acids, for example, alanine-leucine (AL), while a symmetrical one — an anti-dipeptide — has the opposite combination of leucine-alanine (LA). The two dipeptides in a pair are complementary; they can be considered mirror images of each other.

    “We found something remarkable in the phylogenetic tree,” Caetano-Anollés said. “Most dipeptide and anti-dipeptide pairs appeared very close to each other on the evolutionary timeline. This synchronicity was unanticipated. The duality reveals something fundamental about the genetic code with potentially transformative implications for biology. It suggests dipeptides were arising encoded in complementary strands of nucleic acid genomes, likely minimalistic tRNAs that interacted with primordial synthetase enzymes.”

    Dipeptides did not arise as arbitrary combinations but as critical structural elements that shaped protein folding and function. The study suggests that dipeptides represent a primordial protein code emerging in response to the structural demands of early proteins, alongside an early RNA-based operational code. This process was shaped by co-evolution, molecular editing, catalysis, and specificity, ultimately giving rise to the synthetase enzymes, the modern guardians of the genetic code.

    Uncovering the evolutionary roots of the genetic code deepens our understanding of life’s origin, and it informs modern fields such as genetic engineering, synthetic biology, and biomedical research.

    “Synthetic biology is recognizing the value of an evolutionary perspective. It strengthens genetic engineering by letting nature guide the design. Understanding the antiquity of biological components and processes is important because it highlights their resilience and resistance to change. To make meaningful modifications, it is essential to understand the constraints and underlying logic of the genetic code,” Caetano-Anollés said.

    The paper, “Tracing the origin of the genetic code and thermostability to dipeptide sequences in proteomes,” is published in the Journal of Molecular Biology Authors include Minglei Wang, M. Fayez Aziz and Gustavo Caetano-Anollés.

    The study was supported by grants from the National Science Foundation (MCB-0749836 and OISE-1132791), the United States Department of Agriculture (ILLU-802-909 and ILLU-483-625) and Blue Waters supercomputer allocations from the National Center for Supercomputing Applications to Caetano-Anollés.

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  • Kebinatshipi becomes Botswana's first men's world champion with 400m win in Tokyo | News | Tokyo 25 – worldathletics.org

    1. Kebinatshipi becomes Botswana’s first men’s world champion with 400m win in Tokyo | News | Tokyo 25  worldathletics.org
    2. How to watch 200m final at World Athletics Championships 2025  TechRadar
    3. World Athletics Championships Tokyo 2025: Busang Collen Kebinatshipi smokes another world lead to win men’s 400m gold  Olympics.com
    4. ‘The Dream’ sprints to silver medal  Trinidad Express Newspapers
    5. Team SA pin medal hopes on Zakithi Nene in 400m as Wayde van Niekerk cruise in 200m  dailynews.co.za

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