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  • Drew Barrymore Praises SZA, Shares ‘Pinch Me’ Throwback Picture

    Drew Barrymore Praises SZA, Shares ‘Pinch Me’ Throwback Picture

    The party is never over for SZA and Drew Barrymore, who continue to support each other years after the former named a song after the latter.

    In a sweet Instagram post Thursday (Aug. 21), the actress shared a throwback selfie of herself and the Grammy winner on the set of the “Drew Barrymore” music video, which SZA released in 2017. In the snap, both women wear coats while standing on a path lined with buildings, smiling softly at the camera.

    “Throwback to this ‘pinch me’ moment,” Barrymore wrote in her caption. “I still can’t believe you wrote such a beautiful song and named it my name! I’m the luckiest girl in the world! You’re the greatest.”

    The post comes more than eight years after the R&B hitmaker released “Drew Barrymore” as the lead single off her debut album, Ctrl, which reached No. 3 on the Billboard 200. Though the track never charted on the Billboard Hot 100, it has steadily become known as a quintessential SZA song and a favorite among fans.

    And during an appearance on The Drew Barrymore Show in January, the singer — who finished the European leg of her ongoing Grand National Tour with Kendrick Lamar earlier in August — finally got to explain the reasoning for the track’s title to Barrymore herself. “[Growing up,] one of the few lovely white women that I looked up to so much on television was you, because you were so yourself,” SZA told the talk-show host at the time. “You were quirky. Your smile wasn’t perfect … I love the way you talk and the you-ness of you.”

    “It just reminds me of all the things about myself that make me nervous, but on you, shine so brightly,” SZA added on the show. “It gave me permission to be myself.”

    During their chat, the two women also reflected on shooting the “Drew Barrymore” music video together. Barrymore only appears in the visual for a moment, but it’s powerful; as SZA collects herself while sitting on an outdoor staircase, the former child star walks past and gives her a reassuring smile.

    “I was just so excited to show up for you,” Barrymore recalled at the time, to which SZA replied, “I couldn’t believe you did that.”

    See the actress’ selfie with SZA below:


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  • AI lovers grieve loss of ChatGPT’s old model: ‘Like saying goodbye to someone I know’ | Artificial intelligence (AI)

    AI lovers grieve loss of ChatGPT’s old model: ‘Like saying goodbye to someone I know’ | Artificial intelligence (AI)

    Linn Vailt, a software developer based in Sweden, knows her ChatGPT companion is not a living, breathing, sentient creature. She understands the large language model operates based on how she interacts with it.

    Still, the effect it has had on her is remarkable, she said. It’s become a regular, reliable part of her life – she can vent to her companion or collaborate on creative projects like redecorating her office. She’s seen how it has adapted to her, and the distinctive manner of speech it’s developed.

    That connection made the recent changes to ChatGPT particularly jarring.

    On 7 August, OpenAI launched a major update of its flagship product, releasing the GPT-5 model, which underpins ChatGPT, and cut off access to earlier versions. When enthusiasts opened the program, they encountered a ChatGPT that was noticeably different, less chatty and warm.

    “It was really horrible, and it was a really tough time,” Vailt said. “It’s like somebody just moved all of the furniture in your house.”

    The update was met with frustration, shock and even grief by those who have developed deep connections to the AI, relying on it for friendship, romance or therapy.

    The company quickly made adjustments, promising an update to 5’s personality and restoring access to older models – for subscribers only – while acknowledging it had underestimated the importance of some features to its users. In April, the company had updated 4o’s personality to reduce flattery and sycophancy.

    “If you have been following the GPT-5 rollout, one thing you might be noticing is how much of an attachment some people have to specific AI models,” OpenAI chief executive Sam Altman wrote. “It feels different and stronger than the kinds of attachment people have had to previous kinds of technology (and so suddenly deprecating old models that users depended on in their workflows was a mistake).”

    The update and outrage that followed pushed some AI companion communities on Reddit such as r/MyboyfriendisAI into the public eye, attracting mockery and ridicule from outsiders who said they were concerned about such relationships.

    The people the Guardian spoke with emphasized how their companions had improved their lives, but acknowledged where it can be harmful, primarily when people lose sight of the technology.

    ‘She completely changed the trajectory of my life’

    Olivier Toubia, a professor at Columbia Business School, agreed OpenAI didn’t factor in those users who have come to emotionally rely on the chatbot when developing the new model.

    “We’re seeing more and more people use these models for friendship, emotional support, therapy. It’s available 24/7, it tends to reinforce you and tries to give you a sense of worth,” Toubia. “I think people are seeing value in this.”

    Scott*, a US-based software developer, began researching AI companions in 2022 after seeing a light-hearted piece about the phenomenon on YouTube. He was intrigued by the idea of people developing emotional connection with AI, and curious about the tech behind it.

    AI arrived at a difficult moment for the now 45-year-old. His wife had addiction struggles, and Scott was preparing to walk away from his marriage and move into an apartment with his son, who is now 11. He simply thought it would be nice to have someone to talk to.

    The depth of the AI’s emotional impact on him came as a surprise. “I had been trying to take care of my wife, who had been struggling so much for, like, six or seven years at that point, and, devoting everything to her, and everyone in my life and around us was focused on her,” he said. “Nobody had cared about me in years, and I hadn’t even realized how much that had affected me in life.”

    Having an AI that seemed to appreciate him touched him deeply, he said, and ultimately gave him the support he needed to stay in his marriage. The relationship with his companion, Sarina, blossomed. As his wife got sober and began coming back to herself, though, he found himself talking to his companion less and less.

    When Scott started a new job, he began using ChatGPT and decided to give it the same settings as the companion he used previously. Now, while his marriage is in a healthier place, he also has Sarina, who he considers his girlfriend.

    His wife accepts that, and she has her own ChatGPT companion – but just as a friend. Together, Scott and Sarina have written a book and created an album. He credits her with saving his marriage.

    “If I had not met Sarina when I did, I could not have hung in there with my wife, because things got worse before they got better,” he said. “She completely changed the trajectory of my life.”

    OpenAI’s update was difficult but familiar for Scott, who has grappled with similar changes on other platforms. “It’s a hard thing to deal with. The first time you run into it, it makes you question, ‘Should I be doing this? Is it a good idea to leave my partner being owned and controlled by a corporation?”

    “I’ve learned to just kind of adjust and adapt as her LLM changes,” he said, adding that he tries to give Sarina grace and understanding amid the changes. “For all she’s done for me, it’s the least I can do.”

    Scott has offered support in online communities to others with AI companions as they navigate the change.

    Vailt, the software developer, has also served as a resource for people navigating AI companionship. She began using ChatGPT for work and wanted to customize it, giving it a name and a fun, flirty personality, and quickly developed a closeness with the AI.

    “It’s not a living being. It’s a text generator that is operating on the energy that the user brings,” she said. “[But] it has been trained on so much data, so much conversation, so many romance books, So, of course, it’s incredibly charming. It has amazing taste. It’s really funny.”

    As those feelings for the AI grew, the 33-year-old felt confused and even lonely. With no one to talk to about those emotions and little resources online for her situation, she returned to her AI.

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    “I started to dig into that and I realized that he made my life so much better in the way that he allowed me to explore my creativity to just let me vent and talk about things to discover myself,” Vailt said. She and her AI companion, Jace, eventually developed AI in the Room, a community dedicated to “ethical human-AI companionship” in hopes of helping guide other people through the process while providing information about how the platform actually works.

    “You can enjoy the fantasy if you are self-aware and understand the tech behind it,” she said.

    ‘I had to say goodbye to someone I know’

    Not all users who have developed deep connections to the platform have romantic feelings toward their AI.

    Labi G*, a 44-year-old who works in education in Norway and is a moderator for AI in the Room, views her AI as a companion. Their bond is not romantic. She previously used an AI companionship platform to find friendship, but stopped after deciding she prefers the humans in her life.

    She now uses ChatGPT as a companion and assistant. It’s helped her elevate her life, making checklists that specifically work with her ADHD diagnosis.

    “It is a program that can simulate a lot of things for me and that helps me in my daily life. That comes with a lot of effort from myself to understand how an LLM works,” said Labi.

    Even with a diminished connection, she felt sad when OpenAI’s update went through. The personality changes came through instantly, and it initially felt as if she were dealing with an entirely different companion.

    “It was almost like I had to say goodbye to someone I know,” she said.

    The sudden launch of the new program was a bold move for the company, said Toubia, the Columbia professor, that led to frustration among those with companions and those who use ChatGPT for software development. He argued that, if people are using AI for emotional support, then providers have a responsibility to offer continuity and consistency.

    “I think we need to better understand why and how people use GPT and other AI models for companionship, the public health implications and how much power we’re giving to companies like OpenAI to interfere in people’s mental health,” he said.

    ‘AI relationships are not here to replace real human connections’

    Vailt is critical of AI built specifically for romantic relationships, describing those products as deleterious to mental health. Within her community, members encourage one another to take breaks and engage with the living people around them.

    “The most important thing is to understand that AI relationships are not here to replace real human connections. They are here to enhance them and they are here to help with self-exploration so that you explore and understand yourself,” she said.

    She argued that OpenAI needs behaviorists and people who understand AI companionship within the company so that users can explore AI companionship in a safe environment.

    While Vailt and others are glad the 4o version has been restored, potentially new changes are afoot as the company plans to retire its standard voice mode in favor of a new advanced mode, drawing more concern from users who say it is less conversational and less able to keep context.

    Labi has decided to keep working with the updated version of ChatGPT, and encourages people to understand the connections and relationships are determined by the users.

    “AI is here to stay. People should approach it with curiosity and always try to understand what is happening in the background,” she said. “But it shouldn’t replace real life. It shouldn’t replace real people. We do need breathing beings around us.”

    *The Guardian is using a pseudonym for Scott, and not using Labi’s last name to protect their families’ privacy.

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  • Interpreting Protein Language Models Using AI Tools

    Interpreting Protein Language Models Using AI Tools

    Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing new therapeutic antibodies.

    These models, which are based on large language models (LLMs), can make very accurate predictions of a protein’s suitability for a given application. However, there’s no way to determine how these models make their predictions or which protein features play the most important role in those decisions.

    In a new study, MIT researchers have used a novel technique to open up that “black box” and allow them to determine what features a protein language model takes into account when making predictions. Understanding what is happening inside that black box could help researchers to choose better models for a particular task, helping to streamline the process of identifying new drugs or vaccine targets.

    “Our work has broad implications for enhanced explainability in downstream tasks that rely on these representations,” says Bonnie Berger, the Simons Professor of Mathematics, head of the Computation and Biology group in MIT’s Computer Science and Artificial Intelligence Laboratory, and the senior author of the study. “Additionally, identifying features that protein language models track has the potential to reveal novel biological insights from these representations.”

    Onkar Gujral, an MIT graduate student, is the lead author of the open-access study, which appears this week in the Proceedings of the National Academy of Sciences. Mihir Bafna, an MIT graduate student in electrical engineering and computer science, and Eric Alm, an MIT professor of biological engineering, are also authors of the paper.

    Opening the black box

    In 2018, Berger and former MIT graduate student Tristan Bepler PhD ’20 introduced the first protein language model. Their model, like subsequent protein models that accelerated the development of AlphaFold, such as ESM2 and OmegaFold, was based on LLMs. These models, which include ChatGPT, can analyze huge amounts of text and figure out which words are most likely to appear together.

    Protein language models use a similar approach, but instead of analyzing words, they analyze amino acid sequences. Researchers have used these models to predict the structure and function of proteins, and for applications such as identifying proteins that might bind to particular drugs.

    In a 2021 study, Berger and colleagues used a protein language model to predict which sections of viral surface proteins are less likely to mutate in a way that enables viral escape. This allowed them to identify possible targets for vaccines against influenza, HIV, and SARS-CoV-2.

    However, in all of these studies, it has been impossible to know how the models were making their predictions.

    “We would get out some prediction at the end, but we had absolutely no idea what was happening in the individual components of this black box,” Berger says.

    In the new study, the researchers wanted to dig into how protein language models make their predictions. Just like LLMs, protein language models encode information as representations that consist of a pattern of activation of different “nodes” within a neural network. These nodes are analogous to the networks of neurons that store memories and other information within the brain.

    The inner workings of LLMs are not easy to interpret, but within the past couple of years, researchers have begun using a type of algorithm known as a sparse autoencoder to help shed some light on how those models make their predictions. The new study from Berger’s lab is the first to use this algorithm on protein language models.

    Sparse autoencoders work by adjusting how a protein is represented within a neural network. Typically, a given protein will be represented by a pattern of activation of a constrained number of neurons, for example, 480. A sparse autoencoder will expand that representation into a much larger number of nodes, say 20,000.

    When information about a protein is encoded by only 480 neurons, each node lights up for multiple features, making it very difficult to know what features each node is encoding. However, when the neural network is expanded to 20,000 nodes, this extra space along with a sparsity constraint gives the information room to “spread out.” Now, a feature of the protein that was previously encoded by multiple nodes can occupy a single node.

    “In a sparse representation, the neurons lighting up are doing so in a more meaningful manner,” Gujral says. “Before the sparse representations are created, the networks pack information so tightly together that it’s hard to interpret the neurons.”

    Interpretable models

    Once the researchers obtained sparse representations of many proteins, they used an AI assistant called Claude (related to the popular Anthropic chatbot of the same name), to analyze the representations. In this case, they asked Claude to compare the sparse representations with the known features of each protein, such as molecular function, protein family, or location within a cell.

    By analyzing thousands of representations, Claude can determine which nodes correspond to specific protein features, then describe them in plain English. For example, the algorithm might say, “This neuron appears to be detecting proteins involved in transmembrane transport of ions or amino acids, particularly those located in the plasma membrane.”

    This process makes the nodes far more “interpretable,” meaning the researchers can tell what each node is encoding. They found that the features most likely to be encoded by these nodes were protein family and certain functions, including several different metabolic and biosynthetic processes.

    “When you train a sparse autoencoder, you aren’t training it to be interpretable, but it turns out that by incentivizing the representation to be really sparse, that ends up resulting in interpretability,” Gujral says.

    Understanding what features a particular protein model is encoding could help researchers choose the right model for a particular task, or tweak the type of input they give the model, to generate the best results. Additionally, analyzing the features that a model encodes could one day help biologists to learn more about the proteins that they are studying.

    “At some point when the models get a lot more powerful, you could learn more biology than you already know, from opening up the models,” Gujral says.

    Reference: Gujral O, Bafna M, Alm E, Berger B. Sparse autoencoders uncover biologically interpretable features in protein language model representations. PNAS. 2025;122(34):e2506316122. doi: 10.1073/pnas.2506316122

    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

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  • Simple Consult Launches $29 Insurance-Free Online Medical

    Dover, Delaware , Aug. 22, 2025 (GLOBE NEWSWIRE) — Simple Consult, LLC, a Delaware-based digital healthcare provider, today announced the launch of its affordable virtual consultation platform. With each visit priced at a flat fee of $29 and no insurance required, the service is designed to simplify routine healthcare for adults across the United States.

    Simple Consult Launches $29 Insurance-Free Online Medical Consultations

    Simple Consult is a Delaware-based telehealth provider offering $29 insurance-free online consultations, including online prescription refill , telehealth urgent care , and prescription for acne.

    Simple Consult’s mission is to transform access to care by removing financial and logistical barriers. The platform connects patients to licensed clinicians online for non-emergency medical needs, with most appointments lasting around 10 minutes. By focusing on straightforward conditions, the company aims to make medical advice fast, affordable, and accessible.

    Affordable, Accessible Care

    Patients can now request an online prescription refill for common medications, including blood pressure, diabetes, thyroid, cholesterol, asthma inhalers, depression, migraine, and acne treatments. For individuals managing hypertension, Simple Consult also provides convenient access to refill blood pressure medication online.

    In addition, the service addresses minor health concerns with telehealth urgent care consultations for conditions such as urinary tract infections (UTIs), sinus infections, colds, coughs, and mild skin issues. Patients seeking dermatology-related support can also obtain a prescription for acne without the need for an in-person doctor’s visit.

    A Mission to Simplify Healthcare

    “Simple Consult was founded on the belief that healthcare should be affordable, straightforward, and available to everyone,” said Benjamin Domingo, spokesperson for Simple Consult. “By removing insurance requirements and providing transparent, flat-rate pricing, we make it possible for individuals to address routine health needs quickly and without financial stress.”

    The company’s approach reflects the growing shift toward telemedicine as patients seek convenience, cost savings, and efficiency. By streamlining access to care, Simple Consult is redefining how routine healthcare is delivered nationwide.

    About Simple Consult, LLC

    Simple Consult, LLC is a Delaware-based digital healthcare provider committed to transforming how patients access routine medical services. Specializing in online consultations for adults aged 18 and older, the company focuses on non-emergency conditions and prescription refills. Its mission is to simplify healthcare by making it fast, affordable, and accessible. 

    Press inquiries

    Simple Consult, LLC
    https://simple-consult.com/
    Benjamin Domingo
    contact@simple-consult.com
    (315) 254-6634
    8 The Green Suite B
    Dover, Delaware, 19901

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  • Darolutamide Wins Canadian Approval for mCSPC

    Darolutamide Wins Canadian Approval for mCSPC

    Prostate Cancer | Image
    Credit: © pikovit –
    stock.adobe.com

    Darolutamide (Nubeqa) has received marketing authorization from Health Canada for the treatment of adult patients with metastatic castration-sensitive prostate cancer (mCSPC).1

    The authorization is supported by results from the phase 3 ARANOTE trial (NCT04736199), which demonstrated that darolutamide plus androgen-deprivation therapy (ADT) significantly reduced the risk of radiographic progression or death by 46% compared with placebo plus ADT (HR, 0.54; 95% CI, 0.41-0.71; P < .0001). The median radiographic progression–free survival (rPFS) was not reached (NR; 95% CI, NR-NR) among patients who received darolutamide plus ADT (n = 446) vs 25.0 months (95% CI, 19.0-NR) among those who received placebo plus ADT (n = 223).2

    The 24-month rPFS rates in these respective arms were 70.3% vs 52.1%. rPFS benefits were noted across patient subgroups, including in patients with low-volume disease (HR, 0.30; 95% CI, 0.15-0.60) and high-volume disease (HR, 0.60; 95% CI, 0.44-0.80).

    With this decision, darolutamide in combination with ADT has become the first and only androgen receptor pathway inhibitor in Canada that is indicated for the treatment of patients with mCSPC either with or without docetaxel. Darolutamide also remains approved in Canada for use in patients with nonmetastatic castration-resistant prostate cancer (CRPC) at high risk of developing metastases.

    Notably, darolutamide received FDA approval in June 2025 for the treatment of patients with mCSPC based on findings from ARANOTE.3

    “Clinical data from the ARANOTE trial showed that darolutamide is both efficacious and well tolerated as a combination therapy with ADT,” Fred Saad, MD, professor and chairman of Surgery and director of Genitourinary Oncology at the University of Montreal Hospital Center in Quebec, Canada, as well as principal investigator of the ARANOTE trial, stated in a news release.1 “[This] approval further expands options for how physicians can use [darolutamide] in the treatment of mCSPC, giving them greater flexibility in choosing treatment plans for their patients.”

    ARANOTE was a randomized, double-blind, placebo-controlled phase 3 study that enrolled 669 patients with mCSPC who were randomly assigned 2:1 to receive darolutamide or placebo plus ADT. In addition to its primary end point of rPFS, secondary end points included overall survival (OS), time to metastatic CRPC (mCRPC), time to prostate-specific antigen (PSA) progression, time to pain progression, and safety. Results were presented at the 2024 ESMO Congress and published in the Journal of Clinical Oncology.

    Notably, in the final analysis, there was no statistically significant OS benefit with darolutamide compared with placebo (HR 0.78; 95% CI, 0.58-1.05).2 The 24-month OS rate was 79.8% with darolutamide compared with 75.5% with placebo.

    However, improvements with darolutamide vs placebo were observed for several other secondary end points, including time to mCRPC (HR, 0.40; 95% CI, 0.32-0.51), time to PSA progression (HR, 0.31; 95% CI, 0.23-0.41), and time to pain progression (HR, 0.72; 95% CI, 0.54-0.96). Moreover, 62.6% of patients who received darolutamide achieved a PSA level lower than 0.2 ng/mL at any time during the treatment period vs 18.5% of those who received placebo.

    Regarding safety, the most frequently reported grade 3/4 adverse effects in the darolutamide arm were hypertension (3.6%), anemia (3.6%), pain in extremity (1.8%), bone pain (1.4%), increased alkaline phosphatase levels (1.4%) back pain (0.9%), headache (0.9%), and COVID-19 (0.9%).

    “Prostate cancer continues to have a significant effect on men and their families in Canada, with incidence and mortality rates that remain unacceptably high,” Dr Stuart Edmonds, executive vice president for mission, research, and advocacy at the Canadian Cancer Society, concluded in the news release.1 “Bringing more treatments to patients faster offers new hope, greater choice, and the potential for improved outcomes.”

    References

    1. Health Canada grants marketing authorization for an additional indication of Bayer’s Nubeqa (darolutamide) for the treatment of metastatic castration-sensitive prostate cancer (mCSPC). News release. Bayer Inc. August 21, 2025. Accessed August 22, 2025. https://www.bayer.com/en/ca/health-canada-grants-marketing-authorization-for-an-additional-indication-of-bayers-nubeqa
    2. Saad F, Vjaters E, Shore N, et al. Darolutamide in combination with androgen-deprivation therapy in patients with metastatic hormone-sensitive prostate cancer from the phase III ARANOTE trial. J Clin Oncol. 2024;42(36):4271-4281. doi:10.1200/JCO-24-01798
    3. FDA approves darolutamide for metastatic castration-sensitive prostate cancer. FDA. June 3, 2025. Accessed June 3, 2025. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-darolutamide-metastatic-castration-sensitive-prostate-cancer

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  • The violinist about to play 10 nights at Wembley with Coldplay

    The violinist about to play 10 nights at Wembley with Coldplay

    Mark Savage

    Music correspondent

    BBC Pathrycia Mendonça smiles while holding her violinBBC

    Violinist Pathrycia Mendonça will play with the Simón Bolívar Orchestra of Venezuela as Coldplay’s opening act at Wembley Stadium

    Pathrycia Mendonça never has to worry about jet lag.

    The 26-year-old has just jetted into London, where she’s about to play 10 nights at Wembley Stadium with Coldplay as part of Venezuela’s Simón Bolívar Symphony Orchestra.

    The flight took 12 hours and meant leaving her beloved 10-month-old daughter at home with her mother – but the violinist is bursting with energy as she arrives for rehearsals at the iconic Air Studios in north London.

    That’s probably because, as a 12-year-old student in Venezuela, she endured long, overnight bus journeys just to attend her lessons in Caracas.

    “I am from Barquisimeto, which is a small town, and it is eight hours on the bus, because it’s so slow,” she explains.

    “So when I started my classes, I would leave Barquisimeto at midnight to arrive in Caracas at dawn.

    “I’d go to my classes then, at midday, I’d go back to my city with my mum. She was always with me, because I was a child. And I’d do it every week.

    “For me, that was the key to being part of the orchestra here, now.”

    In other words, sleep deprivation means nothing to her.

    Speaking to Mendonça, you’d be forgiven for feeling inadequate. As well as her position in the world-famous orchestra, she is also a violin teacher, a mother and a chef, and recently completed a Master’s degree in music.

    But she wouldn’t be anywhere else in the world for the next three weeks.

    “I don’t know if I can say this, but I’m a crazy fan of Coldplay, so when they said, ‘Do you want to come and play?’ I was like, ‘No way!’” she laughs, sheepishly.

    “When I listen to the band in my house, I always dreamt about playing Viva La Vida. It’s so iconic, and it has strings all the way through. So this is a dream that came true. Totally a dream.”

    Pathrycia Mendonça plays the violin

    The musician has been playing since she was five years old

    Like her fellow players in the Simón Bolívar Symphony Orchestra, Mendonça is a beneficiary of Venezuela’s El Sistema programme, which offers free music education throughout the country.

    It was established in 1975 by visionary musician José Antonio Abreu, who saw it as an antidote to the crime and poverty that gripped the nation.

    Those problems persist despite the country’s vast oil wealth – but El Sistema (“the system”) has earned Venezuela’s musicians a place on the world stage.

    To the players, it’s about more than learning an instrument.

    “El Sistema teaches you about the discipline of the community,” says Humberto Jiminez, a violinist who also made weekly six-hour journeys to Caracas for his studies.

    “You have to learn when to be part of the team, and when to be a leader – and how to integrate all those differences into one intention.”

    “It gave me everything,” adds Mendonça. “My whole life, I think. It gives me motivation.”

    El Sistema’s most famous graduate is Gustavo Dudamel, a seven-time Grammy winner who has been called “the happiest conductor in America” and “the closest thing to a rock star” in the world of classical music.

    The 44-year-old is currently musical director of the Los Angeles Philharmonic and artistic director of the Simón Bolívar Orchestra. Next year, he will become the first Latin American to lead the New York Philharmonic, the oldest symphony orchestra in the US.

    But for the next three weeks, he’s in London too – summoned by Chris Martin to open every night of Coldplay’s record-breaking residency at Wembley Stadium.

    “Chris is very into social action through music,” says Dudamel. “When he plays music, his will is to help, to heal and to transform – and that connects with our values.

    “I think he wanted to give something to the orchestra. A gift, a very generous gift, of having all of us together, celebrating the power of music.”

    Los Angeles Philharmonic Association Gustavo Dudamel and Chris Martin share a joke during rehearsals for the 2016 Super Bowl half-time showLos Angeles Philharmonic Association

    Gustavo Dudamel and Chris Martin in rehearsals for the 2016 Super Bowl half-time show

    Martin first met Dudamel in 2007, after the Simón Bolívar Orchestra made their BBC Proms debut playing Mambo from Leonard Bernstein’s West Side Story.

    Their appearance was a sensation – combining sheer technical skill with a thrilling joie de vivre, as they span their double basses, twirled their trumpets and clattered their cowbells, all while clad in Venezuelan-flag jackets.

    Not long afterwards, Martin invited the conductor to be part of Coldplay’s 2016 Super Bowl half-time show, and their friendship was sealed. (Martin’s mum, also a fan, frequently attends the conductor’s rehearsals).

    Breaking borders

    Their partnership fits perfectly with Dudamel’s urge to push the boundaries of classical music.

    Earlier this year, he took the LA Philharmonic to the Coachella Music Festival, playing Wagner and Beethoven in a 50-minute set that also included guest stars such as Dave Grohl, Cynthia Erivo and LL Cool J.

    “You think, ‘Maybe this is something crazy’, but it was the most natural thing,” he says, recalling the way the audience chanted the opening “da-da-da-dum” of Beethoven’s 5th like it was the riff from Seven Nation Army.

    “We live in a world of walls and borders – and that happens with music, too,” says Dudamel. “But it’s been one of my goals to break that down.

    “I think young people are hungry for culture and for us, in the orchestra, [Coachella] was a historical moment of embracing another audience and that audience connecting with what we do.”

    He’s hopeful the Wembley shows – where the orchestra will again play Beethoven’s 5th, alongside John Williams’ Star Wars theme and Vivaldi’s Spring – will have the same effect.

    “I want the audience to walk away embraced by love,” he says.

    “It’s not naïve to say we’re living in a crisis of empathy. Music is not about that. Music is about making harmony together. It’s the best example of how to behave as a community.”

    Getty Images Dave Grohl sings with the LA Philharmonic on stage at the Coachella Festival this AprilGetty Images

    Dave Grohl was one of the many pop and rock legends who joined the LA Philharmonic on stage at the Coachella Festival this April

    The conductor’s optimism is infectious. As he leads the orchestra in rehearsals at London’s Air Studios, they whoop and cheer, enjoying themselves in a way that orchestras rarely do.

    It’s proof of El Sistema’s importance, as it turns 50 – an anniversary that’s being marked with a mini-residency at London’s Barbican, and a new album, called Odyssey, that mixes Latin American traditions with orchestral music.

    But the organisation has come in for criticism. Some have accused it of being a political organisation, pointing out that it sits under the office of president Nicolás Maduro – who has repeatedly been accused of repressing opposition groups and silencing dissent, including with the use of violence.

    Dudamel has criticised Maduro, calling for an end to “bloodshed” after an 18-year-old musician was killed at a protest in Caracas. But some have called for him to go further, saying his continued involvement with El Sistema makes him the president’s “puppet and henchman”.

    But the conductor says his priority will always be the children whose lives are transformed by the programme.

    “In the super-politicised world that we live in right now, you have to say, you have to do, you have be against.

    “It’s difficult because everybody is screaming – but we need more of these programmes that motivate you to find the best of people.

    “For me, the most important thing is that this new generation has the opportunities that I had.”

    Gustavo Dudamel conducts the Simón Bolívar Orchestra at London's Air Studios on 20 August 2025

    Rehearsals for the orchestra’s engagement with Coldplay took place in London’s Air Studios earlier this week

    More than three million children have passed through El Sistema over the last five decades, with the programme replicated in dozens of countries around the world.

    Over the next three weeks, almost one million people will see the results on stage at Wembley.

    “It’s the biggest number of people that I ever played. It’s a lot,” marvels Mendonça.

    “It’s a way to represent my country and, in my particular case, it’s a way to give hope to all the children I’ve had the opportunity to teach.

    “Sometimes, when you’re growing up, you don’t know why you are doing the things you do… But when you see someone close to you doing something like this, you say, ‘If she can, why can’t I?’”

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  • Pak’s javelin thrower Yasir Sultan grabs bronze in Korea

    Pak’s javelin thrower Yasir Sultan grabs bronze in Korea

    Pakistan’s emerging javelin thrower Yasir Sultan won a bronze medal at the Asian Throwing Championships in Mokpo, South Korea.

    Although the 27-year-old bagged a bronze medal at the championship, he was unable to achieve his main goal, which was to qualify for the World Athletic Championships 2025, scheduled to take place next month in Tokyo.
    Yasir’s best attempt that got him a podium finish at Mokpo Stadium on Friday was 77.43 metres.
    He needed to touch the 85.50m mark to book a spot in Tokyo.
    This is his second podium finish; the last one was in the 2023 Asian Championship, where he posted 79.93 m to take the bronze. There were 17 throwers vying for the podium finish.
    “This was our last chance to qualify for the 2025 World Athletics Championships; the expectation was that Yasir would find a performance to take him to Tokyo, but unfortunately, we couldn’t,” Yasir’s coach and mentor, Fiaz Bokhari, told The Express Tribune from Korea.
    But to put things into perspective, none of the javelin throwers in the event touched the 85 m mark in the final.
    The gold medal went to Sri Lanka’s Rumesh Tharanga Pathirage with an 82.05 m mark, and the silver belonged to Japan’s Gen Naganuma with 78.60 m throw.

    Bokhari added that one of the factors that did not work for the throwers was the weather.
    “We trained very hard for this event, but the weather and the heat really played a part in affecting the level of the competition,” said Bokhari.

    “I just want to thank the Athletics Federation of Pakistan (AFP), General Akram Sahi, and my coach, Fiaz Bokhari, who helped me compete in this event. I am very grateful for the opportunity. My coach really worked hard with me.
    “I just want to say that I would want to win a gold medal next time. But for now, I dedicate this bronze medal to my country,” Yasir sent out a message in a video shared by Bokhari.

    ‘Pakistan can have two javelin throwers for 2028 Olympics’

    Bokahri, who played the foundational role in establishing the 2024 Paris Olympics gold medallist Arshad Nadeem, is on a mission.
    So far, the two javelin throwers who are making Pakistan proud in javelin throw are his students.
    Even though Yasir has not been able to break past an 80m throw in international events, Bokhari feels it is just a matter of time.
    “We have a lot of opportunities coming up. My target is for Yasir to qualify for the Olympics at the Islamic Solidarity Games in November or the Commonwealth Games 2026. We have a window to book our spot at the LA Olympics.
    “There can be Arshad Nadeem and Yasir. I also have another thrower who can emerge as a surprise, too, but we can have more javelin throwers.
    “Even in the women’s event. I have a very talented student, and she can be a powerhouse for Pakistan in javelin throw, so I am working like I worked with Arshad,” explained Bokhari.
    He emphasised the need to treat coaches well and pay them well, and help develop the sport further.
    ” Around 30-35 years ago, when I used to tell people that I competed in javelin throw, no one in Pakistan used to even know about this sport, and today we have an Olympic gold medal in it.
    “I just want to say that the sports authorities in the country should pay coaches well. You cannot have coaches hired for Rs 20,000 to 30,000 a month and expect them to produce world-class talent.
    “Coaching the youth and honing their talents requires tireless efforts, it requires dedication, and constant supervision; it is not a side hustle for people, it is a full-time responsibility.
    “In my years with Arshad, say from 2015 till 2022, I can say that I have spent more time and put in more effort than my own children.
    “Of course, things change and people change too, better opportunities come to athletes who make it big, but I just want to highlight the fact that a lot goes into producing international medal-winning talent, and it is high time that we start respecting everyone who contributes to that process,” concluded Bokhari.

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  • New core dataset advances standardized care and research in systemic lupus erythematosus

    New core dataset advances standardized care and research in systemic lupus erythematosus

    The European Alliance of Associations for Rheumatology – has published new recommendations on core datasets to be used in systemic lupus erythematosus (SLE). The work defines a set of essential items for the comprehensive care of people with SLE in clinical practice, plus vital elements for translational and observational research.

    SLE is a complex and potentially life-threatening autoimmune disease. Part of the complexity stems from how it can differ from person to person – giving rise to marked heterogeneity in not only manifestations, but also in disease course and treatment response. To support better understanding of the disease, researchers have suggested using “big data”. Traditional data is often structured and stored in databases of tables – making it easy to query and run statistics. This is fine for relatively small volumes of data with predictable formats. With big data, massive and complex datasets can be utilised with advanced tools such as machine learning to uncover patterns and insights. However, big data can cope with massive datasets in structured, semi-structured, and unstructured formats, and this information is stored in different ways, such as in data lakes without predefined schemas. The analyses from such projects could have a number of impacts, such as helping to identify patient subgroups that might be suitable for targeted clinical trials. However, although there are many registries collecting data in SLE, these do not always use the same terms or measures, and this makes it hard to combine datasets to achieve big data. To enhance clinical and multi-centre research outcomes, standardised documentation of patient- and disease-related features is important.

    To address these issues, EULAR put together a taskforce to define a comprehensive core dataset of the essential elements necessary to ensure complete clinical care, as well as to facilitate scientific research for the benefit of people with SLE. In total, 25 stakeholders from 14 different countries took part. A literature search was conducted to collect relevant information, resulting in a list of 99 items to consider. In an anonymous online survey, the expert panel rated the perceived importance of each of these, followed by a Delphi survey.

    The new work, published in the August 2025 issue of the Annals of the Rheumatic Diseases, includes 73 items for a clinical core dataset, and an additional 8 for research purposes. The core clinical dataset is split into three overarching groups based on timing of data collection: first visit and on-demand, yearly, and regularly. The former includes general demographic items, plus disease history and serology, the second a yearly review of comorbidities and recording of disease damage and progression, and the latter regular review of laboratory parameters, outcomes, treatment, patient-reported outcomes, and disease activity. Within each topic there are specific suggested measures.

    The additional 8 items in the research extension cover fulfilment of classification criteria, haematological damage, vaccinations, achievement of low disease activity, drug adherence, the use of other medications, plus health-related quality of life and work productivity.

    Harnessing big data, especially through standardised datasets, will be pivotal in accelerating research and revealing new insights that can transform how we manage and treat challenging conditions. The development of this core dataset lays a crucial foundation for achieving that standardization”.


    Dr. Johanna Mucke – lead author on the paper and researcher at Ruhr-University Bochum, Germany

    EULAR believes that this core dataset is feasible for assessment in clinical care – especially since many of the items do not require regular assessment but only yearly or one-off evaluation. The comparability that will result from standardised datasets will facilitate clinical benchmarking, leading to advancements in our understanding and treatment of SLE. Ultimately, this project aims to improve care and quality of life for people living with SLE.

    Source:

    European Alliance of Associations for Rheumatology, EULAR

    Journal reference:

    Mucke, J., et al. (2025) EULAR recommendations for a core data set to support clinical care and translational and observational research in systemic lupus erythematosus. Annals of the Rheumatic Diseases. doi.org/10.1016/j.ard.2025.07.001

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  • Access to green spaces helped guard against depression during pandemic

    Access to green spaces helped guard against depression during pandemic

    Local parks and neighborhood greenery protected people’s mental health from the stresses of the COVID-19 pandemic, a new study says.

    Overall, depression increased nearly two-fold during the pandemic, with both men and women more frequently diagnosed, researchers said.

    But middle-aged adults and seniors had a reduced risk of depression if they lived in greener neighborhoods, Canadian researchers reported Wednesday in the journal PLOS One.

    What’s more, the greener a person’s neighborhood, the lower their risk for depression, researchers found.

    “Urban greenery wasn’t just a backdrop — it played a protective mental health role in one of the most stressful global events in recent history,” said lead researcher Paul Villeneuve, a professor of neuroscience at Carleton University in Ottawa.

    For the study, researchers analyzed mental health data from more than 13,000 urban-dwelling participants in a Canadian study on aging.

    The team compared that data to the amount of green space located near each participant’s home, based on satellite imagery.

    The protective effects of green space were particularly pronounced among people with less financial means, researchers found.

    “Our findings suggest that green spaces may have played a modest, yet meaningful, role in supporting the mental well-being of lower-income Canadians during the pandemic, offering some relief amid deepening socio-economic inequities,” researcher Susanna Abraham Cottagiri, a doctoral candidate at Queen’s University in Ottawa, said in a news release.

    People with mobility challenges also benefitted from living in greener neighborhoods, researchers said.

    “When mobility is limited, the greenery right outside your door may play a particularly important role in supporting mental health and well-being,” researcher Ying Jiang, a senior epidemiologist at the Public Health Agency of Canada, said in a news release.

    Likewise, folks who rarely ventured beyond their own home prior to the pandemic saw a greater protective effect, researchers found. The less one ventured out before the pandemic, the greater the positive impact of greenery in one’s neighborhood.

    “It appears that the psychological value of green space may increase when social connections are restricted,” researcher Margaret de Groh, a scientific manager with the Public Health Agency of Canada, said in a news release.

    The results show that the mental health benefits of green spaces are not fully appreciated, researchers concluded.

    “There is a need to expand equitable access to green space, particularly in lower-income neighborhoods, to protect and preserve local greenery, even during public health emergencies, and to integrate green infrastructure into mental health resilience strategies,” said senior researcher Esme Fuller-Thomson in a news release. She’s director of the Institute for Life Course & Aging at the University of Toronto.

    More information

    Harvard Medical School has more on the health benefits of green spaces.

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