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  • POT1 gene mutation linked to pulmonary fibrosis through telomere dysfunction

    POT1 gene mutation linked to pulmonary fibrosis through telomere dysfunction

    Idiopathic pulmonary fibrosis is a potentially fatal disease currently without treatment, in which lung tissue develops scarring and becomes stiff, making breathing increasingly difficult over time. The process is not yet well understood at the molecular scale and is being actively researched.

    We know that pulmonary fibrosis is strongly linked to dysfunctional telomeres, the structures that protect chromosomes. This finding was discovered a few years ago by the Telomeres and Telomerase Group – Humanism and Science Foundation at the National Cancer Research Centre (CNIO), opening up new avenues to develop therapies against the disease.

    The same group, led by Maria Blasco, is now making even more headway, revealing the mechanism by which a certain genetic mutation results in pulmonary fibrosis.

    As explained in the journal Genes and Development, an in-depth understanding of the effect of mutations such as the one studied “is essential to develop personalized therapies” against so-called telomere syndromes, a group of around a dozen diseases, including pulmonary fibrosis and many types of cancer.

    A mutation that prevents telomeres from repairing

    The current study focuses on a mutation in the POT1 gene, which produces one of the proteins called shelterins that make up the protective shield of telomeres. The CNIO research group has discovered that, when this mutation is present, telomeres cannot be repaired, because the enzyme responsible for such repairs is unable to operate normally.

    “We have shown that this mutation stops telomerase from working in the telomere,” explains Blasco, lead author in this study, which also involved Paula Martínez and Raúl Sánchez-Vázquez, from the same research group.

    The study helps explain why people with this mutation have short telomeres and develop pulmonary fibrosis, just like people with telomerase mutations. These findings emphasise the prevalence of short and dysfunctional telomeres in the development of pulmonary fibrosis in humans.”


    Maria Blasco, lead author

    Altered ‘shelterins’, unprotected telomeres

    Telomeres are molecular structures found at the ends of chromosomes, acting as protective caps for chromosome integrity. Throughout life telomeres become naturally shorter – an unavoidable consequence of cell division – and, if they become too short, cells stop dividing. This means that the tissue does not regenerate. In lung tissue, non-regeneration due to telomere dysfunction causes fibrosis.

    This was proved in previous studies by Blasco’s group, who also discovered that it is possible to reverse fibrosis in animals by activating the telomerase enzyme in affected tissues.

    However, in the current study they note that when the POT1 shelterin protein mutates, telomeres are impossible to repair, even when telomerase is present. Fibrosis appears as a result.

    “We see that this mutation in POT1 is identical to the mutation in telomerase,” Blasco explains. “This is the first time a mutation has been found in a shelterin protein that has the same effect as lacking telomerase.”

    POT1 in cancer and aging

    So far, all POT1 mutations had been associated with cancer, and in fact, Blasco’s group has broken new ground in characterising the role of POT1 mutations in cancer. The POT1 mutation studied in the current research is the first to be associated with a degenerative disease such as pulmonary fibrosis. 

    “The fact that the same telomere protein, POT1, can lead to cancer or ageing demonstrates the essential role of telomeres in these diseases,” says the head of the CNIO Telomere and Telomerase Group – Humanism and Science Foundation.

    Therapeutic strategies

    The CNIO spin off company Telomere Therapeutics, created a few years ago, is currently developing therapies based on the activation of the enzyme telomerase in affected tissues. The now published study, however, shows the importance of personalising treatments, since telomerase activation would not solve the problem in fibrosis caused by POT1 mutations.

    European project SHELTERINS

    Blasco’s group carried out this study with funding from the SHELTERINS project of the European Research Council.

    The aim of this project, led by Maria Blasco, is to gain a better understanding of the role of shelterin proteins in cancer, in order to look for therapeutic strategies that neutralise tumors ability to infinitely divide by disrupting the protection of telomeres, which would block the potential uncontrolled growth of tumors.

    Within this project, the group has studied several mutations in POT1, which is mutated in many types of tumors.

    Source:

    Centro Nacional de Investigaciones Oncológicas (CNIO)

    Journal reference:

    Sánchez-Vázquez, R., et al. (2025). Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations. Genes & Development. doi.org/10.1101/gad.352855.125

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  • BMA Report provides insights into the resilience of Bermuda’s commercial long-term reinsurance sector – Kennedys Law LLP

    1. BMA Report provides insights into the resilience of Bermuda’s commercial long-term reinsurance sector  Kennedys Law LLP
    2. Bermuda re/insurers’ global claims surpass US$1 trillion  Insurance Business America
    3. BMA Releases 2025 Global Stress Test Results  Bernews
    4. Bermuda reinsurers show strong capital resilience in BMA stress test  Insurance Business America

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  • Afghanistan crash out of Asia Cup after six-wicket loss to Sri Lanka – France 24

    1. Afghanistan crash out of Asia Cup after six-wicket loss to Sri Lanka  France 24
    2. Afghanistan in must-win territory, Sri Lanka look to avoid big defeat  ESPNcricinfo
    3. Asia Cup 2025: Sri Lanka eliminate Afghanistan as Bangladesh also go through  BBC
    4. Asia Cup: Pakistan beat UAE to enter Super Fours; face India on Sunday  Al Jazeera
    5. The equation for Bangladesh to confirm Asia Cup Super 4  Bangladesh Sangbad Sangstha (BSS)

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  • Massive Attack remove music from Spotify to protest against CEO Daniel Ek’s investment in AI military | Massive Attack

    Massive Attack remove music from Spotify to protest against CEO Daniel Ek’s investment in AI military | Massive Attack

    Massive Attack have become the latest act – and first major-label one – to pull their catalogue from Spotify in protest at founder Daniel Ek investing €600m (£520m) in the military AI company Helsing.

    In June, Ek’s venture capital firm Prima Materia led the defence tech firm’s latest funding round. Helsing’s software uses AI technology to analyse sensor and weapons system data from battlefields to inform real-time military decisions. It also makes its own military drone, the HX-2. Ek is also chairman of Helsing.

    The band made the announcement at the same time that they signed up to a new initiative, No Music for Genocide, in which a group of more than 400 artists and labels are blocking their music from streaming services in Israel.

    In a statement, the band said:

    Unconnected to this initiative and in light of the (reported) significant investments by its CEO in a company producing military munition drones and AI technology integrated into fighter aircraft, Massive Attack have made a separate request to our label that our music be removed from the Spotify streaming service in all territories.

    In our view, the historic precedent of effective artist action during apartheid South Africa and the apartheid, war crimes and genocide now being committed by the state of Israel renders the No Music for Genocide campaign imperative.

    In the separate case of Spotify, the economic burden that has long been placed on artists is now compounded by a moral and ethical burden, whereby the hard-earned money of fans and the creative endeavours of musicians ultimately funds lethal, dystopian technologies.

    Enough is more than enough.

    Another way is possible.

    The Guardian has contacted Spotify for comment.

    Helsing said in a statement: “Currently we see misinformation spreading that Helsing’s technology is deployed in war zones other than Ukraine. This is not correct.

    “Our technology is deployed to European countries for deterrence and for defence against the Russian aggression in Ukraine only.”

    Massive Attack join Australian psych group King Gizzard and the Lizard Wizard, Canadian post-rock group Godspeed You! Black Emperor, the Third Man Records-signed US band Hotline TNT, alternative US group Deerhoof and Manchester band Wu Lyf in removing their music from Spotify as a result of Ek’s investment in Helsing.

    Unlike those acts, Massive Attack will not be able to host their music on the widely used alternative Bandcamp, which is only available to acts on independent record labels. After moving to Bandcamp – and making their albums pay-what-you-want, including £0 – King Gizzard’s entire 27-album catalogue took the top 27 spots on the platform.

    The No Music for Genocide initiative also includes artists such as MJ Lenderman, Amyl and the Sniffers, Rina Sawayama, Jockstrap, KeiyaA, John Glacier, Erika de Casier, Smerz, Wednesday, Nourished by Time, Mike, Yaeji and Faye Webster. The artists involved either edited their release territories or asked their distributor or label to geo-block their releases.

    Massive Attack expanded on their participation in an Instagram post:

    In 1991 the scourge of apartheid violence fell from South Africa, aided from a distance by public boycotts, protests, and the withdrawal of work by artists, musicians and actors. Complicity with that state was considered unacceptable. In 2025 the same now applies to the genocidal state of Israel. As of today, there’s a musician’s equivalent of the recently announced @filmworkers4palestine campaign (signed by 4,500 filmmakers, actors, industry workers & institutions) – it can be found @nomusicforgenocide & supports the wider asks of the growing @bds.movement . We’d appeal to all musicians to transfer their sadness, anger and artistic contributions into a coherent, reasonable & vital action to end the unspeakable hell being visited upon the Palestinians hour after hour.

    Massive Attack previously formed a syndicate for artists speaking out in support of the Palestinian people alongside Brian Eno, Kneecap and Fontaines DC, to protect musicians from being “threatened into silence or career cancellation” by organisations such as UK Lawyers for Israel (UKLFI), which reported Bob Vylan to police for leading a chant of “death to the IDF” at Glastonbury, as well as reporting the BBC for broadcasting the set.

    Of the syndicate, Massive Attack told the Guardian: “This collective action is really about offering some kind of solidarity to those artists who are living day after day in a screen-time genocide, but are worried about using their platforms to express their horror at that because of the level of censorship within their industry or from highly organised external legal bodies, terrifying them and their management teams with aggressive legal actions. The intention is clear and obvious: to silence them.”

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  • Mouth Microbes Linked to Pancreas Cancer Risk – MedPage Today

    1. Mouth Microbes Linked to Pancreas Cancer Risk  MedPage Today
    2. Can the oral microbiome help predict pancreatic cancer risk?  American Medical Association
    3. Oral Microbes Linked to Increased Risk of Pancreatic Cancer  NYU Langone Health
    4. Mouth bacteria may increase pancreatic cancer risk threefold, experts say  Irish Examiner
    5. How your dirty mouth may be upping your risk of pancreatic cancer  New York Post

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  • Calls grow to boycott ABC owner Disney over Jimmy Kimmel suspension | US news

    Calls grow to boycott ABC owner Disney over Jimmy Kimmel suspension | US news

    The indefinite suspension of Jimmy Kimmel’s late-night show has prompted impassioned calls for a boycott against Disney, ABC’s parent company, and other major media conglomerates that have refused to air Kimmel’s show.

    Boycott calls grew after ABC announced it would indefinitely suspend the popular show following complaints from the Federal Communications Commission chair, Brendan Carr. Carr’s complaints stem from Kimmel’s recent monologue in which he addressed the killing of the rightwing activist Charlie Kirk by saying: “Many in Maga land are working very hard to capitalize on the murder of Charlie Kirk.”

    Carr, who was appointed by Donald Trump earlier this year, said Kimmel’s comments were “truly sick” and that ABC had violated its “public interest” broadcast obligations. ABC’s suspension of the show also came after Nexstar Media, one of the US’s largest owners of TV stations, said it “strongly object[ed]” to Kimmel’s comments and would pre-empt, or halt, any of the show’s episodes set to air on its stations “for the foreseeable future”.

    Meanwhile, the conservative TV conglomerate Sinclair announced it would run a tribute to Kirk during Kimmel’s time slot on Friday. It also called on Kimmel to issue a formal apology and make a personal donation to Kirk’s family and his rightwing political advocacy group, Turning Point USA.

    Overnight, calls to boycott ABC and Disney emerged, with Nelini Stamp, organizing director of the pro-labor union political group Working Families Party, sharing a viral boycott resource guide online that says: “Jimmy Kimmel wasn’t suspended because of what he said. He was suspended because the FCC threatened his employer. That’s state-sanctioned censorship and it is a giant red flag … Authoritarianism isn’t coming, it’s already here. Today it’s Jimmy. Tomorrow it’s the rest of us.

    Stamp added: “Nexstar Media Group and Sinclair Broadcast Group own the largest number of local ABC affiliates. These two companies are currently seeking approval from the FCC for business deals. In other words these media giants have every incentive to bend the knee to authoritarian pressure coming from the FCC and the administration to get their deals across the finish line. We’re done watching this unfold in silence … It’s time we speak in the only language they seem to respect – their money.”

    The boyott guide urged the public to write to ABC, Nexstar and Sinclair with the following script: “I object to the cancellation of Jimmy Kimmel Live after pressure from the administration. This is censorship plain and simple and it’s not what American values stand for. We need leaders to protect freedom of speech, not punish it.”

    In a statement to the Guardian, grassroots political advocacy group 50501, which shared Stamp’s boycott efforts, said: “The government is using absurd accusations of hate speech to silence comedians who offend the wannabe king.

    “Now more than ever, all Americans need to stand up in protest against censorship and for the First Amendment. As such, 50501 is calling on all Americans to boycott Nexstar, Sinclair, and ABC-Disney.”

    Boycott calls have also emerged on numerous Reddit threads as well as on X via the hashtag #BoycottDisney.

    One user wrote on BlueSky: “Heard from a friend at Disney+ that there are multiple levels of freakout internally, both from internal dissatisfaction, concerns about subscription cancelations, and of course the big one: concern about a boycott spilling over into parks and cruises.”

    On Wednesday, the CNN correspondent Brian Stelter wrote on X that he asked Carr if he had any new comments following Kimmel’s show suspension. “He sent me this gif,” Stelter said, alongside a gif from The Office, where two characters, Michael Scott and Dwight Schrute, are shown celebrating with their hands in the air.

    The Guardian has contacted ABC, Disney, Nexstar, Sinclair and the FCC for comment.

    Reacting to the news of Kimmel’s show suspension, Trump responded gleefully, saying: “Great News for America: The ratings challenged Jimmy Kimmel Show is CANCELLED. Congratulations to ABC for finally having the courage to do what had to be done.” He added that Kimmel had “worse ratings than even Colbert, if that’s possible”.

    In July, Trump celebrated Paramount’s decision to cancel The Late Show With Stephen Colbert – the US’s highest rated late-night show – after Colbert also mocked Trump. Writing on TruthSocial, Trump said: “I hear Jimmy Kimmel is next. Has even less talent than Colbert!”

    The suspension of Kimmel’s show has also prompted condemnation from the public and lawmakers, with House Democratic leaders demanding the resignation of Carr.

    The free speech advocacy group Pen America, decried ABC’s decision, saying: “This marks a dark new level of capitulation and censorship of speech more redolent of autocracies than democracies.”


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  • WXV Global Series: Women’s home nations gain control of autumn games

    WXV Global Series: Women’s home nations gain control of autumn games

    England, Scotland, Ireland and Wales have gained control of their autumn fixtures as part of World Rugby’s alterations to the women’s global calendar.

    The new WXV Global Series, which will replace the WXV competition, will run from 2026-2028 and feature the top 12 teams in the world.

    Seeking to build on the success of the Women’s Rugby World Cup in England, national federations and unions will be able to choose their own home and away games in September and October.

    Alongside each of the home nations, Australia, Canada, France, Italy, Japan, New Zealand, South Africa and the United States qualify as the top 12 sides.

    Those 12 nations are locked in to the WXV Global Series until the next Rugby World Cup in 2029.

    Each side will receive the same amount of money from World Rugby to compete in the fixtures no matter how many Tests they choose to play.

    Fixtures will be announced by each nation after the World Cup.

    “This is really important in the context of [breakaway league] R360 and other competitions that are being discussed as we need to give the national federations, players and fans certainty,” World Rugby chief executive Alan Gilpin said.

    “This allows that certainty over a four-year cycle that allows the national federations and unions to go and have those conversations [on contracts] with the player groups. It is a really important milestone.”

    Teams ranked 13-18, who World Rugby describe as facing greater “financial challenges”, will play their fixtures in a single destination in 2026 and 2028, funded by the global governing body.

    Those teams are Brazil, Fiji, Hong Kong China, the Netherlands, Samoa and Spain.

    This means WXV – a three-tier competition introduced in 2023 to supply more meaningful games before the World Cup – will no longer run.

    BBC Sport understands the top 12 sides will play between 9-16 Tests in a calendar year, outside of World Cup years, with a maximum of six Tests.

    The total of games will include fixtures played by home nations in 2027 when they also provide players for the first British and Irish Lions women’s tour to New Zealand.

    World Rugby says there will be over 100 games across the three-year Global Series competition and £9m will be invested, which is hoped will build on the World Cup in England that has seen record viewing figures and the final at Twickenham on 27 September sold out.

    “The launch of the WXV Global Series marks another landmark moment for the women’s game, following what will be an era-defining Women’s Rugby World Cup in England,” World Rugby chairman Brett Robinson added.

    “It delivers on our commitment to raise standards, provide consistent and competitive fixtures, a clear international calendar that prioritises welfare, and create sustainable commercial outcomes for the women’s game globally.”

    In 2023, World Rugby announced a new men’s competition starting in 2026 made up of 24 teams, split into two divisions.

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  • Ghost Sharks Use Teeth on Their Forehead to Have Deep-Sea Sex : ScienceAlert

    Ghost Sharks Use Teeth on Their Forehead to Have Deep-Sea Sex : ScienceAlert

    Are those teeth on your forehead or are you just happy to see me? In the curious case of chimaeras, also called ghost sharks, the answer is ‘both.’

    These forehead-teeth are attached to a retractable stalk called a tenaculum, and they help chimaeras have sex. Because of course.

    Whether these nodules are true teeth in every sense of the word, or some kind of dermal protrusion, has never been clear. So biologists Karly Cohena and Gareth Fraser from the University of Florida and Michael Coates from the University of Chicago took a closer look at this most unusual marine creature.

    Related: Meet Bumpy: The Unexpectedly Cute Creature Discovered in The Abyss

    Chimaeras are strange, sometimes venomous deep-sea fish that sport an evolutionarily unique body part, the tenaculum, an appendage that extends from the males’ forehead like a retractable Rolls-Royce hood ornament.

    This appendage is covered in many rows of hooked, flexing teeth that males use to grasp onto females’ pectoral fins during copulation, to avoid drifting away.

    Despite their mystic moniker, these animals aren’t actual sharks, having diverged from the shark lineage around 400 million years ago.

    Though chimaeras also have cartilage skeletons, they lack the ferocious rows of regenerating teeth that sharks have. Instead, chimaeras have toothy, grinding dental plates adapted for crushing shelled creatures, like crabs and molluscs.

    Chimaeras are also nude. Unlike sharks, they generally don’t have protective, hydrodynamic scales. Called dermal denticles, these scales are a modified version of teeth, rather than the skin-based scales that adorn reptiles, for example.

    On chimaeras, dermal denticles are limited to the claspers on their pelvis, which they use alongside their tenaculum to grasp onto females during copulation.

    Yet here’s the scientific mystery: since vertebrates usually have all their teeth in their mouth, chimaeras are an excellent, ancient opportunity to explore the evolution of extra-oral dentition, or teeth occurring outside the mouth.

    To find out whether these anatomical oddities qualify as teeth, the researchers turned to Puget Sound to study the unfortunately labeled spotted ratfish (Hydrolagus colliei), so named because its tail comprises half its body length. The researchers studied fossil data, performed CT scans of the ratfish, and conducted a genetic analysis on the forehead-teeth themselves.

    First, going back in time, fossil evidence from 315-million-year-old chimaeras (Helodus simplex) showed that the tenaculum grew on the upper jaw, before migrating to the top of the head.

    Ancient ratfish relative, Helodus simplex, with the tenaculum on the upper jaw rather than on the forehead. (Ray Troll)

    Intriguingly, this tooth-growing process is similar to the tooth-growing process seen in the jaws of modern sharks. In fact, it grows from a tissue known as the dental laminate, which has never before been documented outside the jaw.

    It’s a “beautiful example” of evolutionary bricolage, or taking what’s available to make something new.

    “We have a combination of experimental data with paleontological evidence to show how these fishes co-opted a preexisting program for manufacturing teeth to make a new device that is essential for reproduction,” explains Coates.

    ratfish skeleton
    Basic anatomy of the unfortunately named spotted ratfish, showing key features including overall body plan (C) as well as dorsal spine (D), pelvic claspers used for mating (F), and adult tenaculum with teeth (G and H). (Tiare Boyes/Cohen et al., PNAS, 2025)

    So, there you have it, the forehead-teeth used for sex today are genetically transferred versions of the mouth-teeth used for consuming sustenance, though given the choice, many creatures may choose the former over the latter.

    In addition to making for great headlines, this research shows one of nature’s core principles of creativity; evolution frequently reuses designs or repurposes existing structures in strange, unexpected ways.

    Accordingly, scientists previously wondered whether teeth evolved inwardly, turning from dental denticles on the skin to oral teeth within the mouth, or if they evolved outwardly, turning from pharyngeal (throat) spikes that migrated outwards to occupy the mouth.

    The findings of this study suggest that both scenarios may be true for different species across evolutionary time, showing that teeth deployment is incredibly and surprisingly flexible in the development of early vertebrates.

    Finally, this study opens a door to a more tooth-ful future, overturning the assumption that teeth are solely dental features.

    “I think the more we look at spiky structures on vertebrates, the more teeth we are going to find outside the jaw,” concludes Cohen.

    This research is published in Proceedings of the National Academy of Sciences.

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  • Advanced imaging exposes breakdown in brain cell communication linked to Alzheimer’s

    Advanced imaging exposes breakdown in brain cell communication linked to Alzheimer’s

    Research led by The Ohio State University Wexner Medical Center and College of Medicine explores the ways brain cells communicate, revealing fresh insight into the progression of Alzheimer’s disease.

    A multidisciplinary team used advanced imaging and computational modeling to analyze the “crosstalk” between neurons and their supporting glial cells in the human brain. This approach highlights the brain’s interconnected cellular network.

    “By mapping these cell interactions at the molecular level, we identified key pathways that could be pivotal in both the onset and progression of neurodegeneration,” said study co-author Oscar Harari, PhD, director of the Division of Neurogenetics and director of the Center for Neurobiology of Aging and Resiliency at The Ohio State University Neuroscience Research Institute.

    Study findings are published in Science Translational Medicine.

    “This insight is critical for developing effective treatments, as ‘cellular crosstalk’ may serve as an attractive molecular target for drug development. Many of these cell-to-cell communication pathways include proteins at the cell membrane, which are often regarded as promising targets for therapeutic intervention,” said Harari, who is also the Helen C. Kurtz Associate Professor of Neurology at Ohio State.

    Harari, who joined Ohio State in early 2024, completed the manuscript for the research he started while at the Washington University School of Medicine. He collaborated equally with study co-author Tae-Wan Kim, PhD, associate professor of Pathology and Cell Biology at Columbia University Vagelos College of Physicians and Surgeons in New York.

    Our research shows that Alzheimer’s is not only driven by plaques and tangles, but also by a breakdown in communication between brain cells. By uncovering the SEMA6D–TREM2 crosstalk pathway, we reveal a new way to enhance the amyloid-clearing functions of microglia and potentially slow Alzheimer’s progression.”


    Tae-Wan Kim, PhD, associate professor of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York

    The study included investigators from The Ohio State University Comprehensive Cancer Center, as well as collaborators from Australia, South Korea, Massachusetts General Hospital, Harvard Medical School, Indiana University School of Medicine, and the Dominantly Inherited Alzheimer Network.

    This research is supported by funding from the National Institute on Aging; National Institute of Neurological Disorders and Stroke; Department of Defense; Chan Zuckerberg Initiative; Alzheimer’s Association; German Center for Neurodegenerative Diseases; Raul Carrea Institute for Neurological Research; Japan Agency for Medical Research and Development; Korea Health Industry Development Institute; Spanish Institute of Health Carlos III; Canadian Institutes of Health Research; Canadian Consortium of Neurodegeneration and Aging; Brain Canada Foundation; Fonds de Recherche du Québec – Santé; Arizona Department of Health Services; Arizona Biomedical Research Commission and Michael J. Fox Foundation for Parkinson’s Research.

    Source:

    Ohio State University Wexner Medical Center

    Journal reference:

    Albanus, R. D., et al. (2025). Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease. Science Translational Medicine. doi.org/10.1126/scitranslmed.adx0027

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  • News Archive | NVIDIA Newsroom

    News Archive | NVIDIA Newsroom

    September 17, 2025

    Meet the Streamlabs Streaming Assistant, Accelerated by NVIDIA RTX

    Today’s creators are equal parts entertainer, producer and gamer, juggling game commentary, scene changes, replay clips, chat moderation and technical troubleshooting — all while trying to play their best. Agentic AI presents huge potential for …

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