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  • Rupert Grint nearly quit acting after ‘Harry Potter’ fame?

    Rupert Grint nearly quit acting after ‘Harry Potter’ fame?

    Rupert Grint wanted to walk away from spotlight after ‘Harry Potter’

    The Harry Potter star almost gave up on acting after being in the spotlight.

    Rupert Grint, who is famously known for playing Ron Weasley in the Harry Potter films from the age of 11, has admitted that he thought of changing career after the intense fame.

    The actor, who turns 37 today, told The New York Times, “I definitely did think, ‘Is it too late to pick something else?”

    Grunt reportedly bought the iconic Mr Whippy ice cream van on the last day of shooting and drove it back to his family. Moreover, the actor was reportedly very serious about becoming an ice cream man.

    However, after a year off from the business he gave acting another chance.

    After the final Harry Potter film came out in 2011, Grint appeared in many films including the White (2012), Charlie Countryman (2013), CBGB (2013), and the Moonwalkers (2015).

    Most recently, Rupert Grint reprised his role as the stalker from Ed Sheeran’s 2011 Lego House music video in the latest music video for A Little More.


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  • Meghan Markle warned about lacking a fresh stack of ‘fatted calves’ for Hollywood

    Meghan Markle warned about lacking a fresh stack of ‘fatted calves’ for Hollywood

    Meghan Markle handed shocking comparison: ‘Looks like she’s tired boiling her own egg’

    Meghan Markle’s pace with Netflix, Spotify and all her old employers has just led royal commentator Daniela Elser to get up close and honest about what she thinks of the Duchess’ shelf life.

    The whole thing got combed through in a piece for News.com.au.

    In it the expert started right off the bat and said, “For all of this year the Duchess of Sussex has been working to Princess Anne levels of industriousness as to establish herself as a businessperson and was the most domestically inclined member of the royal family since the Queen Mother once bravely tried to boil her own egg.”

    “Questions remain over Meghan and her husband Prince Harry, The Duke of Sussex’s future.”

    For one, “Their shows have met with very up and down success and there are no fatted calves to go around in Hollywood these days,” the expert admitted.

    Only With Love, Meghan is set to receive a second installment, compared to projects like Live To Lead, Polo, Harry & Meghan, or even The Bench and the Archetypes podcast. However, “The numbers are not quite as bubbly” for that either,” Ms Elser admitted.

    Before concluding though, she did offer her two cents on the entire thing and noted the bright side in all this.

    “What ‘With Love’ might have lacked in cold hard numbers, it certainly made up for in publicity noise, attention and general consumption of media oxygen, hardly a bad thing for a company battling for eyeballs and subscription revenue,” she said in the end.


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  • Why tiny bee brains could hold the key to smarter AI

    Why tiny bee brains could hold the key to smarter AI

    A new discovery of how bees use their flight movements to facilitate remarkably accurate learning and recognition of complex visual patterns could mark a major change in how next-generation AI is developed, according to a University of Sheffield study.

    iversity of Sheffield built a digital model of a bee’s brain that explains how these movements create clear, efficient brain signals, allowing bees to easily understand what they see

  • This discovery could revolutionize AI and robotics, suggesting that future robots can be smarter and more efficient by using movement to gather relevant information, rather than relying on huge computer networks
  • The study highlights a big idea: intelligence comes from how brains, bodies and the environment work together. It demonstrates how even tiny insect brains can solve complex visual tasks using very few brain cells, which has major implications for both biology and AI
  • A new discovery of how bees use their flight movements to facilitate remarkably accurate learning and recognition of complex visual patterns could mark a major change in how next-generation AI is developed, according to a University of Sheffield study.

    By building a computational model — or a digital version of a bee’s brain — researchers have discovered how the way bees move their bodies during flight helps shape visual input and generates unique electrical messages in their brains. These movements generate neural signals that allow bees to easily and efficiently identify predictable features of the world around them. This ability means bees demonstrate remarkable accuracy in learning and recognizing complex visual patterns during flight, such as those found in a flower.

    The model not only deepens our understanding of how bees learn and recognize complex patterns through their movements, but also paves the way for next-generation AI. It demonstrates that future robots can be smarter and more efficient by using movement to gather information, rather than relying on massive computing power.

    Professor James Marshall, Director of the Centre of Machine Intelligence at the University of Sheffield and senior author on the study, said:”In this study we’ve successfully demonstrated that even the tiniest of brains can leverage movement to perceive and understand the world around them. This shows us that a small, efficient system — albeit the result of millions of years of evolution — can perform computations vastly more complex than we previously thought possible.

    “Harnessing nature’s best designs for intelligence opens the door for the next generation of AI, driving advancements in robotics, self-driving vehicles and real-world learning.”

    The study, a collaboration with Queen Mary University of London, is published recently in the journal eLife. It builds on the team’s previous research into how bees use active vision — the process where their movements help them collect and process visual information. While their earlier work observed how bees fly around and inspect specific patterns, this new study provides a deeper understanding of the underlying brain mechanisms driving that behavior.

    The sophisticated visual pattern learning abilities of bees, such as differentiating between human faces, have long been understood; however the study’s findings shed new light on how pollinators navigate the world with such seemingly simple efficiency.

    Dr. HaDi MaBouDi, lead author and researcher at the University of Sheffield, said: “In our previous work, we were fascinated to discover that bees employ a clever scanning shortcut to solve visual puzzles. But that just told us what they do; for this study, we wanted to understand how.

    “Our model of a bee’s brain demonstrates that its neural circuits are optimized to process visual information not in isolation, but through active interaction with its flight movements in the natural environment, supporting the theory that intelligence comes from how the brain, bodies and the environment work together.

    “We’ve learnt that bees, despite having brains no larger than a sesame seed, don’t just see the world — they actively shape what they see through their movements. It’s a beautiful example of how action and perception are deeply intertwined to solve complex problems with minimal resources. This is something that has major implications for both biology and AI.”

    The model shows that bee neurons become finely tuned to specific directions and movements as their brain networks gradually adapt through repeated exposure to various stimuli, refining their responses without relying on associations or reinforcement. This lets the bee’s brain adapt to its environment simply by observing while flying, without requiring instant rewards. This means the brain is incredibly efficient, using only a few active neurons to recognize things, conserving both energy and processing power.

    To validate their computational model, the researchers subjected it to the same visual challenges encountered by real bees. In a pivotal experiment, the model was tasked with differentiating between a ‘plus’ sign and a ‘multiplication’ sign. The model exhibited significantly improved performance when it mimicked the real bees’ strategy of scanning only the lower half of the patterns, a behaviour observed by the research team in a previous study.

    Even with just a small network of artificial neurons, the model successfully showed how bees can recognise human faces, underscoring the strength and flexibility of their visual processing.

    Professor Lars Chittka, Professor of Sensory and Behavioural Ecology at Queen Mary University of London, added: ‘Scientists have been fascinated by the question of whether brain size predicts intelligence in animals. But such speculations make no sense unless one knows the neural computations that underpin a given task.

    “Here we determine the minimum number of neurons required for difficult visual discrimination tasks and find that the numbers are staggeringly small, even for complex tasks such as human face recognition. Thus insect microbrains are capable of advanced computations.”

    Professor Mikko Juusola, Professor in System Neuroscience from the University of Sheffield’s School of Biosciences and Neuroscience Institute said: “This work strengthens a growing body of evidence that animals don’t passively receive information — they actively shape it.

    “Our new model extends this principle to higher-order visual processing in bees, revealing how behaviorally driven scanning creates compressed, learnable neural codes. Together, these findings support a unified framework where perception, action and brain dynamics co-evolve to solve complex visual tasks with minimal resources — offering powerful insights for both biology and AI.”

    By bringing together findings from how insects behave, how their brains work, and what the computational models show, the study shows how studying small insect brains can uncover basic rules of intelligence. These findings not only deepen our understanding of cognition but also have significant implications for developing new technologies.

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  • SpaceX eyes Starship reusability milestones in rocket's tenth flight test – Reuters

    1. SpaceX eyes Starship reusability milestones in rocket’s tenth flight test  Reuters
    2. The most powerful rocket ever built is set for its next test. Here’s why some experts are worried  CNN
    3. Starship prepares to launch Flight 10 in penultimate Block 2 test  NASASpaceFlight.com –
    4. SpaceX’s Starship Flight 10 launches today: How to watch  NewsBytes
    5. SpaceX transfers its best engineers due to the Starship crisis  drivingeco.com

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  • Call of Duty: Black Ops 7 will showcase Zombies mode and multiplayer next month

    Call of Duty: Black Ops 7 will showcase Zombies mode and multiplayer next month

    Activision has been slow with the Call of Duty reveals this year. We had an initial teaser trailer at the end of this year’s Xbox Games Showcase in June, followed by another campaign-focused trailer at Gamescom earlier this week. We won’t have to wait much longer to see our lingering questions answered though. 

    Call of Duty NEXT is returning in 2025. This year’s event will take place on September 30th. During the event, we’ll get reveals for Black Ops 7 multiplayer and the Zombies mode.

    One of the big hooks for Black Ops 7 is the return of content from Black Ops 2, a fan-favourite in the long-running series. This should include the return of select maps, including the Survival Maps from past iterations of the Zombies mode.

    Call of Duty: Black Ops 7 is set to release on November 14th for Xbox and PlayStation consoles, and PC. No version has been announced for the Nintendo Switch 2.

    KitGuru Says: Battlefield 6 has been soaking up all of the spotlight this summer. Do you think this may finally be the year Battlefield rises above COD? 

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  • Observational Study Associates BRCA and Other HRR Gene Alterations With Poorer Outcomes in mHSPC

    Observational Study Associates BRCA and Other HRR Gene Alterations With Poorer Outcomes in mHSPC

    Prostate Cancer | Image
    Credit: © Sebastian
    Kaulitzki – stock.adobe.com

    Evaluating the prognostic implications of homologous recombination repair (HRR) gene alterations, including BRCA1/2 mutations, in patients with metastatic hormone-sensitive prostate cancer (mHSPC) helps build on prior evidence demonstrating the negative impact of these mutations in later disease settings, according to David Olmos, MD, PhD.

    In the prospective, multi-cohort CAPTURE study, findings presented at the 2025 ASCO Annual Meeting showed that patients with mHSPC harboring BRCA mutations experienced a median radiographic progression-free survival (rPFS) of 13.6 months compared with 30.4 months for those without BRCA mutations (HR, 2.4; 95% CI, 1.8-3.3; P < .001).1 The median overall survival (OS) was 26.2 months vs. 55.1 months, respectively (HR, 2.7; 95% CI, 2.0-3.6; P < .001).

    For patients harboring HRR alterations, the median rPFS was 20.5 months compared with 30.6 months for those lacking HRR alterations (HR, 1.6; 95% CI, 1.3-2.0; P < .001). The respective median OS were 39.0 months and 55.7 months (HR, 1.5; 95% CI, 1.1-2.0; P = .003).

    Earlier findings from the observational CAPTURE study in metastatic castration-resistant prostate cancer (mCRPC) showed that BRCA and other HRR mutations correlated with worse outcomes across standard therapies compared with wild-type disease.2

    In an interview with OncLive®, Olmos discussed the clinical rationale for assessing HRR alterations in mHSPC, described the design and eligibility criteria of the CAPTURE cohort, and addressed how evolving treatment standards may influence outcomes in this biomarker-defined population.

    OncLive: What is the rationale for evaluating the impact of homologous recombination repair (HRR) gene mutations, such as BRCA, on outcomes in patients with metastatic hormone-sensitive prostate cancer?

    Olmos: This is the second cohort that we have reported on [from] the CAPTURE study. The CAPTURE study is a multi-cohort study in which we are analyzing the prevalence and impact of HRR DNA deficiency in multiple settings. Two years ago at [the 2023] ASCO [Annual Meeting], the impact in[metastatic castration-resistant prostate cancer [mCRPC], and we demonstrated that BRCA and [other] HRR gene mutations were associated with worse outcomes than those patients [who did not harbor HRR alterations], with any standard treatment.

    In this [analysis presented at ASCO 2025], we reported on the cohort [of patients with] mHSPC. Here, the rationale was to look at whether [HRR alterations have] the same impact from the beginning of disease, with respect to treatment effect, and at the same time whether the biology associated with these alterations is more or less important than traditional prognostic factors that we use on a daily basis in our clinic, such as disease volume, when deciding treatment.

    What were the key elements of the study design, including eligibility criteria and methodology, that should be considered when interpreting the results of this cohort study?

    First, it is important to say that this is a prospective study [and] contemporaneous, because recruitment started in January 2018, and the last patient enrolled in December 2023, for a total of 556 patients. All [patients were] metastatic by conventional imaging. [Fifty-five percent of patients had] high-volume [disease], and [45%] were low volume. [The rate of] metachronous disease was also low, at [18.9%]. The majority of patients, reflecting the practice that we usually see in Spain, Italy, and Portugal—the three countries participating in the study—had de novo disease [81.1%].

    Outside [those criteria], all standard treatment options were allowed. What we can see [from] the trial recruitment is a reflection of how the standard has changed. We have very little exposure to [only] androgen deprivation therapy [ADT] at less than 13.5%, which was higher at the beginning of the trial. Then we saw a lot of docetaxel plus ADT in the first 2 years, but since the COVID-19 pandemic, we saw a rise in the prescription of androgen receptor pathway inhibitors along with ADT, such as abiraterone acetate [Zytiga], apalutamide [Erleada], and more recently, darolutamide [Nubeqa]. Triplet therapy [use] was very low at the beginning of the study, [with much] higher exposure during the last years of recruitment.

    What were the key efficacy findings observed in patients with BRCA mutations compared with those harboring other HRR mutations or non-HRR alterations, and how consistent were these outcomes across subgroups?

    The first thing to highlight before discussing outcomes: we found the frequency of BRCA2 alterations and HRR mutations, defined by 11 genes in the study, was almost the same as in mHSPC [as we observed in patients with mCRPC]. This is an important finding and builds on the fact that many of these mutations are already present at the beginning of the disease. The percentage of germline vs somatic mutations was again very similar to mCRPC, with a slightly higher proportion of germline BRCA2 mutations. This is consistent with previous reports in the literature associating germline BRCA2 mutations with a higher rate of metastasis.

    From an efficacy perspective, we demonstrated again that BRCA mutations are a poor prognostic factor. Patients with either germline or somatic mutations in BRCA1 and BRCA2 had shorter rPFS, shorter time to castration resistance, and worse overall survival. This was independent of disease volume.

    Patients with BRCA2 or BRCA1 mutations and high-volume disease had a median rPFS of 12.8 months compared with 21.8 months in [patients without BRCA mutations]. For low-volume disease, the median rPFS was 16.8 months in the BRCA-mutated population vs 43.0 months in the non-[mutated] population, reflecting the significant prognostic impact of BRCA mutations, even when patients are diagnosed with low-volume disease.

    Similar results were observed for patients with other HRR mutations, although the effect was not as pronounced as with BRCA. Within the HRR gene set—as we already knew from the mCRPC cohort—these genes are not all equal from a prognostic standpoint.

    Finally, an important analysis we conducted, since there were enough patients, examined whether patients with BRCA or HRRalterations had different outcomes if they were treated with ADT plus docetaxel intensification vs ADT plus a novel hormonal agent. We could not identify differences in the BRCA-mutated population; rPFS and OS were equal across both strategies. However, for patients [without BRCA mutations], the rPFS was much longer with novel hormonal agents compared with docetaxel-based doublets, although OS was similar.

    References

    Olmos D, Lorente D, Jambrina A, et al. Impact of somatic/germline homologous recombination repair (HRR) alterations on metastatic hormone-sensitive prostate cancer (mHSPC) outcomes by disease volume. J Clin Oncol. 2025;43(suppl 16):5094. doi:10.1200/JCO.2025.43.16_suppl.5094

    Olmos D, Lorente D, Alameda D, et al. Presence of somatic/germline homologous recombination repair (HRR) mutations and outcomes in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) receiving first-line (1L) treatment stratified by BRCA status. J Clin Oncol. 2023;41(suppl 16):5003. doi:10.1200/JCO.2023.41.16_suppl.5003

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  • World TrailO Championships – competition in two countries  

    World TrailO Championships – competition in two countries  

    The 2025 World TrailO Championships begin with two PreO days in Hungary – and then Slovakia takes over, organizing the Relay and TempO competitions. 170 competitors from 24 nations will be taking part in the championships, which run from Tuesday until Sunday.

    This year’s top TrailO event has attracted 41 physically challenged competitors (P class) from all over the world together with 129 competitors in the Open (O class). There is an increase in the number of juniors entered, the outcome of a campaign to attract even more young people in a discipline of orienteering with a very big age range. Many of these, such as the Czech star Ondřej Macek who will be defending the TempO crown at these championships, are proving to be very talented.

    Sümeg, a town north of Lake Balaton in Hungary, is the venue for the first stage. For the PreO competition, where only two control tasks each day have timed answers, some spectacular terrain has been chosen. The first day will be held at an abandoned basalt mine with its many rocks, ledges and ridges, whilst the second day is in an area with traces of former mining activity in mixed-visibility forest terrain. Specially enlarged maps (1:2000) are being provided for parts of this competition, to help participants cope with the complexity of the rock detail. The standard map scale is 1:3000 with 2 m contour interval.

    The PreO medals are decided on the sum of the two days. Defending champions from 2023 Michael Johansson, Sweden (P class) and Arno Grønhovd, Norway (O) will be striving hard to retain their titles.

    Terrain with complex rock and contour detail can be expected   Photo: ETOC 2024

    The Championships then move to Slovakia, with the Event Centre in the capital Bratislava and the competitions sited in a hilly area north-east of the city. There are two days of competition also in Slovakia: first the Relay for teams of 3, which has both PreO and TempO components, and then the day after, the TempO Qualification and Final. In TempO all tasks are timed, and the first 18 from each of two qualification heats progress to the final.

    The relay area is a semi-open area with an old quarry and a steep-sided valley, whilst the TempO competitions will be held in deciduous forest with areas of small stones, linked with a castle park. Finland and Germany will be defending their P and O class titles respectively from 2023, along with the TempO winner from two years ago, Ondřej Macek; in TempO, P and O classes compete together on equal terms.

    Reports and leading results will appear here on each competition day. Full information on every aspect of the event can be found in Bulletin 4, which can be accessed on the event website www.wtoc2025.org.

    Competition Programme

    Wednesday 27 August   PreO 1

    Thursday 28 August   PreO 2

    Saturday 29 August   Relay

    Sunday 31 August   TempO Qualification (a.m.), Final (p.m.)

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  • NeurologyLive® Brain Games: August 24, 2025

    NeurologyLive® Brain Games: August 24, 2025

    Welcome to NeurologyLive® Brain Games! This weekly quiz series, which goes live every Sunday morning, will feature questions on a variety of clinical and historical neurology topics, written by physicians, clinicians, and experts in the fields of neurological care and advocacy.

    Test your mettle each week with 3 questions that cover a variety of aspects in the field of neurology, with a focus on dementia and Alzheimer disease, epilepsy and seizure disorders, headache and migraine, movement disorders, multiple sclerosis, neuromuscular disorders, sleep disorders, and stroke and cerebrovascular disease.

    This week’s questions include the theme of the GLP-1 RAs to treat neurologic conditions.

    Click here to check out the prior iterations of Brain Games.

    Interested in submitting quiz questions? Contact our editor, Marco Meglio, via email: mmeglio@neurologylive.com.

    Which potential neuroprotective mechanism of GLP-1 receptor agonists has been most consistently demonstrated in preclinical models of neurodegenerative disease?

    Which GLP-1 receptor agonist has advanced to phase 2 clinical trials for Parkinson disease, showing signals of disease modification?

    What is the proposed rationale for investigating GLP-1 RAs in Alzheimer disease?

    How did you do on this week’s quiz? Let us know with a response to the poll below. Don’t forget to share and compare your results with your friends!

    How many questions did you get correct?

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  • Florence Pugh’s brother ditches Game of Thrones for drastic new path

    Florence Pugh’s brother ditches Game of Thrones for drastic new path



    Toby Sebastian offers private songwriting classes

    Florence Pugh’s brother Toby Sebastian is swapping the screen for the studio in a dramatic career move.

    The actor, who fans will remember as Trystane Martell in Game of Thrones and as Andrea Bocelli in the biopic The Music of Silence, has now turned his focus to music and he’s inviting fans to join him on the journey.

    This month he reached out to his mailing list to announce that he’s launching private songwriting sessions. 

    The former Game of Thrones actor is now advertising 90 minute private sessions for £150, or a discounted package of four lessons for £500. 

    Beginners are welcome, but there’s one catch students must already know how to play either piano or guitar.

    Promising to “dive deep into the art of writing,” Toby brings more than star power to the table. 

    With over 50,000 monthly Spotify listeners, two studio albums, and several singles under his belt, he has firmly established himself as a rising singer-songwriter.

    Music clearly runs in the family. In 2021, he teamed up with his Oscar-nominated sister Florence for the dreamy track Midnight, with Toby on guitar and vocals and Florence providing backing harmonies. 

    The pair also performed together in its intimate music video, showcasing their sibling bond.

    Meanwhile, Florence continues to dominate Hollywood, with standout roles in Little Women, Don’t Worry Darling, Oppenheimer, and Dune: Part Two

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  • Tariffs ‘starting to show up’: how Trump’s strategy could increase back-to-school costs | Trump tariffs

    Tariffs ‘starting to show up’: how Trump’s strategy could increase back-to-school costs | Trump tariffs

    Summer is drawing to a close and as parents and children get ready for a new school year, their first lesson will be in economics.

    Most of Donald Trump’s tariffs went into effect at the beginning of August. We are still waiting on a deal with China. But with school supplies so dependent on imports, consumers have been anxiously waiting to see how tariffs will affect the prices they see in stores.

    A survey from the National Retail Federation (NRF) found that 12% more parents started back-to-school shopping earlier this year compared with last year, largely because of concerns over tariffs, and 72% of parents expect higher prices this year.

    A graphic showing the tariffs levied by Trump on different countries, reimagined as a school shelving system with empty trays and some slots filled with school supplies.

    The NRF estimated the total expected spending for back-to-school shopping, from new clothes and electronics to pencils and paper, will total $39.4bn – the second highest on record, after 2023. Families with kids in kindergarten through 12th grade are budgeting, on average, $874.68 for everything they need for the year.

    It’s still unclear exactly how much Trump’s new tariffs will affect prices. Companies have the power to increase prices as much as they want, but at the risk of losing customers to competitors.

    “There’s a lot happening behind the scenes, like importers trying to renegotiate with their foreign suppliers, they’re trying to get their foreign suppliers to absorb some of the costs, they’re trying to absorb costs themselves,” said Sarah Dickerson, a research economist at the University of North Carolina at Chapel Hill.

    At the beginning of the summer, Target announced it would maintain its 2024 prices for 20 “must-have supplies”, a move the company hopes will keep customers loyal during the back-to-school shopping season.

    However, economists argue that retailers will eventually have to pass on the costs. A recent analysis from Goldman Sachs estimated that consumers paid 36% of tariff costs three months and 67% of costs four months after a levy was set.

    These increases are only just starting to show up in inflation data. After dipping down in the spring, inflation has been rising since April, something that’s caught the attention of officials at the US Federal Reserve.

    A graph showing inflation trends for US consumers.

    Tariffs “are starting to show up in consumer prices … [and] we expect to see more of that”, Fed chair Jerome Powell said in July. “We know from surveys that companies feel they have every intention of putting this through to the consumer.”

    This of course is contrary to how the White House thinks. Trump has said that tariffs will either bring manufacturing back to America or help the country negotiate better trade deals. Trump has largely brushed aside the potential price increases and while conceded that the tariffs “won’t be easy, the end result will be historic”.

    For parents starting their back-to-school shopping, Dickerson recommends taking the time to compare prices between stores since they may vary between retailers.

    “Those individual prices are going to vary, which is why it makes sense, if you’re a parent, to shop around a bit and see what the different prices are out there,” she said.

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