Blog

  • Record 256,000 Afghan Migrants Return from Iran as IOM Warns of Dire Funding Shortfall – ReliefWeb

    1. Record 256,000 Afghan Migrants Return from Iran as IOM Warns of Dire Funding Shortfall  ReliefWeb
    2. Over 230,000 Afghans left Iran in June ahead of deadline  Dawn
    3. Nowhere to run: The Afghan refugees caught in Israel’s war on Iran  Al Jazeera
    4. No Safe Return: The Case Against Deporting Afghan Refugees  The Diplomat – Asia-Pacific Current Affairs Magazine
    5. TAWDIKHABARI – Deportation of Afghan Refugees from Iran, Pakistan Discussed  TOLOnews

    Continue Reading

  • Households’ subjective expectations: Disagreement, common drivers, and reaction to aggregate shocks

    Household expectations are usually thought to play a central role in the transmission of macroeconomic policy. Yet we still know too little about how households perceive and interpret the complex relationships and feedback between relevant economic variables that are at the core of general equilibrium. In a recent project (Ferreira and Pica 2025), we use new euro area household level survey data to show that households interpret contractionary demand and supply shocks as inflationary, contrary to conventional macroeconomic models. Our paper contributes to a recent literature investigating households’ mental models about economic relationships (e.g. André et al. 2022, Piccolo et al. 2025).

    The misalignment we uncover emerges consistently across time, countries, demographic groups, and levels of financial literacy. Although disagreement is pervasive, there is a clear structure in household expectations: two common factors explain a large share of the variation in beliefs within and across individual households in different countries.

    These patterns challenge standard assumptions in macroeconomic models and raise important questions about the communication and effectiveness of monetary policy. When central banks raise interest rates, they do so partly to influence expectations. However, if households’ understanding of and attention to transmission mechanisms differ from those assumed in the models that justify such rate changes – and if the households act on these beliefs – the impact of a policy may diverge from its intended effect. The links between expectations, real outcomes, and monetary policy has been explored in other Vox columns (e.g. Gorodnichenko et al. 2019, 2021, Weber et al. 2021).

    The effect of aggregate demand and supply shocks on expectations

    A natural way to explore the mental models that households entertain about economic dynamics is to evaluate the impact that exogenous shifts in demand and supply curves have on beliefs. Under rational expectations, these shifts should affect expectations about prices and quantities in a specific direction. We study how households in six major euro area economies – Belgium, France, Germany, Italy, the Netherlands, and Spain – respond to aggregate shocks using the ECB’s high-frequency Consumer Expectations Survey. This monthly panel captures detailed, household-level expectations about inflation, unemployment, interest rates, the general economic outlook, and other variables.

    Our first key finding is that contractionary monetary policy shocks raise inflation expectations. Specifically, following an ECB rate increase, households expect not only slower economic growth and higher unemployment, but also higher inflation over the next 12 months (Figure 1). This response is surprising. In textbook New Keynesian models, tighter monetary policy reduces demand and dampens inflation. Households’ expectations in our data move in the opposite direction and do so persistently. This result is in line with André et al. (2022) and Piccolo et al. (2025). One of our contributions to this literature is to validate these results internally across different identification strategies – including an event-study around ECB meetings – using alternative data sources going back to 2000. In addition, we show a surprising robustness across countries and demographic groups.

    Figure 1 Impulse responses of household expectations to a contractionary monetary policy shock

    Note: Impulse response functions of household expectations following a contractionary monetary surprise that raises the short rate by 25 basis points on impact. These responses are estimated using the panel local projections with Newey-West standard errors clustered at the monthly level. The 95% confidence intervals are shown in light blue; the 68% confidence intervals in dark blue. The estimation sample spans April 2020 to January 2024 for all variables except interest rate expectations, which are available from September 2020 onward.

    Turning to oil shocks, household-level responses align closely with the expected effects of a stagflationary shock: a rise in the real oil price leads to higher expected inflation while lowering expected economic growth (Figure 2).

    We therefore conclude that households consistently interpret contractionary supply and demand shocks as inflationary.

    Figure 2 Impulse responses of household expectations to a contractionary oil shock

    Notes: Impulse response functions of household expectations following a contractionary oil shock that raises the real oil price by 10% on impact. These responses are estimated using panel local projections with Newey-West standard errors clustered at the monthly level. The 95% confidence intervals are shown in light blue; the 68% confidence intervals in dark blue. The estimation sample spans April 2020 to June 2024 for all variables except interest rate expectations, which are available from September 2020 onward.

    Common drivers of beliefs

    Despite significant and persistent disagreement, household expectations move together in systematic ways. We uncover two latent drivers (principal components) that explain around 40% of the variation in expectations across households and countries.

    The first component reflects a broad perception that inflation is bad for the economy due, for example, to its origin on supply side shocks or to its erosion of disposable real incomes (Kamdar and Ray 2024, Binetti et al. 2024). Households that expect higher inflation also anticipate slower growth and weaker labour markets. This ‘inflation pessimism’ dominates the structure of expectations and suggests a mental model wherein price increases are interpreted as a sign of worsening real conditions.

    The second component captures concerns about interest rates and unemployment. Households that expect higher interest rates also expect weaker economic outcomes, suggesting that they associate rate hikes with cost increases and labour market deterioration, rather than with disinflationary effects.

    Strikingly, these latent drivers are not systematically linked to observable characteristics like age, education, housing tenure, or financial literacy. Nor are they specific to any one country. This points to a shared cognitive framework – a simplified but common view of the business cycle – that shapes how households interpret macroeconomic developments.

    Building on this, we estimate a two-factor structure for the cross-section of all expectations. The structure is general enough to capture individual time-invariant biases and disturbances, and can be mapped onto most equilibrium models with a generalised expectation formation process. The first factor, which explains the bulk of the time-series variation, tracks inflation-related sentiment potentially emerging from attention to media outlets, including the supply bottlenecks of 2021, the energy crisis, and ECB rate hikes from mid-2022 onward. The second factor correlates closely with unemployment dynamics, suggesting that demand-side perceptions are linked primarily to real activity (Figure 3).

    Figure 3 Evolution of identified factors over the sample period

    Note: Figure plots factors identified through sign restrictions on household expectations data; sample covers the period from September 2020 to December 2024. The two thick lines represent the optimal uncorrelated factors, identified using a standard Euclidean metric. The thinner lines show the 10th, 25th, 50th, 75th, and 90th percentiles of the distribution of distances for alternative valid models (i.e. rotations). Blue lines correspond to the first factor, identified by loadings that capture opposite correlations between expected economic growth and expected inflation. Red lines correspond to the second factor, identified based on demand-type signs on expected economic growth and expected inflation. Vertical solid lines mark key events: (1) disruptions in the Suez and Panama Canals (May 2021), (2) the Russian invasion of Ukraine (February 2022), and (3) the ECB’s first post-pandemic interest rate hike (July 2022).

    Conclusions and implications for policy

    Understanding how households interpret macroeconomic policy is vital for the effectiveness of central bank action. Our study shows that households often react in ways that contradict the standard theoretical playbook. This misalignment is systematic and rooted in a shared structure of beliefs, not idiosyncratic noise.

    These findings have important implications. If households believe that contractionary monetary policy fuels rather than curbs inflation, then standard policy levers may be less effective than models suggest. Communication strategies that rely on rational expectations may fall flat if the public’s mental model of the economy diverges fundamentally from that of policymakers.

    Moreover, if inflation expectations are not anchored by policy signals but are instead shaped by perceived cost pressures, there is a risk of self-fulfilling inflation dynamics. Policymakers may inadvertently reinforce inflation fears if rate hikes are seen as signs of economic trouble rather than tools to stabilise prices.

    Our evidence suggests that households interpret shocks through a lens shaped by recent crises – such as the energy shock following Russia’s invasion of Ukraine – and by deep-rooted concerns about real purchasing power. Addressing these perceptions may require more than technical briefings or forecasts. Clear, relatable narratives about how policy affects inflation and the broader economy are essential.

    References

    Andre, P, C Pizzinelli, C Roth and J Wohlfart (2022), “Subjective Models of the Macroeconomy: Evidence from Experts and Representative Samples”, Review of Economic Studies 86(6): 2958–91.

    Binetti, A, F Nuzzi and S Stantcheva (2024), “People’s understanding of inflation”, Journal of Monetary Economics 148, 103652.

    Coibion, O, Y Gorodnichenko and M Weber (2022), “Monetary Policy Communications and Their Effects on Household Inflation Expectations”, Journal of Political Economy 130(6): 1537–84.

    Ferreira, C and S Pica (2005), “Households’ Subjective Expectations: Disagreement, Common Drivers, and Reaction to Monetary Policy”, Banco de Espana Working Paper No. 2445.

    Gorodnichenko, Y, M Weber and O Coibion (2019), “Monetary policy communications and their effects on household inflation expectations”, VoxEU.org, 22 February.

    Gorodnichenko, Y, M Weber and O Coibion (2021), “How inflation expectations affect households’ spending decisions”, VoxEU.org, 19 March.

    Kamdar, R and W Ray (2024), “Attention-Driven Sentiment and the Business Cycle”, University of Oxford Working Paper.

    Piccolo, J, A Russo, E Granziera and E Castelnuovo (2025), “Households’ Macroeconomic Beliefs: The Role of Education”, Marco Fanno Working Paper 316, Universita Degli Studi di Padova.

    Weber, M, G Kenny, D Georgarakos, Y Gorodnichenko and O Coibion (2021), “The effect of macroeconomic uncertainty on household spending”, VoxEU.org, 31 July.

    Continue Reading

  • Lundin Mining Announces Updated Share Capital, Provides Update on Share Buybacks and Announces Filing of ESTMA Report and Modern Slavery Report

    Lundin Mining Announces Updated Share Capital, Provides Update on Share Buybacks and Announces Filing of ESTMA Report and Modern Slavery Report

    Lundin Mining Announces Updated Share Capital, Provides Update on Share Buybacks and Announces Filing of ESTMA Report and Modern Slavery Report

    June 30, 2025

    VANCOUVER, BC, June 30, 2025 /CNW/ – (TSX: LUN) (Nasdaq Stockholm: LUMI) Lundin Mining Corporation (“Lundin Mining” or the “Company”) reports the following updated share capital and voting rights, in accordance with the Swedish Financial Instruments Trading Act. View PDF.

    The number of issued and outstanding shares of the Company has increased by 179,029 to 855,997,663 common shares with voting rights as of June 30, 2025. The increase in the number of issued and outstanding shares from May 31, 2025 to date is a result of the exercise of employee stock options or the vesting of employee share units. During this period, the Company did not purchase any shares for cancelation under its Normal Course Issuer Bid program.

    Normal Course Issuer Bid

    Under the Company’s shareholder distribution policy, the Company is committed to allocating up to US$150 million in annual share buybacks through the NCIB program. So far during 2025, Lundin Mining has acquired 12,629,000 common shares at a cost of approximately US$104 million.

    ESTMA Report and Modern Slavery Report

    Lundin Mining has filed its ESTMA Report and Modern Slavery Report for the year ended December 31, 2024, which can be found on the Company’s website (lundinmining.com).

    About Lundin Mining

    Lundin Mining is a diversified base metals mining company with operations or projects in Argentina, Brazil, Chile, and the United States of America, primarily producing copper, gold and nickel.

    The information in this release is subject to the disclosure requirements of Lundin Mining under the Swedish Financial Instruments Trading Act. The information was submitted for publication, through the agency of the contact persons set out below on June 30, 2025 at 16:00 Pacific Time.

    Lundin Mining Announces Updated Share Capital, Provides Update on Share Buybacks and Announces Filing of ESTMA Report and Modern Slavery Report (CNW Group/Lundin Mining Corporation)

    SOURCE Lundin Mining Corporation

    For further information, please contact: Stephen Williams, Vice President, Investor Relations: +1 604 806 3074; Robert Eriksson, Investor Relations Sweden: +46 8 440 54 50

    Continue Reading

  • Susan Sarandon ‘terrified but excited’ to make UK theatrical debut in September | Theatre

    Susan Sarandon ‘terrified but excited’ to make UK theatrical debut in September | Theatre

    Susan Sarandon is to make her UK theatre debut alongside Andrea Riseborough, when the pair portray the same woman at different ages, in Tracy Letts’ drama Mary Page Marlowe.

    The play will be staged this autumn at the Old Vic in London by Matthew Warchus, in his final season as artistic director. Several actors portray the title character, which is described as a “time-jumping mosaic” spanning 70 years in the life of an accountant and mother of two in Ohio.

    It marks a high-profile return to the stage for Sarandon, who made her Broadway debut in 1972 in An Evening with Richard Nixon and … by Gore Vidal before her breakout film role in The Rocky Horror Picture Show. By the time she was next on Broadway, in Exit the King in 2009, she was a household name and five-time Oscar nominee (who won for Dead Man Walking). Sarandon said: “I’m so honoured to be asked to be in a play during Matthew Warchus’s final season at the Old Vic,” adding that she was “terrified but excited”.

    Riseborough, similarly better known as a film star, has not acted on stage for 15 years. Her last major London role was in Ivanov opposite Kenneth Branagh at the Donmar Warehouse in 2008. She recently appeared in Warchus’s screen version of Matilda the Musical. Riseborough said: “It’s an honour to be taking on the role of Mary – amongst others – in Tracy Letts’ poignant play, alongside the extraordinary Susan Sarandon. I’m so very grateful to be working with Matthew again and thrilled to finally work at the Old Vic, a beautiful space.”

    Warchus called Letts “one of America’s greatest living writers” and said the play would be staged in-the-round – as will all the productions in his final season. Mary Page Marlowe will run from 23 September to 1 November.

    Letts is best known for his Pulitzer winner August: Osage County, which was directed by Anna D Shapiro in a Chicago Steppenwolf production that played at London’s National Theatre in 2008. Shapiro directed the premiere of Mary Page Marlowe for the Steppenwolf theatre in 2016. In his review, the New York Times critic Charles Isherwood wrote: “Some may find the play’s form frustrating; I found it beautiful and affecting, like flipping through a friend’s photo album in no particular order, finding some faces familiar, others unexpected. And then you come upon someone entirely unknown – who obviously meant much to your friend – and you realize, with a pang of sadness, that your knowledge of even those closest to you will always be fragmentary and incomplete.”

    This will be the play’s UK premiere. Letts said: “From my first experiences as a playwright here 30 years ago, to the run of August: Osage County at the National, London is an integral part of my development as an artist. I’m deeply gratified to have Mary Page Marlowe at the Old Vic, directed by Matthew, featuring these remarkable actresses. A genuine thrill.”

    Warchus will step down from the Old Vic in September next year, when he will be succeeded by Rupert Goold, who in turn will be replaced in the top job at the Almeida theatre by Dominic Cooke.

    Continue Reading

  • BBC Sounds announces Mad for Oasis, new 10-part series exploring the enduring legacy of the band

    BBC Sounds announces Mad for Oasis, new 10-part series exploring the enduring legacy of the band

    As Liam and Noel Gallagher get set to return to stage this summer, BBC Sounds explores the lasting impact of one of Britian’s most iconic bands in a brand-new ten-part series, Mad For Oasis.

    Made by BBC Local teams at BBC Radio Manchester, and hosted by Noel’s daughter, Anais, Mad For Oasis tells the stories of their music through the eyes of the superfans.

    We hear from the Oxford-based artist Paul Fellows, who first saw the band more than 20 years ago, and the experience left a lasting impression. His deep love for Oasis inspired him to create artwork dedicated to the band – work that has since helped raise funds for Great Ormond Street Hospital. It’s a cause close to his heart, as the hospital once cared for his ill son.

    Paul said: “Oasis have had a massive influence on my life. If someone came up to me in the field of Knebworth and said in 25 years’ time, you’re going to meet him on stage and raise money for a great cause, I would never have believed it!”.

    Karen from New Ross, in Ireland has been a devoted Oasis fan since day one. Their music has been a constant companion through both her teenage years and adult life. She recalls how one song in particular became the bridge that helped her reconnect with her mother, who had dementia. She said: “An Oasis song helped me connect with my mother in a way I never thought I’d be able to again. Happy or sad, it will always be a massive part of me”.

    Host of the series Anais Gallagher said: “Obviously, Oasis have always been a big part of my life. But to have the opportunity to hear these incredible stories from people about how their music has impacted their lives, has been amazing. I’m thrilled to be a part of it.”

    The artwork for this series was specially commissioned, it was created by Manchester Artist and Oasis fan Stanley Chow who said: “I’m thrilled to have to been asked to work on the series cover. I had so much fun researching the illustration. It’s a lovely thing to be part of!”

    Chris Burns, Head of Local Audio Commissioning said: “Whether it’s your favourite band reuniting, your football team winning, or losing, our BBC teams live and breathe the rollercoaster of local life with our audiences. BBC Radio Manchester really gets to the heart of how this local band made its mark upon ordinary people’s lives and is told fantastically through Anais.”

    Mad For Oasis is a BBC Local production for BBC Sounds and will be available on BBC Sounds on Tuesday 1 July 2025.

    HM3

    Follow for more

    Continue Reading

  • Household energy bills fall but may not go much lower

    Household energy bills fall but may not go much lower

    Kevin Peachey

    Cost of living correspondent

    Getty Images Couple cook on a hob in a kitchen.Getty Images

    Energy prices will fall from Tuesday for 21 million households in England, Scotland and Wales but uncertainty remains over whether costs will stay down for winter.

    The bill for a household using a typical amount of gas and electricity is dropping by £11 a month, under regulator Ofgem’s latest price cap.

    While billpayers have welcomed the 7% cut, there is concern that bills will still hit hard later in the year when it is colder and darker.

    People are being encouraged to shop around to see whether a fixed deal which could provide more certainty over payments would be more suitable.

    The future direction of prices is hard to predict. While little change had been expected for prices this autumn, uncertainty in the Middle East could still have an impact on wholesale prices, with a knock-on impact on household bills.

    Analysts at the energy consultancy Cornwall Insight have forecast a further 1% drop in October.

    This would take the annual bill for a household using a typical amount of gas and electricity to £1,697 a year – but Cornwall Insight said there was “significant uncertainty” over the forecast.

    “The cap still remains hundreds of pounds above pre-pandemic prices, even when adjusting for inflation. Furthermore, there is little indication that prices will reduce substantially over the next few years,” it said.

    Ofgem is urging people to consider fixed deals, which the regulator said could lead to a £200 annual saving.

    Those already on fixed deals will not see any change to their monthly payments following Tuesday’s price cap change.

    Currently 35% of billpayers are on a fixed tariff, up from just 15% a year ago when fewer offers were available.

    However, a fixed deal only sets the unit rate. Actual household bills depend on how much energy is used.

    At this time of year heating is usually off, so families typically focus on the cost of cooking, particularly as food prices have been rising sharply.

    Budgeting

    Nadina Hill, a mother-of-two who works part-time at an emergency services control room, has been trying to keep on top of her cooking and energy costs.

    “It is a struggle, because the price of everything always goes up,” the 45-year-old said. “I have to budget carefully.”

    She took part in an eight-week course with her daughter Gracie, 14, that taught them about cooking healthy food more cheaply.

    “We made some meals we’d never made before and used different types of ingredients,” she said.

    Hannah Marsh, Gracie and Nadina Hill stand on the pitch at Stevenage Football Club with stands in the background

    Nadina (right) and her daughter gathered tips through a project run by Stevenage Football Club’s Hannah Marsh (left)

    The Community Kitchen, run by Stevenage Football Club Foundation, has helped hundreds of families, and focuses on menus with portions costing £1 or less.

    Hannah Marsh, head of health and wellbeing at the foundation – the charitable arm of the club, who created the programme, said key tips included:

    • Using recipes like pizza in a pan, to avoid having to use the oven
    • Bulk cooking meals, some of which can be frozen for later
    • Planning and budgeting for what you will cook throughout the week
    • Considering using tinned or frozen vegetables which could be cheaper

    Gracie said that even her pet rabbit Clover, and guinea pigs, Miles and Patch, benefitted from the course.

    “Instead of wasting all the peelings and putting them in the bin, we would give those as a treat,” she said.

    How the price cap works

    Every three months, the regulator’s price cap sets a maximum that suppliers can charge for each unit of energy, which applies to anyone on a variable tariff in England, Scotland and Wales. The price cap does not apply in Northern Ireland, which has its own energy market.

    Customers on variable deals can estimate how much their energy bill will fall by knocking 7% off their previous monthly direct debit.

    Ofgem illustrates the change in prices by showing the impact on the annual bill for a household using a typical amount of energy and paying by direct debit. This has dropped by £129, to £1,720.

    A bar chart showing the energy price cap for a typical household on a price-capped, dual-fuel tariff paying by direct debit, from January 2022 to September 2025. The figure was £1,216 based on typical usage in January 2022. This rose to a high of £4,059 in January 2023, although the Energy Price Guarantee limited bills to £2,380 for a typical household between October 2022 and June 2023. Bills dropped to £1,568 in July 2024, before rising slightly to £1,717 in October, £1,738 in January 2025, and £1,849 a year from April. From July to September, the figure will fall to £1,720.

    Prices are still considerably higher than before the Covid pandemic. That means people have had to adapt their lifestyles and finances.

    Jenny David, who lives in Bridgend with her husband, Mark and two children, Anwen and Hywel, said the family had worked out new ways to save.

    “It’s become [our] new norm,” she said “You don’t even notice you’re doing things.”

    Jenny David at home with a picture and door behind her.

    Jenny David says she plans food shopping meticulously

    She is a nurse and her husband works in his family’s kitchen and bathroom fitting business.

    They invested in an air fryer and meticulously plan their shops. Jenny said she was used to being active, but to save money on the cost of gym membership and classes she now attended a free weekly outdoor fitness class.

    New energy prices

    Another strategy for managing energy expenditure is for households to provide regular meter readings to suppliers, to ensure companies charge for energy use at the correct rate.

    The latest changes mean variable tariffs for a customer who pays by direct debit are as follows:

    • Gas prices are capped at an average of 6.33p per kilowatt hour (kWh) down from 6.99p
    • Electricity is capped at 25.73p per kWh down from 27.03p
    • Standing charges vary by region but have fallen on average to 51.37p a day for electricity, from 53.8p
    • Standing charges for gas have fallen to 29.82p a day for gas, from 32.67p

    In addition:

    • A typical household uses 2,700 kWh of electricity a year, and 11,500 kWh of gas
    • Households on pre-payment meters pay slightly less than those on direct debit, with a typical annual bill of £1,672
    • Those who pay their bills by cash or cheque pay more, with a typical annual bill of £1,855.

    The regulator is considering changes to the system of standing charges, although that has brought renewed debate over how they operate.

    Winter fuel payment U-turn

    The government’s decision last year to limit eligibility for the winter fuel payment, focused concern on the cost of energy for pensioners.

    However, opposition from charities, backbench Labour MPs and unions, led to a U-turn from the prime minister and chancellor.

    The reversal means 75% of pensioners in England and Wales will receive the payment in winter 2025, and the rules will be similar in Scotland.

    From this winter, the payment of £200 or £300 per pensioner household, will go to those with an annual income of £35,000 or less.

    The Warm Home Discount, which is worth £150, will also be extended this winter.

    Anyone on means-tested benefits will automatically see the money knocked off their bills no matter what size of property they live in.

    Additional reporting by Abi Smitton

    Continue Reading

  • Menstrual Cups Tested in Space Flight Conditions for the First Time

    Menstrual Cups Tested in Space Flight Conditions for the First Time

    Scientists have launched menstrual cups into space for the first time, testing whether these reusable devices can withstand the extreme conditions of space travel. The AstroCup mission represents a key step toward giving female astronauts sustainable menstrual health options during long duration missions to the Moon and Mars.

    Since Sally Ride’s historic space shuttle flight in 1983, when NASA famously asked if 100 tampons would be enough for a week long mission, managing menstruation in space has been an ongoing challenge. Currently, most female astronauts use hormonal contraception to suppress menstruation entirely during missions. While this approach has practical advantages, it’s not suitable for everyone and raises health concerns for extremely long missions as we step further out into the Solar System.

    Sally Ride was the first American woman in space. (Credit : NASA)

    With ambitious plans for lunar bases and Mars expeditions that could last years or even decades, researchers recognised the urgent need for sustainable alternatives. An astronaut participating in multiple Artemis missions for example could face over a decade of menstrual suppression, while someone involved in the full program from 2025 to 2035 might require nearly 20 years of hormonal treatment.

    Artemis I successfully launched from the Kennedy Space Center on November 16, 2022. (Credit : Bill Ingalls) Artemis I successfully launched from the Kennedy Space Center on November 16, 2022. (Credit : Bill Ingalls)

    The AstroCup team, led by L ́ıgia F. Coelho from Cornell University, launched four commercially available menstrual cups aboard the Baltasar rocket during a European competition in October 2022 with two cups flying into space while two remained on the ground as controls. The rocket reached over 3 kilometres altitude during a 9 minute flight that subjected the cups to forces 16 times greater than Earth’s gravity. Before and after the flight, researchers conducted rigorous testing using water and glycerol to evaluate the cups’ structural integrity and leak proof performance.

    The space flown menstrual cups performed flawlessly. Visual inspections revealed no signs of wear or tear but more importantly, the cups showed no leakage of either test liquid, maintaining their seal integrity despite experiencing extreme acceleration forces, temperature changes, and pressure variations during flight. The payload’s onboard sensors recorded challenging conditions throughout the journey with temperatures ranging from 32-34°C, humidity dropping to 40%, and atmospheric pressure falling below 70,000 Pascals at peak altitude.

    These results suggest that menstrual cups could be a viable solution for managing menstruation during space missions. Unlike disposable tampons or pads, reusable cups would dramatically reduce waste, a critical consideration in space where every gram matters and disposal options are limited. Beyond practical benefits, this research addresses astronaut autonomy and choice in healthcare.

    A record four women simultaneously in space aboard the International Space Station in 2010. Clockwise from lower left: Tracy Caldwell Dyson, Dorothy Metcalf-Lindenburger, Naoko Yamazaki, and Stephanie Wilson. (Credit : NASA) A record four women simultaneously in space aboard the International Space Station in 2010. Clockwise from lower left: Tracy Caldwell Dyson, Dorothy Metcalf-Lindenburger, Naoko Yamazaki, and Stephanie Wilson. (Credit : NASA)

    While encouraging, the AstroCup experiment was just a first step. The test occurred in Earth’s atmosphere and gravity, while the Moon has one-sixth Earth’s gravity and Mars has one-third. These different gravitational conditions could affect how menstrual fluid behaves when cups are removed or repositioned. Future studies must examine how the devices perform across multiple menstrual cycles, including cleaning and storage procedures in the environment of space.

    The AstroCup mission proves that testing women’s health technologies for space is both feasible and necessary. With more women joining space programs around the world and missions growing longer, ensuring that female astronauts have safe, effective menstrual management options isn’t just a technical challenge, it’s a fundamental requirement for the future of human space exploration.

    Source : One Giant Leap for Womankind: First Menstrual Cups Tested in Space Flight Conditions

    Continue Reading

  • A Spacecraft Carrying Human Remains and Cannabis Crashes into the Ocean

    A Spacecraft Carrying Human Remains and Cannabis Crashes into the Ocean

    We’ve sent some pretty interesting payloads to space since the first satellite (Sputnik 1) launched on October 4th, 1957. As access to space has increased, thanks largely to the commercial space industry, so too have the types of payloads we are sending. Consider the Nyx capsule created by German aerospace startup The Exploration Company, which launched on June 23rd from the Vandenberg Space Force Base atop a Falcon-9 rocket as part of a rideshare mission (Transporter-14). The payload for this flight (dubbed “Mission Possible”) included the ashes and DNA of more than 166 deceased people provided by Celestis, a Texas-based memorial spaceflight company.

    While the mission achieved orbit and a controlled reentry, the capsule’s landing parachutes failed to deploy before landing. This caused the Nyx capsule to crash in the Pacific Ocean on June 24th, causing all of its cargo to be lost at sea. This was the first time The Exploration Company sent customer payloads to space, equivalent to roughly 300 kg (660 lbs) of cargo. In a statement posted on LinkedIn, the company described the flight as a “partial success (partial failure).” Per their statement:

    The capsule was launched successfully, powered the payloads nominally in-orbit, stabilized itself after separation with the launcher, re-entered and re-established communication after black out. But it encountered an issue afterwards, based on our current best knowledge, and we lost communication a few minutes before splashdown. We are still investigating the root causes and will share more information soon. We apologize to all our clients who entrusted us with their payloads.

    We thank our teams for their hard work and their dedication to success. We have been pushing boundaries in record time and cost. This partial success reflects both ambition and the inherent risks of innovation. Leveraging the technical milestones achieved yesterday and the lessons we will extract from our ongoing investigation, we will then prepare to re-fly as soon as possible.

    Artist’s impression of The Exploration Company’s Nyx capsule in orbit. Credit: The Exploration Company

    This is also the second time Celestis has lost a payload, the previous having taken place in 2023 when a rocket containing the cremated remains of the late NASA astronaut Philip K. Chapman exploded over New Mexico. Celestis also released a statement of condolences to the families of the people whose remains were lost:

    In the coming days, our team will reach out to each family individually to offer support and discuss possible next steps. Though we currently believe that we cannot return the flight capsules, we hope families will find some peace in knowing their loved ones were part of a historic journey, launched into space, orbited Earth, and are now resting in the vastness of the Pacific, akin to a traditional and honored sea scattering.

    In addition to the human remains and other payloads, Nyx also carried cannabis plant matter and seeds provided by Martian Grow, an open-source citizen science project. The purpose was to study the effects of microgravity on the germination and resilience, potentially providing insight into how life could adapt and fare in the Martian environment. The first, Mission Bikini, launched a smaller reentry capsule in July 2024 atop an Ariane 6 rocket, but the capsule remained in orbit after the rocket’s upper stage failed to launch it on its reentry trajectory.

    This latest mission aimed to test key technologies and verify the Nyx capsule’s ability to transport cargo to space. It is hoped that future iterations of the capsule will fly spacecraft to destinations in Low Earth Orbit (LEO), including the International Space Station (ISS) and/or its successor stations. To this end, the company plans to conduct a demonstration flight to the ISS in 2028, which is pending support from the European Space Agency. In the meantime, the company plans to move forward and incorporate the lessons of this latest mission.

    Further Reading: Gizmodo

    Continue Reading

  • Levothyroxine’s Role in Mild Pregnancy Hypothyroidism Queried

    Levothyroxine’s Role in Mild Pregnancy Hypothyroidism Queried

    (Boston)—While severe maternal hypothyroidism (low thyroid hormone levels) in pregnancy is known to increase risks of adverse pregnancy outcomes, it is unclear whether mild (subclinical) hypothyroidism causes similarly adverse pregnancy complications. It is also not clear whether maternal hypothyroidism in pregnancy increases risks of gestational diabetes.

    A new study in the journal Lancet Diabetes and Endocrinology (Osinga et al “Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes mellitus: a systematic review and individual-participant meta-analysis”) investigated a potential association between maternal thyroid function in pregnancy and risk of gestational diabetes. The study, which used data from a large sample of patients from several different studies, found low free thyroxine (FT4) levels in pregnancy was associated with increased risk of gestational diabetes (6.5% vs 3.5% in those with normal FT4 levels). However, patients with mild subclinical hypothyroidism (high thyrotropin, or TSH, and normal FT4 level) were not at increased risk of gestational diabetes.

    “Since TSH is used as the screening test for thyroid dysfunction, it is unclear whether these new findings should change the current practice of thyroid function screening in pregnancy,” says Sun Young Lee MD, MSc, assistant professor of medicine at Boston University Chobanian & Avedisian School of Medicine in an accompanying commentary, (https://www.thelancet.com/journals/landia/article/PIIS2213-8587(25)00126-3/fulltext). “Currently available laboratory tests can also result in falsely low FT4 levels in pregnancy because of interference from normal changes in protein levels in pregnancy,” adds Lee who also is an endocrinologist at Boston Medical Center.

    Presently, routinely checking thyroid hormone levels in pregnancy is not recommended. In her commentary, Lee points out that other clinical trials have not shown that treatment of mild maternal hypothyroidism in pregnancy decreases risks of pregnancy complications. “It is unclear whether the findings of this study would advocate for universal screening and treatment of mild subclinical maternal hypothyroidism.”

    Lee believes further clinical trials are needed to study the potential benefit of levothyroxine treatment of low FT4 levels in pregnancy in decreasing risks of pregnancy. In the meantime, she feels more vigilant screening of gestational diabetes in patients with known thyroid disease is important.

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

    Continue Reading

  • New Statistical Method Identifies Hidden Gene Programs Linked to Poor Survival in Aggressive Pancreatic Cancer

    New Statistical Method Identifies Hidden Gene Programs Linked to Poor Survival in Aggressive Pancreatic Cancer

    Newswise — Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer, known for its aggressive behavior and resistance to treatment. Treating PDAC is challenging because the tumors are extraordinarily complex, with a chaotic mix of cells with different behaviors, vulnerabilities, and gene expression patterns.

    In a study published in Nature Genetics, researchers from the University of Chicago developed a powerful statistical method called Generalized Binary Covariance Decomposition (GBCD) to better understand this complexity. This method enables researchers to analyze massive single-cell RNA sequencing datasets and uncover recurring patterns of gene activity across diverse patient tumors.

    By applying GBCD to thousands of individual cancer cells from multiple studies, the team discovered previously hidden gene expression programs, particularly a stress-response signature that is linked to poor survival outcomes. This new method could be a powerful tool for identifying high-risk patients and developing more personalized treatment strategies.

    Understanding tumors’ mixed make-up through variations in gene expression

    Genetic and epigenetic alterations are major drivers of fatal diseases like cancer. These alterations impact cellular function by changing gene expression and leading to transcriptional heterogeneity—a phenomenon in which patterns of gene activity differ across cells. Every tumor contains a complicated mix of cell types and states. Some cells grow rapidly, others remain dormant; Some respond to drugs, others are resistant to treatment.

    “A big question in cancer is, how does gene expression predict or causally impact the way a tumor develops or how patients respond to therapy?” said senior author Matthew Stephens, PhD, FRS, Professor and Chair of the Department of Statistics and Professor of Human Genetics at UChicago. “If we understood how transcriptional variation predicts prognosis and therapy response, then we could improve therapies because transcriptional variation is relatively easy to measure.”

    Sometimes it is not just a single gene, but a set of genes that exhibit coordinated transcriptional changes. These are known as gene expression programs, which can characterize cancer molecular subtypes, influence tumor progression, and affect therapy response.

    Revealing layers within tumor complexity

    Historically, most transcriptomic data came from bulk RNA sequencing, which measures gene expression in a group of cells rather than in individual cells. The issue with bulk transcriptomic data is that it provides measurement at the patient level. In contrast, single-cell RNA sequencing (scRNA-seq) data measures gene expression at single-cell resolution, revealing transcriptional heterogeneity among cells from the same patient.

    Modern technologies like scRNA-seq allow researchers to measure the activity of thousands of genes in individual cancer cells, offering much higher resolution of the transcriptional heterogeneity within tumors. However, the resulting massive datasets pose a challenge: distinguishing meaningful signals from noise.

    In the current study, the team focused on analyzing transcriptional variation using scRNA-seq data. “Studying single-cell data allows us to see much more structure than what we can observe with bulk RNA-seq,” said Yusha Liu, PhD, a former postdoctoral researcher in the Stephens lab who led the study. Unified analysis of scRNA-seq data from multiple studies and patients can identify recurrent patterns of transcriptional variation related to cancer etiology, such as molecular subtypes. There may also be other biological activities or cellular processes occurring in tumor cells that aren’t directly tied to known molecular subtypes but still have significant implications for patient outcomes.

    “Although tumor subtype identification is helpful in guiding treatment choices, the molecular landscape is very complex,” Stephens said. “We are trying to identify gene expression programs using Generalized Binary Covariance Decomposition (GBCD), a statistical method designed to analyze transcriptional heterogeneity in single-cell RNA data and detect patterns beyond known subtypes.” This method allows researchers to break down the complex variation in gene activity into distinct, interpretable components.

    Stress response signature offers clues to pancreatic cancer survival

    To test the new GBCD method, researchers analyzed 35,000 cancer cells from 59 patients with PDAC. GBCD not only identified the well-known “classical” and “basal” PDAC subtypes but also uncovered a previously underappreciated stress-response program strongly associated with poor survival.

    They found that many critical genes in this stress-response program are regulated by ATF4, a key transcription factor involved in the “integrated stress response,” a survival mechanism exploited by cancer cells under harsh conditions. Importantly, this stress program predicted worse outcomes in cancer patients independent of tumor stage or known subtype. Identifying this signature could help explain PDAC’s aggressive nature and inform treatment strategies.

    “The benefit of our approach is that we can perform a unified or integrative analysis of single-cell RNA-seq data from multiple samples across studies,” Liu said. “This greatly increases the number of patient samples and cells, enhancing our power to identify shared transcriptional patterns. The challenge, however, is the high degree of variability between patients, which can mask these subtle shared patterns and that is what GBCD is designed to tackle.”

    According to researchers, the GBCD approach offers a deeper characterization of the transcriptional landscape in pancreatic cancer and could be applied to other cancer types. They hope the tool will advance understanding of cancer biology and etiology, while offering valuable insights to study tumor progression and metastasis.

    The study “Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition” was supported by grants from the National Institutes of Health, the University of Chicago Medicine Comprehensive Cancer Center, the Leona M. and Harry B. Helmsley Charitable Trust, the Neuroendocrine Tumor Research Foundation, an Ullman Family Dream Team Award, and the Government of Ontario.

    Additional authors included Scott A. Oakes and Kay F. Macleod from the University of Chicago, and Jason Willwerscheid from Providence College, RI.


    Continue Reading