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  • Divesiran Shows Promise as RNA-Based Approach in Polycythemia Vera

    Divesiran Shows Promise as RNA-Based Approach in Polycythemia Vera

    Marina Kremyanskaya, MD, PhD

    Novel RNA-based therapeutic strategies and hepatocyte-directed delivery platforms are generating increasing interest for the management of polycythemia vera, according to Marina Kremyanskaya, MD, PhD.

    In an interview with OncLive®, Kremyanskaya, an associate professor and hematologist/oncologist at Mount Sinai Hospital, discussed findings from the ongoing phase 1/2 SANRECO trial (NCT05499013) evaluating divesiran, a GalNAc-conjugated small interfering RNA (siRNA) agent designed to selectively silence gene expression implicated in disease pathophysiology. Findings presented at the 2025 EHA Congress showed that the agent was safe and well tolerated at doses of up to 9 mg/kg. The agent also led to an increase in hepcidin levels, translating to lower hematocrit levels and a decrease in required phlebotomies.

    She also noted how novel agents such as divesiran could ultimately expand treatment options beyond cytoreductive therapies and JAK inhibitor–based strategies for patients with suboptimal responses or intolerance to existing standards of care.

    Kremyanskaya is an associate professor of medicine, hematology, and medical oncology at Icahn School of Medicine at Mount Sinai in New York, New York.

    OncLive: What is the mechanism of action of divesiran?

    Kremyanskaya: The mechanism of action of this drug is a novel approach for patients with polycythemia vera. It uses a technology called siRNA. It binds to mRNA of a molecule called TMPRSS6, which is a negative regulator of hepcidin production. When it binds to this molecule in liver cells—hepatocytes—it interferes with the mRNA and leads to its destruction.

    As a result, the expression of TMPRSS6 decreases. TMPRSS6 is a negative regulator of hepcidin production; by removing that negative regulator, endogenous hepcidin production goes up. Because of the increased hepcidin in the bloodstream, there is restriction of total iron available to the bone marrow for production of red blood cells. This eventually results in control of erythrocytosis and hematocrit in patients with polycythemia vera.

    Divesiran is one of the few agents using the hepcidin-iron pathway. The first drug developed in this space was rusfertide, which is a hepcidin mimetic that [delivers] hepcidin directly. Both work through a similar concept of increasing hepcidin and restricting iron, but divesiran does it indirectly by using siRNA to increase endogenous hepcidin production.

    What was the design of the phase 1 portion of the study, and which patients were eligible?

    The SANRECO trial is a phase 1/2 study. The data presented here at EHA are from the phase 1 portion. Three different cohorts of patients were enrolled at three dose levels, for a total of 21 patients.

    Patients had polycythemia vera diagnosed per WHO 2016 criteria and had to be heavily phlebotomy dependent. That was defined as [either] at least 3 phlebotomies in the 6 months prior to enrollment or 5 phlebotomies in the year prior. These were patients either getting phlebotomies alone or receiving cytoreductive therapy but still needing phlebotomies.

    This is a phase 1 study, so the primary end point was safety and tolerability, but efficacy was also assessed.

    What safety findings have been observed so far?

    The drug was well tolerated. The most common adverse effect [AE] was injection-site reaction. Divesiran is given as a subcutaneous injection every 6 weeks. In the study, patients received an injection every 6 weeks for 4 doses, followed by a 16-week observation period.

    Injection-site reactions were self-limited and resolved in all patients. There were no AEs leading to drug discontinuation and no serious AEs related to the study drug.

    What preliminary efficacy signals were observed?

    The number of phlebotomies these patients required was significantly reduced compared with the period before starting divesiran. Patients entered the study with a wide range of hematocrit [levels]. Interestingly, those who already had controlled hematocrit at baseline did not require any additional phlebotomies while on the study drug. That is an exciting finding—these patients really don’t seem to need phlebotomies once on divesiran.

    What are the next steps for this research?

    Phase 2 enrollment is ongoing at multiple sites worldwide. The phase 2 study is randomized: one group receives the drug every 6 weeks, one receives it every 12 weeks, and the third group receives placebo. The hope is that enrollment will be completed by the end of this year, and we will have prospective, randomized results.

    What potential future clinical implications could this approach have?

    As the field develops, we hope these drugs will be available for patients with polycythemia vera who need frequent phlebotomies. Because of the nature of the disease and repeated phlebotomies, many [patients] become iron deficient, leading to symptoms related to iron deficiency. Better hematocrit control could also reduce thrombosis risk.

    Reference

    Kremyanskaya M, Hoffman R, Ginzburg Y, et al. SANRECO: an ongoing phase 1/2 study evaluating divesiran, a novel GalNAc-conjugated siRNA, in patients with polycythemia vera. Presented at: 2025 EHA Congress; June 12-15, 2025; Milan, Italy. Abstract S224.

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  • Saoirse Ronan and Jack Lowden Get a Head Start on Cool Parent Style

    Saoirse Ronan and Jack Lowden Get a Head Start on Cool Parent Style

    As far as pregnancy announcements go, Saoirse Ronan’s was one for the books. Back in May, the actor arrived at Louis Vuitton’s resort 2026 show in Avignon, France, dressed in a black lace-trimmed slip, bump on display.

    Saoirse Ronan at the Louis Vuitton resort 2026 show.

    Photo: Getty Images

    This weekend, though, Ronan opted for a bolder answer to maternity dressing. The actor took a stroll through London with her husband, Jack Lowden, and their dog. For their walk, Ronan donned a leopard print button-up midi shirtdress from maternity brand Isabella Oliver, belted under the bust to accentuate her baby bump. As for her accessories? She kept it comfortable in a pair of sky blue Birkenstocks, gold wire-rimmed oval sunglasses, and a pair of gold hoop earrings.

    Saoirse Ronan and Jack Lowden Get a Head Start on Cool Parent Style

    Photo: Backgrid

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  • Russian oil refineries, terminals burn as Ukraine hits Putin's war economy – Reuters

    1. Russian oil refineries, terminals burn as Ukraine hits Putin’s war economy  Reuters
    2. Oil prices edge up as traders mull supply risks  Reuters
    3. Weakening Russian war machine: Why Kyiv is targeting its energy sector  Euronews.com
    4. Russian refinery still burns as Kyiv targets energy sector  TVP World
    5. Oil Prices Rise Amid Supply Concerns: What Investors and Businesses Should Prepare for in Oman  omanet.om

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  • Kneecap cancel US tour dates amid court case

    Kneecap cancel US tour dates amid court case

    In a statement posted on social media, the band said “due to the proximity of our next court hearing in London to the first date of the tour” they have to “cancel all 15 tour dates in October”.

    “With every show fully sold out, to tens of thousands of fans, this is news we are sad to deliver,” it continued.

    “But once we win our court case, which we will, we promise to embark on an even bigger tour to all you great heads.”

    The rap trio, who performed in Paris on Sunday night, said their planned Canadian shows in Vancouver and Toronto will still go ahead.

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  • John Cena confirms he is a pure coffee aficionado

    John Cena confirms he is a pure coffee aficionado



    John Cena confirms he is a pure coffee aficionado

    John Cena has recently opened up that he’s a pure coffee connoisseur in a new video interview.

    The Barbie star gave his verdict that Melbourne is the “coffee-first city” as they serve the best “flat white” over there.

    The TikTok clip, originally produced by Bon Appétit magazine, features John sampling coffee from the Condé Nast office café in New York City.

    “When it comes to coffee, John Cena is a purist. The actor explains why he judges a coffee shop based on how they make their flat whites,” read the caption.

    In the clip, Heads of State actor shared that the coffee presented to him for the test was an “American version” of a flat white.

    “I can tell cause it’s too big and there’s too much milk and the milk are not steamed,” explained the 48-year-old.

    John further said that the reason “I love a flat white is because coffee is a universal language throughout the world. So, I will judge a place based on its flat white”.

    The Suicide Squad actor then divided cafes into two categories, saying, “A lot of places are food first and coffee is an accoutrement.”

    John mentioned that the Condé Nast Cafe is not a “coffee-first” establishment, as he noted, “The best flat whites I’ve had are in Melbourne, Australia; they are coffee-first people.”

    Meanwhile, John also pointed out that the best way to “prepare a flat white would be 170 grams (six ounces), which gives the double-shot of coffee a stronger taste”.

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  • China get the job done against Colombia and advance

    Despite the defeat, Colombia had the match’s top scorer in outside hitter Ana Karina Olaya, who left the court with 21 points (19 kills, one block, one ace). Outside hitter Laura Pascua, with 14 points (12 kills, two aces), and opposite Dayana Segovia, with 12 (ten kills, two blocks), also had solid shifts.

    “We feel better today because our first game wasn’t good,” setter María Alejandra Marín commented. “I think we have a really good team and that we could do better than we did against the Dominican Republic. We’re enjoying here and now we need to focus on our last match against Mexico. We have an opportunity to win that match and we want to do it.”

    Colombia’s errors were too much for them to endure as the South Americans gave up 28 points to China’s 11. The Asians were better in kills (56 to 50) and blocks (12 to seven), while the South Americans had the most aces (three to two).

    2025 FIVB Volleyball Women’s World Championship: full schedule and results

    Pool F will complete its schedule in Chiang Mai on Wednesday, with Colombia and Mexico playing for their first victory at 16:00 local time (9:00 GMT) and China and the Dominican Republic battling for first place at 19:30 (12:30 GMT).

    Quick links:
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  • Harmonized Landsat and Sentinel-2: Collaboration Drives Innovation

    Harmonized Landsat and Sentinel-2: Collaboration Drives Innovation

    Introduction

    Landsat, a joint program of NASA and the U.S. Geological Survey (USGS), has been an invaluable tool for monitoring changes in Earth’s land surface for over 50 years. Researchers use instruments on Landsat satellites to monitor decades-long trends, including urbanization and agricultural expansion, as well as short-term dynamics, including water use and disaster recovery. However, scientists and land managers often encounter one critical limitation of this program: Landsat has a revisit time of eight days (with Landsat 8 and 9 operating), which is too long to capture events and disasters that occur on short timescales. Floods, for example, can quickly inundate a region, and cloud cover from storms can delay Landsat’s ability to get a clear observation on damage.

    In 2015, the European Space Agency’s (ESA) Copernicus Sentinel-2A mission joined Landsat 7 and 8 in orbit. It was designed to collect comparable optical land data with the intention of leveraging Landsat’s archive. Two years later, ESA launched Sentinel-2B, a satellite identical to Sentinel-2A.

    Led by a science team at NASA’s Goddard Space Flight Center (GSFC), the USGS, NASA, and ESA began to work on combining the capabilities of Sentinel-2 and Landsat satellites. This idea was the impetus behind Harmonized Landsat and Sentinel-2 (HLS) project, a NASA initiative that created a seamless product from the Operational Land Imager (OLI) and Multi-Spectral Instrument (MSI) aboard Landsat and Sentinel-2 satellites, respectively. HLS Version 2.0 (V2.0) is the most recent version of these data and had a global median repeat frequency of 1.6 days in 2022 by combining observations from Landsat 8 and 9 and Sentinel-2A and B. The recent addition of Sentinel-2C data will provide even more frequent observations. With near-global coverage and improved harmonization algorithms, HLS V2.0 paves the way for new applications and improved land monitoring systems – see Animation 1. HLS data are available for download on NASA Earthdata: HLSL30v2.0 and HLSS30v2.0. These data can also be accessed through Google Earth Engine: HLSL30v2.0 and HLSS30v2.0. 

    The Dawn of HLS

    The story of HLS begins before the launch of Sentinel-2A in 2015. Jeffrey Masek [GSFC], who was at that time project scientist for Landsat 8, led a group of researchers who wanted to find a way to harmonize Landsat data with other satellite data. Their aim was to create a “virtual constellation” similar to how weather satellites operate.

    “HLS meets a need that people have been asking for for a long time,” said Masek.

    What began as a research question with an experimental product evolved into an operational project with the involvement of the Satellite Needs Working Group (SNWG). SNWG is an interagency effort to develop solutions that address Earth observation needs of civilian federal agencies. Every two years, SNWG conducts a survey of federal agencies to see how their work could benefit from satellite data. The answers span the gamut of application areas, from water quality monitoring to disaster recovery to planning how best to protect and use natural resources. SNWG brings these ideas to NASA, USGS, and the National Oceanic and Atmospheric Administration (NOAA) – the three main U.S. government providers of satellite data. These agencies work together to create and implement solutions that serve those needs. NASA plays a critical role in every step of the SNWG process, including leading the assessment of survey responses from over 30 federal agencies, managing and supporting the implementation of identified solutions, and encouraging solution co-design with federal partners to maximize impact.

    The HLS surface reflectance product was an outcome of the very first SNWG solution cycle in 2016. This product was expanded, following additional SNWG requests in 2020 and 2022. The 2020 cycle saw the creation of nine HLS-derived vegetation indices, and the 2022 cycle aimed for a six-hour latency product.

    The U.S. Department of Agriculture (USDA) now uses HLS to map crop emergence at the field scale in the corn belt, allowing farmers to better plan their growing seasons. Ranchers in Colorado use the dataset to decide where to graze their cattle during periods of drought. HLS also informs the use and termination of cover crops in the Chesapeake Bay area. In 2024, the Federal Emergency Management Agency (FEMA) employed HLS to identify where to focus aid in the aftermath of Hurricane Helene.

    A New and Improved HLS

    In the July 2025 issue of Remote Sensing of Environment, a team of researchers outlined the HLS V2.0 surface reflectance dataset and algorithms. The team included seven NASA co-authors, members of the 2018–2023 Landsat Science Team, and ESA. The lead author, Junchang Ju [GSFC—Remote Sensing Scientist], has been the technical lead on HLS since its inception. Co-author Christopher Neigh [GSFC—Landsat 8/9 Project Scientist] is the principal investigator on the HLS project. V2.0, which was completed in Summer 2023, incorporates several major improvements over HLS V1.4, the most recent publicly available HLS product. HLS V1.4 covered about 30% of the global land area, providing data on North America and other select locations. HLS V2.0 provides data at a spatial resolution of 30 m (98 ft) with near-global coverage from 2013 onward. The dataset includes all land masses except Antarctica. HLS V2.0 also has key algorithmic improvements in atmospheric correction, cloud masking, and bidirectional reflectance distribution function (BRDF) correction. Together, these algorithms “harmonize” the data, or ensure that the distinct Landsat and Sentinel-2 datasets can effectively be used interchangeably – see Animation 2.

    HLS V2.0 in Action

    The increased frequency of observations improved the ability of the scientific community to track disaster recovery, changes in phenology, agricultural intensification, rapid urban growth, logging, and deforestation. Researchers are already putting these advances to use.

    The land disturbance product (DIST-ALERT) is a global land change monitoring system that uses HLS V2.0 data to track vegetation anomalies in near real-time – see Figure 1. DIST-ALERT captures agricultural expansion, urban growth, fire, flooding, logging, drought, landslides, and other forces of change to vegetation. Amy Pickens [University of Maryland, Department of Geographical Sciences—Assistant Research Professor] said that HLS is the perfect dataset for tracking disturbances because of the frequency of observations.

    DIST-ALERT was created through Observational Products for End-Users from Remote Sensing Analysis (OPERA), a project at NASA/Jet Propulsion Laboratory (JPL). OPERA products respond to agency needs identified by the SNWG. In 2018, SNWG identified tracking surface disturbance as a key need. OPERA partnered with the Global Land Analysis and Discovery (GLAD) lab at University of Maryland to develop the change detection algorithm.

    To track changes in vegetation, the DIST-ALERT system establishes a rolling baseline – meaning that for any given pixel, the vegetation cover is compared against vegetation cover from the same 31-day window in the previous three years. The primary algorithm detects any vegetation loss relative to the established baseline. A secondary algorithm flags any spectral anomaly (i.e., any change in reflectance) compared to that same baseline. This approach ensures that the algorithm catches non-vegetation change (e.g., new building or road projects in unvegetated areas). Used together, these algorithms can identify long-term changes in agricultural expansion, deforestation, and urbanization alongside short-term changes in crop harvest, drought, selective logging, and the impacts of disasters. On average, DIST-ALERT is made available on LP DAAC within six hours of when new HLS data is available. Currently, the dataset does not provide attribution to disturbances.

    Disturbance alerts already exist in some ecosystems. Brazil’s National Institute for Space Research [Instituto Nacional de Pesquisas Espaciais (INPE)] runs two projects that detect deforestation in the Amazon: Programa de Cálculo do Desflorestamento da Amazônia (PRODES) and Sistema de Detecção de Desmatamento em Tempo Real (DETER). The GLAD lab created its own forest loss alerts – GLAD-L and GLAD-S2 – using Landsat and Sentinel-2 data respectively. Global Forest Watch integrates GLAD-L and GLAD-S2 data with Radar for Detecting Deforestation (RADD) observations – derived from synthetic aperture radar data from Copernicus Sentinel-1 – into an integrated deforestation alert.

    The implementation of these alert systems, some of which have been around for decades, have been shown to impact deforestation rates in the tropics. For example, a 2021 study in Nature Climate Change found that deforestation alerts decreased the probability of deforestation in Central Africa by 18% relative to the average 2011–2016 levels.

    DIST-ALERT is distinct from other alert systems in a few ways. First, it has global coverage. Second, the rolling baseline allows for tracking changes in seasonality and disturbances to dynamic ecosystems. When HLS V2.0 data are input to DIST-ALERT, the system is also better at identifying disturbances in cloudy ecosystems than other individual alert systems – because it is more likely to obtain clear observations. This also enables it to identify the start and end of the disturbance more precisely.

    Pickens said that the DIST-ALERT team is already working with end-users who are implementing their data product. She has spoken to some who use the system to help logging companies prove that they are complying with regulations. The U.S. Census Bureau is also using DIST-ALERT to monitor fast-growing communities so that they can do targeted assessments in the interim between the larger decennial census.

    Alongside DIST-ALERT, OPERA has also been developing the Dynamic Surface Water eXtent (DSWx) product suite, which employs HLS to track surface water (e.g., lakes, reservoirs, rivers, and floods) around the globe – see Figure 2. These new products represent the new applications made possible by the HLS interagency and international collaboration.

    Conclusion

    HLS is set to continue improving land monitoring efforts across the globe. Meanwhile, the HLS science team is working to improve the algorithms for a more seamless harmonization of Landsat 8 and 9 and Sentinel-2 data. They are also working to improve the cloud-masking algorithm, have recently released vegetation indices, and are working on developing a low-latency (six-hour) HLS surface reflectance product, all while incorporating user feedback.

    Looking ahead, the launch of future Sentinel and Landsat satellites will further the development of HLS. The additional data and unique capabilities will continue to meet researchers’ need for more frequent, high-quality satellite observations of Earth’s land surface.

    Madeleine Gregory
    NASA’s Goddard Space Flight Center/Science Systems and Applications Inc.
    madeleine.s.gregory@nasa.gov

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  • ‘AI hallucinations’ cause real-world disaster for family-run business: Stop trusting AI search results blindly

    ‘AI hallucinations’ cause real-world disaster for family-run business: Stop trusting AI search results blindly

    The rise of artificial intelligence in online search has transformed how people discover restaurants, plan meals, and make reservations. However, recent incidents highlight a concerning trend: AI-generated information can be entirely fabricated, leading to real-world confusion and frustration. Small businesses, in particular, are facing the consequences of these “AI hallucinations,” where chatbots or AI summaries confidently present false details as facts.

    Stefanina’s Pizzeria: A Case Study

    Stefanina’s, a family-run restaurant in Wentzville, Missouri, recently found itself at the center of such confusion. According to First Alert 4, the restaurant had to publicly caution customers against trusting AI-generated suggestions about its specials. Hungry patrons were arriving expecting discounts and menu items that did not exist. The family posted a clear message on Facebook urging diners to verify offers on the restaurant’s official website or social media pages, emphasizing that Google’s AI tools were providing inaccurate information.
    Eva Gannon, a member of the family, explained that the AI tool sometimes claimed the restaurant offered large pizzas at the price of small ones, among other nonexistent deals. She noted the strain this put on staff, who faced complaints and angry customers demanding promotions that were never valid.

    Broader Implications

    The problem extends beyond restaurants. As per Futurism, in Minnesota, a solar company sued Google after its AI-generated summaries falsely suggested the business faced legal action for deceptive sales practices, even though no lawsuits existed. Such errors demonstrate the reputational risks posed by overreliance on AI for information.

    Tech giants are actively promoting AI-driven search, encouraging users to trust AI for routine decisions, from booking tables to planning schedules. While these tools promise convenience, they are prone to generating convincing but incorrect content. The industry term “AI hallucinations” captures this phenomenon—AI outputs that appear credible yet are entirely fabricated.

    How Consumers Can Protect Themselves

    Experts advise that customers double-check AI-generated information through official channels, including restaurant websites, social media, or direct contact. For now, relying solely on AI summaries for specials, deals, or reviews can lead to disappointment and unnecessary conflict.As AI becomes increasingly integrated into everyday decision-making, users must remain cautious, recognizing that speed and convenience should not replace verification and critical thinking.

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  • PDS0101 Plus Pembrolizumab Yields Durable Survival Benefit in HPV16+ HNSCC

    PDS0101 Plus Pembrolizumab Yields Durable Survival Benefit in HPV16+ HNSCC

    Head and Neck Cancer | Image credit:

    © G.Go – stock.adobe.com

    Versamune HPV (formerly PDS0101) in combination with pembrolizumab (Keytruda) generated a median overall survival (OS) of 39.3 months (95% CI, 23.9-not evaluable [NE]) in patients with HPV16-positive recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) with a combined positive score (CPS) of at least 1, according to final topline results from the single-arm phase 2 VERSATILE-002 trial (NCT04260126).1

    These findings represent an improvement compared with historically published outcomes of 17.9 months with pembrolizumab alone or in combination with chemotherapy in this population, according to a news release. The durable survival outcome was supported by high levels of long-lasting, multifunctional, HPV16-specific CD8-positive T cells induced by Versamune HPV. Investigators reported that survival outcomes were consistent across patient demographics and clinical characteristics, including age, CPS status, and prior treatment.

    “We believe this final readout of topline survival data from our VERSATILE-002 clinical trial supports the durable clinical effect of [Versamune HPV], with similarly promising outcomes reported in other studies,” Kirk Shepard, MD, chief medical officer of PDS Biotech, stated in the news release. “We look forward to publishing the full dataset later [in 2025].”

    The VERSATILE-001 trial is an open-label, multicenter study designed to assess the safety and efficacy of Versamune HPV in combination with pembrolizumab in patients with unresectable, recurrent, or metastatic HPV16-positive HNSCC. In total, 53 patients were enrolled in the first- line recurrent/metastatic HNSCC arm of VERSATILE-002. Patients received subcutaneous Versamune HPV injections alongside pembrolizumab intravenous infusions during the first 4 treatment cycles. A fifth and final Versamune HPV dose was administered at cycle 12, with pembrolizumab monotherapy continuing every other cycle through cycle 35 or until disease progression or death.

    Previously presented data from the 2025 ASCO Annual Meeting showed that at a median follow-up of 18.4 months (range, 0.2-42.7), the median OS among patients with a CPS of at least 1 (n = 53), between 1 and 19 (n = 32), and at least 20 (n = 21) was 30 months (95% CI, 23.9-NE), 29.5 months (95% CI, 15.3-NE), and 39.3 months (95% CI, 18.4-NE).2 The overall response rates in these respective arms were 35.8%, 28.1%, and 47.6%. Furthermore, in the population of patients with a CPS of at least 1, the disease control rate was 77.4%, the median duration of response was 21.8 months (95% CI, 11.5-NE), and the median progression-free survival was 30.0 months (95% CI, 23.9-NE).

    No patients discontinued treatment in VERSATILE-002 due to treatment-related adverse effects (TRAEs).1 The most commonly reported TRAEs included injection site reactions (74.2%), fatigue (38.7%), headache (19.4%), pruritus (14.5%), diarrhea (12.9%), rash (9.7%), pain (8.1%), increased alanine aminotransferase levels (8.1%), and arthralgia (8.1%).2 The rate of grade 3 TRAEs was 16.1%, 1 patient experienced a grade 4 TRAE, and no patients experienced grade 5 TRAEs.

    “HPV16-positive head and neck cancer represents one of the fastest-growing cancer segments in the United States and Europe, yet treatment options remain limited,” Frank Bedu-Addo, PhD, president and chief executive officer of PDS Biotech, added in the news release.1 “These results suggest that [Versamune HPV] plus pembrolizumab may offer patients both survival benefit and tolerability, and we are well positioned to advance this therapy further.”

    The phase 3 VERSATILE-003 trial (NCT06790966) is ongoing. This trial is investigating Versamune HPV plus pembrolizumab vs pembrolizumab alone in the first-line setting in patients with HPV16-positive recurrent or metastatic HNSCC.3

    References

    1. PDS Biotech announces final topline survival data from VERSATILE-002 phase 2 trial in head and neck cancer. News release. PDS Biotech. August 25, 2025. Accessed August 25, 2025. https://pdsbiotech.com/index.php/investors/news-center/press-releases/press-releases1/132-2025-news/1016-pds-biotech-announces-final-topline-survival-data-fromvers2025-08-25-053503
    2. Weiss J, Kaczmar J, Harrington K, et al. Versatile-002: overall survival of HPV16-positive recurrent/metastatic head and neck squamous cell carcinoma patients treated with T cell stimulating immunotherapy PDS0101 and pembrolizumab. J Clin Oncol. 2025;43(suppl 16):6037. doi:10.1200/JCO.2025.43.16_suppl.6037
    3. Price KAR, Harrington KJ, Worden FP, et al. VERSATILE-003: a phase 3, randomized, open-label trial of PDS0101 and pembrolizumab compared with pembrolizumab for first-line treatment of patients with HPV16-positive recurrent/metastatic head and neck squamous cell carcinoma. J Clin Oncol. 2025;43(suppl 16):TPS6111. doi:10.1200/JCO.2025.43.16_suppl.TPS6111

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  • Populous Expands Footprint in Canada with New Toronto Office

    Populous Expands Footprint in Canada with New Toronto Office

    Global design firm Populous, the architects and designers behind some of the most iconic destinations, has opened a new office in Toronto’s Financial District. Located in the historic Canada Permanent Trust Building, the space reflects Populous’ ongoing growth in Canada and its commitment to working within the communities it serves.

    The Toronto office is steps from Rogers Centre and Union Station, providing convenient access for clients and collaborators. The Financial District location places Populous in the center of one of Canada’s most active urban areas, surrounded by a diverse mix of commercial, cultural, and entertainment destinations.

    “We have been designing projects in Canada for over a decade. Our expansion into the international City of Toronto symbolizes our commitment to the country and how much we have enjoyed working there,” said Jonathan Mallie, Managing Director of the Americas at Populous. “We have designers across Montreal, Calgary, Winnipeg and now Toronto which emphasizes our global perspective and reflects our commitment to our clients and living and working in the places where we design.”

    Populous has delivered more than a dozen projects across eight provinces, including major renovations at Rogers Centre in Toronto and BC Place Stadium in Vancouver, the Montreal Olympic Stadium Modernization project, and the completion of the BMO Centre expansion in Calgary.

    Populous’ current Canadian portfolio includes:

    • Toronto Performance Venue and Hotel – Toronto, ON
    • Rogers Centre Renovations – Toronto, ON
    • BC Place Stadium Renovation – Vancouver, BC
    • Montreal Olympic Stadium Modernization Project – Montreal, QC
    • Canada Life Centre Renovations – Winnipeg, MB
    • Brantford New OHL Arena – Brantford, ON
    • Southeast Event Centre – Steinbach, MB
    • IGA Stadium Redevelopment – Montreal, QC

    With offices across the Americas, Europe, Asia, and Australia and New Zealand, Populous continues to expand its global footprint while remaining deeply connected to local markets. The firm is known for designing some of the world’s most iconic venues, including Yankee Stadium, Allianz Field, Tottenham Hotspur Stadium, and Kansai International Airport, each created to bring people together through unforgettable experiences.

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