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  • Guillermo Del Toro’s ‘Frankenstein’ To Play In Some IMAX Theaters

    Guillermo Del Toro’s ‘Frankenstein’ To Play In Some IMAX Theaters

    Frankenstein — writer-director Guillermo del Toro’s adaptation of the classic Mary Shelley novel — will play in some IMAX theaters during the film’s upcoming theatrical run before it heads to Netflix.

    Frankenstein, which is the Oscar-winning filmmaker’s lifelong passion project, will begin its limited run in theaters on Oct. 17 before arriving on Netflix on Nov. 7. The film held its world premiere at the Venice International Film Festival in late August and also played at the Toronto International Film Festival earlier this month.

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    While the exact number of theaters Frankenstein will be playing in is yet to be announced, IMAX CEO Rich Gelfond revealed Thursday at the Axios Media Live conference in New York that some of the theaters are IMAX venues.

    “It really is a theatrical movie,” Gelfond told attendees at the conference (via Deadline). “You know, Frankenstein and IMAX [are] great synergy. He’s big. IMAX is big, loud,” noting it will debut in “a couple of weeks.”

    While Gelfond didn’t indicate the number of IMAX theaters Frankenstein will be playing in, Deadline noted that “it will be a quite limited footprint of about 10 screenings.”

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    One audience has already had a look at Frankenstein in IMAX. According to The Hollywood Reporter, del Toro screened his IMAX cut of the film at the Busan International Film Festival in Busan, South Korea.

    Frankenstein stars Oscar Isaac as Dr. Victor Frankenstein, Jacob Elordi as Frankenstein’s Monster and Goth as Victor’s fiancée, Elizabeth Lavenza. The film also stars Christoph Waltz, Ralph Ineson, Burn Gorman, Felix Kammerer, Lars Mikkelsen, David Bradley, Christian Convery and Charles Dance.

    How Long Will Guillermo Del Toro’s ‘Frankenstein’ Play In Theaters?

    In an interview before the film’s world premiere at the Venice International Film Festival in August, Guillermo del Toro discussed the film’s upcoming theatrical release with Variety but did not specify how many theaters the film was going to play beginning on Oct. 17.

    “Well, we will get the biggest theatrical release that Netflix gives its films. I don’t know the exact number, but it’s three weeks exclusively and then it can stay in theaters longer,” del Toro told Variety.

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    “And Netflix is also going to release it on physical media, just like they did with [del Toro’s 2022 stop-motion film] Pinocchio,” he added. “The theatrical experience is very important. I believe in it. But if the choice is between being be able to make the movie and have portions of the release be theatrical and portions be streaming or not make the movie, that’s an easy decision to make. For a filmmaker, you want to tell your stories.”

    Frankenstein is opening in theaters on Oct. 17 and begins streaming on Netflix on Nov. 7.

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  • More research needed into psychedelics for mental illness treatment, says Royal College of Psychiatrists – The Pharmaceutical Journal

    1. More research needed into psychedelics for mental illness treatment, says Royal College of Psychiatrists  The Pharmaceutical Journal
    2. Few Answers, Many Risks in Psychedelic Medicine  Medscape
    3. Experts say ketamine should be used as a cure for depression  The Independent
    4. Healing Together: Ketamine Therapy and a New Era in Mental Health – by David Miller, MD  Hudson Valley Style Magazine
    5. Psychedelics could help with mental health, but not yet, say doctors  Euronews.com

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  • Seattle Reign FC Defender Ryanne Brown Signs One-Year Contract Extension, Returns to Active Roster Off Season-Ending Injury List — Seattle Reign FC

    Seattle Reign FC Defender Ryanne Brown Signs One-Year Contract Extension, Returns to Active Roster Off Season-Ending Injury List — Seattle Reign FC

    The fourth-year defender, sidelined with an ACL injury in July 2024, signs extension through 2026 and returns to the active roster

    Seattle Reign FC today announced that defender Ryanne Brown has signed a one-year contract extension and has been elevated from the season-ending injury (SEI) list after recovering from an ACL injury suffered in July 2024. Brown joins the active roster immediately and begins training as a full participant.

    “We’re thrilled to extend Ryanne’s time with the club through 2026 and to have her back and available for the remainder of the season,” said Seattle Reign FC General Manager Lesle Gallimore. “Her resilience through injury reflects the spirit of our club, and her pace, drive and versatility bring tremendous value to our style of play. Even off the pitch, Ryanne has remained a respected leader and steady presence in our locker room.”

    Originally selected as the 21st overall pick in the 2022 NWSL Draft, Brown made her professional debut on July 17, 2022 against the Kansas City Current. Since then, the 26-year-old has made 28 appearances in all competitions as a defender. Brown featured in all six group-stage matches of the 2023 NWSL Challenge Cup, helping the team advance without conceding a goal.

    “I’m incredibly grateful to our medical staff for their care and guidance throughout this journey, along with my teammates for their unwavering support,” said Brown. “This experience has given me an even greater appreciation for the game, and I can’t wait to be back on the field wearing our crest with pride.”

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  • ‘No basis’: Judge dismisses Trump’s $15 billion NYT lawsuit; gives 28 days to refile

    ‘No basis’: Judge dismisses Trump’s $15 billion NYT lawsuit; gives 28 days to refile

    US President Donald Trump (Leon Neal, Pool via AP)

    A federal judge on Friday threw out US President Donald Trump’s $15 billion defamation lawsuit against The New York Times, ruling that the complaint was not “legally sufficient.” US district judge Steven Merryday of Florida said the filing “failed to provide a proper basis” for the court to consider.“As every lawyer knows, or is presumed to know, a complaint is not a public forum for vituperation and invective − not a protected platform to rage against an adversary. A complaint is not a megaphone for public relations or a podium for a passionate oration at a political rally,” Merryday wrote, according to USA Today.The judge gave Trump 28 days to refile. The Republican had accused NYT of publishing “malicious accusations” against him through a series of articles and an editorial declaring him “unfit” for office ahead of the 2024 election. The suit also cited “Lucky Loser: How Donald Trump Squandered His Father’s Fortune and Created the Illusion of Success” – a 2024 book by Penguin written by NYT reporters Susanne Craig and Ross Buettner. Reporters Craig, Buettner, Peter Baker, and Michael Schmidt were named as defendants alongside the newspaper and publisher. An earlier statement by NYT dismissed the case as “baseless”: “It lacks any legitimate legal claims and instead is an attempt to stifle and discourage independent reporting. The New York Times will not be deterred by intimidation tactics. We will continue to pursue the facts without fear or favour and stand up for journalists’ First Amendment right to ask questions on behalf of the American people.”The lawsuit was filed on September 15.


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  • UN Security Council decides not to lift Iran sanctions, but still time to agree delay

    UN Security Council decides not to lift Iran sanctions, but still time to agree delay



    Reuters
     — 

    The United Nations Security Council did not adopt a draft resolution on Friday to permanently lift sanctions on Iran, but Tehran and key European powers still have eight days to try and agree to a delay.

    The 15-member UN Security Council was required to vote on the draft resolution on Friday after Britain, France and Germany launched a 30-day process on August 28 to reimpose UN sanctions, accusing Tehran of failing to abide by a 2015 deal with world powers that aimed to prevent it from developing a nuclear weapon. Iran denies having any such intention.

    Russia, China, Pakistan and Algeria voted in favor of the draft text on Friday. Nine members voted against it, while two abstained.

    The Security Council vote has now set up a week of intense diplomacy while world leaders – including Iran’s President Masoud Pezeshkian – are in New York for the annual high-level UN General Assembly.

    Britain, France and Germany have offered to delay reinstating sanctions for up to six months – to allow space for talks on a long-term deal on Tehran’s nuclear program – if Iran restores access for UN nuclear inspectors, addresses concerns about its stock of enriched uranium, and engages in talks with the United States.

    “Without these most basic conditions being met, there is no clear path to a swift diplomatic solution. We regret that Iran has so far failed to take these steps, and we urge them to act now,” Britain’s UN Ambassador Barbara Woodward told the council. “We are ready for further engagements, diplomatically, in the next week, and beyond to seek to resolve differences.”

    Any delay on reimposing sanctions would require a Security Council resolution. If a deal on an extension can’t be reached by the end of September 27 then all UN sanctions will be reimposed.

    Acting US Ambassador Dorothy Shea said that while the US voted “no” on Friday, it “does not impede the possibility of real diplomacy,” adding that a return of sanctions on Iran “does not preclude later removal through diplomacy.”

    “More importantly, President Trump has continued to reiterate the United States’ ongoing readiness for meaningful, direct, and timebound dialog with Iran – be it prior to the conclusion of the snapback process on September 27, or after,” she told the council.

    French UN Ambassador Jerome Bonnafont said that since the 30-day process – known as snapback – was triggered, the foreign ministers of Germany, France and Britain had met twice with their Iranian counterpart.

    “Our hand remains outstretched to find a negotiated solution,” he told the council before the vote.

    Separately, Iran’s strategic allies Russia and China finalized a draft Security Council resolution late last month that would extend the 2015 deal for six months and urge all parties to immediately resume negotiations. But they have not yet asked for a vote.


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  • F.C.C. TSR Honda France qualifies in fourth p…

    F.C.C. TSR Honda France qualifies in fourth p…

    The final round of the 2025 FIM Endurance World Championship takes place this weekend at Circuit Paul Ricard (France) from September 18–21 for the 88th Bol d’Or.

    Still mathematically in contention, F.C.C. TSR Honda France aims for a second victory this year to end the 2025 season on a high, and for this final round, Spaniard Isaac Viñales joined the team’s rider lineup Alan Techer, Corentin Perolari and Taiga Hada, as reserve rider.

    On Thursday, after taking part in the free practice, the Honda’s endurance specialist aboard the Honda CBR1000RR-R Fireblade SP took part in the first qualifying session, in the afternoon and sunny conditions, placing the Honda #5 in a provisional seventh position with an average time of 01:52.653.

    During the night session, F.C.C. TSR Honda France was the second-fastest team on track with a lap of 1:53.156.

    The following day, during the second qualifying session scheduled from 11am in similar track conditions, all the riders significantly improving on the lap times set the previous day.

    Techer led the charge with a best lap of 1:51.445, placing him second in his group. Perolari posted 1:51.630, securing a top-three spot in the yellow rider group. Hada, riding in the red group, made steady progress with 1:53.871, while Viñales contributed with a best lap of 1:54.213.

    Averaging the two best times, F.C.C. TSR Honda France team took fourth place on the grid with a time of 01:51.538 and scored 2 additional points in the championship.

    Tati Team AVA6 Racing completed the combined qualifying sessions with an average lap time of 1:52.166, securing sixth place on the grid aboard the Honda CBR1000RR-R Fireblade SP.

    The Honda #4 returns to the Bol d’Or with this season’s line-up of Hugo Clère, Randy Krummenacher, and Martin Renaudin.

    Clère and Krummenacher both improved on their previous lap times, while Renaudin, coming back from a serious injury, is steadily regaining rhythm and pace. Having all three riders back on track together is a major boost for the squad, whose clear objective is to start at the front and remain in contention throughout the race.

    Wójcik Racing Team #777 SST qualified on pole in the Dunlop-equipped Superstock category with a lap time of 1:53.663, earning an impressive 10th place on the overall grid.

    Following a strong 4th-place finish at the Suzuka 8 Hours, the rider trio of Jordi Torres, Mateusz Molik, and Philipp Steinmayr are confident of delivering a strong performance aboard the Honda #777.

    No Limits Honda will start fourth in class with Roberto Tamburini, Gabriele Giannini, and Kaito Toba aboard the Honda CBR1000RR-R Fireblade SP #44.

    Kaedear-Dafy-Rac41-Honda, one of the FIM Endurance World Cup title contenders, posted the fifth-fastest time. Currently third in the standings and just 18 points behind the championship leader, riders Chris Leesh, Takeshi Ishizuka, and Kevin Manfredi showed consistent front-running pace throughout qualifying and are aiming for a podium finish in the season finale aboard the Honda #41.

    National Motos Honda FMA, currently second in the standings and just five points behind the leader, was focused during qualifying on race pace and on defending their FIM Endurance World Cup title.

    In the production-based FIM Endurance World Trophy, Tati-run Moto Revue Moto Journal aboard Honda CBR1000RR-R Fireblade SP  #87 was the fastest team with several timee EWC champion Vincent Philippe, Bertrand Gold and themultiple X-Games and Red Bull X-Fighters Freestyle Motocross winner Tom Pagès.

    The 88th Bol d’Or race will start at 3 pm (CEST) on Saturday, September 20, and will finish at 3 pm (CEST) on Sunday, September 21.

    Alan Techer
    5

    F.C.C. TSR Honda France

    Since Tuesday, we’ve been working hard on our race pace. That’s where we’ll score the most points and aim for victory. Taiga is a little slower, so we’ll work as a team to help him. Yesterday in qualifying session 1, we did some race simulations and everything went very well. And today, thanks to the qualifying tyres, we took a big step forward. I did 51.4, Corentin 51.6, so we have a very good average. We are happy with our performance and very motivated for the race. We will have good weather. So now we are going to stay focused and aim for the best possible result.

    Corentin Perolari

    Corentin Perolari
    5

    F.C.C. TSR Honda France

    Alan and I had a very good qualifying session. Starting 4th is very good. We’re scoring 2 points for the overall standings. And we have a very good pace for the race. So if our third rider can keep up, it could be a very good race.

    Taiga Hada

    Taiga Hada
    5

    F.C.C. TSR Honda France

    In qualifying yesterday and today, we focused more on race simulations with the race tyres. I feel there’s still some pace to find, so we’ll go through the data and work on taking a step forward to really improve the pace tomorrow.

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  • Addition of Sintilimab to Total Neoadjuvant Treatment in Locally Advanced Rectal Cancer

    Addition of Sintilimab to Total Neoadjuvant Treatment in Locally Advanced Rectal Cancer

    In a Chinese single-center phase II trial (SPRING-01) reported in The Lancet Oncology, Tian et al found that the addition of the PD-1 inhibitor sintilimab to chemotherapy following short-course radiotherapy as part of total neoadjuvant treatment significantly improved the pathologic complete response rate in patients with locally advanced rectal cancer.

    As stated by the investigators, “Neoadjuvant short-course radiotherapy combined with chemotherapy as total neoadjuvant therapy increases the pathologic complete response rate for patients with locally advanced rectal cancer. The potential synergistic effects of combining radiotherapy and immunotherapy might benefit patients with locally advanced rectal cancer.”

    Study Details

    In the open-label trial, 98 patients with newly diagnosed disease from Shandong Provincial Hospital were randomly assigned between October 2021 and September 2023 to receive short-course radiotherapy (5 × 5 Gy over 5 days) followed by six cycles of capecitabine plus oxaliplatin (oxaliplatin at 130 mg/m² on day 1 and capecitabine at 1,000 mg/m² twice daily on days 1–14 of each 3-week cycle) with (n = 49) or without (n = 49) sintilimab at 200 mg/m² on day 1 of each 3-week cycle, starting 1 week after completion of radiotherapy. Total mesorectal excision was performed 2 to 3 weeks after completion of total neoadjuvant therapy. The primary outcome measure was pathologic complete response in the intention-to-treat population.

    Key Findings

    Pathologic complete response was achieved in 29 patients (59.2%, 95% confidence interval [CI] = 45.4%–72.9%) in the sintilimab group vs 16 patients (32.7%, 95% CI = 19.5%–45.8%) in the control group (P = .015).

    Postoperative complications occurred in 11 (24%) of 45 patients in the sintilimab group who underwent surgery and in 5 (11%) of 44 in the control group who underwent surgery.

    The most common treatment-related adverse events of any grade in the sintilimab group and the control group were thrombocytopenia (37% vs 53%), leukopenia (39% vs 53%), and anemia (55% vs 67%). Grade 3 to 4 treatment-related adverse events were observed in 33% vs 35% of patients, most commonly thrombocytopenia (12% vs 22%). Immune-related adverse events occurred in 36% of patients in the sintilimab group, most commonly dermatitis (8%) and kidney injury (8%). No treatment-related deaths were observed.

    The investigators concluded: “In patients with locally advanced rectal cancer, short-course radiotherapy combined with sintilimab and capecitabine–oxaliplatin as a total neoadjuvant treatment significantly increased the [pathologic complete response] rate while maintaining a manageable safety profile. These findings suggest that this regimen might be a promising neoadjuvant treatment approach for locally advanced rectal cancer.”

    Changqing Jing, MD, of the Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, is the corresponding author for The Lancet Oncology article.

    Disclosure: The study was funded by The National Natural Science Foundation of China, Natural Science Foundation of Shandong Province, Innovent Biologics, and others. For full disclosures of all study authors, visit thelancet.com.

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  • Neutrino Mix Alters Neutron Star Merger Dynamics

    Neutrino Mix Alters Neutron Star Merger Dynamics

    the incredibly dense remnants of collapsed stars – are some of the most energetic events in the universe, producing a variety of signals that can be observed on Earth. New simulations of neutron star mergers by a team from Penn State and the University of Tennessee Knoxville reveal that the mixing and changing of tiny particles called neutrinos that can travel astronomical distances undisturbed impacts how the merger unfolds, as well as the resulting emissions. The findings have implications for longstanding questions about the origins of metals and rare earth elements as well as understanding physics in extreme environments, the researchers said.

    The paper, published in the journal Physical Review Letters, is the first to simulate the transformation of neutrino “flavors” in neutron star mergers. Neutrinos are fundamental particles that interact weakly with other matter, and come in three flavors, named for the other particles they associate with: electron, muon and tau. Under specific conditions, including the inside of a neutron star, neutrinos can theoretically change flavors, which can change the types of particles with which they interact.

    “Previous simulations of binary neutron star mergers have not included the transformation of neutrino flavor,” said Yi Qiu, graduate student in physics in the Penn State Eberly College of Science and first author of the paper. “This is partly because this process happens on a nanosecond timescale and is very difficult to capture and partly because, until recently, we didn’t know enough about the theoretical physics underlying these transformations, which falls outside of the standard model of physics. In our new simulations, we found that the extent and location of neutrinos mixing and transforming impacts the matter that is ejected from the merger, the structure and composition of what remains after the merger – the remnant – as well as the material around it.”

    The researchers built a computer simulation of a neutron star merger from the ground up, incorporating a variety of physical processes, including gravity, general relativity, hydrodynamics and the neutrino mixing. They also accounted for the transformation of electron flavor neutrinos to muon flavor, which the researchers said is the most relevant neutrino transformation in this environment. They modeled several scenarios, varying the timing and location of the mixing as well as the density of the surrounding material.

    The researchers found that all of these factors influenced the composition and structure of the merger remnant, including the type and quantities of elements created during the merger. During a collision, the neutrons in a neutron star can be launched at other atoms in the debris, which can capture the neutrons and ultimately decay into heavier elements, such as heavy metals like gold and platinum as well as rare earth elements that are used on Earth in smart phones, electric vehicle batteries and other devices.

    “A neutrino’s flavor changes how it interacts with other matter,” said David Radice, Knerr Early Career Professor of Physics and associate professor astronomy and astrophysics in the Penn State Eberly College of Science and an author of the paper. “Electron type neutrinos can take a neutron, one of the three basic parts of an atom, and transform it into the other two, a proton and electron. But muon type neutrinos cannot do this. So, the conversion of neutrino flavors can alter how many neutrons are available in the system, which directly impacts the creation of heavy metals and rare earth elements. There are still many lingering questions about the cosmic origin of these important elements, and we found that accounting for neutrino mixing could increase element production by as much as a factor of 10.”

    Neutrino mixing during the merger also influenced the amount and composition of matter ejected from the merger, which the researchers said could alter the emissions detectable from Earth. These emissions typically include gravitational waves – ripples in space time – as well as electromagnetic radiation like X-rays or gamma rays.

    “In our simulations, neutrino mixing impacted the electromagnetic emissions from neutron star mergers and possibly the gravitational waves as well,” Radice said. “With cutting-edge detectors like LIGO, Virgo and KAGRA and their next generation counterparts, such as the proposed Cosmic Explorer observatory that could start operations in the 2030s, astronomers are poised to detect gravitational waves more often than we have before. Better understanding how these emissions are created from neutron star mergers will help us interpret future observations.”

    The researchers said modeling the mixing processes was similar to a pendulum being turned upside down. Initially, many changes occurred on an incredibly rapid timescale, but eventually the pendulum settles to a stable equilibrium. But much of this, they said, is an assumption.

    “There’s still a lot we don’t know about the theoretical physics of these neutrino transformations,” Qiu said. “As theoretical particle physics continues to advance, we can greatly improve our simulations. What remains uncertain is where and how these transformations occur in neutron star mergers. Our current understanding suggests they are very likely, and our simulations show that, if they take place, they can have major effects, making it important to include them in future models and analyses.”

    Now that the infrastructure for these complex simulations has been created, the researchers said they expect other groups will use the technology to continue to explore the impacts of neutrino mixing.

    “Neutron star mergers function like cosmic laboratories, providing important insights into extreme physics that we can’t replicate safely on Earth,” Radice said.

    In addition to Qiu and Radice, the research team includes Maitraya Bhattacharyya, postdoctoral scholar in the Penn State Institute for Gravitation and the Cosmos, and Sherwood Richers at the University of Tennessee, Knoxville. Funding from the U.S. Department of Energy, the Sloan Foundation and the U.S. National Science Foundation supported this work.

    At Penn State, researchers are solving real problems that impact the health, safety and quality of life of people across the commonwealth, the nation and around the world.

    For decades, federal support for research has fueled innovation that makes our country safer, our industries more competitive and our economy stronger. Recent federal funding cuts threaten this progress.

    Learn more about the implications of federal funding cuts to our future at Research or Regress.

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

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  • SpaceX launches 24 Starlink internet satellites to orbit from California (photos)

    SpaceX launches 24 Starlink internet satellites to orbit from California (photos)

    SpaceX just sent two dozen more of its Starlink internet satellites to space.

    A Falcon 9 rocket topped with 24 Starlink craft lifted off from foggy Vandenberg Space Force Base on California’s central coast today (Sept. 19) at 12:31 p.m. EDT (1631 GMT; 9:31 a.m. local California time).

    About 8.5 minutes later, the Falcon 9’s first stage returned to Earth as planned, landing on the SpaceX drone ship “Of Course I Still Love You,” which was stationed in the Pacific Ocean. It was the 10th launch and landing for this particular booster, which carries the designation B1088.

    Today’s Starlink launch was the 10th mission for this Falcon 9 first stage. (Image credit: SpaceX)

    The Falcon 9’s upper stage continued carrying the 24 Starlink satellites to low Earth orbit. It will deploy the spacecraft there a little over 62 minutes after liftoff, if all goes to plan.

    Previous Booster 1088 missions

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  • Heavy rain floods Gujrat within an hour; disruptions reported in several Punjab cities

    Heavy rain floods Gujrat within an hour; disruptions reported in several Punjab cities

    An hour-long spell of heavy rain once again inundated Gujrat city, submerging low-lying areas and causing severe inconvenience for residents.

    Several feet of water accumulated in neighborhoods and streets, and in a worrying incident, a motorcyclist fell into an open manhole but was rescued by bystanders.

    Government offices, including the Deputy Commissioner’s office, were also flooded, halting official work.

    Meanwhile, parts of Lahore also received rainfall, while heavy rain and hail in Faisalabad brought relief from the sweltering heat. In Sangla Hill, the downpour caused multiple power feeders to trip, disrupting the electricity supply.


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