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  • Digital Psychological Intervention for Inflammatory Rheumatic Diseases: A Pilot Randomized Clinical Trial

    Digital Psychological Intervention for Inflammatory Rheumatic Diseases: A Pilot Randomized Clinical Trial

    1. In patients with inflammatory rheumatic diseases (IRD), digital psychological intervention was associated with improved psychological outcomes and quality of life at 3 months of follow-up.

    Evidence Rating Level: 1 (Excellent) 

    Inflammatory rheumatic diseases (IRD) are a series of diseases, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA), which are becoming more prevalent. Women are disproportionately affected, specifically more prone to systemic lupus erythematosus (SLE). Although these conditions are characterized as physical, many patients also experience significant psychological challenges, such as anxiety and depression. This eventually contributes to a feedback loop, further intensifying physical symptoms and worsening quality of life. Previous studies have demonstrated the effectiveness of cognitive behavioural therapy (CBT) along with other therapy treatments in managing psychological distress in these patients. However, there have been shortages of mental health treatment available for these patients. This randomized controlled trial sought to address these gaps by assessing the effectiveness of a web-based CBT intervention at reducing psychological distress in patients with IRD. The online questionnaires were sent out at baseline, 6 weeks, and 12 weeks. 102 participants (mean [SD] age, 47.2 [12.9] years; 92 [90.2%] female). Change in psychological distress levels was assessed using the Hospital Anxiety and Depression Scale (HADS-D), and quality of life was assessed using the Assessment of Quality of Life-8 Dimensions (AQoL-8D). There was a significantly greater reduction in psychological distress (least-squares mean difference, -3.60 [1.07]; 95% CI, -5.73 to -1.47; P<.001; Cohen d=-0.71) and improvement in quality of life (least-squares mean [SE] difference, 0.04 [0.02]; 95% CI, 0.00-0.09; P=.047; Cohen d=0.49) in the intervention group compared to the control group at follow up. Overall, this study found that the use of online therapy was associated with a reduction in psychological distress and an improvement in quality of life.  

    Click to read this study in JAMA Network Open

    Image: PD

    ©2024 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

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  • Queen Elizabeth statue will show ‘grandeur and dignity,’ sculptor says

    Queen Elizabeth statue will show ‘grandeur and dignity,’ sculptor says

    PA Media A mock-up of St James's Park with a large statue of Queen Elizabeth II on horseback high above ground. The statue sits on a plinth in between two rows of tall trees. People are milling about around it and on the pavement off to the right. It is daytime.PA Media

    An artist’s impression of the design for the memorial indicated how a statue of the queen might look

    The sculptor chosen to create a statue of Queen Elizabeth II for her national memorial has said he wants to capture the “grandeur and dignity” of Britain’s longest-reigning monarch.

    Martin Jennings, who has previously depicted King Charles III and the Queen Mother, said he was “elated” to be chosen to portray the late queen.

    “She was loved and admired across the globe for her steadfast devotion to duty, borne with grace, decency and restraint.”

    The statue will be of the memorial in central London’s St James’s Park, with the final design to be revealed in 2026.

    The British sculptor told the PA news agency that he did not have a “defined idea” of how the statue would look yet, and that he would want the Royal Family’s approval.

    But he said he hoped to convey the appropriate “grandeur and dignity” and that “a certain amount of stillness” would be beneficial.

    Mr Jennings added that people had “strong feelings about the queen”.

    “I will be going through a period of listening to not only what invested organisations and individuals want of it, but taking the temperature of how the populace at large might want to see this representation.”

    PA Media Martin Jennings at Marlborough Gate, St James's Park. It is sunny outside and he wears a beige linen suit and is smiling with his hands held casually behind his backPA Media

    Martin Jennings said he would like royal approval of his design

    A section of St James’s Park visible from Buckingham Palace will be re-landscaped for the national memorial, with a budget previously said to be between £23m and £46m.

    The anti-monarchy campaign group Republic has called for the Royal Family to pay for the memorial rather than the government.

    “They can pay for their own statue,” the group’s chief executive Graham Smith said.

    The winning design for the memorial, chosen from a shortlist of five concepts, will feature a bridge with a balustrade made of glass, inspired by the shape of the late queen’s wedding tiara.

    There will also be a statue of her and Prince Philip, to whom she was married for 73 years until his death in 2021, a Prince Philip Gate and new gardens.

    The final designs will be put to the King and the prime minister next year.

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  • Intervision 2025 – Russia’s answer to Eurovision has less kitsch, more Kremlin

    Intervision 2025 – Russia’s answer to Eurovision has less kitsch, more Kremlin

    Steve RosenbergRussia editor in Moscow

    BBC Shohruhmirzo Ganiyev singing on stage with a drumBBC

    Shohruhmirzo Ganiyev is representing Uzbekistan at Intervision

    At a Moscow concert hall, Shohruhmirzo Ganiyev is crooning about love and his motherland, Uzbekistan.

    “Put your legs together like a man,” suggests his voice coach and choreographer. “And spread your arms wider!”

    It’s just a rehearsal, but Shohruhmirzo is singing his heart out. He’s performing traditional Uzbek melodies to a modern beat and playing a doira, the ancient drum of Central Asia.

    Uzbekistan is among 23 countries competing at the Intervision Song Contest.

    It’s Russia’s answer to Eurovision. With less kitsch – and more Kremlin.

    Intervision 2025 is Vladimir Putin’s brainchild. He signed a decree reviving the Soviet-era songfest with the aim of “developing international cultural and humanitarian co-operation”.

    The more obvious objective is creating an international song contest in which Moscow can actually take part. In 2022 Russia was banned from competing in Eurovision after its full-scale invasion of Ukraine.

    A sphere with an advert for the Intervision song contest sits in Moscow

    Ukraine says Intervision is an attempt to distract the world from Russia’s ongoing invasion

    A pattern’s emerging.

    When Team Russia was banned from the Olympic Games, Moscow tried to create alternatives, like the Games of the Future and the World Friendship Games.

    Now the Kremlin’s come up with its own version of Eurovision.

    But what does it look like and who is taking part?

    For Intervision, the Russians have cast their musical net far and wide, inviting allies from Asia, Africa, the Middle East and Latin America. The starting line-up reflects the political and economic alliances of which Russia is part, like the Brics group of nations, the Shanghai Cooperation Organisation and the Commonwealth of Independent States.

    The list of participating countries includes China, India, Brazil, South Africa, Vietnam, Venezuela, Qatar, Saudi Arabia and Madagascar: a very different musical map from Eurovision, and an opportunity for the Kremlin to show that, despite its invasion of Ukraine, Russia still has friends.

    The United States, too, is taking part: a sign of the thaw in US-Russian relations since Donald Trump’s return to the White House.

    Thaw doesn’t mean problem-free. America’s original Intervision entrant Brandon Howard pulled out on the eve of the contest.

    “Unfortunately, I had some… family issues that happened here domestically, that I wasn’t [going] to be able to go abroad and do that,” the singer, who performs as B.Howard, tells me on a call from the US.

    “However, I really believe that it’s such a wonderful event.”

    “Were there some people who said to you ‘Brandon, you shouldn’t go, because of the war?’” I asked.

    “Some fans would mention some things like that and expressed slight concern. However, for the most part, everyone was very supportive of me going there, being sent to be a beacon of light.”

    B.Howard has been replaced by Australian-Greek singer Vassy who lives in Los Angeles.

    “4.3 billion people live in the 23 participating countries,” boasted senior Kremlin official Sergei Kiriyenko. “That’s more than half the world’s population.”

    Traditionally dressed Russians perform at a rehearsal for Intervision

    Russian culture is a big part of Intervision – like these Russian ravers dressed in traditional costumes

    Mr Kiriyenko, President Putin’s deputy chief of staff, chairs the song contest’s supervisory board. He made a brief appearance this week at an Intervision press conference alongside Foreign Minister Sergei Lavrov and Deputy Prime Minister Dmitry Chernyshenko.

    “I know some people think there’s an element of politics in Eurovision,” I tell Mr Lavrov. “But look who’s represented here: the Kremlin, the foreign ministry and the Russian government. Isn’t that proof that Intervision is a purely political or geopolitical project?”

    “If the governments of some countries make no effort to create mechanisms for supporting culture, that’s their choice,” Mr Lavrov replies. “In our country the state is engaged in the promotion of the arts. Your question is rooted in the fear of competition.”

    In Ukraine they fear something quite different: that Moscow is using Intervision to divert global attention from the war.

    “The Ministry of Foreign Affairs of Ukraine considers that the Intervision 2025 song contest organised by Russia is an instrument of hostile propaganda and a means of whitewashing the aggressive policy of the Russian Federation,” the ministry stated back in May.

    The war is on some people’s minds at Intervision.

    “The scary thing is with the war, with whatever’s happening. These are the things we were thinking about,” says Renee Kruger from South African group Mzansi Jikelele.

    “But we were assured: ‘Just come, guys, nothing’s wrong’. Obviously, we are [nervous], but we’re here and we’ve been treated very well.”

    Mzansi Jikelele, South Africa's entrant at Intervision, speak to the BBC

    Mzansi Jikelele, South Africa’s entry, say they’ve been treated well in Russia – but were nervous about attending

    Representing Russia at Intervision 2025 is Yaroslav Dronov, better known by his stage name Shaman. Last year the European Union sanctioned him for “supporting actions and policies that undermine the territorial integrity and sovereignty of Ukraine.”

    His previous hits include I’m Russian, a patriotic pop song that declares:

    “I’m Russian, I go to the end… I’m Russian, to spite the whole world.”

    Not exactly Love Shine A Light or Save Your Kisses for Me.

    But Russia is using Intervision to project a softer image than the one forged by three-and-a-half years of its war in Ukraine.

    At the official song contest draw to decide the running order, international delegations are being treated to a Russian feast, including cottage cheese pancakes and gingerbread sporting the Intervision logo. As folk dancers put on a spectacular show, volunteers hand out giant necklaces of bread rings, a symbol of Russian hospitality.

    One by one the participants approach a gigantic samovar, select a tea cup and fill it with hot water. The magic mugs reveal the performance slot number for each country.

    From the folk costumes to the blinis, the emphasis here is on tradition.

    Vietnam's entry Duc Phuc pours hot water from a samovar at the Intervision contest draw

    Vietnam’s entry Duc Phuc poured hot water from a samovar as part of the Intervision contest draw

    It’s the same with the songs. The official goal of the contest is to “get to know the unique cultural traditions and achievements of participating countries [and] promote universal, spiritual, family, cultural, ethical and religious traditions of different nations.”

    The international performers have read the rulebook.

    “My song tells about culture from Vietnam,” Vietnamese entrant Duc Phuc informs me. “I need to share the culture of Vietnam with everyone.”

    “How were you chosen to represent your country?” I ask.

    “The Ministry of Culture chose me.”

    “Our song is about a woman called Maria,” says Brazilian entrant Tais Nader. “Maria is like any Brazilian woman. She works hard to live. But she’s always smiling and her eyes are shining.”

    “Have you heard of Eurovision?” I ask.

    “Actually, we searched online about Intervision and discovered Eurovision! Before, we didn’t know about Intervision or Eurovision. It’s new for us.”

    For many Russians, too, Intervision is something new. In fact it is a ghost from communist times summoned from the grave of song contests past.

    The original Intervision Song Contest was born behind the Iron Curtain at a time when East and West competed in everything. In the Cold War there was a space race, an arms race and culture wars, too.

    From the mid-1950s Eurovision quickly established itself as a big deal in Western Europe, while in the Eastern bloc song festivals in Czechoslovakia and Poland acquired the occasional tag of ‘Intervision’.

    There was, though, some crossover. Finland took part in both Eurovision and Intervision, and big names from the West made guest appearances in the East. Gloria Gaynor, Petula Clarke and Boney-M all performed at Intervision.

    After the fall of communism Russia and Eastern Europe embraced the political changes sweeping the continent and were eager to compete in Eurovision. I saw that first hand in 1996 when, by a quirk of fate, I co-presented Russian TV’s Song for Europe competition to select a Eurovision entry.

    During a guided tour of Russian TV, I’d got chatting to the show’s director. When I told him I was a huge Eurovision fan he’d asked me to come back that evening to help anchor the programme. I’ll never forget how excited everyone in the studio was that night: not only about Eurovision, but about Russia being part of the European family.

    YouTube/RTR/Programma A/Pesnya dlya Evropy A bespectacled Steve Rosenberg (right) appearing in a suit and tie on Russia's Song for Europe in 1996YouTube/RTR/Programma A/Pesnya dlya Evropy

    Steve Rosenberg (right) appeared on Russia’s Song for Europe in 1996

    But as the Kremlin’s relationship with the West soured and Moscow’s attacks on Western liberalism and “non-traditional values” intensified, so did Russia’s beef with the Eurovision Song Contest.

    Especially after Austrian drag queen Conchita Wurst won Eurovision in 2014.

    “Giving first place to a bearded lady is a slight on humanity,” Russian MP Valery Rashkin told me at the time.

    Mr Rashkin called on Russia to ditch Eurovision and organise its own Voice of Eurasia contest. Another MP suggested “Goodvision” as a possible replacement.

    It was clear then that the Eurovision Song Contest and Russia were on a collision course. Eurovision made a point of welcoming the LGBTQ community, presenting itself as a showcase for inclusivity and diversity. In contrast, Russia launched a crackdown on gay rights, and has criminalised public expressions of LGBTQ identity.

    There will be no sign of camp at the Intervision Song Contest.

    Intervision 2025 A photo of a camera filming the rehearsal for Intervision 2025Intervision 2025

    Entrants know that their performances will be closely watched at Intervision

    But will people watch it? Will the Intervision singers and songs capture the public’s imagination across so many continents? The considerable time differences between the participating countries will likely preclude the kind of shared viewing experience you get with Eurovision.

    And there’ll be no public vote. Just a jury: one member per country. But how will the voting take place?

    “The voting system is specially invented by a very famous scientist and mathematician,” Russian TV’s Intervision commentator Yana Churikova tells me. “Specially for Intervision.”

    Back in the rehearsal room, Uzbekistan’s entrant Shohruhmirzo Ganiyev admits he doesn’t know the intricacies of the voting system. He’s just excited to be here. So is his mother. She’s looking on proudly as her son rehearses.

    Even though his country isn’t in Eurovision, Shohruhmirzo tells me that contest is famous in Uzbekistan. Right now, though, he’s focused on his performance here.

    “I’m very happy to come to Intervision,” he tells me. “I’m leaving Eurovision in the past.”

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  • I’m nothing like Tommy, says Cillian Murphy

    I’m nothing like Tommy, says Cillian Murphy

    Wiktor Szymanowicz/Anadolu via Getty Images Cillian Murphy appears at a red carpet event. He smiles at the cameras and is wearing a blue striped shirt and black waistcoatWiktor Szymanowicz/Anadolu via Getty Images

    Murphy won an Oscar last year for his leading role in Christopher Nolan’s Oppenheimer

    Actor Cillian Murphy has said he is nothing like his Peaky Blinders character Tommy Shelby, because he is not a “psychopathic gangster”.

    Murphy, 49, told BBC News playing the violent patriarch for a quarter of his life “has been a gift and a privilege”.

    A Peaky Blinders film will be released soon by Netflix, although Murphy said the plot line is still under lock and key.

    It comes as the Irish actor promotes his new film, Steve, which follows his titular character’s attempt to turn around a 1990s reform school for troubled boys.

    Teasing the Peaky Blinders film, which has been written by the show’s creator Steven Knight, Murphy said: “I think it’s better to keep it under wraps, keep it a surprise.”

    Viewers have seen Murphy lead the Shelby organised crime gang with tortured efficiency since 2013 and across six series

    The actor said the length of time he has played Shelby has been “defining” for him.

    “To grow older with a character, you don’t really get to do that, and that is the joy of long-form television,” he said.

    “We never anticipated that the TV show would have that impact, would be so adored and have that longevity. It is defining.”

    Sine the original series concluded in 2022, Murphy has also starred in Small Things Like These and won an Oscar for his leading role in Christopher Nolan’s Oppenheimer.

    Discussing the key to Peaky Blinders’ success, Murphy said it is a sort of “magic”. “Mostly the writing, I think, but also it was a moment in time.”

    He added: “The beauty of that show is that I have gone off and done other things in the meantime and played lots of other characters.”

    BBC Studios Cillian Murphy in character as Tommy Shelby, wearing the iconic hat and dressed in smart clothingBBC Studios

    Murphy’s Tommy Shelby will be on the big screen soon, Netflix has said

    Among them is Steve, the headteacher of a reform school in 1996, battling the emotions and behaviour of the teenage boys living there as well as his own personal demons.

    The new film chronicles a single day at the school where what can go wrong, does go wrong.

    A documentary crew with questionable morals is filming, a local MP is visiting and both Steve (played by Murphy) and Shy (Jay Lycurgo), one of the pupils, receive devastating news.

    Both characters are pushed to the brink leaving the audience, taking the audience on an emotional and often heartbreaking journey.

    Murphy described the film as a love letter to teachers, as they are “custodians of next generation.”

    Netflix Cillian Murphy as headteacher Steve at the front of a group of boys who are all in various poses. Steve holds a tennis ball to his face and has his hands over his ears.Netflix

    Steve is set in a 1990s reform school for boys

    The similarities between Shy and Steve are apparent throughout – even if they are at different stages of life.

    “It’s a flip-side of a coin what these characters are experiencing and they just can’t reach each other,” Murphy explained.

    The film’s themes touch on education in challenging circumstances, men’s mental health and adolescent violence.

    Even though it is set 30 years ago, “It is just demonstrating that this stuff is always there,” he added

    “The conversations are kind of manifold and different,” Murphy said of the reaction to the film so far. “Everyone sees it through the prism of their own life experience”.

    Steve was based on the 2023 novella, Shy, written by Max Porter. The author has adapted the story for the screen.

    He and Murphy previously worked together on the play, Grief Is the Thing with Feathers, also based on an original book by Porter.

    As for Lycurgo, he will also appear in the upcoming Peaky Blinders film, but followed Murphy’s lead in keeping the details secret.

    Steve is in cinemas now and will be released on Netflix next month.

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  • The Weir review – a riveting return for Conor McPherson’s lonesome barflies | Theatre

    The Weir review – a riveting return for Conor McPherson’s lonesome barflies | Theatre

    Conor McPherson’s rural Irish bar-room drama seeps into your bones. Almost 30 years since its first production, I can still recall the chill that came across Rae Smith’s snug set, hear the humorous sneer in the line “the Harp drinkers” and sense the despair beneath the banter.

    McPherson’s aptitude for atmosphere was later deployed in his Bob Dylan musical Girl from the North Country, set during the Great Depression, and will be tested when he evokes the dystopian Panem for an immersive version of The Hunger Games. But first here is The Weir, back for another round, designed again by Smith and this time directed by McPherson in a revival of such exactness it appears effortless.

    The headline star is Brendan Gleeson but The Weir is an ensemble: its characters are on different frequencies yet see each other for who they are. That goes for the locals as well as a stranger like Valerie, relocating from Dublin as a “blow-in” while literal gales whistle outside in Gregory Clarke’s sound design. Her arrival prompts a troubling exchange of tall tales, dreams, memories and confessions but McPherson judiciously uses humour to clear the air between them. Much like a weir, the effect is simultaneously of free flow and stillness.

    Barnstorming … Tom Vaughan-Lawlor, right, with Seán McGinley in The Weir. Photograph: Rich Gilligan

    To tell a story is to make yourself vulnerable. Each teller here has their own style but seeks reassurance from their listeners. With knotted brow, Gleeson’s Jack first unsteadily threads together a bit of local folklore but also gives the aching closer, a Krapp-like remembrance of romance unseized in youth that has dogged him daily since. It’s heightened by Gleeson’s age (he is 70, the character is written as in his 50s) and by coming at the end of a performance rich with quips (“That fella’d peel a banana in his pocket”) and perplexed grimaces (starting with a lovely bit of physical comedy with a bar tap).

    Finbar is altogether more of a raconteur. Tom Vaughan-Lawlor plays him as equal parts theatrical showman and school-class showoff in a caffeinated, barnstorming performance that you initially fear will overwhelm the others – but proves irresistible. Each line comes with a lick of the lips, a pointed finger or a boxer’s footwork, yet Vaughan-Lawlor keenly reveals Finbar’s insecurities and sense of absence.

    Cool and bemused … Kate Phillips as Valerie. Photograph: Rich Gilligan

    Then there’s Jim, played by the wonderful Seán McGinley, also significantly older than his character was envisioned by McPherson. His lengthy grave-digging tale is all the more compelling coming from this sleepy-seeming onlooker who elsewhere can raise a laugh with the briefest of utterances. (Much humour comes in the play’s pregnant pauses, too.)

    The only British actor in the cast is Kate Phillips, emphasising Valerie’s outsider status. She is coolly bemused by the men before delivering a painful account that shares unsettling similarities with the others: defenceless children, uncanny noises, altered states. Phillips makes clear that it’s a story Valerie is still getting used to telling, aware it will define her.

    Owen McDonnell harbours heaviness as barkeeper Brendan, keeping himself busy with routines that bring a comfort akin to Finbar superstitiously preparing the stock for banquets at his businesses. Weddings and funerals are all part of the talk but it’s tiny day-to-day kindnesses that define these lives in a room dimly lit by Mark Henderson to evoke personal isolation and the blanket darkness of rural night.

    You wouldn’t want to match them drink for drink but all five characters stay with you: it’s an endlessly rewarding evening that proves McPherson’s play is built to last.

    At Harold Pinter theatre, London, until 6 December

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  • DNA Phenotyping May Help Police, Or Spur Racial ‘Dragnets’

    DNA Phenotyping May Help Police, Or Spur Racial ‘Dragnets’

    By Jack Karp | September 19, 2025, 7:00 PM EDT
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