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  • New genome-wide CRISPR screening tool boosts natural killer cells to fight cancer

    New genome-wide CRISPR screening tool boosts natural killer cells to fight cancer

    Natural killer (NK) cells became markedly better at killing cancer cells after scientists removed key gene targets identified through a new genome-wide CRISPR screening tool, according to new research from The University of Texas MD Anderson Cancer Center.

    The study, published today in Cancer Cell, opens new avenues for discovering approaches to enhance the antitumor activity of chimeric antigen receptor (CAR) NK cell therapies against multiple cancer types via PreCiSE, a comprehensive CRISPR discovery platform optimized for primary human NK cells.

    Targeted gene editing is a powerful tool to enhance the anticancer activity of NK cells. PreCiSE is more than a screening tool. It is a roadmap that reveals how tumors suppress our cells and how to reengineer CAR NK cells to resist those pressures across many cancer types.”


    Katy Rezvani, M.D., Ph.D., corresponding author, professor of Stem Cell Transplantation and Cellular Therapy and vice president and head of the Institute for Cell Therapy Discovery & Innovation

    The research was led by Rezvani together with co first-authors Alexander Biederstaedt, M.D., formerly a postdoc in the Rezvani laboratory and now with the Technical University of Munich and Rafet Basar, M.D., Ph.D., assistant professor of Stem Cell Transplantation & Cellular Therapy.

    Using PreCiSE, which was developed by the research team, investigators uncovered multiple checkpoints and pathways that control NK cell activity when facing pressures found in the environment surrounding a tumor. This tumor microenvironment tends to have numerous factors suppressing immune activity.

    Editing these targets strengthened both innate and CAR-mediated NK cell function, improved metabolic fitness, increased pro-inflammatory cytokine production and expanded cytotoxic NK subsets in models of cancer that no longer responded to treatment.

    While the study highlights three validated targets – MED12, ARIH2 and CCNC – the significance extends far beyond any single gene. PreCiSE delivers an unbiased map of NK cell regulators that can be prioritized, edited and combined to design more effective CAR NK cell therapies.

    In the study, researchers validated top targets in vivo using multiple tumor models and under defined immune-suppressive stressors. Some regulators, such as MED12 and CCNC, intersect with pathways known in T cell biology, while others, including ARIH2, appear NK specific, underscoring the value of a platform built for NK cells themselves.

    “This has given us significant insight into the next generation of cell therapies that have the potential to be more powerful, precise and resistant to cancer.” Rezvani said.

    The Rezvani Laboratory has led advances in engineered NK cell therapy and has taken CAR NK approaches into clinical trials for patients with advanced hematologic and solid malignancies. Through the Institute for Cell Therapy Discovery & Innovation, Rezvani and her team will continue to develop and advance impactful cell therapies for patients in need. The current findings will be key in further enhancing the efficacy and activity of CAR NK cells for more cancer types.

    Source:

    University of Texas M. D. Anderson Cancer Center

    Journal reference:

    Biederstädt, A., et al. (2025). Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency. Cancer Cell. doi.org/10.1016/j.ccell.2025.07.021.

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  • Church of Scotland to sell ‘real gem’ Mackintosh buildings this year

    Church of Scotland to sell ‘real gem’ Mackintosh buildings this year

    Church of Scotland A church building with two cars parked in front of it. Part of the building is a red brick style, with a cross and The Mackintosh Halls on the wall. Church of Scotland

    The Mackintosh Halls were purpose built for church use in 1899

    The Church of Scotland is planning to sell church buildings in Glasgow designed by Charles Rennie Mackintosh by the end of the year.

    The Mackintosh Halls, which include a large meeting area and a janitor’s house, were purpose built for church use in 1899 in the city’s Ruchill area.

    The sale comes following the union of the congregations of Ruchill Kelvinside Church of Scotland and Maryhill in 2022, with the Church of Scotland facing financial issues.

    Rev Stuart Matthews said he hoped a sale to a buyer “with better resources” would secure the building’s long-term future.

    Rev Matthews said: “The Mackintosh Halls are a real gem and we are hoping someone with better resources will recognise the building’s significance and undertake to preserve its future appropriately.

    “Whilst we don’t have an exact timetable yet we are expecting that the buildings will go on sale towards the end of the year.”

    The site also features a church sanctuary, although this was built at a later date and is not by Mackintosh.

    A large re brick church building, with cars parked in front and greenery behind it

    The buildings date from around the same time as the Glasgow School of Art and the nearby Queen’s Cross Church

    Stuart Robertson, Director of the Charles Rennie Mackintosh Society, said the Halls display Mackintosh’s “trademark style”, with his “art nouveau motifs scattered throughout the building”.

    He said the Ruchill buildings were designed “at the start of Mackintosh’s extraordinary creative period” from 1895 to 1906, when he designed the Glasgow School of Art.

    The art school was almost completely destroyed by two fires in 2014 and 2018.

    Earlier this year a former school designed by Mackintosh was sold by Glasgow City Council to the Bishops’ Conference of Scotland, who intend to turn it into a Scottish Catholic museum.

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  • EU cave in on vehicle trade rules will cost European lives as…

    EU cave in on vehicle trade rules will cost European lives as…

    According to the EU-US trade pact published on 21 Aug, the EU and US “intend to accept and provide mutual recognition to each other’s standards” for cars.

    “To allow more US SUVs and pick-ups to be sold with far lower safety and air pollution standards would be a betrayal of all EU citizens. The EU’s planned capitulation on vehicle trade rules is set to cost lives on European roads. To implement this disastrous pact would mean scrapping European laws that mandate emergency braking, seat belt reminders, and ban razor sharp edges on vehicles. These are laws Member States and MEPs would have to ‘unmake’. It will be over to MEPs and Member States to see if they are actually going to undo 20 years of road safety improvements”, said James Nix, Vehicles Policy Manager at T&E.

    Even before this trade pact, 7,000 monster American SUVs – the vast majority being RAM pick-ups – were sold in the EU during 2024 according to sales data analysed by T&E. These large US pick-up trucks were imported and registered in the EU without meeting European safety, air pollution or climate standards under a loophole known as Individual Vehicle Approval (IVA). In more detail:

    • Of the 7,000 American pick-ups sold in the EU last year through the IVA loophole, nearly 5,200 of these were RAM pick-up trucks.

    • CO2 emissions from RAMs average 347g per kilometre, over three times the average for newly-sold cars (106 g/km), and almost double the emissions of average new vans (185 g/km)

    • Pedestrian road deaths in the US are now three times higher than in Europe (after having been roughly the same in 2009), with the rapid rise in monster SUVs heavily implicated in the sharp increase in pedestrians killed on US roads (see graph below).

    • The EU-US trade deal lowers the sales price of RAM pick-ups by an average of €6,000 in Europe.

    RAM pick-up truck captured by T&E in Brussels, image free to use.

    Sales of RAMs in the EU rose 6% last year to around 5,200, bringing the total number of RAM pick-ups on European roads to around 25,000. Pre-2019 import data points to very few RAMs on Europe’s roads just six years ago. The bonnet height of RAM pick-ups trucks is around 130 cm, nearly twice as high as mid-sized family cars such as the VW Golf (approx 75 cm). RAM bonnets are so high that children aged up to nine years old standing directly in front cannot be seen by the average driver.

    RAM pick ups are not type-approved to be sold on the EU market, but are imported under IVA, ostensibly to be sold on a one-off or ‘individual’ basis. Already, the IVA rule, intended for niche uses, is being roundly abused by German and Dutch Type Approval entities, which approve 69% and 30% of RAMs respectively, said T&E. Imports of three other pick-up trucks – the Ford F-150, the Chevrolet Silverado and the GMC Sierra 1500 – have skyrocketed from 157 in 2019 to approx 1,700 in 2024 [1].

    The EU Commission’s proposals to close the IVA loophole tabled in early July are now at risk from an EU-US trade pact which states that the EU and US “intend to accept and provide mutual recognition to each other’s standards” for cars.

    CO2 emissions from RAMs average 347g per kilometre, over three times the average for newly-sold cars (106.8 g/km), and nearly double the emissions of average new vans (185.4 g/km). Safety features mandatory for all newly sold cars and vans from July 2024 are not required in RAM pick-ups and other IVA-imported vehicles. In a collision, a pick-up truck is almost three times more likely to kill a pedestrian or cyclist than a normal car, previous studies have shown [3].

    “The sad reality, as shown by US crash data, is that oversized US pick-up trucks kill more pedestrians and are a particular threat to the safety of children. We need urgent action to keep non-compliant US pick-ups out – not let more in”, said Nix.

    The EU pledge to recognise US automotive standards will cost European lives. EU road safety standards protect citizens, according to road fatality data analysed by T&E. Pedestrian road deaths in the US are now three times higher than in Europe, having been roughly the same in 2009. Sky-rocketing sales of pick-ups in the US are heavily implicated in its elevated pedestrian death rate.

    EU rules also include pedestrian protection on vehicle fronts which have been further strengthened since 2009 in Europe, but are not mandatory in the US. In contrast to the US, the EU also requires automatic emergency braking (AEB) on newly-sold cars and vans, and seat belt reminders for all seats.

    The new EU-US trade deal also makes it cheaper to sell US vehicles in the EU. A RAM pick-up will be €6,000 cheaper as a result of the lower tariff, T&E estimates [4].

    ENDS

    Notes to editor

    [1] IVA imports of Ford F-150 pick-ups have gone from 126 in 2019 to 850 in 2024, and over the same period, Chevy Silverados went from 17 to 695, while GMC Sierra 1500s have increased from 14 to 151.

    [2] In early July, the EU Commission published a draft Delegated Act which would:

    • Count the CO2 emissions of IVA vehicles in the fleet average emissions of vehicle makers towards their EU emissions targets (e.g. RAM pick-ups would be counted under Stellantis);

    • Require IVA vehicles to comply with EU on-road air pollution limits (i.e. real-world tests)

    • Require IVA vehicles to increasingly meet more recent EU safety rules (with rules phased in over the late 2020s and early 2030s);

    The Commission is currently taking feedback and is expected to put a proposal before member states for formal approval by the end of the year.

    [3] Link to VIAS Institute study.

    [4] Price difference calculated using the average suggested retail price (net) for RAM 1500 models provided by official importer AEC Europe (€73,770), with an assumed VAT rate of 20%. The average price has been recalculated to reflect a reduced import tariff of 2.5% instead of the original 10%, in order to estimate the impact on final retail prices after lowering the tariffs.

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  • The Hundred 2025 results: Trent Rockets women beat Oval Invincibles to keep slim qualification hopes alive

    The Hundred 2025 results: Trent Rockets women beat Oval Invincibles to keep slim qualification hopes alive

    Trent Rockets kept their slim qualification hopes alive with a six-wicket win over Oval Invincibles in the women’s Hundred.

    Rockets made hard work of chasing just 110 at The Kia Oval after a flurry of middle-order wickets, but Heather Graham held her nerve with an unbeaten 19 from 11 balls and they reached their target with 16 balls to spare.

    The visitors had a flying start from Bryony Smith and Grace Scrivens, who added 51 in 35 balls together, but the Invincibles fought back to remove Smith for 24 and claimed the huge wickets of Nat Sciver-Brunt for two and Ash Gardner for 11.

    Scrivens then fell for 34, but Graham and Jodi Grewcock, with 21 not out, settled the Rockets’ nerves and sealed their first win against the Invincibles.

    In contrast to the Rockets’ rapid start, Invincibles had crawled to 13-1 from their powerplay, which included 16 dot balls, as captain Lauren Winfield-Hill fell for seven from 14.

    Former Australia skipper Meg Lanning revived the innings as she kicked on to 45 from 35 balls, but Ash Gardner changed the course of the game as she dismissed Lanning and Marizanne Kapp in the space of three balls.

    Paige Scholfield clubbed the last ball for six to take Invincibles to 109-7 but her 16 not out was the second highest score of the innings as they failed to put partnerships together throughout.

    Both Rockets and Invincibles, who are two-time Hundred winners, need to win all of their remaining games and still hope for other results to go their way if they are to finish in the top three.

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  • When Paul McCartney met Michael Tippett at the opera | Paul McCartney

    When Paul McCartney met Michael Tippett at the opera | Paul McCartney

    Elizabeth Alker’s article on Paul McCartney’s interest in avant-garde music is fascinating (‘The King Lear in I Am the Walrus? That came from John Cage’: Paul McCartney on the Beatles’ debt to great avant-garde composers, 19 August). But she omits his attendance at a production of Michael Tippett’s last opera, New Year, whose music incorporated rap and reggae, reduced the strings in the orchestra, and included saxophones, percussion and electronic space music. McCartney was so fascinated that he requested a meeting with the composer, which I arranged. The octogenarian Tippett and the young McCartney got on like a house on fire.
    Meirion Bowen
    London

    Your article (Teach boys and girls together about menstruation, UCL study argues, 20 August) brought me the lovely memory of my then seven-year-old son, who returned from school one day in the 1980s saying that they had had sex education. The boys were in a separate room from the girls, but he told me it didn’t matter because he talked to a girl at breaktime and “she told me all about periods and cemetery towels”.
    Alyson Elliman
    Carshalton, London

    Your article on pulses (17 August) might have added one further tip: a pressure cooker makes cooking dried beans almost effortless. Many varieties can be cooked, without soaking, in much less than an hour.
    William Hawkins
    London

    Malcolm Rush suggests that the inclusion of Mar-a-Lago in the territories to be ceded to Russia would help get the Trump-Putin deal over the line (Letters, 18 August). Many would suggest it has already been ceded.
    Ian Reissman
    Henley-on-Thames, Oxfordshire

    Thanks to Keith Flett for providing his age (Letters, 20 August), but it’s dispiriting to find that, when you’ve long regarded him as the grandaddy of the letters page, you’re older than him.
    Anne Cowper
    Swansea

    The return of “Smarty-pants” for rare words in Wordiply is sheer prestidigitation and I am flabbergasted at the speed of your capitulation (Letters, 20 August).
    Maria Koval
    London

    Have an opinion on anything you’ve read in the Guardian today? Please email us your letter and it will be considered for publication in our letters section.

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  • After furore over ‘abduction’, police say Aleema Khanum’s son ‘arrested’ in May 9 case – Pakistan

    After furore over ‘abduction’, police say Aleema Khanum’s son ‘arrested’ in May 9 case – Pakistan

    Hours after the PTI announced late Thursday that men in plainclothes had “abducted” the son of Aleema Khanum, the sister of party founder and ex-premier Imran Khan, from her residence, Lahore police announced that Shahrez Khan had been arrested in connection with a May 9 case.

    Shortly after the ‘abduction’ was reported, police officials had expressed ignorance of Shahrez’s whereabouts and said they could only look into the matter if an official complaint was lodged.

    Earlier, PTI Lawyer Rana Mudassar Umar had told Dawn.com that Aleema’s son, Shahrez Khan, was “kidnapped” from his home in Lahore.

    “People dressed in plain clothes entered the house and took Aleema Khan’s son with them,” he claimed. “No case has been registered against Shahrez, nor is he related to politics.”

    Mudassar said that no information had been given about Shahrez’s whereabouts and that he would approach the Lahore High Court for his recovery.

    PTI Information Secretary Sheikh Waqqas Akram wrote on X: “During an attack, people dressed in plain clothes abducted the son of Aleema Khan, the sister of Mr Imran Khan, from her home.

    “We strongly condemn this thuggery and oppression. We demand from the current government and the Chief Justice that her son be immediately recovered and safely returned to her,” he added.

    A post from the PTI’s official X account said that Aleema’s home, from where Shahrez was taken, was “attacked by individuals in plain clothes”.

    “Her son Shahrez has been abducted, family members were harassed and staff were beaten,” the post alleged, calling the incident “fascism” and adding that Shahrez must be recovered immediately.

    A longer statement from the party’s central information department termed the incident “the height of thuggery and oppression”.

    “Shahrez Khan was abducted from his bedroom after breaking the doors of the house, the servants were subjected to brutal violence and Shahrez Khan was tortured in front of his two innocent children after forcibly entering the room,” the party alleged in the statement.

    The statement highlighted that Shahrez was stopped from travelling with his wife at Lahore Airport yesterday and “illegally offloaded”. The PTI branded this treatment a “blatant violation of basic human rights”.

    Khyber Pakhtunkhwa Chief Minister Ali Amin Gandapur took to X to condemn the incident and demand Sharez’s immediate release.

    “The abduction of Aleema Khan’s son Shahrez from her home by men in plain clothes is despicable,” he wrote.

    Former opposition leader in the National Assembly Omar Ayub Khan also condemned the incident.

    “Plain clothes unknown people attacked the house, abducted her son Shahrez and beat the household staff,” he wrote on X. “Such cowardly acts prove that PM Imran Khan, his family members and PTI activists cannot be defeated.”

    PTI Secretary General Salman Akram Raja also highlighted that during the incident, household staff were allegedly attacked and the family was harassed.

    Born in Lahore, Shahrez completed his schooling at Aitchison College before heading to Oxford University for his MBA. At present, he works as the regional head at Simba Global, a linen supplier based in Australia. He is also a triathlete.

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  • ADB to Provide $410 Million for Pakistan’s Reko Diq Copper-Gold Project

    ADB to Provide $410 Million for Pakistan’s Reko Diq Copper-Gold Project

    The Asian Development Bank (ADB) has approved a $410 million financing package to support the development of Pakistan’s Reko Diq copper and gold mine in Balochistan, one of the world’s largest untapped mineral deposits, set to be operated by Barrick Gold.

    According to a report by Reuters, the project, estimated at $6.6 billion, could become a catalyst for attracting more foreign investment into Pakistan’s mineral sector, including rare earth exploration. Islamabad has already drawn interest from the U.S., offering concessions to American firms for future ventures.

    Under the financing arrangement, Barrick will receive two loans totaling $300 million, while the remaining $110 million will be provided as a financing guarantee to the Government of Pakistan.

    Reko Diq, jointly owned by Barrick (50 percent) and the federal and provincial governments (50 percent), is expected to begin production in 2028, with projected lifetime free cash flows of nearly $70 billion.


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  • PTI alleges Aleema Khanum’s son ‘abducted’ from Lahore home – Pakistan

    PTI alleges Aleema Khanum’s son ‘abducted’ from Lahore home – Pakistan

    The PTI on Thursday alleged that “men in plain clothes abducted” the son of Aleema Khanum, the sister of party founder and ex-premier Imran Khan.

    PTI Lawyer Rana Mudassar Umar told Dawn.com that Aleema’s son, Shahrez Khan, was “kidnapped” from his home in Lahore.

    “People dressed in plain clothes entered the house and took Aleema Khan’s son with them,” he claimed. “No case has been registered against Shahrez, nor is he related to politics.”

    Mudassar said that no information had been given about Shahrez’s whereabouts and that he would approach the Lahore High Court for his recovery.

    When approached for comment, Lahore Police said they were unaware of the matter and would act only after receiving a complaint.

    PTI Information Secretary Sheikh Waqqas Akram wrote on X: “During an attack, people dressed in plain clothes abducted the son of Aleema Khan, the sister of Mr Imran Khan, from her home.

    “We strongly condemn this thuggery and oppression. We demand from the current government and the Chief Justice that her son be immediately recovered and safely returned to her,” he added.

    A post from the PTI’s official X account said that Aleema’s home, from where Shahrez was taken, was “attacked by individuals in plain clothes”.

    “Her son Shahrez has been abducted, family members were harassed and staff were beaten,” the post alleged, calling the incident “fascism” and adding that Shahrez must be recovered immediately.

    A longer statement from the party’s central information department termed the incident “the height of thuggery and oppression”.

    “Shahrez Khan was abducted from his bedroom after breaking the doors of the house, the servants were subjected to brutal violence and Shahrez Khan was tortured in front of his two innocent children after forcibly entering the room,” the party alleged in the statement.

    The statement highlighted that Shahrez was stopped from travelling with his wife at Lahore Airport yesterday and “illegally offloaded”. The PTI branded this treatment a “blatant violation of basic human rights”.

    Khyber Pakhtunkhwa Chief Minister Ali Amin Gandapur took to X to condemn the incident and demand Sharez’s immediate release.

    “The abduction of Aleema Khan’s son Shahrez from her home by men in plain clothes is despicable,” he wrote.

    Former opposition leader in the National Assembly Omar Ayub Khan also condemned the incident.

    “Plain clothes unknown people attacked the house, abducted her son Shahrez and beat the household staff,” he wrote on X. “Such cowardly acts prove that PM Imran Khan, his family members and PTI activists cannot be defeated.”

    PTI Secretary General Salman Akram Raja also highlighted that during the incident, household staff were allegedly attacked and the family was harassed.

    Born in Lahore to Aleema, Shahrez completed his schooling at Aitchison College before heading to Oxford University for his MBA. At present, he works as the regional head at Simba Global, a big linen supplier based in Australia and is also a triathlete.

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  • Government takes over Liberty Steel plants in South Yorkshire after collapse | Steel industry

    Government takes over Liberty Steel plants in South Yorkshire after collapse | Steel industry

    The government has taken control of the UK’s third-largest steelworks as ministers try to protect 1,450 jobs after Liberty Steel’s operations in South Yorkshire were put into administration.

    The high court in London said on Thursday that Speciality Steel UK (SSUK), which has plants in Rotherham and Stocksbridge, would be wound up, despite the company’s request for more time to find new financial backers.

    The company, previously part of the metals tycoon Sanjeev Gupta’s Liberty Steel group, was put under the control the government’s official receiver who appointed special managers from the advisory firm Teneo to run it.

    The judge, Mr Justice Mellor, said there was too much uncertainty over whether Gupta could come up with funding. “It is quite clear that there are special managers lined up who have the support of the government,” he said. “I consider by far the preferable approach is to make a winding-up order.”

    The steelworks and its workers have been described by the business minister, Jonathan Reynolds, as important strategic assets for the UK.

    The government has said it has received approaches from “independent third parties who have expressed an interest in returning some or all of the sites to steelmaking”, according to a letter from the Department for Business and Trade entered in court.

    It also indicated that it hoped for a buyer who would restart production at Rotherham, where no products have been made for a year.

    The development marks the second government intervention in the steel industry this year, after ministers took control of British Steel’s Scunthorpe plant, fearing that its Chinese owners would let the blast furnaces cool beyond repair.

    Unions said the government needed to protect the company. Charlotte Brumpton-Childs, national officer for the GMB union, said: “This is another tragedy for UK steel – and the people of South Yorkshire – this time brought on by years of chronic mismanagement by the owners.

    “But this represents an opportunity for the UK government to take decisive action, as it did with British Steel, to protect this vital UK industry.”

    Indian-born Gupta was once known as the “saviour of steel” for his plans to turn around struggling operations. From a business founded as a student at the University of Cambridge he built up a collection of assets spanning the UK, eastern Europe and Australia.

    However, he had been scrambling to find new financing for his businesses since the collapse in 2021 of Greensill Capital, which had lent his Gupta Family Group (GFG) Alliance business about $4.5bn (£3.3bn). Administrators for Greensill are trying to recover that money on behalf of creditors, including the US lender Citibank, which is owed £233m.

    GFG Alliance has also been under investigation by the UK’s Serious Fraud Office since 2021 over allegations of “fraud, fraudulent trading and money laundering in relation to the financing and conduct of the business”, including in relation to Greensill.

    Gupta, who is based in the United Arab Emirates, had already lost control of businesses in the UK, Europe, Singapore and Australia. However, SSUK is his key metals asset in the UK, where he also bought two large country estates.

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    Jeffrey Kabel, Liberty Steel’s chief transformation officer, said Gupta was in Sydney, managing GFG’s remaining Australian business. He said the case had left Gupta “sad, because he’s put a lot into this”.

    Outside the courtroom after the judgment Kabel said he was “extremely disappointed”. “We are by far the best company to run this business. We’ve run this company for 10 years. We’ve put a lot of blood, sweat, huge amount of money into it.”

    Kabel said Liberty will continue to operate the rest of its UK businesses, including a plate mill and aluminium smelter in Scotland, plus a pipe mill in Hartlepool.

    The special managers will seek to keep the business operating, with temporary government funding, before trying to find a buyer which will cover those costs. Kabel raised the prospect of Gupta trying to mount a bid to buy back the business from the special managers, although it was unclear whether he would be able to secure financing.

    Gupta’s lawyers had pushed for him to be allowed another month to try to pursue a “pre-pack” administration of the business, which would have enabled him to buy it out of insolvency while reducing its debts. The pre-pack administration was prepared by the insolvency consultancy Begbies Traynor and would have been funded by BlackRock, the world’s largest investment manager.

    A government spokesperson said: “We know this will be a deeply worrying time for staff and their families, but we remain committed to a bright and sustainable future for steelmaking and steelmaking jobs in the UK.

    “It is now for the independent official receiver to carry out their duties as liquidator, including ensuring employees are paid, while we also make sure staff and local communities are supported.”

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  • First security guarantees, then Putin summit, Zelenskyy says

    First security guarantees, then Putin summit, Zelenskyy says

    Ukrainian President Volodymyr Zelenskyy said he could meet with Russian counterpart Vladimir Putin, but only after his allies agree on security guarantees for Ukraine to deter future Russian attacks once the fighting stops.

    In comments released Thursday, he also warned that both sides were preparing for further fighting. Russia was building up troops on the southern front line and Ukraine was test-launching a new long-range cruise missile, he said.

    Russia said Thursday that Ukraine did not appear to be interested in “long-term” peace, accusing Kyiv of seeking security guarantees completely incompatible with Moscow’s demands.

    U.S. President Donald Trump is trying to end Russia’s three-and-a-half-year invasion of Ukraine through talks with Mr. Zelenskyy and Mr. Putin.

    While he has upended a years-long Western policy of isolating the Russian leader, he has made little tangible progress towards a peace deal.

    “We want to have an understanding of the security guarantees architecture within seven to 10 days,” Zelensky said, in comments to reporters released for publication Thursday.

    “We need to understand which country will be ready to do what at each specific moment,” he added.

    A group of allies led by Britain and France are putting together a military coalition to support the guarantees.

    Fresh Russian barrage

    Once an outline of the security guarantees is agreed upon, Mr. Trump would like to see a bilateral meeting between Mr. Putin and Mr. Zelenskyy, the Ukrainian leader said.

    But any meeting with the Russian leader should he held in a “neutral” European country, he added, ruling out any summit in Moscow.

    He also rejected the idea of China playing a role in guaranteeing Ukraine’s security, citing Beijing’s alleged support for Moscow.

    Mr. Zelenskyy’s comments came as Russia launched hundreds of drones and missiles against Ukraine overnight — the biggest barrage since mid-July — killing one person in the western city of Lviv and wounding many others.

    Russian missiles also targeted an American-owned factory complex in town of Mukachevo in the west of Ukraine, Ukrainian Prime Minister Yulia Svyrydenko said on social media. That attack wounded 19 people, she added.

    President of the American Chamber of Commerce in Ukraine Andy Hunder said that the factory was “one of the largest American investments in Ukraine.

    “Russia continues to destroy and humiliate U.S. businesses in Ukraine, targeting companies that invest and trade on the US stock markets,” Hunder said on Facebook.

    France on Thursday condemned the overnight strikes as showing Moscow’s “lack of will to seriously engage in peace talks”, describing them as the “most massive attack in a month”.

    A later shelling of the city of Kherson killed one person and wounded more than a dozen, a local official said.

    Russia claims advances

    On the front lines, Russia said it had captured the village of Oleksandro-Shultyne in the eastern Donetsk region, the latest in a long string of territorial gains.

    The village lies less than eight kilometres (five miles) from Kostiantynivka, a fortified town in the Donetsk region that Russia has been pressing towards on both sides.

    In comments to journalists Thursday, Russian Foreign Minister Sergei Lavrov accused Ukraine of making unrealistic security demands.

    Any deployment of European troops to the country would be “absolutely unacceptable”, he said.

    Rhetorics of the Ukrainian officials “was directly showing that they are not interested in a sustainable, fair, long-term settlement,” Lavrov added.

    Mr. Zelenskyy also announced that Ukraine had tested a long-range cruise missile, known as Flamingo, that can strike targets as far as 3,000 kilometres (1,864 miles) away.

    “The missile has undergone successful tests. It is currently our most successful missile,” he told reporters.

    Mass production could begin by February, he added.

    Since Mr. Trump returned to the White House in January and began pushing for an end to the fighting, Russian forces have continued to slowly but steadily gain ground across the front line.

    Zelensky said Russian forces were building up troops along the front in the Zaporizhzhia region, which Moscow claims as its own — along with four other Ukrainian regions.

    Trump met Putin in Alaska last Friday, before bringing Zelensky and European leaders to Washington for separate talks on Monday.

    Mr. Zelenskyy has said the only way to end the war is a meeting with Mr. Putin, and has said Mr. Trump should be present too.

    But Moscow has played down the prospect of a summit between Mr. Putin and Mr. Zelenskyy any time soon, saying it wants to be included in discussions on future security guarantees for Ukraine.

    Published – August 21, 2025 09:59 pm IST

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