Blog

  • Five Decades of Decline: U.S. Construction Sector Productivity

    Five Decades of Decline: U.S. Construction Sector Productivity

    Historically, the U.S. economy has displayed robust, positive productivity growth. According to data from the Bureau of Economic Analysis, labor productivity (that is, real output per worker) has more than tripled over the period 1948-2023. Moreover, this positive trend is visible in almost every broad sector of the U.S. economy.

    However, there is one notable exception: construction. Labor productivity in U.S. construction in 2023 was essentially the same as it was in 1948. More importantly, as displayed in Figure 1, labor productivity in U.S. construction has actually been falling since the 1970s.

    This phenomenon of falling productivity in U.S. construction was emphasized by the 2023 working paper “The Strange and Awful Path of Productivity in the U.S. Construction Sector.”1 Real output per worker in 2020 was more than 30 percent lower than in 1970, following one of the most persistent productivity declines in any major industry.

    This presents a puzzling contradiction: While other goods-producing sectors (such as mining and manufacturing) have achieved remarkable productivity gains over the past few decades, the construction sector — which is responsible for building the homes, offices and infrastructure needed for our growing economy — has experienced a prolonged and quite severe productivity decline.

    This decline has significant implications not only for housing affordability but for overall economic growth. Construction represented about 4.5 percent of U.S. GDP in 2024. While this sector is less than half of manufacturing in terms of value added, the importance of a decline in construction productivity for its aggregate counterpart cannot be overstated.

    The construction sector is an important supplier of capital to other sectors, so a decline in construction productivity can be amplified to the aggregate. In fact, a 2022 paper concludes that the construction sector alone accounted for about one-third of the decline in trend GDP growth since WWII.2 This loss is equivalent to about $1 trillion every five years.3 Similarly, a 2023 working paper estimates that, if construction productivity had grown at even a modest 1 percent annually since 1970, annual aggregate labor productivity growth would have been roughly 0.18 percentage points higher.4 This difference would have resulted in current aggregate productivity — and likely income per capita — being about 10 percent higher than actual levels.

    The magnitude of this decline becomes particularly striking when compared to overall economic performance. During the 1950s and 1960s, construction productivity actually grew at rates that matched or exceeded the broader economy. However, around 1970, construction productivity began a sustained downward trajectory that has continued for five decades. While aggregate U.S. labor productivity tripled between 1950 and 2020, its measure for construction remained essentially the same. This divergence is especially notable when compared with manufacturing, which experienced a large increase in labor productivity over the same period despite dealing with similar physical assembly and configuration challenges.

    Is the Productivity Decline Driven by Measurement Error?

    Given the overall growth of the U.S. economy and the construction sector’s apparent importance to the economy, a secular decline in U.S. construction productivity seems peculiar at first. As a result, some observers in the literature were initially skeptical about this phenomenon and believed that the drop in construction productivity was primarily driven by measurement issues.

    Labor productivity requires only two components:

    • Real output (that is, value added in constant dollars)
    • A measure for labor

    The latter is typically measured by the number of either full-time equivalent payroll workers or hours worked by these employees.

    It is important to point out that construction establishments use a lot of subcontractors and/or undocumented immigrants, which are not included in traditional measures of labor. However, correcting these measurement “errors” does not reverse the declining trend in construction productivity. On the contrary, correcting productivity figures for subcontractors or undocumented immigrants would only display a larger decline in its productivity, since such a correction would mean more workers producing the same level of output. As a result, a decline in labor productivity cannot be solely caused by mismeasurement in labor variables.

    Productivity Measurement and Deflators

    One of the main points of controversy in the construction productivity debate lies in its deflators.5 When labor productivity is deflated using the GDP deflator for the whole economy, construction productivity essentially follows the economy’s upward trend, as seen in Figure 1. It is important to note that this observation does not immediately imply that commonly used deflators for the construction sector are wrong. However, increasing output prices do play a big role in understanding productivity for the construction sector.

    Given that construction productivity calculations depend heavily on price deflators used to convert nominal construction spending into real output measures, the question of measurement error in these deflators has been central in the construction productivity debate. A 2025 working paper specifically investigated whether measurement problems in these deflators could account for the observed productivity decline.6 It focuses on potential biases arising from unobserved improvements in structure quality — such as better insulation, more energy-efficient systems and higher-quality materials — that are not fully captured in official price measurements.

    Using three different analytical approaches — econometric techniques, detailed construction cost data and observable quality measures from property tax assessors and homeowner surveys — this paper finds evidence of upward bias in construction price deflators. However, the magnitude of this bias was not large enough to fundamentally alter existing conclusions about poor construction productivity performance. Its most generous estimates suggest that unobserved quality improvements may have biased construction sector productivity growth downward by at most 0.5 percentage points per year from quality-related factors, with additional small biases from other measurement issues.

    Even accounting for these measurement problems, this paper concludes that “productivity growth may well have been quite low in construction, even if it has not been as low as implied by official statistics.” Construction productivity growth would still be essentially flat rather than negative, but it would remain far below other major industries: After adjusting for all potential measurement biases, construction productivity growth would still lag behind the next-lowest performing industries by about 1 percentage point annually and behind overall economic productivity growth by nearly 2 percentage points. These findings reinforce that the construction sector’s productivity challenges represent a real economic phenomenon with substantial implications for long-term U.S. economic growth.

    This view is also supported by earlier studies and has been recently corroborated as well.7 When these studies examined physical measures of productivity (such as housing units built per worker), they found similar patterns of stagnation or decline that do not rely on potentially problematic price adjustments. Additionally, the sector has shown deteriorating efficiency in converting materials into finished products, and there appears to be limited reallocation of resources from less productive to more productive areas, which is a mechanism that typically helps drive productivity growth in well-functioning markets.

    Construction Productivity Decline and Land-Use Regulation

    Since the decline in construction productivity does not seem to be a mere measurement problem, a natural follow-up question is: What caused this decades-long decline in the productivity of the construction sector? An interesting hypothesis has recently been put forward by a 2024 working paper: the rise of land-use regulation.8

    Using historical data from the Census Bureau and the Bureau of Labor Statistics, the authors construct a series on construction productivity (that is, housing units started per worker) from 1900-2023. Its analysis reveals an inverted U-shaped curve — what the authors term a “Kuznets curve” — for construction where labor productivity displayed no noticeable trend between 1900 and 1940, boomed after WWII and then sharply decreased again after 1970. This historical pattern demonstrates that technological progress in construction is not inherently impossible, making the post-1970 decline all the more striking. Then, the authors show that the timing of this productivity reversal roughly coincides with America’s embrace of increasingly restrictive land-use controls and building regulations.

    The paper’s argument is relatively straightforward: Project-level building regulations systematically reduce the size of individual construction projects by making larger developments more difficult to approve through lengthy permitting processes and community opposition. Through a structural model, the paper demonstrates that, when developers face lower approval probabilities for larger projects, it is optimal for these construction firms to pursue smaller developments. In turn, this leads to smaller construction companies since these firms cannot efficiently manage numerous small projects scattered across different locations.

    This regulatory constraint creates a vicious cycle that undermines productivity growth. Smaller construction firms have reduced incentives to invest in technological innovation and process improvements because the benefits of such investments cannot be spread across as many projects or housing units. Empirical evidence from the paper supports this theory: Areas with stricter land-use regulation have significantly smaller and less productive construction establishments. Furthermore, patenting activity in construction stagnated after 1970, while manufacturing patents continued to grow. In the end, the paper estimates that construction productivity could be 60 percent higher if firm sizes matched those in manufacturing. This regulatory explanation helps explain why construction has diverged so sharply from other sectors that have continued to benefit from technological progress and economies of scale.

    Conclusion

    The decline in construction productivity represents one of the most significant and persistent sectoral challenges facing the U.S. economy. While measurement issues may account for some of the observed decline, most evidence seems to point out that genuine productivity problems have plagued the industry for more than five decades.

    The stakes of addressing this challenge extend far beyond construction companies themselves. With construction productivity problems contributing to reduced housing affordability and slower overall economic growth, finding solutions has become critical. The regulatory hypothesis offers a potentially actionable path forward, suggesting that reforms to land-use and building approval processes could help restore the technological dynamism that the sector demonstrated during its post-World War II boom.

    As policymakers grapple with housing shortages and infrastructure needs, understanding and addressing the root causes of construction’s productivity stagnation will be essential for promoting U.S. productivity growth.


    Chen Yeh is a senior economist in the Research Department at the Federal Reserve Bank of Richmond.


    This article may be photocopied or reprinted in its entirety. Please credit the author, source, and the Federal Reserve Bank of Richmond and include the italicized statement below.

    Views expressed in this article are those of the author and not necessarily those of the Federal Reserve Bank of Richmond or the Federal Reserve System.

    Continue Reading

  • Watch: ‘Astonishing’ video shows human embryo implanting in real time

    Watch: ‘Astonishing’ video shows human embryo implanting in real time

    1 of 4 | A human embryo is shown implanting itself inside a simulated uterine wall in an image taken from the first real-time video of the process ever recorded. Spanish researchers say they hope their video will lead to a deeper understanding of infertility. Photo courtesy Institute for Bioengineering of Catalonia

    Aug. 11 (UPI) — A team of Spanish researchers announced Friday they have for the first time recorded video of a human embryo implanting itself in a simulated uterine wall, revealing never-before-seen details of how 5-day-old embryos carry out the mysterious process.

    Using advanced microscopy techniques allowing the scientists to record the human embryo in full color and 3D, the “astonishing” videos provide the first-ever, real-time glimpse of the implantation process and have provided key insights into how it actually works, they said.

    Researchers from the Institute for Bioengineering of Catalonia and Dexeus University Hospital in Barcelona, Spain, said the videos reveal for the first time that embryos exert “considerable force” and employ digging traction as they “invade” the uterine tissue, becoming completely integrated with it.

    The findings, published in journal Science Advances, found crucial differences between how mouse and human embryos move in connecting to the uterus wall, the authors said.

    An “ex vivo” platform they developed using an artificial uterine matrix made of gel and collagen which allows for implantation outside of a human uterus made the videos possible. The system could have a “significant impact” on efforts to counter infertility and help those who are unable to conceive naturally, they predicted.

    Failure of the implantation process is the main reason behind the relatively low effectiveness of assisted reproductive technologies, such as in-vitro fertilization, in which embryos are conceived in a lab and then transferred to the womb. Implantation occurs in only 25% to 30% of transferred embryos — whether conceived in vivo or in-vitro — with embryo quality cited as the most significant feature affecting implantation.

    “We’ve opened a window into a stage of development that was previously hidden,” the co-authors said in a statement to UPI. “After Day 5, when an embryo has 100 to 200 cells, it must implant, but until now, doctors couldn’t observe it again until an ultrasound weeks later.

    “With our system, we can test culture conditions or compounds that might improve implantation.”

    For example, the scientists say they have already developed a protein supplement that can be used in clinics to enhance implantation rates, available through their spin-off company Serabiotics and in collaboration with the Spanish pharmaceutical major Grifols.

    “In short, this is a new tool for extending embryo observation and optimizing conditions for success,” they said.

    The videos show a donated human embryo powerfully pulling on the uterine matrix and reshaping it as it goes, illustrating the importance of “optimal matrix displacement.”

    Lead author Samuel Ojosnegros, principal investigator of IBEC’s Bioengineering for Reproductive Health Group, said the initial real-time look at a human embryo implanting itself was a profound experience for him.

    “We had some experience making time-lapse movies of mouse embryos, but the first time we saw a human embryo implanting was truly astonishing,” he said. “Everything was different, the size, the shape, the behavior. They were stronger, more forceful, digging a hole into the matrix in a remarkably invasive way. Every detail felt unique.

    “Watching it alive, in action, for the first time was absolutely mind-blowing.”

    Embryo implantation is the “holy grail” of reproduction — and unlike in the animal world, in humans it can be a problematic process, resulting in about 1 in 6 people around the world having trouble making a baby, noted Dr. Mark Trolice, a professor at the University of Central Florida College of Medicine and founder/director of The IVF Center, a full-service reproductive medicine clinic in Orlando.

    “Even though scientists have studied this for many years, they still do not fully understand how implantation works or what makes the uterus ready for an embryo,” he told UPI. “One big mystery is why a woman’s body can grow a baby made from sperm — which is a ‘foreign’ tissue — without rejecting it, as well as the ability to carry a donated egg.”

    The new study, he said, “gives researchers a closer look at implantation. They used an ex vivo model, which means they studied the process outside the body. This let them watch how embryos interact with the uterine lining (called the endometrium) and measure the tiny pulling and pushing forces from both mouse embryos and donated human embryos.”

    The videos showed for the first time that each species makes its own unique pattern of forces during implantation.

    Trolice noted that while there are “some limits” to the Spanish study, “this work could lead to new ways of adjusting the uterine environment, which might help more embryos successfully implant.

    “Before any treatment can be used, scientists will need to do human clinical trials. There are also important ethical and legal rules about using human tissues and embryos, which researchers must follow,” he added.

    Continue Reading

  • Atmospheric Characterisation With The Twinkle Space Telescope Following Advances From JWST Observations

    Atmospheric Characterisation With The Twinkle Space Telescope Following Advances From JWST Observations

    The sweep of Twinkle’s FOR and location of currently known exoplanets (red) and TESS objects of interest (blue). — astro-ph.IM

    The Twinkle Space Telescope is a satellite designed for spectroscopic observations of a wide range of extrasolar and solar system objects.

    Equipped with a 0.45 m diameter telescope and a spectrometer covering from 0.5 to 4.5 microns simultaneously, Twinkle will be launched in a sun-synchronous, low-Earth orbit, and it is expected to operate for seven years.

    Twinkle is developed, managed and operated by Blue Skies Space (BSSL), a space science data company whose vision is to accelerate and expand the availability of new, high-quality datasets to researchers worldwide, complementing the space observatories delivered by government space agencies.

    Over its lifetime, Twinkle will conduct large-scale survey programs. The scientific objectives and observational strategy of these surveys are defined by researchers who join the Science Team.

    Leveraging advances made possible by recent observations with the James Webb Space Telescope, we present here updated simulations evaluating Twinkle’s observational capabilities in the context of exoplanet atmospheres.

    Through retrieval analyses of HD 209458 b, WASP-107 b, GJ 3470 b, and 55 Cnc e, we demonstrate how increasing observational investment enhances the retrieval of atmospheric parameters and molecular abundances. Our sensitivity study highlights Twinkle’s capability to detect less abundant or less detectable molecules depending on the observing strategies adopted.

    This work provides practical guidance for developing targeted observational strategies to maximise Twinkle’s scientific return.

    Tailong Zhang, Benjamin Wilcock, Sushuang Ma, Giovanna Tinetti, Lawrence Bradley, Marcell Tessenyi, Jonathan Tennyson
    Subjects: Instrumentation and Methods for Astrophysics (astro-ph.IM); Earth and Planetary Astrophysics (astro-ph.EP)
    Cite as: arXiv:2508.10386 [astro-ph.IM] (or arXiv:2508.10386v1 [astro-ph.IM] for this version)
    https://doi.org/10.48550/arXiv.2508.10386
    Focus to learn more
    Submission history
    From: Tailong Zhang
    [v1] Thu, 14 Aug 2025 06:41:48 UTC (16,940 KB)
    https://arxiv.org/abs/2508.10386
    Astrobiology,

    Continue Reading

  • UN says at least 1,760 killed while seeking aid in Gaza since late May – World

    UN says at least 1,760 killed while seeking aid in Gaza since late May – World

    JERUSALEM: The UN human rights office said Friday that at least 1,760 Palestinians had been killed while seeking aid in Gaza since late May, a jump of several hundred since its last published figure at the beginning of August.

    “Since 27 May, and as of 13 August, we have recorded that at least 1,760 Palestinians have been killed while seeking aid; 994 in the vicinity of GHF (Gaza Humanitarian Foundation) sites and 766 along the routes of supply convoys. Most of these killings were committed by the Israeli military,” the agency’s office for the Palestinian territories said in a statement.

    That compares with a figure of 1,373 killed the office reported on August 1.

    The update came as Gaza’s civil defence agency said at least 31 people were killed by Israeli fire on Friday, including 12 who were waiting for humanitarian aid.

    The Israeli military said its troops were working to “dismantle Hamas military capabilities”, adding its forces were taking precautions “to mitigate civilian harm”.

    Media restrictions in Gaza and difficulties accessing swathes of the territory mean AFP is unable to independently verify the tolls and details provided by the civil defence agency and the Israeli military.

    Israel’s Gaza plan risks ‘another calamity’: UN

    On Wednesday, the chief of staff of the Israeli military said plans had been approved for a new offensive in Gaza, aimed at defeating Hamas and freeing all the remaining hostages.

    The military intends to take control of Gaza City and nearby refugee camps, some of the most densely populated parts of the territory, which has been devastated by more than 22 months of war.

    In recent days, Gaza City residents have told AFP of more frequent air strikes targeting residential areas, while earlier this week Hamas denounced “aggressive” Israeli ground incursions in the area.

    The Israeli government’s plans to expand the war have sparked an international outcry as well as domestic opposition.

    UN-backed experts have warned of widespread famine unfolding in the territory, where Israel has drastically curtailed the amount of humanitarian aid it allows in.

    Hamas’s October 2023 attack which triggered the war resulted in the deaths of 1,219 people, according to an AFP tally based on official figures.

    Israel’s offensive has killed at least 61,827 Palestinians, according to figures from the health ministry in Hamas-run Gaza which the United Nations considers reliable.

    Continue Reading

  • Watch a human embryo implant itself — with brute force

    Watch a human embryo implant itself — with brute force

    A microscopic view of a nine-day-old human embryo shows a protein found in embryonic stem cells in green, developing tissue in magenta and DNA in blue. Credit: Institute for Bioengineering of Catalonia (IBEC)

    A time-lapse film offers a glimpse of a hidden milestone of human development: the moment when the newly formed embryo latches onto the uterine lining. Researchers have captured real-time footage of an embryo pulling on a high-fidelity replica of the lining to bury itself inside, effectively remodelling its new home.

    The team reports its findings today in Science Advances1.

    Hidden figures

    The authors were inspired to simulate the implantation process because the actual events are so difficult to capture. “It’s very inaccessible because it’s all happening inside the mother,” says co-author Samuel Ojosnegros, a bioengineer at the Institute for Bioengineering of Catalonia (IBEC) in Barcelona, Spain. “It’s such an important process for human reproduction, but at the same time, we don’t have the technology to study it.”

    A short gif of a human embryo showing the process of cell compaction

    A human embryo contracts itself to minimize its exposure to the outside environment.Credit: Institute for Bioengineering of Catalonia (IBEC)

    Although previous studies have investigated how human embryos interact with glass, the embryo can’t penetrate this material as it does real human tissue. So the team set out to create a more lifelike mock-up, devising a faux uterine lining from a gel rich in collagen and proteins that are crucial for embryonic development.

    To shoot their stop-motion film, researchers placed human embryos donated by a local hospital near the gel. As the embryo attached to the ‘uterus’, the team used a microscope to capture an image about every 20 minutes for 16–24 hours, and then stitched the stills together.

    Co-author Amélie Godeau, a biomechanics researcher at IBEC, was shocked to see how quickly the embryo burrowed down into the gel. “My first reflex was to think my experiment had gone wrong and there was some drift in the microscope,” Godeau says. By contrast, the team found that mouse embryos adhere to the surface of the uterus rather than embedding itself inside.

    A short gif of a human embryo showing the embryo invading the platform

    A human embryo plunges into a synthetic uterine lining tissue by applying force to pull the tissue apart.Credit: Institute for Bioengineering of Catalonia (IBEC)

    Continue Reading

  • Scientists sequence avian flu genome found in Antarctica

    Scientists sequence avian flu genome found in Antarctica

    Penguins line the shore in South Georgia, Antarctica. A team of Chilean scientists has sequenced the first complete genomes of the H5N1 avian influenza virus found in birds in Antarctica. File Photo by L.A. Kelly Whybrow/Royal Nacy/EPA

    Aug. 15 (UPI) — A team of Chilean scientists has sequenced the first complete genomes of the H5N1 avian influenza virus found in birds in Antarctica.

    The work, led by the University of Chile and the Chilean Antarctic Institute, was published in Emerging Infectious Diseases, a journal of the U.S. Centers for Disease Control and Prevention, marking a milestone in pathogen research on the frozen continent.

    The study, which included sequencing the virus in birds such as Antarctic skuas and terns, provides crucial information for understanding the evolution of H5N1 and its potential spread to other species.

    Sequencing a virus’s genome is like reading its complete genetic code. In this case, genomic analysis of avian flu found in Antarctica showed the virus is part of the variant that has affected South America.

    “Sequencing and genetically characterizing this virus in Antarctic birds allows us to understand its behavior in an extreme, pristine and particularly vulnerable ecosystem,” said Víctor Neira, a professor at the University of Chile’s Faculty of Veterinary and Animal Sciences and a member of the research team.

    Specifically, the phylogenetic analysis showed a high genetic similarity to viruses detected in gulls and fur seals on South Georgia Island, confirming the existence of a viral migration route from South America to Antarctica.

    The finding underscores the need for constant global epidemiological surveillance and highlights the virus’s risk of mutation, experts said. By infecting new species in a different environment, the virus could become more dangerous and pose a threat to human and animal health worldwide.

    According to the research team, its greatest contribution to Antarctic science is providing essential data on biodiversity and emerging risks in the region.

    In late 2023, H5N1 reached Antarctica for the first time, breaking the isolation that had kept the continent free of the virus.

    The first cases were recorded in skuas on South Georgia Island, and during 2024 and 2025, the virus spread to the Antarctic Peninsula and the Weddell Sea, affecting birds such as penguins, cormorants and gulls, as well as marine mammals including fur seals and elephant seals.

    Recent scientific expeditions detected nearly 200 infected animals from 13 species in more than 20 locations, confirming the outbreak has taken hold in the region and poses a serious threat to its fragile biodiversity.

    Continue Reading

  • Pak taekwondo athletes grab medals at Kazakhstan Open

    Pak taekwondo athletes grab medals at Kazakhstan Open


    KARACHI:

    Pakistani taekwondo athletes Noman Khan and Hamza Omer concluded their campaign at Kazakhstan Open 2025 with two bronze medals. Noman got his medal in the -63 kg event, while Hamza had his podium finish in the +87 kg men’s events in Astana.

    The Kazakhstan Open International Taekwondo Championship was scheduled from 14-16 August 2025.

    The G1-ranked event will see participation from 21 nations, including Pakistan, China, India, Kazakhstan, Nepal, UAE, Palestine, Saudi Arabia, Afghanistan, and teams competing under the WT Refugee flag.

    The Pakistani contingent is led by Lt. Col Zeeshan Aslam as the head of the yeam. The squad includes, national head coach Master Yousef Karami along with the athletes, Shahzaib Khan (-54 kg), Hamza Omar Saeed (+87 kg), Noman Khan (-68 kg), Abu Bakar Siddique (-58 kg), Kaif Anwar (-74 kg), Arbaz Khan (-63 kg), and female athlete Fatemah Zahra in (-49 kg).

    Shahzeb reached the quarterfinal but lost the match, and Abu Bakar, Arbaz, and Fatemah faced the loses after booking their places among the last-eight of their events as well.
    Kaif, however, lost in his first fight.

    Team head Lt. Col Zeeshan Aslam had expressed confidence in the squad’s preparations and he was confident of the athletes’ ability to win medals, “The team has been training intensively, with high spirits. Competing during the month of Independence adds to the motivation. Our goal is to win gold for Pakistan.”

    Meanwhile, coach Karami added: “Athletes have also taken part in joint training sessions alongside other international teams, gaining valuable exposure ahead of the high-profile event.”

    Pakistani athletes were in action on 14th August in their respective weight categories.

    Continue Reading

  • Effect of Digoxin Versus Bisoprolol for Heart Rate Control in Atrial Fibrillation With Heart Failure on Quality of Life: A Prospective Randomised Comparative Study

    Effect of Digoxin Versus Bisoprolol for Heart Rate Control in Atrial Fibrillation With Heart Failure on Quality of Life: A Prospective Randomised Comparative Study


    Continue Reading

  • Novel KRAS G12D Inhibitor Shows Promising Efficacy in Advanced NSCLC

    Novel KRAS G12D Inhibitor Shows Promising Efficacy in Advanced NSCLC

    Microscopic image of non-small cell lung cancer – Generated with Google Gemini AI

    Updated clinical data from a phase 1/2 study (NCT07020221) in China of the investigational oral KRAS G12D inhibitor, VS-7375 (GFH375), have demonstrated compelling efficacy in patients with advanced non–small cell lung cancer (NSCLC) harboring a KRAS G12D mutation.1 The findings, which represent a significant increase in response rates from previously reported data, are scheduled for presentation at the IASLC 2025 World Conference on Lung Cancer (WCLC) in Barcelona, Spain. The data highlight the potential of this agent in a patient population with high unmet clinical need.

    The study, a collaboration between Verastem Oncology and GenFleet Therapeutics, provides the latest insights into the clinical profile of VS-7375, a dual “ON/OFF” KRAS G12D inhibitor. According to the late-breaking abstract, the objective response rate (ORR) at the recommended phase 2 dose of 600 mg once daily was 68.8% (n = 11/16).

    “These data at WCLC build on the encouraging data presented at [the American Society of Clinical Oncology (ASCO) Annual Meeting] earlier this year, where GenFleet initially reported an ORR of 42% in 12 patients with advanced non-small cell lung cancer harboring a KRAS G12D mutation,” said Dan Paterson, president and chief executive officer of Verastem Oncology, in a press release.

    Across all dose levels in the NSCLC cohort, the ORR was 57.7% (n = 15/26), with a disease control rate (DCR) of 88.5% (n = 23/26). All patients in the NSCLC cohort had metastatic disease at baseline, with the vast majority (64.3%) having received at least 2 prior lines of systemic therapy and nearly all (96.4%) having been previously treated with an anti–PD-1/PD-L1 agent. These patient characteristics underscore the advanced and heavily pretreated nature of the study population, making the observed response rates particularly encouraging.

    The phase 1/2 trial, initiated in July 2024, included a total of 142 patients across multiple tumor types,2 with a median follow-up time of 4.5 months as of the July 15, 2025, data cutoff.1 The study population was composed of patients with advanced NSCLC, pancreatic ductal adenocarcinoma (PDAC), and other solid tumors, with 28, 85, and 29 patients, respectively. While efficacy data were specified for the NSCLC cohort, the safety profile was reported cumulatively across all 142 patients. The safety analysis revealed that treatment-related adverse events (TRAEs) were predominantly grade 1 or 2 in severity. The most common TRAEs, occurring in at least 20% of patients, included diarrhea, vomiting, nausea, and decreased appetite. The incidence of grade 3 or higher TRAEs and severe AEs was 27.5% and 7.7%, respectively. Of the 142 patients in the safety population, 11 required dose reduction and 6 discontinued treatment due to TRAEs, with no TRAE-related deaths reported. These data suggest a manageable safety profile for VS-7375 at the doses studied.

    The KRAS G12D mutation is the most prevalent KRAS mutation, accounting for 26% of all KRAS-mutated cancers. It is particularly common in pancreatic cancer (37%) and colorectal cancer (12.5%), as well as NSCLC (5%). Despite its prevalence, there are currently no FDA-approved therapies specifically targeting this mutation. The dual “ON/OFF” mechanism of VS-7375 represents a novel approach to inhibiting both the active and inactive states of the KRAS G12D protein, distinguishing it from other agents that may only target 1 state.

    In April 2025, the FDA cleared the investigational new drug application of VS-7375.3 Last month, the FDA granted fast track designation to VS-7375 in KRAS G12D-mutated PDAC.4

    REFERENCES:
    1. Verastem Oncology Announces Late-Breaking Abstract from Partner GenFleet Therapeutics’ Study in China of GFH375 (VS-7375) in Advanced Non-Small Cell Lung Cancer at IASLC 2025 World Conference on Lung Cancer. News release. August 13, 2025. Accessed August 15, 2025. https://tinyurl.com/mr24mmuk
    2. A Phase 1/​2a Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors. ClinicalTrials.gov. Updated July 18, 2025. Accessed August 15, 2025. https://clinicaltrials.gov/study/NCT07020221
    3. Verastem Oncology announces US IND clearance of VS-7375, oral KRAS G12D (ON/OFF) inhibitor, enabling phase 1/2a trial in advanced solid tumors. News release. Verastem Oncology. April 24, 2025. Accessed August 15, 2025. https://tinyurl.com/3db7zt28
    4. Verastem Oncology Granted Fast Track Designation for VS-7375 for the Treatment of KRAS G12D-mutated Locally Advanced or Metastatic Pancreatic Cancer. News release. Verastem Oncology. July 24, 2025. Accessed August 15, 2025. https://tinyurl.com/5e7ftfd9

    Continue Reading

  • Lazio Region Leads Italy’s West Nile Virus Outbreak — Vax-Before-Travel

    Lazio Region Leads Italy’s West Nile Virus Outbreak — Vax-Before-Travel

    (Vax-Before-Travel News)

    While West Nile virus (WNV) has been determined to be endemic throughout most of Italy, the current outbreak has been centered in the Lazio Region, one of the 20 administrative regions. Situated in the central peninsular area, Lazio has over 5.7 million inhabitants.

    According to the health ministry Bollettino N. 5, Lazio has reported 140 WNV cases as of August 14, 2025.

    Overall, a total of 275 cases of WNV infection, including 19 related fatalities, have now been confirmed in Italy since the beginning of 2025.

    Local media reported in early August 2025, the health ministry has said the situation is under control and there is no need for alarm, as while areas of Italy previously unaffected have been hit, the contagion and fatality figures are in line with those of recent years.

    In 2022, human cases were reported in 25 provinces (128 municipalities) of the regions Emilia-Romagna, Friuli-Venezia Giulia, Lombardia, Piemonte, Sardegna, Toscana, and Veneto. 

     

    Since the beginning of 2025, five other European countries have reported human cases: Bulgaria, France, Greece, Hungary, and Romania.

    Currently, there are no vaccines approved to prevent WNV cases.

    Continue Reading