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  • Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident cardiovascular disease in middle-aged and older Chinese adults: a nationwide cohort study | Cardiovascular Diabetology

    Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident cardiovascular disease in middle-aged and older Chinese adults: a nationwide cohort study | Cardiovascular Diabetology

    Study design and participants

    This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative longitudinal survey employing multistage stratified sampling. The initial national baseline survey (Wave 1) was conducted in 2011, enrolling 17,708 middle-aged and older adults across 450 villages from 150 districts in 28 Chinese provinces. Demographic and clinical information was collected via standardized questionnaires. Follow-up surveys were conducted biennially to triennially thereafter to monitor health outcomes. No additional interviews were conducted for this analysis. The study incorporated five waves of existing CHARLS data (2011, 2013, 2015, 2018, and 2020). The detailed methodologies and data collection procedures for CHARLS have been previously described [22]. Ethical approval was granted by the Peking University Biomedical Ethics Review Committee (IRB00001052-11015), and all participants provided written informed consent.

    Fasting status, blood glucose, and triglyceride levels were obtained from blood samples collected during Waves 1 and 3. The exclusion criteria were as follows: (1) age ≤ 45 years; (2) prior CVD event or missing CVD data before Wave 3 (2015); (3) nonfasting status; (4) missing data for age, sex, C-reactive protein (CRP), fasting blood glucose (FBG), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), or total cholesterol (TC); and (5) missing or abnormal waist circumference measurements (defined as values exceeding three standard deviations from the mean). The detailed inclusion and exclusion process is outlined in Fig. 1. The final analysis cohort comprised 4157 participants.

    Fig. 1

    Flowchart of the study population.

    Assessment of CTI changes

    The TyG index, CTI, and cumulative CTI (cuCTI) were calculated via the following formulas: TyG index = ln [triglycerides (mg/dL) × glucose (mg/dL)/2]; CTI = 0.412 × ln(CRP [mg/L]) + ln(TG [mg/dL] × FPG [mg/dL])/2 [15].

    The cumulative CTI (cuCTI) was calculated via a linear model as the product of the mean CTI values from 2012 and 2015 and the time interval, following the formula: cuCTI = (CTI₂₀₁₂ + CTI₂₀₁₅)/2 × time interval (2015 − 2012). CTI₂₀₁₂ and CTI₂₀₁₅ denote CTI measurements from 2012 (Wave 2) and 2015 (Wave 3), with a 3-year interval between measurements. The mean of these two time points was computed to reflect the average exposure level, then multiplied by the time duration to calculate long-term cumulative exposure. This approach adheres to the methodology for cumulative metabolic indices in the CHARLS cohorts, which is consistent with the approach described by Zou [23] and Lu [24].

    Assessment of incident CVD

    The presence of heart disease was determined by asking, “Have you been doctor-diagnosed with heart attack, coronary heart disease, angina, congestive heart failure, or other heart problems? Or have you been doctor-diagnosed with stroke?” CVD was defined as self-reported heart disease and stroke. CVD determination was consistent with prior studies using CHARLS data [20]. Time to CVD onset was determined as the period between the last study interview and the first documented CVD event.

    Covariates

    Covariates included sociodemographic characteristics (age, sex, marital status, education level, smoking status, alcohol consumption), health indicators (systolic blood pressure [SBP], diastolic blood pressure [DBP], hypertension, diabetes, dyslipidemia), and laboratory parameters (C-reactive protein [CRP], fasting blood glucose [FBG], total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], glycated hemoglobin [HbA1c]. Hypertension was defined as SBP ≥ 140 mmHg, DBP ≥ 90 mmHg, or self-reported hypertension. Diabetes was defined as FBG ≥ 7.0 mmol/L, HbA1c ≥ 6.5% or self-reported diabetes diagnosis. Dyslipidemia was defined as TC ≥ 240 mg/dL, TG ≥ 150 mg/dL, LDL-C ≥ 160 mg/dL, or self-reported dyslipidemia.

    Covariates included sociodemographic characteristics (age, sex, marital status, education, smoking, and drinking status), health status (systolic blood pressure (SBP), diastolic blood pressure (DBP), hypertension, diabetes, and dyslipidemia), and laboratory measurements (CRP, FBG, TG, TC, HDL-C, LDL-C).

    Statistical analysis

    Data analysis was performed via R Studio. Two-tailed P values < 0.05 were considered statistically significant. Continuous variables with a normal or approximately normal distribution are presented as the means ± standard deviations (SDs), whereas nonnormally distributed variables are reported as medians (interquartile ranges). Categorical variables are presented as frequencies and percentages. Baseline characteristics were compared across groups via analysis of variance (ANOVA) or the Kruskal‒Wallis test for continuous variables and the chi‒square test for categorical variables. Three multivariable models were constructed to evaluate associations between cuCTI and incident CVD: Model 1: unadjusted; Model 2: adjusted for sex, age, marital status, and education level; Model 3: further adjusted for BMI, drinking status, smoking status, depression, hypertension, dyslipidemia, diabetes, antihypertensive medication, antidiabetic medication, and lipid-lowering medication. The Benjamini‒Hochberg method was used to correct for multiple comparisons, controlling the false discovery rate (FDR) to reduce false-positive results. Kaplan‒Meier survival analysis was used to estimate cumulative CVD risk by cuCTI categories. Mediation analysis was performed to explore interactions between the CRP and TyG components of the CTI. A four-knot restricted cubic spline (RCS) model was used to assess nonlinear dose‒response relationships between cuCTI and CVD risk. Subgroup analyses were conducted stratified by age, sex, marital status, education level, BMI, hypertension, dyslipidemia, and diabetes via Cox proportional hazards regression. Sensitivity analyses were performed to validate the robustness of the findings: logistic regression models were used to evaluate associations between cuCTI and CVD incidence. Participants were clustered into subgroups on the basis of CTI trajectory patterns via K-means clustering, followed by logistic regression analysis. Analyses were repeated after excluding deceased participants. Participants in the 2020 follow-up were excluded from analysis to prevent potential COVID-19 pandemic effects on data reliability and endpoint event reporting.

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  • Ciarán Hinds: ‘Who is my celebrity crush? Penélope Cruz and Javier Bardem’ | Life and style

    Ciarán Hinds: ‘Who is my celebrity crush? Penélope Cruz and Javier Bardem’ | Life and style

    Born in Belfast, Ciarán Hinds, 72, studied at Rada. In 1987, he joined Peter Brook’s cast of The Mahabharata – an epic play that toured the world; he went on to perform for the RSC and the National Theatre. His films include The Cook, the Thief, His Wife and Her Lover, Belfast and Frozen. On television, he has appeared in Game of Thrones and The Terror, and will star in the new BBC adaptation of The Narrow Road to the Deep North. He is married to actor Hélène Patarot with whom he has a daughter, and lives in London and Paris.

    What is your greatest fear?
    I’m not fond of snakes.

    What is the trait you most deplore in yourself?
    Vagueness.

    What is the trait you most deplore in others?
    Pomposity.

    What was your most embarrassing moment?
    Falling off the stage and on to the pianist during the opening number in the Mother Goose pantomime at the Citizens theatre in Glasgow.

    Describe yourself in three words
    Hopeful, egalitarian, overweight.

    What makes you unhappy?
    The slaughter of innocents.

    What do you most dislike about your appearance?
    My gut.

    What is your most unappealing habit?
    Where to begin?

    If you could edit your past, what would you change?
    My penchant for having just one too many.

    What scares you about getting older?
    Not being able to fend for myself and being a burden to others.

    Who is your celebrity crush?
    Penélope Cruz and Javier Bardem.

    Which book are you ashamed not to have read?
    Ulysses by James Joyce, but I might make a start next week – or the week after that …

    What is the worst thing anyone’s said to you?
    As a young actor, again at the Citizens theatre, I was making an exit and a theatregoer leaned over the balcony and said, “You’re terrible!”

    What is your guiltiest pleasure?
    A perfect pint of Guinness.

    What or who is the greatest love of your life?
    My wife and daughter – in no particular order.

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    What does love feel like?
    Overwhelming, discombobulating, irrational and unreasonable.

    Have you ever said ‘I love youand not meant it?
    Oh yes, many times – and then had to do another take because it didn’t look like I meant it.

    What has been your closest brush with the law?
    I was once approached by a New York cop who said he was sorry but he was going to have to book me for impersonating a Roman emperor.

    What keeps you awake at night?
    An inability to get myself to bed at a reasonable hour.

    Would you rather have more sex, money or fame?
    Oh, all right then, sex.

    How would you like to be remembered?
    As not being a total bollix.

    What is the most important lesson life has taught you?
    We’re not here for long so don’t be wreaking havoc along the way.

    Tell us a joke
    Two cows in a field. One of them says, “I hear there’s another outbreak of mad cow disease.” The other one says, “Yep, thank God I’m a penguin.”

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  • Happy Birthday, Sandra Bullock! 15 Stunning Vintage Photos of the Star

    Happy Birthday, Sandra Bullock! 15 Stunning Vintage Photos of the Star

    Born in Arlington County, Virginia, in 1964 and raised in West Germany and Austria, Sandra Bullock was a high school cheerleader with big dreams before she headed to East Carolina University, graduating in 1987 with a BFA in drama. Then it was off to New York City, where, after taking classes in the Meisner Technique, Bullock landed a string of gigs on television and in independent films before booking her breakout role as Annie Porter in 1994’s Speed.

    Nabbing her first Golden Globe nomination in 1995 for her performance in While You Were Sleeping, Bullock has gone on to win an Academy Award, a Golden Globe, an MTV Movie Award, a whopping seven People’s Choice Awards, and more accolades, gaining worldwide recognition for her roles in films including The Proposal, The Blind Side, and Gravity.

    Here, in honor of her 61st birthday—Sandra, if you’re reading this, drop the skincare routine posthaste!—a roundup of deepy charming photos from the early years of Bullock’s storied career.

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  • Reinsurance Group of America’s Tony Cheng on staying humble in leadership

    Reinsurance Group of America’s Tony Cheng on staying humble in leadership

    It’s rare to be offered a big promotion and turn it down, but it’s even rarer to warn superiors you don’t feel prepared for the role and be appointed anyway.

    Yet that’s precisely what happened to Reinsurance Group of America boss, Tony Cheng, in his early years with the business. Cheng has worked his way up the ranks of RGA over the past three decades, helping grow the company to its current position of $3.9 trillion of reinsurance covering active policyholders.

    In 2025, RGA announced a landmark $1.5 billion deal with Equitable to reinsure $32 billion worth of life insurance policies, securing its place as an industry leader and expected to boost earnings for quarters come.

    Sitting down for an exclusive interview with Fortune this summer, Cheng reflected on that all-important promotion to CEO, and the value of staying humble even in the C-suite.

    The following has been condensed and edited for clarity.

    Tony, in an era where job-hopping is often seen as the fast track to career growth, you’ve chosen a different tactic—working up through RGA since 1997. Where did your work ethic come from, and what’s inspired your long-standing commitment to the company?

    I was born in Hong Kong, and my parents—both teachers—felt for the future of their four kids (of which I was the youngest) Australia would provide the Western education they wanted. So I grew up in Australia from nine months to the age of 20 and didn’t travel overseas much.

    My parents worked incredibly hard. Mom looked after the four kids and Dad unfortunately had to give up his love for teaching because it just wouldn’t pay the bills. Eventually they opened up small businesses and then we, the four kids, on the weekend would go work there—12 hour days—and didn’t think otherwise. That really bred in the sacrifice of the parents, the hard work, all things I’d wish to pass onto my kids.

    Growing up as many of us in a Western country but very Asian family do, I think I went to Asia once in my life, so [I took] an opportunity to join RGA in 1997 in Malaysia. 

    Between 1999 and 2002 you returned to the States to earn an MBA while working for RGA, before leaving to head up the Hong Kong office. When you arrived, you had a team of 10. The Asia Pacific region now has more than 1,000 employees and revenues of $4 billion. Are there untapped career opportunities in emerging markets as opposed to progressing in established regions?

    We had a very small operation, but we were actually covering about 500 million people. It was Hong Kong and Southeast Asia so Malaysia, Thailand, all those countries. I went there as the actuary, and a year and a half later they promoted me to be the CEO of that business. It was daunting, right? 

    The first time I was asked to take it by my boss, I sort of said, ‘No, I’m too young.’ At the time I was 29. He ignored that. 

    The equation in my mind was I’ve probably got a 10% chance of success—and that would be great—or a 90% chance of failure, but hey, I’m gonna learn a hell of a lot. I had no mortgage, no kids, so just wanted to learn. Maybe that instinct, that desire and drive to keep learning was from my parents being teachers.

    In its latest financial results RGA reported revenues of $22.1 billion. How has the start-up mentality you learned in Asia helped grow the business globally?

    We built that business up with incredible hard work. I’d joke internally that once every month or so pest control would come in, and that meant we could go home at 5 o’clock because what else were we going to do with ourselves? That was the spirit. In the early days, you solve problems. I’d say to the team: ‘Let’s just try. We know it’s really hard, but let’s just try.’

    In the U.S., people usually don’t create new products or create new things because the market’s so big, a lot of it’s already played out and it’s been created. Any good idea has been thought of, and that’s truly okay.

    It’s actually more connecting the dots in the U.S., but with a drive to not just settle on: ‘Hey, here’s the market, we want a share of it’ it’s a drive to create new things or a new combination of things so that we [can] increase the pie and share in that greater value creation. That’s always been in the company spirit, it was just really about bringing that out again to the forefront.

    Like a lot of other Fortune 500 CEOs we speak to, you clearly have a love for learning. In a world where AI is expected to disrupt the labor market, what are the skills you’re looking for in new talent?

    I can only think of what I advise my son, who’s in his second year of college. As the younger generation already knows, AI is gonna accelerate, and therefore number one they’ve absolutely got to be able to use it and partner with it.

    Ultimately AI, one would think, is gonna replace whatever is mathematically easier to replace. Had a conversation at one of the town halls with some risk professionals in the U.S. last week and I said all those soft skills really matter, you’ve still got to learn the hard skills, you’ve got to understand your subject matter expertise regardless of technology, but increasingly all those abilities to interact, to communicate, to join the dots, to be able to understand information, communicate it, and just put those dots together is the stuff that’s gonna be obviously harder for AI to replicate. 

    Maybe it will one day, but then you’ve just got to keep elevating yourself. So, what is that a lesson of? It is a lesson of continually adapting, continually learning, a bit like a sports person. When they’ve lost their passion to play and fight, it’s time to retire. 

    For me, when I’ve lost that passion to learn and grow, you’re probably not gonna give it your full go, hence maybe the learning really just keeps me going. It’s not like I ever said, ‘Hey, I want to be the CEO of the company.’ I was so far away, I just wanted to be treated right and enjoy the journey and the growth,

    So the lesson to individuals is you’ve just got to keep learning, you’ve got to be humble. If you’re not humble, you’re not gonna listen to yourself or your failings, you’re gonna blame them on something else as opposed to, ‘Well, what was my role in that?’ so I can learn. 

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  • Yu Zidi: The 12-year-old taking the swimming world by storm

    Yu Zidi: The 12-year-old taking the swimming world by storm

    At just 12 years old, China’s Yu Zidi is already one of the fastest swimmers in the world.

    Her times are so quick in fact, that she’s already in contention to win medals at the World Aquatics Championships in Singapore in the coming days.

    World Aquatics has a minimum age requirement of 14 for the world championships, but Yu’s times are so fast that she qualifies regardless.

    The youngster, not yet a teenager, will race in the 200m and 400m meter individual medleys, as well as the 200m butterfly. The precocious pre-teen may also be selected for China’s relay teams.

    It will mark the first time in her incredibly short career that Yu will come up against the very best in the world – many of whom will have paid attention to the staggering times she has set in her country so far.

    At the national championships back in May, the Chinese prodigy swam the 200m individual relay in 2:10.63. Not only did it win her a silver medal, but it was also the fastest time ever recorded by a 12-year-old, man or woman, in that discipline

    She then swam the 200m butterfly, arguably her best stroke, in 2:06.83. That time would have put her fourth in last year’s Olympics, but it was also the fifth-fastest time in the world this year.

    During the 2024 world championships, the time would have been enough to win her a gold medal.

    While her personal bests are breathtaking, it’s even more impressive when you consider her age.

    Yu celebrates on the podium after competing in the women's 400m individual medley event at the National Championships in China.

    It’s an incredible rise for a girl who, according to the Associated Press (AP), only started swimming when she was six.

    “The summer was too hot, and my dad took me to the water park,” she told China’s official Xinhua News Agency, per the Associated Press.

    “I enjoyed the coolness of the water and spent a lot of time in different small pools for kids. One day, a coach approached me and asked if I wanted to swim faster.”

    It’s true that swimmers, particularly women, can compete on a world level when they are still very young. You only have to look at Canadian star Summer McIntosh as an example.

    At the Tokyo Games in 2021, aged just 14, McIntosh made her Olympic debut, finishing fourth in the 200-meter freestyle.

    She bagged gold in the 200m butterfly and 400m medley at the world championships in 2022, as well as two golds at the Commonwealth Games in the 200m and 400m medleys.

    Now 18, the Canadian is one of the greatest swimmers in the world, recently posting the second-fastest 200m butterfly in history.

    American Katie Ledecky is another swimmer who started early, making her Olympic debut in London when she was just 15.

    Now, she’s the most decorated female US Olympian of all time, with 14 medals to her name, including nine golds.

    Both will serve as inspiration for Yu, who will look to continue her trajectory over the coming years.

    Yu (left) in training in January this year.

    The LA Olympics in 2028 are the obvious target. Yu will be 15 by then and would surely be among the medal contenders if things keep progressing as they are.

    There are risks, naturally, that Yu could burn out as she is introduced to tougher competition and years of training, but for now, the 12-year-old is keeping her feet on the ground.

    “Since I am not competitive in the sprint events, I have to choose the 400-meter individual medley and the 200-meter butterfly as my favorites,” she said.

    “My age is currently an advantage and I hope to grow and develop more strength in the future.”


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  • World Economy Latest: ECB Holds For First Time in a Year

    World Economy Latest: ECB Holds For First Time in a Year

    The European Central Bank kept interest rates unchanged for the first time in more than a year as it looks for clarity on the European Union’s trade ties with the US.

    Policymakers pushing for another cut in interest rates face an uphill battle, with inflation at 2% and the economy withstanding trade turbulence, Bloomberg reported. A hold looks like the baseline for September after eight reductions since June 2024.

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  • Silent Threats: Cyber Vulnerabilities in Aviation Industry

    Silent Threats: Cyber Vulnerabilities in Aviation Industry

    In the modern age of technology and globalization, the aviation industry is facing a silent threat in the form of cyberattacks. The aviation industry has undertaken a massive digital transformation in the last two decades to enhance operational effectiveness and the experience of travelers. Thales’ 2025 report revealed a drastic 600% increase in digital attacks at the global level in just one year. On 9th July, Qantas Air faced a digital breach that compromised the personal data of 5.7 million customers, further exposing underlying cybersecurity vulnerabilities in this industry. The rising frequency of cyberattacks in the global aviation industry due to heavy digitalization is equally alarming for Pakistan, signaling the need to strengthen its cyber defense promptly.

    The threat landscape is expanding in this industry, as it has been proclaimed that cyber-attacks targeted around 65 percent of airports and 35 percent of airlines over the last 24 years. This indicates that the threat vectors, including distributed denial-of-service (DDoS), phishing, malware, and ransomware, are impacting the aviation industry, ranging from targeting an entity to widespread attacks on complete systems. Notably, the most prevalent cyber threat to the aviation industry is ransomware, as a report says it alone caused 41 percent of data loss and 38 percent of operational disruption in 2024.

    In the face of evolving threats, the aviation-related international regulatory bodies have established several cybersecurity frameworks. The International Civil Aviation Organization (ICAO) adopted a multifaceted strategy based on cooperation, governance, regulations, and capacity building. The Federal Aviation Authority (FAA), on the other hand, unveiled its cybersecurity strategy, which focuses on protecting airspace systems and preventing any digital attack with a Zero Trust architecture, and introduced new rules to protect the cyber infrastructure. Other international bodies are also working to mitigate the surging threats, including the International Air Transport Association (IATA), which developed a shared cyber risk requirement for all stakeholders, and the European Union (EU), which has designed an information security management system to improve cybersecurity that will be operational in 2026. Despite numerous attempts to secure a digital space through certain policies and frameworks, the threats are still looming, which requires a holistic approach for robust digital security in the aviation sector.

    As cybersecurity is a cross-cutting issue that requires the support of a team, different parts of the industry need to work together to detect, mitigate, and respond. While international bodies are establishing regulations and adopting rules to minimize cyber threats, states and airline companies also need to cooperate to improve aviation digital security. For this, they can incorporate digital defense strategies and technologies, including the implementation of network encryption and segmentation strategies that secure sensitive data and ensure protection against attacks by immediately denying unauthorized access to spread any threat vectors. Also, Digital twin technology can be operationalised in the aviation sector, as it will create a virtual replica of any operational technology that further assists the security teams in detecting potential cyber threats and taking quick action. In addition, the attacks on aviation supply chains are a serious risk that is often underestimated. To deal with them, there is a need to enable security audits that will assess the security practices of suppliers and evaluate their compliance with defined standards, along with deploying layered perimeter defenses within the network systems of the supply chain to enhance its security through encryption and access control.

    The cyber vulnerabilities exposed in the global aviation industry have taught Pakistan the lesson that it needs to enhance the security and resilience of the aviation sector before it experiences a major breach. To overcome digital threats, in the short term, Pakistan should invest in building a skilled digital workforce for the aviation sector and conduct regular assessments of the digital systems incorporated at various international airports. In addition, the Pakistan Civil Aviation Authority (PCAA) is relying on legacy systems that are susceptible to cyber threats. It has to adopt a cybersecurity-focused technology modernization program that complements NextGen technologies, such as artificial intelligence that can detect digital intrusions much faster than humans.

    At the long-term level, Pakistan should abide by the rules and regulations provided by the international aviation regulatory bodies, along with the adoption of key digital defense strategies and technologies discussed above. Likewise, Pakistan should establish a cybersecurity infrastructure program for the strategic defense of airports. This can be done through offering financial support for all the international airports across the country, and in collaboration with the Ministry of Defence (MOD), PCAA assesses cyber security vulnerabilities of these airports and takes appropriate steps to address them. Insights from these efforts can be further shared with key stakeholders, such as airlines, aviation suppliers, and key technicians, to strengthen industry-wide cyber resilience.

    The silent threats in the form of digital intrusions and breaches are undermining the security of the aviation industry. While these vulnerabilities can be addressed through increasing cooperation among international bodies, states, and key stakeholders, along with the adoption of network strategies and layered perimeter defences at a global level. The most important aspect, in the context of Pakistan, is that it needs to incorporate both short-term and long-term countermeasures to lay the pathway for sustainable digital modernization in the future.

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  • Exclusive: Jo Whiley is calling for an end to ‘cruel’ TV talent shows

    Exclusive: Jo Whiley is calling for an end to ‘cruel’ TV talent shows

    Jo Whiley has revealed why she believes shows like The X Factor should be banned following the tragic death of One Direction star Liam Payne.

    The 31-year-old reportedly fell to his death from a balcony in Argentina in October 2024, following a drink and drugs binge. Liam was just 14 when he was initially turned away after auditioning for The X Factor in 2008, and 16 when he was chosen to be a member of One Direction, who went on to become one of the biggest boy bands in history.

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  • PM approves to develop modern, digital ecosystem in FBR – RADIO PAKISTAN

    1. PM approves to develop modern, digital ecosystem in FBR  RADIO PAKISTAN
    2. PM Shehbaz Sharif approves modern digital ecosystem for FBR  Ptv.com.pk
    3. Premier directs FBR to tighten enforcement  Dawn
    4. Prime Minister Muhammad Shehbaz Sharif chairs a meeting regarding civil services reforms.  Associated Press of Pakistan
    5. Pakistan moves closer to IMF target as tax-to-GDP ratio climbs to 10.6 percent  Arab News

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  • Could we ever build a transatlantic tunnel?

    Could we ever build a transatlantic tunnel?

    The vision sounds irresistible: step onto a train in New York, and emerge 54 minutes later in London, having traveled through a tunnel beneath the Atlantic Ocean. This kind of travel is described in some recent proposals. But is a trans-Atlantic tunnel really possible or the stuff of science fiction?

    The short answer: It’s probably not possible with current technology.

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