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  • Elderly people being excluded from medical research in UK, charities warn | Older people

    Elderly people being excluded from medical research in UK, charities warn | Older people

    People aged over 75 are being excluded from health research due to arbitrary age cut-offs, potentially stalling the development of life-saving treatments, leading charities and research institutes have warned.

    Some clinical studies restrict participation for older people due to concerns about the potential frailty of participants and a belief that age may reduce the effect of the drug or device being studied.

    Such restrictions are contributing to health inequity by excluding an important demographic from medical research, according to more than 40 charities and leading research funders, including the National Institute for Health and Care Research (NIHR), Cancer Research UK, the British Heart Foundation, and the Medical Research Council.

    Their joint statement warned that these age restrictions are unethical and lead to “research not being representative of the groups who have [the] most disease”.

    The statement added: “[These restrictions] can result in treatments that are less effective for the very people who most need support … These exclusions are rarely justified and fail to align with the principles of equity and scientific excellence.”

    One example of this exclusion is dementia research, where only one in 10 people living with the disease are offered the opportunity to take part, with participation one of the biggest barriers to progress in this area, according to the Alzheimer’s Society.

    Prof Chris Whitty, the chief medical officer, has warned that older adults are being “frequently left out of research that directly affects their care”, despite “often having the highest levels of need”.

    “This exclusion can lead to gaps in evidence, less effective treatments, and care that isn’t properly tailored to those who use services the most. As the population ages, it’s essential that research reflects the people it aims to serve,” he said.

    Some clinical studies have imposed age restrictions out of a misconception that older people with multiple morbidities could skew research results, while some studies are not designed in a way to accommodate older people, for example by requiring frequent visits to test centres that may be far away from where the participants live.

    The NIHR, which is the biggest health funder in the UK, said that the low proportion of older adults participating in research is both a scientific and ethical concern.

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    “We should not assume that treatments that work in healthy, younger people will have the same effect in older adults,” said Prof Terry Quinn, the ageing lead at the NIHR. “So excluding the predominant users of health and social care from research is at best inefficient, and at worst may produce misleading results.”

    The health minister Karin Smyth said: “We know that older people are more likely to face long-term health conditions like cancer and dementia – yet recent data shows that only one in seven people taking part in vital medical research studies are over 75.

    “If we want tomorrow’s treatments to work for everyone today, older people must be part of the research that creates them. Through our 10-year health plan, we’re turbocharging research and clinical trials – including by the NIHR launching a UK-wide recruitment drive for participants to get involved in research.”

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  • Lightcraft’s Spark could finally give filmmakers the “Google Docs of 3D”

    Lightcraft’s Spark could finally give filmmakers the “Google Docs of 3D”

    For anyone who’s ever tried to make a movie, really make one, you know the drill. Before a single shot is framed, you’re already knee-deep in budgeting spreadsheets, calendar clashes, and a hundred tiny decisions about tools and workflows. Somewhere along the way, the creativity that started it all gets buried.

    But what if the process could start differently? What if, instead of waiting for funding, locations, or crew availability, you could open a browser and start visualising your film today?

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  • Apple’s Subtle Hints About Its Future Products

    Apple’s Subtle Hints About Its Future Products

    On the rare occasions Apple has allowed visitors inside its secretive product design labs, gray blankets covered the tables, shielding any future products from prying eyes.

    So what might be under the cloth?

    Apple is famously secretive about what’s around the corner, but it’s left some breadcrumbs here and there for the careful observer. CEO Tim Cook and other executives have dropped subtle hints in recent years on earnings calls and in interviews.

    Other times, Cook or other execs will be asked about the competition or what Apple’s role in a future product category could look like, and their answers help signal how the company may position itself in the coming years.

    The iPhone’s role in a world with AI devices

    During Apple’s recent fiscal third-quarter earnings call on July 31, for example, Cook was asked about a potential future where screen-based devices become secondary to AI-powered gadgets without screens. To that, Cook highlighted some of the iPhone’s most essential uses, like the camera, Apple Pay, and available apps.

    In short, Cook appeared to suggest the iPhone isn’t going anywhere.

    “It’s difficult to see a world where iPhone’s not living in it,” Cook told investors.

    “That doesn’t mean that we are not thinking about other things as well, but I think that the devices are likely to be complementary devices, not substitution,” Cook said.


    tim cook jony ive iphones

    Apple’s former chief design officer Jony Ive (L) and Apple CEO Tim Cook inspect the iPhone XR during an Apple event in 2018. Ive has since joined OpenAI to help it design an AI device.

    Justin Sullivan/Getty Images



    The elephant in the room, of course, is that Apple’s former design chief and the man behind the iPhone, Jony Ive, left the company and has since joined OpenAI’s efforts to create a non-wearable AI gadget.

    Smart glasses

    Other companies are exploring or launching AI devices that you can wear, investing heavily in the space. Meta’s AI Ray-Bans are the most successful smart glasses so far, with CEO Mark Zuckerberg saying sales have exceeded expectations.

    While Meta and other tech giants like Google are looking into AI eyewear, Apple is also reportedly exploring a rival set of smart specs.


    Meta Connect 2024 orion

    Meta’s Orion prototype smart glasses contain integrated waveguide displays inside the lenses. Apple’s Vision Pro could ultimately take on a similar form factor in the future.

    Meta



    Interestingly enough, Cook was once a skeptic of smart glasses for years.

    “We always thought that glasses were not a smart move, from a point of view that people would not really want to wear them,” Cook told the New Yorker in 2015.

    By 2023, he’d changed his tune. When GQ asked about his quote from 10 years ago, Cook said his “thinking always evolves,” as he learned from his predecessor Steve Jobs.

    Cook continues to hype up augmented reality, with the Apple CEO launching the $3,499 Vision Pro in 2024 and saying it was the “early innings of AR” and that “it will only get better.”

    When asked about smart glasses on its most recent earnings call, Cook used the opportunity to talk about the Vision Pro but hinted at further innovation in the wearables space.


    A person wearing an Apple Vision Pro

    Apple’s Vision Pro has been said to be in need of a “killer app.” I’m not convinced it’s there yet.

    Michael M. Santiago/Getty Images



    “We continue to be very focused on it,” Cook said. “I don’t want to get into the road map on it, but this is an area that we really believe in.”

    Apple is widely believed to be hard at work shrinking down the form factor and making future iterations more affordable, with the ultimate goal of smart glasses with integrated lenses. Meta has publicly shown off a prototype of such a device, called “Orion,” though the tech is too expensive to mass-produce.

    A foldable iPhone or iPad

    While competitors, like OpenAI, work on their own secretive new products, Apple is taking its signature approach to not rush into a new product category.

    “Not first, but best,” as Cook likes to say.

    It’s a strategy that worked for devices like the iPod, the iPhone, and the Apple Watch, but it comes with risk. Apple was notably late to the AI arms race with the rollout of Apple Intelligence, and its overhauled AI-powered Siri has been delayed.


    The Samsung Z Fold7 phone can fold in half.

    The Samsung Z Fold7 phone can fold in half.

    Jung Yeon-je / AFP



    Foldable phones are another product category that Apple’s rivals including Google, Huawei, and Samsung have already entered. Apple is reportedly working on foldable devices but has so far demurred when publicly asked about it publicly.

    When Apple executives Craig Federighi and Greg Joswiak were recently asked in an interview about it, Joswiak replied, “Who’s to say?”

    When Cook was asked during Apple’s fiscal first-quarter earnings call about the iPhone’s form factor and opportunities to innovate, he hinted that there was.

    “I think there’s a lot of innovation left on the smartphone,” Cook said.


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  • Internxt secure cloud storage: Get a 20TB lifetime license for $499.99

    Internxt secure cloud storage: Get a 20TB lifetime license for $499.99

    TL;DR: Internxt Cloud Storage just dropped the price for a 20TB lifetime subscription to $499.99 (reg. $4,900).


    Cloud storage is one of those things you sign up for without thinking much about it. Subscription fees seem cheap, but you’re never done paying for them, so the longer you pay them, the worse of a value it is. Functionally, you’re paying for space you can’t live without but never really own.

    If you’re ready to stop renting storage and just pay once, Internxt Cloud Storage has a 20TB lifetime subscription on sale for $499.99 right now (reg. $4,900).

    A lifetime of cloud storage

    Whether you’re backing up years of photos, storing large creative projects, or archiving documents for work, 20TB gives you the space to do it all without juggling multiple plans or worrying about monthly charges creeping up.

    Internxt also puts a strong emphasis on privacy. Your files are encrypted on your device before they’re uploaded, then broken into fragments and distributed across a secure network of servers. It’s a zero-knowledge setup, which means even Internxt doesn’t have access to your data. The platform is also open source and GDPR-compliant, so you have more transparency and control than you’ll find with many big-name providers.

    You can access your files through apps for Windows, macOS, Linux, iOS, and Android, or just log in through a browser. File syncing is automatic, and the interface is clean and straightforward. You can also set permissions and share links securely if you need to collaborate or deliver files to others.

    For anyone running a small business, freelancing, or just managing a large personal archive, this is a practical way to stop worrying about cloud storage for good.

    Mashable Deals

    Right now, it’s only $499.99 to get an Internxt 20TB Cloud Storage Lifetime Subscription. Sale ends soon.

    StackSocial prices subject to change

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  • Montreal woman is worried about husband’s gambling addiction — now he owes $1.1M. Ramsey Show hosts said to do this ASAP

    Montreal woman is worried about husband’s gambling addiction — now he owes $1.1M. Ramsey Show hosts said to do this ASAP

    A Montreal woman called The Ramsey Show for advice about her husband’s gambling addiction that is threatening to ruin their finances.

    It’s common for spouses to combine finances — but sometimes, even when you keep your money separate, one partner’s bad habits can impact the other’s financial future.

    Such is the case for Sarah from Montreal, Quebec, who called into The Ramsey Show two weeks after learning that her husband has a gambling addiction.

    Despite having been together for 11 years, Sarah only recently discovered that her husband has racked up $1.1 million in debt over the past decade. Now, she’s taken over his finances and wants to help him tackle his debts.

    “He had like maybe $1,000 left in his bank account and everything was maxed, so he needed help,” said Sarah.

    The problem? She has no idea where to start.

    Sarah has long wanted to combine her finances with her husband, but he has always pushed back on the idea. On top of dealing with a gambling addiction that he had kept a secret, his debts have also made him fall behind on his taxes.

    Sarah’s husband likely wanted to keep his finances separate so that he didn’t drag her down into his mess, but as Sarah explained to hosts George Kamel and Jade Warshaw, her husband’s actions have impacted them both.

    For one thing, the Canadian couple had plans to buy a home in Florida when Sarah thought they were doing well financially. Sarah herself has been saving well and thought her husband was doing the same. This gambling news came as a major blow, especially since it caught her off guard.

    “I was, like, totally, totally shocked,” Sarah shared on the show.

    Now, the one saving grace is that Sarah’s husband earns a high income from his business, which earns an annual revenue of about $1.3 million. And while that’s not all profit, Sarah says her husband earns about $100,000 a month and they pay taxes on those earnings.

    However, he owes over $1 million, broken down as follows:

    • $64,000 in back taxes from 2024

    • $550,000 in provisional taxes for the upcoming year (a requirement in Canada for high earners)

    • $438,000 in a mortgage line of credit, or home equity line of credit (HELOC)

    • $125,000 in a personal line of credit

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  • Seven daily habits to control, destroy cancer cells: Expert explains | Health

    Seven daily habits to control, destroy cancer cells: Expert explains | Health

    In his book ‘Cancer Wardile Chiri,’ Malayalam actor Innocent famously terms cancer as a friend and explains how he handled the disease through laughter. Innocent’s decision to use humour as medication is said to have helped him reduce stress a great deal and handle the disease with grace. Dr Thomas N Seyfried, a researcher and professor of Boston College, who spent more than three decades studying cancer cells and their growth, recently recommended seven everyday habits that can help destroy and control cancer.

    One of them is reducing stress and understanding how to do it effectively. The researcher focused mainly on the metabolic activities of the human body rather than the genetic factors. His research focused on specific factors within the body that enable cancer cells to proliferate. Here are the habits he recommended:

    Regulate sugar intake
    Keeping the blood sugar levels under control can make it difficult for the cancer cells to grow. The sudden or rapid increase in the blood sugar level proves to be a threat to the cancer cells. They draw the energy to spread from the sudden rise in the glucose levels. So, staying away from food that causes sudden blood sugar spikes, like refined carbohydrates and sweetened drinks, is key in controlling the growth of cancer cells. Instead, try to eat a balanced diet that is rich in fibre and nutrients.

    Reduce carbohydrates
    Ketogenic foods that are high in fats and low in carbs can prevent the cancer cells from growing at a rapid pace. The body begins to burn fat instead of sugar when you switch to healthy fats like avocado, olive oil, ghee and nuts. This process, called ketosis, produces ketones that can control the growth of cancer cells. However, Dr Thomas reminds us to consult a medical practitioner or a nutrition expert before starting the ketogenic diet.

    Body movement
    Body movements and exercises are key in the fight against cancer. It improves insulin resistance, ensures hormone balance and reduces inflammation. Taking short walks, swimming, dancing, squats or light exercises done at home could be helpful. Consistency matters more than the intensity of the exercise. Dr Thomas recommends moving your body or working out regularly, as exercise is essential to ensure the health of the mitochondria, which prevents the unusual growth of cancer cells.

    Fasting
    Intermittent fasting allows the body to enter ketosis. The low insulin production cuts off the energy to the cancer cells. During fasting, our cells initiate a self–cleansing process. This process, called autophagy, removes the damaged cells.
    Reduce stress
    Chronic stress can alter the body’s sugar levels, increase inflammation and destroy the mitochondria. Stressful events could cause the rapid growth of cancer cells. The cortisol hormones rise due to stress and adversely affects the body’s immune system, causing inflammation. Activities like taking deep breaths for ten minutes, spending time in nature and journaling can reduce stress and help you relax.

    Proper diet
    A healthy and well-balanced diet containing vegetables, fruits, whole grains and healthy fats is essential for the body. Meanwhile, overly processed food increases the risk of severe diseases like cancer.
    Chronic inflammation
    Chronic inflammation in the body can provide energy to cancer cells and weaken the body’s immune system. So, it is better to avoid foods or activities that cause inflammation in the body.   

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  • GSPCA makes way for new kennels

    GSPCA makes way for new kennels

    An animal charity has demolished a series of buildings as part of its expansion plans.

    The GSPCA has pulled down structures that housed its cattery, small animal areas, dog grooming space, staff room and laundry for the past 40 years.

    The charity has planned to replace these buildings with a 12-kennel facility designed to house dogs in isolation, abused and stray dogs and those waiting to be adopted.

    The new section will also include a laundry and dog grooming area which manager Steve Byrne said would ensure “every animal receives the care and dignity they deserve”.

    Also under construction is a wildlife hospital which will provide specialist care for Guernsey’s injured, orphaned and endangered wildlife.

    Mr Byrne said the charity had raised £1.5m so far towards the construction but needed a further £2.2m to complete the projects for November 2026.

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  • Europe’s leaders raise pressure on Trump to involve Ukraine in Putin talks | Ukraine

    Europe’s leaders raise pressure on Trump to involve Ukraine in Putin talks | Ukraine

    Europe’s leaders have raised the pressure on Donald Trump to involve Ukraine in a planned summit with Vladimir Putin, as Germany warned the White House against any deal hatched “over the heads of Europeans and Ukrainians”.

    Speaking before a bilateral meeting expected to take place between the US and Russian leaders on Friday in Alaska, the German chancellor, Friedrich Merz, said he hoped and assumed that Ukraine’s president, Volodymyr Zelenskyy, would also be involved.

    Merz told the broadcaster ARD that Berlin was working closely with Washington to try to ensure Zelenskyy’s attendance at the talks.

    “We cannot accept in any case that territorial questions are discussed or even decided between Russia and America over the heads of Europeans and Ukrainians,” he said. “I assume that the American government sees it the same way.”

    Vladimir Putin (left) and Donald Trump are expected to meet in Alaska this Friday. Photograph: Ilya Pitalev/SPUTNIK/AFP/Getty Images

    The secretary general of Nato, Mark Rutte, said the summit would be about testing Putin on how serious he was about “bringing this terrible war to an end.”.

    In pointed remarks, Rutte added: “It will be, of course, about security guarantees, but also about the absolute need to acknowledge that Ukraine decides on its own future, that Ukraine has to be a sovereign nation, deciding on its own geopolitical future.”

    Announcing there would be an emergency meeting of EU ministers for Monday, Brussel’s top diplomat, Kaja Kallas, echoed that sentiment.

    “President Trump is right that Russia has to end its war against Ukraine. The US has the power to force Russia to negotiate seriously. Any deal between the US and Russia must have Ukraine and the EU included, for it is a matter of Ukraine’s and the whole of Europe’s security,” Kallas said.

    Kaja Kallas, the EU’s top diplomat, said: ‘Any deal between the US and Russia must have Ukraine and the EU included.’ Photograph: Yves Herman/Reuters

    The US vice-president, JD Vance, speaking a day after meeting the UK foreign minister, David Lammy, during his holiday in England, said Washington was working towards talks between Putin, Zelenskyy and Trump. But Vance said he did not think it would be productive for the Russian president to meet his Ukrainian counterpart before speaking with Trump.

    “We’re at a point now where we’re trying to figure out, frankly, scheduling and things like that, around when these three leaders could sit down and discuss an end to this conflict,” he told Fox News.

    As the diplomacy ramped up, there was no let-up in hostilities. Five people were killed in Russian shelling and drone attacks in Ukraine on Sunday, authorities said, while Russia said one person had been killed in a Ukrainian drone strike in its southern Saratov region.

    Five people were killed in Russian shelling and drone attacks in Ukraine on Sunday. Photograph: Genya Savilov/AFP/Getty Images

    On Saturday, two people died and 16 others were injured when a Russian drone hit a minibus in the suburbs of the Ukrainian city of Kherson, said the region’s governor, Oleksandr Prokudin. Two others died after a Russian drone struck their car in the Zaporizhzhia region, according to the regional governor.

    On Saturday night, European leaders issued a coordinated statement that said the “path to peace” in Ukraine could not be decided without Kyiv. Welcoming Trump’s attempts to end the war, leaders from the UK, France, Italy, Germany, Poland and Finland, along with the president of the European Commission, Ursula von der Leyen, emphasised that negotiations could only take place in the context of a ceasefire or reduction of hostilities.

    It added: “Only an approach that combines active diplomacy, support to Ukraine and pressure on the Russian Federation to end their illegal war can succeed.”

    Map

    On Sunday, Zelenskyy welcomed the support, saying on X: “The end of the war must be fair, and I am grateful to everyone who stands with Ukraine and our people today for the sake of peace in Ukraine, which is defending the vital security interests of our European nations.

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    “Ukraine values and fully supports the statement by President Macron, Prime Minister Meloni, Chancellor Merz, Prime Minister Tusk, Prime Minister Starmer, President Ursula von der Leyen, and President Stubb on peace for Ukraine.”

    In a Telegram post on Saturday, Zelenskyy had said that any decisions made without Kyiv were “dead decisions” and “[would] never work”.

    On Saturday, David Lammy hosted JD Vance, along with Ukrainian and European partners aimed at driving peace in Ukraine. Photograph: Kin Cheung/AP

    On the same day, at Chevening, a country mansion in Kent traditionally used by the foreign secretary, Lammy hosted Vance along with Ukrainian and European partners aimed at driving peace in Ukraine.

    If the Trump-Putin summit goes ahead, it will be the first time a US president has met the Russian leader since the full-scale invasion of Ukraine in February 2022. The last meeting Putin had with a US president was with Joe Biden in Geneva in June 2021.

    Details of a potential deal have not been announced, but Trump said ending the war would involve “some swapping of territories to the betterment of both”, meaning Ukraine could be required to renounce significant parts of its territory.

    Zelenskyy on Saturday stressed that Ukrainians would “not give up their land to occupiers”.

    A European official confirmed a counterproposal was put forward by European representatives at the Chevening meeting but declined to provide details.

    Friedrich Merz told ARD that Germany was working closely with the US to try to ensure Volodymyr Zelenskyy’s attendance at the talks. Photograph: Nadja Wohlleben/Reuters

    According to a report in the Wall Street Journal, the counterproposal included demands that a ceasefire must take place before any other steps were taken and that any territory exchange must be reciprocal, with firm security guarantees.

    It was not clear what, if anything, had been agreed at Chevening, but Zelenskyy called the meeting constructive.

    “All our arguments were heard,” he said in his evening address to Ukrainians. “The path to peace for Ukraine should be determined together and only together with Ukraine. This is [a] key principle.”

    Merz said he hoped for a breakthrough at the summit, despite lingering uncertainty of the attenders. “We hope that there will be a breakthrough on Friday,” he said. “Above all [we hope] that there will finally be a ceasefire and that there can be peace negotiations in Ukraine.”

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  • Is your liver at risk? Doctors explain the top 3 causes of liver damage and how you can prevent it | Health – Hindustan Times – Hindustan Times

    1. Is your liver at risk? Doctors explain the top 3 causes of liver damage and how you can prevent it | Health – Hindustan Times  Hindustan Times
    2. Harvard liver doctor ranks 10 foods that heal or harm a fatty liver: Some might shock you  The Times of India
    3. Living With Chronic Hepatitis? Doctor Reveals How Simple Daily Choices Can Protect Your Liver  The Daily Jagran
    4. Prioritise liver health with conscious nutrition, say experts  The Hans India
    5. 7 foods and drinks that naturally boost liver health  India.Com

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  • Labuschagne Eyes Test Recall, Ready to Open in Ashes

    Labuschagne Eyes Test Recall, Ready to Open in Ashes

    Melbourne: Eyeing a recall into Australia’s squad for the Ashes, the doughty Marnus Labuschagne is doing everything in his capacity to “find a way back” and “prove the doubters wrong”, including putting his hand up for opening the innings against England.

    Labuschagne was dropped from the Test side for the first time since 2019 at the start of the recent series in the West Indies having averaged 27.82 with one hundred over the previous two years.

    He spent the time away from the Test team training extensively with the coaching staff at home instead of doing a stint in Country cricket or turning out for Australia A.

    “This (being left out) has given me an opportunity to reflect and not having the pressure of the media saying, ‘Marnus has got to go’,” Labuschagne told News Corp in his first interview since losing his spot, according to ESPNCricinfo.

    “I mean that’s part of the game. There is a tipping point but it’s something I thrive on… proving the doubters wrong and being able to find a way. Missing those West Indies Tests gave me the chance to back and think, ‘This is where I want to be and this is how I’m going to get there’.”

    The 31-year-old Labuschagne’s last Test appearance was in June’s World Test Championship (WTC) final against South Africa, where he managed just 17 and 22 opening the innings.

    Despite the poor outing at the top of the order, Labuschagne says he is ready to take on the role if it means playing for Australia again.

    “I’d be happy to do that – I’d love to,” he said.

    “If opener is where I need to bat to be playing in the Test team, that’s fine. If you had asked me where I prefer to bat obviously I have batted at three my whole career, but at this stage you don’t get a choice.”

    “I opened in the World Test Championship final and felt I batted quite well. I got in but did not go on with it.”

    Labuschagne’s willingness to open comes amid teenager Sam Konstas’ issues with consistency at the top order.

    The veteran of 58 Tests will return to action for Australia in three home one-dayers against South Africa this month, after which he will focus on the Sheffield Shield and look to impress the selectors to earn a recall for the five-Test Ashes series starting in Perth on November 21.

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