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  • Yamaha Factory Racing

    The highly anticipated Yamaha V4-powered prototype unveiling event took place today inside the Monster Energy Yamaha MotoGP hospitality at the Misano World Circuit Marco Simoncelli. Yamaha’s management proudly presented the brand-new bike, designed to suit the V4 engine.

    The introduction of the prototype at only Round 16 of the MotoGP World Championship reflects Yamaha’s long-term commitment to advancing motorcycle innovation and their new ‘more aggressive approach’ to bike development.

    Yamaha Motor Company’s General Manager of Motor Sports Development Division Takahiro Sumi, Yamaha Motor Racing Managing Director Paolo Pavesio, Project Leader Kazuhiro Masuda, and Technical Director Max Bartolini shared their excitement to start this new chapter, discussing Yamaha’s dedication towards the V4 engine and bike development, the new Yamaha structure and mindset in 2025, and the preparations for 2026.

    Test Rider and Rider Performance Advisor Andrea Dovizioso and Official MotoGP Test Rider for the Yamaha Factory Racing Team Augusto Fernández were also put in the spotlight as major contributors to the V4 project. Through their expertise and precision, the two riders have shown themselves to be a cohesive and highly effective team, providing valuable support to the collaborative efforts of Yamaha’s test riders, engineers, and the full-time MotoGP teams and riders.

    The unveiling event included a first view of Fernández’s bike, sporting a full-blue Yamaha corporate livery.

    Fernández will be riding the V4-powered prototype as a wild card during the San Marino GP, allowing MotoGP enthusiasts the world over to see the brand-new prototype in action for the very first time.

    Fernández, who announced he has recently signed on as an Official Test Rider for Yamaha in 2026-2027, has already ridden the new bike in various private Yamaha tests, one of them held at the Misano track.

    With the upcoming wild-card entry for the Grand Prix of San Marino, Yamaha aims to have Fernández try the prototype bike in a MotoGP race-weekend setting.

    The sole purpose of the wild card is data gathering. No bike development decisions will be based on this weekend’s results.

    MotoGP media and fans will also be able to get a first glimpse of Fabio Quartararo and Álex Rins in action aboard the new bike on Monday 15th during the San Marino MotoGP Test.

    Want to see exclusive behind-the-scenes footage of the V4-powered prototype development? Check out Yamaha’s ‘The Blue Shift’ YouTube Series latest episode:

    The Blue Shift | Episode 3 – Plan V

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  • EuroBasket 2025 semi-finals preview: Schedule, match-ups, key players, stats & more – Olympics.com

    EuroBasket 2025 semi-finals preview: Schedule, match-ups, key players, stats & more – Olympics.com

    1. EuroBasket 2025 semi-finals preview: Schedule, match-ups, key players, stats & more  Olympics.com
    2. Classification confirmed for teams placed 9-16 at FIBA EuroBasket 2025  fiba.basketball
    3. Utah Jazz’s Lauri Markkanen Set for Historic Clash vs. Germany  Sports Illustrated
    4. Solo Luka, Sengun’s glow-up & Giannis the cheat code: EuroBasket quarterfinals preview with Donatas Urbonas  Yahoo Sports
    5. Türkiye, Greece clash in EuroBasket semis clash of Mediterranean | Daily Sabah  Daily Sabah

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  • New genetic test redefines diagnosis and management of hereditary pancreatitis

    New genetic test redefines diagnosis and management of hereditary pancreatitis

    A new genetic test developed at Mayo Clinic is redefining how clinicians diagnose and manage hereditary pancreatitis. Pancreatitis, inflammation of the pancreas, is a complex condition that can lead to chronic pain, repeated hospitalizations and serious complications including diabetes, kidney failure and pancreatic cancer. 

    The new hereditary pancreatitis gene panel available through Mayo Clinic Laboratories (Mayo ID: PANGP) resulted from collaboration among Mayo Clinic laboratories’ scientists, clinicians, and genetic counselors, serving as a prime example of innovation driven by patient need. 

    Pancreatitis can be difficult to diagnose and manage. It can be acute, recurrent, or chronic. In many cases, the underlying cause remains elusive. Symptoms can include belly pain, fever, an upset stomach, a rapid pulse and unintended weight loss. Pancreatitis can cause serious complications, including breathing problems, infections, diabetes, kidney failure and pancreatic cancer. 

    Internationally, roughly 2.75 million new cases of pancreatitis were diagnosed in 2021, and when existing cases were added, 5.9 million people had the disease, according to the most recent statistical sheet from the Institute for Health Metrics and Evaluation. 

    Pancreatitis is a complex disease with many potential causes – alcohol, smoking, autoimmune, toxins, and yes, genetics. When we can’t find a clear cause, genetic testing becomes key.” 


    Motaz Ashkar, M.B.B.S., gastroenterologist in the pancreatic clinic at Mayo Clinic

    The new panel expands Mayo’s previous test from four genes to nine, incorporating the latest research and clinical insight. Unlike many commercial panels that include dozens or even hundreds of genes, Mayo’s test is intentionally focused. 

    “There’s a mindset in genetic testing that bigger is better,” says Linda Hasadsri, M.D., Ph.D., a clinical molecular geneticist at Mayo Clinic. “But if you include genes with weak or unproven associations, you risk giving patients results that are confusing or meaningless.” 

    The result of that focus is a panel that includes well-established genes such as PRSS1, SPINK1, CFTR, and CTRC and newer additions such as CPA1, CASR, and CLDN2 that are increasingly recognized for their role in pancreatitis and pancreatic cancer risk. 

    The test is built on whole exome sequencing, which looks at all disease-causing genes in an individual’s DNA blueprint, allowing for comprehensive analysis of coding regions across the genome. That approach comes with challenges, especially when it comes to tricky genes like PRSS1. 

    “PRSS1 is the most common cause of hereditary pancreatitis worldwide, especially in children,” Dr. Hasadsri says. “But it’s notoriously difficult to test accurately. We’ve seen a lot of false positives and false negatives from other labs over the years.” 

    To address this, Mayo developed a custom assay with multiple supplemental methods to help confirm results and avoid misdiagnosis. The lab also built in reflex testing capabilities – meaning if a provider orders the panel and the result is inconclusive, the lab can automatically perform additional testing without requiring a new sample or billing the patient again. 

    The clinical impact of the test is significant. A positive result can help explain a patient’s symptoms, guide treatment decisions, and even inform cancer surveillance strategies. 

    “If someone has PRSS1 pathogenic mutation, their risk of pancreatic cancer is higher,” Dr. Ashkar says. “We can start monitoring them earlier and more frequently.” 

    It also opens the door to family testing. 

    “If a patient tests positive, we can screen their relatives – even those who are asymptomatic,” Dr. Hasadsri explains. “That allows for early intervention and lifestyle changes that could prevent disease progression.” 

    Even a negative result can be meaningful, helping to rule out hereditary causes and reducing unnecessary testing or anxiety,” she adds. 

    While the current panel focuses on single-gene variants, the team is already thinking ahead to the potential of creating a polygenic risk score test for pancreatitis – a test that would assess multiple risk factors to calculate a person’s risk for the disease. 

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  • David Bowie’s 15 Favorite Songs Revealed in Unearthed Document

    David Bowie’s 15 Favorite Songs Revealed in Unearthed Document

    In just two days, the David Bowie Center will open at the V&A East Storehouse in London, giving the public access to a vast archive of 90,000 items from the singer’s life and career. One of the more intriguing artifacts is a list of Bowie’s 15 favorite songs from a document entitled “Memo for radio show — list of favourite records.”

    The list contains some unsurprising picks like Roxy Music’s “Mother of Pearl,” Sonic Youth’s “Tom Violence,” and Jeff Beck’s “Beck’s Bolero.” There are also songs he covered throughout his long career, including the Beatles’ “Across the Universe,” Ronnie Spector’s “Try Some, Buy Some,” and Legendary Stardust Cowboy’s “I Took a Trip on a Gemini Spaceship. (The first song appeared on 1975’s Young Americans, the second on 2003’s Reality, and the third on 2002’s Heathen.)

    There are also 1950s obscurities he likely remembered from childhood, including Alan Freed and His Rock ’N’ Roll Band’s “Right Now Right Now” and Little Richard’s “True Fine Mama.” The list also touches on jazz numbers like Charlie Mingus’ “Ecclusiastics” and “Miles Davis’ “Some Day My Prince Will Come.”

    The final batch of songs are eclectic tunes from multiple eras, including the Hollywood Argyles’ “Sho Know a Lot About Love,” Edgar Froese’s “Epsilon in Malaysian Pale,” and Ralph Vaughan Williams’ “Fantasia on a Theme by Thomas Tallis.”

    When the public gains access to the David Bowie Center, many more tantalizing documents like his are likely to surface. And this week, the 12-disc box set David Bowie 6. I Can’t Give Everything Away (2002 to 2016) arrives. It documents the final 14 years of Bowie’s career, and is packed with unheard material along with recordings from his final live appearances in 2005 and 2006.

    Trending Stories

    Here is the complete listing of Bowie’s 15 favorite songs:

    Ralph Vaughan Williams – “Fantasia on a Theme by Thomas Tallis”
    Richard Strauss – “Four Last Songs”
    Alan Freed and His Rock ’N’ Roll Band – “Right Now Right Now”
    Little Richard – “True Fine Mama”
    The Hollywood Argyles – “Sho Know a Lot About Love”
    Miles Davis – “Some Day My Prince Will Come”
    Charles Mingus – “Ecclusiastics”
    Jeff Beck – “Beck’s Bolero”
    Legendary Stardust Cowboy – “I Took a Trip on a Gemini Spaceship”
    The Beatles – “Across the Universe”
    Ronnie Spector – “Try Some, Buy Some”
    Roxy Music – “Mother of Pearl”
    Edgar Froese – “Epsilon in Malaysian Pale”
    The Walker Brothers – “The Electrician”
    Sonic Youth – “Tom Violence”

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  • RAB26 identified as a critical regulator of prostate cancer aggressiveness

    RAB26 identified as a critical regulator of prostate cancer aggressiveness

    Prostate cancer (PCa) is one of the most common malignant tumors in men worldwide. While early detection has improved patient outcomes, effective therapies for advanced disease remain limited. Identifying the molecular drivers of PCa growth and metastasis is therefore essential to developing new treatment strategies that can overcome resistance to standard therapies.

    In a recent study published in Genes & Diseases, researchers from Chongqing Medical University, revealed the pivotal role of RAB26-a regulator of cell signaling and trafficking-in prostate cancer progression.

    Using single-cell RNA sequencing data (GSE141445), researchers found that RAB26 is mainly expressed in luminal and basal/intermediate prostate cancer cells. Elevated RAB26 expression was significantly correlated with advanced pathological stage, higher Gleason score, and poor patient prognosis. Subsequent analyses showed that RAB26 promotes proliferation, migration, and invasion of PCa cells, inhibits apoptosis, and enhances stemness and sphere formation of prostate cancer stem cells (PCSCs).

    Transcriptome sequencing analysis indicated that RAB26 drives the metastatic potential of PCa by promoting epithelial–mesenchymal transition through cascades of MAPK/ERK pathways. The team also discovered that RAB26 facilitates the nuclear localization of TWIST1, a key EMT transcription factor, while TWIST1 in turn increases RAB26 expression – creating a positive feedback loop that accelerates cancer progression. Furthermore, the findings were validated in vivo, where RAB26 knockdown significantly reduced tumor size, stemness markers, and lung metastases.

    Taken together, these findings identify RAB26 as a critical regulator of prostate cancer aggressiveness. The study underscores its potential both as a prognostic biomarker and as a molecular target for the development of novel therapies aimed at combating advanced and drug-resistant prostate cancer.

    Source:

    Journal reference:

    Wang, H., et al. (2025). RAB26 promotes prostate cancer progression via the MAPK/ERK-TWIST1 signaling axis. Genes & Diseases. doi.org/10.1016/j.gendis.2025.101689

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  • India lose 4-1 to China in Super 4

    India lose 4-1 to China in Super 4

    The Indian hockey team lost 4-1 against the People’s Republic of China in their second Super 4s match at the Women’s Asia Cup 2025 in the Gongshu Canal Sports Park Hockey Field in Hangzhou on Thursday.

    Mumtaz Khan (38′) was the only goal-scorer for India, ninth in the women’s hockey rankings, while Zou Meirong (4′, 56′), Chen Yang (31′) and Tan Jinzhuang (47′) scored for world No. 4 China.

    It was a lively first quarter with both sides attacking the circles and creating good opportunities but it was China who secured the opening goal early on.

    In the fourth minute, India did well to make a good save but the ball went to Zou Meirong on the rebound, allowing her to tap it into the empty net.

    India, on the other hand, weren’t clinical enough in front of goal and won their first penalty corner in the 10th minute but couldn’t make it past the Chinese rushers.

    The second quarter too saw plenty of end-to-end action but neither side could find the net. In the last five minutes of the first half, India increased the tempo of the game as they applied constant pressure on the Chinese defence and controlled possession in search of a goal.

    In the 27th minute, India won another penalty corner but that too didn’t amount to a goal as they headed back into the break a goal behind.

    In the very first minute of the third quarter, China increased their lead after India gave away the ball in their own circle to an unmarked Chen Yang, who scored with a simple finish.

    In the 38th minute, Mumtaz Khan scored an incredible field goal for India to reduce the deficit.

    Lalremsiami passed the ball to Mumtaz Khan at the edge of the circle from where she launched a powerful back-handed shot from distance to score India’s only goal.

    Moments later, Zou Meirong took a shot from close range on goal but India’s Bichu Devi showcased great reflexes to make a save and maintain the scoreline.

    China started the final quarter strong, adding another goal to their tally. They won a penalty corner in the 47th minute which was converted by Tan Jinzhuang off a deflection from a defender’s stick.

    They scored their last goal of the match in the 56th minute courtesy of another field goal from Zou Meirong to seal the fixture and progress into the final of the Women’s Asia Cup.

    India will next play defending champions Japan on September 13 in their third Super 4s match. They will be looking for a win to secure a spot in the final, where they would once again clash with hosts China.

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  • Malaika Mihambo on jumping with purpose: “I want to be remembered for who I am, not just my medals”

    Malaika Mihambo on jumping with purpose: “I want to be remembered for who I am, not just my medals”

    Turning Olympic pain into life purpose

    Indeed, for Mihambo it’s never over…until the last jump. The long jump queen fought hard to stay in contention, and it paid off.

    “I know how it is to have people in my life who give everything for me and who make my life like a top priority for them, my family, my mother but also in sports you’re never alone, it’s a team. I have my coach for example, my management, and I know they really see the person in me. I also never stopped believing in myself, and I think that is what made the silver possible.”

    “I tried to remind myself that I can go through pain and if I survive, I will have more clarity and more power.”

    The consistency of the Heidelberg native will again be put to the test at the World Championships, where she starts as the world leader (according to the World Athletics September 2025 world rankings) ahead of the reigning Olympic gold medallist Tara Davis-Woodhall.

    Although a third gold medal would be inspiring, Mihambo’s leaps transcend competition accolades. She is more motivated by the opportunity to showcase her unwavering spirit and perseverance on a bigger stage.

    “I’m quite sure that this will be a good year as well,” said Mihambo, whose 7.07m jump in Karlsruhe has her lying second behind her American rival Davis-Woodhall, who qualified for Tokyo with 7.12m.

    “I want to be in a mindset where I’m independent of results, medals and performances, fame… Maybe this is something special about me, that I’m not focusing on winning that much. Because I’ve learned so much in those 31 years, I’m on Earth. I learned that there’s much more to the world or to life than just focusing on the materials and the things right in front of you.”

    Mihambo’s passion for making an impact and leaving a legacy is closely linked to her sports-focused foundation, which helps families and children get into track and field.

    “I have this idea that if we ignite some fires of passion for sports, for social engagement, for fair play, tolerance, peace of mind among the children, we can build up a society that’s focussed more on values that you cannot count.”

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  • Piers Morgan launches new attack on Prince Harry after King Charles reunion

    Piers Morgan launches new attack on Prince Harry after King Charles reunion

    Prince Harry to blame for monarchy’s decline, claims Piers Morgan

    Piers Morgan launched another scathing attack on Prince Harry following his recent reunion with King Charles.

    During ITV’s This Morning, the journalist blamed the Duke of Sussex for the decline of monarchy.

    He said Harry has hurt the Royal family while trying to control how people see him while discussing about the monarchy’s falling popularity.

    Piers said Harry and Meghan Markle have played a big part in the declining popularity of the monarchy by speaking badly about the royals while living in California.

    “They (Harry and Meghan) spent five years enriching themselves in California for trashing their family. You can’t get away from that,” he said.

    On his UK visit, Piers said, “My thing is you can’t have your cake and eat it. What he wants to do is cherry pick certain things that make him look good.”

    Piers added that Harry’s recent visit to the UK for charity work seems like an attempt to improve his image, but he can’t “have his cake and eat it too.”

    “The most intrusive person into royal privacy ever has been Prince Harry – with his book and with his Netflix series,” said Piers. 


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  • NASA’s Webb Spots Blowtorch of Gas on Milky Way’s Outskirts

    NASA’s Webb Spots Blowtorch of Gas on Milky Way’s Outskirts

    NASA’s James Webb Space Telescope has captured a jaw-dropping sight: a massive jet of glowing gas blasting out from a newborn star like a fiery blowtorch. This stellar eruption stretches 8 light-years across, which is twice the distance between our Sun and Alpha Centauri, our closest neighboring star system.

    The jet, located in the Sharpless 2-284 nebula, is rare in both size and power. Racing through space at hundreds of thousands of miles per hour, it looks uncannily like a double-bladed lightsaber straight out of Star Wars.

    At the heart of this spectacle is a protostar, a baby star still forming, about ten times heavier than our Sun, sitting 15,000 light-years away on the edge of the Milky Way. It’s a galactic birth announcement, written in plasma and speed.

    Lead author Yu Cheng of the National Astronomical Observatory of Japan said, “The Webb discovery was serendipitous. We didn’t really know there was a massive star with this kind of super-jet out there before the observation. Such a spectacular outflow of molecular hydrogen from a massive star is rare in other regions of our galaxy.”

    When a star is being born, it doesn’t arrive quietly; it shoots out blazing jets of plasma in opposite directions, like cosmic fireworks. These highly focused outflows, called protostellar jets, are nature’s way of saying, ‘A new star is here!’.

    As gas falls into the star, some of it gets blasted out along the star’s spin axis, likely guided by magnetic fields. These jets are narrow and powerful, and they help scientists understand the star’s growth, energy, and environment.

    Most of the jets we’ve seen come from low-mass stars, but each one offers clues about how stars form and evolve. By studying their shape, speed, and lifespan, researchers can fine-tune models of stellar birth.

    Co-author Jonathan Tan of the University of Virginia in Charlottesville and Chalmers University of Technology in Gothenburg, Sweden said, “I was really surprised at the order, symmetry, and size of the jet when we first looked at it.”

    Scientists found that the jet’s scale grows with the mass of the star powering it. In other words, the bigger the baby star, the more dramatic its plasma outburst.

    Captured in stunning infrared detail, the jet shows a filamentary structure, a sign that it’s crashing into clouds of interstellar dust and gas. This collision creates knots, bow shocks, and linear chains, like ripples from a cosmic splash.

    At the far ends of the jet, stretching in opposite directions, lie clues to the star’s past. These tips act like timestamps, preserving the history of the star’s formation as it grew and evolved.

    “Originally, the material was close to the star, but over 100,000 years, the tips were propagating out, and then the stuff behind is a younger outflow,” said Tan.

    The proto-cluster hosting the massive jet in Sh2-284 sits far out on the fringes of the Milky Way, nearly twice as far from the galactic center as our Sun. It’s a quiet, remote region where hundreds of stars are still forming, like cosmic seedlings in a sparse field.

    Because it’s so far out, this region has low metallicity, meaning its stars contain very few elements heavier than hydrogen and helium. That’s typical of the early universe, before generations of stars enriched space with metals through supernovae and stellar winds.

    In this way, Sh2-284 acts as a local time capsule, giving scientists a rare glimpse into how stars may have formed in the universe’s youth.

    Cheng said, “Massive stars, like the one found inside this cluster, have significant influences on the evolution of galaxies. Our discovery is shedding light on the formation mechanism of massive stars in low metallicity environments, so we can use this massive star as a laboratory to study what was going on in earlier cosmic history.”

    Tan said, “Webb’s new images are telling us that the formation of massive stars in such environments could proceed via a relatively stable disk around the star that is expected in theoretical models of star formation known as core accretion.”

    “Once we found a massive star launching these jets, we realized we could use the Webb observations to test theories of massive star formation. We developed new theoretical core accretion models that were fit to the data, to basically tell us what kind of star is in the center. These models imply that the star is about 10 times the mass of the Sun and is still growing and has been powering this outflow.”

    For over 30 years, astronomers have debated how massive stars form. One idea, called competitive accretion, suggests stars grow through a chaotic process, pulling in gas from all directions, causing their disks to wobble and their jets to twist.

    But new observations from the James Webb Space Telescope tell a different story. Scientists saw jets shooting out in perfectly opposite directions, like a straight arrow. That means the disk around the star stayed steady, supporting a calmer theory called core accretion, where stars grow from a stable, rotating disk.

    And there’s more: in this quiet corner of the Milky Way, where stars are still forming, researchers found another dense core that might be the next massive star in the making, spotted by the Atacama Large Millimeter Array in Chile.

    Journal Reference:

    1. Yu Cheng, Jonathan C. Tan, Morten Andersen, Rubén Fedriani, Yichen Zhang, Massimo Robberto, Zhi-Yun Li, and Kei E. I. Tanaka. LZ-STAR Survey: Low-metallicity Star Formation Survey of Sh2-284. I. Ordered Massive Star Formation in the Outer Galaxy. The Astrophysical Journal. DOI 10.3847/1538-4357/addf4b

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  • ‘The Morning Show’ Season Four Won’t Address Trump’s Reelection

    ‘The Morning Show’ Season Four Won’t Address Trump’s Reelection

    When the fourth season of The Morning Show drops on Apple TV+ next week, audiences will catch up with Jennifer Aniston‘s Alex Levy and Reese Witherspoon‘s Bradley Jackson almost two years after the events of season three, with a time jump into early 2024.

    For a show that regularly hits on of-the-moment topics like the #MeToo movement and COVID-19 pandemic, viewers may expect this season to address the 2024 presidential election — but that will not be the case.

    At the show’s New York premiere on Tuesday, director and executive producer Mimi Leder told The Hollywood Reporter, “We did not touch the election — this season ends right before the election. Our show is not about elections; our show is about the world, about AI, about deepfakes, about environmental tragedies. It’s about democracy. It’s about journalists in jeopardy, journalists under threat, and our main theme this season is trust — who can you trust?”

    Showrunner Charlotte Stoudt added that with the season set in the spring of 2024 when the presidential race was still between Joe Biden and Donald Trump, “We try to go at it sideways. We don’t really have, directly, an election story, but we do touch on the idea of: Why were two older white men running for president. Why do we still need daddy?”

    There are a few moments that reference the political climate at that time, though, as then-President Biden makes a brief appearance in season four via a media clip, and is mentioned as part of a storyline involving Alex Levy, who is now steering the season three finale merger between The Morning Show‘s parent company and their rival media company to create the newly formed UBN. Big tech, AI, fringe media, employment and reproductive rights are also election-related topics tackled this year.

    Co-star Nestor Carbonell explained, “I think this season, there was less of an emphasis on the political side and more on the social implications of these things. There are politics but they’re politics within the station, less so on the political election.”

    Hannah Leder, William Jackson Harper, Nicole Beharie, Boyd Holbrook, Néstor Carbonell, Billy Crudup, Mark Duplass, Reese Witherspoon, Jennifer Aniston, Jeremy Irons, Karen Pittman, Marion Cotillard and Jon Hamm.

    Eric Charbonneau/Apple TV+ via Getty Images

    On top of the already starry cast of Aniston, Witherspoon, Billy Crudup, Jon Hamm, Mark Duplass and Karen Pittman, season four welcomes new additions Marion Cotillard, Jeremy Irons, William Jackson Harper and Boyd Holbrook.

    But even with that supersized cast, Witherspoon promised “a lot more” moments between her and Aniston’s characters — after they were in largely separate storylines in season three, and left off with a cliffhanger that set them even further apart. “You’re going to see Alex and Bradley from the very beginning, almost in a little tension too. They’re maybe not as friendly as they were last season,” she teased.

    The Morning Show season four starts streaming Sept. 17 on Apple TV+.

    Neha Joy and Jackie Strause contributed to this report.

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