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  • Digested week: Tales of royal tantrums and hostilities in the House of Beckham | UK news

    Digested week: Tales of royal tantrums and hostilities in the House of Beckham | UK news

    Monday

    I’m not sure I can bring myself to actually read it, but the publication this week of Entitled: the Rise and Fall of the House of York, by Andrew Lownie, promises to enliven a dead patch of summer with – putting Jeffrey Epstein aside – a wealth of petty revelations, a jog back through Prince Andrew’s most ridiculous episodes and an opportunity to use the phrase, “the disgraced Duke”. Shall we?

    Lownie’s unauthorised 400-page book goes deep into the history of the royal family’s biggest liability, a man who, per the author’s sources, screams at his staff (sample quote: “who’s the fucking idiot who cut the meat up?”) in a way reminiscent of no one more so than that other, famously rude member of the royal family, the late Princess Margaret. It covers the Battle for Royal Lodge, in which the late Queen’s second son is depicted as hanging on by his fingernails to the 30-room property in Windsor while behind the scenes, Prince William works to get him out.

    Disappointingly, there are no specifics as to the exact nature of the “rude” remark Andrew allegedly made to Kate, the Princess of Wales. But the duke’s many eccentricities are itemised, including the stuffed animals on his bed well into adulthood, the daily “air showers” in which he sits on the balcony with his eyes shut sucking in air, and the enduring oddness of his relationship with his ex-wife, Sarah Ferguson, whose long life of grift and overspending, according to Lownie, includes running up £4,000 in extra baggage charges by taking 25 suitcases on holiday. Ryanair would never allow it.

    On Andrew’s friendship with Jeffrey Epstein the author writes, shrewdly I think, that “the prince was a useful idiot who gave [Epstein] respectability and access to political leaders and business opportunities”. Per the book, Andrew is venal, thick and often just nasty. One story recounts a camping trip he took at the age of 13, during which he threw his friends’ groundsheets in the river as a joke. “He thinks he’s funny, handsome and clever,” says the source of the story. “And he isn’t … He was a tosser.” Which, funnily enough, if Lownie is to be believed, is the same word used by Prince William to describe his uncle.

    Tuesday

    To the country’s second royal family, the House of Beckham, where trouble comes this week in the form of the latest round of hostilities between eldest son Brooklyn, and the rest of the clan . It’s now jumped from online snubs and coded insults to IRL estrangement as Brooklyn renews his wedding vows in America in a ceremony to which none of his family are invited.

    The real story, however, continues to play out most forcefully on Instagram, a mirror world in which the family arguably lives their fullest and most meaningful life. It’s no trivial breach, in these circumstances, that Romeo and Cruz have blocked Brooklyn on the platform (they have also blocked Brooklyn’s wife, Nicola Peltz). It’s hugely significant, as the Sun noted this week, that Cruz dropped the comment “wrong brother, mate” when a follower teased him on Insta for changing jobs every five minutes.

    And now, this: Victoria Beckham, who has been faithfully liking her oldest’s son’s interminable cooking videos even as the rest of the family has held firm and ignored him, has finally hit her ceiling. At the time of writing, Brooklyn’s mother hasn’t liked any of the photos of the renewal ceremony to which she and the rest of the Beckhams were excluded.

    Kemi handing over ice cream: ‘No you can’t have a Flake.’ Photograph: Jonathan Brady/PA

    Wednesday

    Hang on to your attention spans, a second season of With Love, Meghan is coming down the pike on Netflix and promises to be even more enchanting and whimsical than the first. Per the trailer, it looks as if Mindy Kaling is out after appearing to irritate Meghan in the first season, and her rival lifestyle influencer Chrissy Teigen is in to help Meghan get out of her “comfort zone” by slicing a loaf of bread and handling a salad. The show also promises “a confession about Prince Harry’s diet”. (Spoiler alert: he doesn’t like lobster.)

    To followers of the Archewell story, meanwhile, it might come as a surprise to learn that a second season has been ordered at all, although the volume of hate watchers of the first season probably pushed it towards modest success. But season two comes at a moment when Netflix is, reportedly, downgrading its relationship with the couple by moving from an original deal reported to have been worth $100m, to a less lucrative “first look” arrangement after a slew of projects never came to fruition.

    Thursday

    It’s A-level results day and while teenagers celebrate their results and weather the opinion pieces, Tatler magazine puts together a helpful reminder of royal exam success over the ages. Let’s start with the king, bless him, who had a notoriously rough ride at Gordonstoun, where he passed five O-levels and two A-levels, achieving a B in history and a C in French.

    A generation down and the country’s most expensive education won Prince William three A-levels, in geography (A), art (B) and biology (C), while his brother managed two, a B in art and a D in geography – and unlike his father, made the sensible decision not to use the royal wild card and use these results to go on to Cambridge. And while it isn’t known what grades Prince Andrew achieved with his six O-levels and three A-levels, in 2008 the Duke’s daughter, Princess Eugenie, succeeded in gaining by far the most impressive A-level tally of any recent royal with two As and a B in art, the history of art, and English. As Tatler notes, the palace was so thrilled by this anomaly “they actually sent out a statement so they could tell the world”.

    Friday

    An alarm call put out by English Heritage announces the demise of the traditional British pudding, and until recently I’d have said not a moment too soon. I am just old enough to remember someone putting a steaming bowl of yellow slop in front of me and calling it “spotted dick”. Young people who grew up eating Shake Shack frozen custard have no idea what “custard” used to mean, or encountered the spirit-sinking associations that come with the phrase “hot pudding”. Anyway, after eating an amazing sticky toffee pudding innocently ordered by my 10-year-old on the Isle of Wight last week, I have completely changed my mind and am joining the campaign. Save humid sponge-based puddings with gluey sauces before it’s too late!

    Lammy and Vance: ‘Sure, make the Brokeback Mountain joke and I will laugh all the way to a supreme court challenge to marriage equality.’ Photograph: Suzanne Plunkett/AFP/Getty Images

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  • Premier League to pay tribute to Jota and Silva – Manchester United

    Premier League to pay tribute to Jota and Silva – Manchester United

    1. Premier League to pay tribute to Jota and Silva  Manchester United
    2. ‘Diogo’s day’ – emotional Anfield tribute for Jota  BBC
    3. Arne Slot pays Diogo Jota tribute ahead of emotional Liverpool Premier League opener at Anfield  Sky Sports
    4. Emotional Mohamed Salah in tears as Liverpool fans sing Jota tribute at Anfield  India Today
    5. Anfield pays heartfelt tribute to Diogo Jota and Andre Silva at Liverpool vs Bournemouth game; check details  Mint

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  • US Fed to cut rates in September and once more this year, say most economists: Reuters poll – Reuters

    1. US Fed to cut rates in September and once more this year, say most economists: Reuters poll  Reuters
    2. Bessent Urges Fed to Lower Rates by 150 Basis Points or More  Bloomberg.com
    3. Federal Reserve Rate Cut Storm: A Group of Madmen Flip Tables, the Casino is About to Collapse!  Binance
    4. US Stocks Brief: S&P Futures Flat To Slightly Lower As US Treasury Secretary, Scott Bessent, Pushes For Jumbo Rate Cut In September  MarketScreener
    5. Is It Time to Talk About a 50bp Cut?  Investing.com

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  • IBD Linked to Higher Risk for Interstitial Lung Disease

    IBD Linked to Higher Risk for Interstitial Lung Disease

    TOPLINE:

    Patients with inflammatory bowel disease (IBD) had a significantly higher risk for developing interstitial lung disease (ILD) compared with the general population and siblings who do not have the condition.

    METHODOLOGY:

    • Although pulmonary complications of IBD have been recognized for over a decade, they remain largely unstudied.
    • Researchers conducted a population-based cohort study in Sweden between 1969 and 2019 to assess the long-term risk for ILD in 85,705 patients diagnosed with IBD (median age, 41 years; 48% women).
    • They matched these patients to 412,677 control individuals from the general population (median age, 41 years; 48% women) and to 101,278 IBD-free siblings of the patients (median age, 39 years; 49% women).
    • The primary outcome was incident ILD, a broad group of lung diseases characterized by inflammation and fibrosis that often lead to respiratory failure.

    TAKEAWAY:

    • During a median follow-up of 14 years, ILD was diagnosed in 0.51% of patients with IBD vs 0.30% of control individuals, corresponding to incidence rates of 34 and 20 per 100,000 person-years, respectively.
    • Patients with IBD had a 48% higher risk of developing ILD than the matched control individuals and an 81% higher risk than their siblings.
    • Subgroup analyses found similar adjusted hazard ratios (aHRs) for ILD across IBD subtypes (ulcerative colitis, 1.59; Crohn’s disease, 1.34; and IBD unclassified, 1.24) vs the general population.
    • The highest risk for ILD diagnosis was observed within the first 2 years after the diagnosis of IBD (aHR, 2.14); however, the risk remained elevated even after 10 years (aHR, 1.24).
    • A subgroup analysis showed that the relative risk for ILD was notably higher in women with IBD and in adults aged 40 years or older with IBD.

    IN PRACTICE:

    “The findings from this study highlight the need for further data on lung function and capacity in patients with IBD, with a special focus on patients with additional risk factors for ILD. These data also support clinicians maintaining a higher index of suspicion for ILD in their IBD patients with pulmonary symptoms,” the authors wrote.

    SOURCE:

    This study, led by Bharati Kochar, MD, MS, Division of Gastroenterology, Massachusetts General Hospital, Boston, was published online on August 4 in The American Journal of Gastroenterology.

    LIMITATIONS:

    Researchers were unable to confirm diagnoses of ILD with chest imaging and pulmonary function testing. The patient cohort lacked granular disease-level detail on some risk factors for the development of ILD, including laboratory measures and endoscopic data. Limited data on medication use in the cohort prevented the consideration of potential relationships between treatments for IBD and the development of ILD.

    DISCLOSURES:

    The study was funded by a National Institute on Aging grant to Kochar and support from Karolinska Institutet for another author. Three authors reported receiving consulting fees, advisory fees, or financial support or having other ties with pharmaceutical companies.

    This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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  • Premier League 2025-26 preview No 20: Wolves | Wolverhampton Wanderers

    Premier League 2025-26 preview No 20: Wolves | Wolverhampton Wanderers

    Guardian writers’ predicted position: 16th (NB: this is not necessarily Ben Fisher’s prediction but the average of our writers’ tips)

    Last season’s position: 16th

    Home and away kits

    Prospects

    Wolves surely crave a campaign where relegation is off the menu. After a nightmarish start to last season, they turned to Vítor Pereira to pick up the pieces and the Portuguese reversed the direction of travel, in effect ensuring survival by mid-March. Wolves proved they could win without Matheus Cunha when the Brazilian missed four games through suspension in the spring and have retained André and João Gomes, a menacing pair of midfielders, but there will be pressure on Jørgen Strand Larsen to repeat an impressive first season in which he contributed 14 goals.

    The squad appears undercooked after another round of headline departures, with Cunha and Rayan Aït-Nouri who, combined, contributed to 59% of their 54 goals last season, departing for Manchester; Aït-Nouri played more minutes than any other Wolves player and of the five who played the most, three have left: Aït-Nouri, Cunha and Nélson Semedo. Fringe players have departed but Pereira wants a right-wing back to replace Semedo, the club captain who turned down a new contract in favour of a move to Fenerbahce, plus a striker and a midfielder. Wolves need the powerful Colombia winger Jhon Arias, a standout performer for Fluminense at the Club World Cup, to have an immediate impact.

    The mood surrounding the club is subdued, with supporters frustrated at the owner, Fosun, owing to a perceived lack of ambition heading into their eighth consecutive season in the top tier. A winless pre-season served to exacerbate concerns that they will at best stand still, and now Newcastle have Strand Larsen on their bottomless striker shortlist. The death of Diogo Jota, an integral part of the most successful period in the club’s recent history, also hit hard, with one member of the backroom staff attending Jota’s wedding and his funeral 13 days later. Wolves will pay tribute to Jota before their game against Manchester City on Saturday, a visit that will bring the return of Aït-Nouri and provide Pereira an indicator of how much work there is to do.

    How they finished in the past five seasons

    The manager

    Hoisting Wolves clear of trouble means Pereira has plenty of credit and he further endeared himself to supporters by mixing with them in the city-centre Wetherspoon’s. His “first the points, then the pints” mantra ended up on a banner at Molineux. Pereira is 57 – only David Moyes is older – and his Premier League opportunity was a long time in the making. He previously had job offers from Arsenal, Everton, Crystal Palace and arch-rivals West Brom. Now Pereira believes he is ready to prove why he is among the best managers in the division. “If I’m in the right place to challenge myself, I can do magic,” he said.

    Off-field picture

    Wolves announced a five-man “football leadership team” in June, led by the director of football, Domenico Teti, who has reunited with Pereira, with whom he worked at the Saudi Arabian club Al-Shabab. Teti replaced Matt Hobbs, the sporting director, who was influential in recruitment. The finances are broadly thought to be healthy after another summer of high-profile sales. The chair, Jeff Shi, has confirmed he would like to redevelop the Steve Bull Stand – the oldest at Molineux. “The next plan is to try to change a bit there and build more areas for hospitality for more business clients to come and enjoy there,” said Shi.

    Last season’s results

    Star signing

    Wolves hope Fer López, who in joining from Celta Vigo has followed a path trodden by Strand Larsen, will be their next gem. The 21-year-old attacking midfielder, a £19.5m buy, has shown plenty of promise despite only seven starts in La Liga last season. Perhaps it should be no surprise López, tracked by Wolves for several years, appears to have settled quickly; in 2018, aged 14, the Madrid-born player lived in Suffolk for three months, boarding at a private school near Stowmarket, and he trained with Norwich, until they told him he was too small, and with Bacton United 89 in Suffolk.

    Wolves feel that Fer López, who joined from Celta Vigo this summer, can be their next gem. Photograph: Wolverhampton Wanderers FC/Getty Images

    Stepping up

    There is excitement around Mateus Mané, who this summer signed his first professional contract after being formally promoted to Pereira’s squad. The England youth international, who made his Premier League debut against Brighton in May after training with the senior group towards the end of last season, has in effect been fast-tracked into the first team, bypassing the under-21s after registering seven goals and four assists for the under-18s last season. The Portugal-born forward, 18 next month, joined Wolves from non-league Rochdale 18 months ago. He is eligible for Portugal and England and has made seven appearances for the latter’s under-18s. A Next Generation pick last year.

    A big season for …

    Ki-Jana Hoever, named after the former NFL player Ki-Jana Carter, has not featured in a competitive game for Wolves since March 2022 but the Dutchman is primed to begin the season at right-wingback. Hoever, who has spent the previous four seasons on loan, most recently at Auxerre, seized his opportunity in pre-season, impressing Pereira. The overriding sense earlier this summer was that Hoever’s days were numbered but Pereira has given the former Liverpool defender another chance. “I’m trying to do my best to take it,” he said last month. “I hope I can be important for the club.” Sasa Kalajdzic, the 6ft 7in striker, could add to his 14 appearances in old gold after several serious injuries.

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  • CRISPR Study Reveals New Gene-Silencing Method

    CRISPR Study Reveals New Gene-Silencing Method

    A new generation of CRISPR technology developed at UNSW Sydney offers a safer path to treating genetic diseases like Sickle Cell, while also proving that chemical tags on DNA – often thought to be little more than genetic cobwebs – actively silence genes.

    For decades, scientists have debated whether methyl groups – small chemical clusters that accumulate on DNA – are simply detritus that accumulates in the genome where genes are turned off, or the actual cause of gene repression.

    But now researchers at UNSW, working with colleagues in the US at the St Jude Children’s Research Hospital (Memphis), have shown in a paper published recently in Nature Communications that removing these tags can switch genes back on, confirming that methylation is not just correlated with silencing, but directly responsible for it.

    “We showed very clearly that if you brush the cobwebs off, the gene comes on,” says study lead author Professor Merlin Crossley, UNSW Deputy Vice-Chancellor Academic Quality.

    “And when we added the methyl groups back to the genes, they turned off again. So, these compounds aren’t cobwebs – they’re anchors.”

    A brief history of CRISPR

    CRISPR – otherwise known as Clustered Regularly Interspaced Short Palindromic Repeats – forms the basis of gene-editing technology that allows scientists to find and change faulty sections of DNA, often by replacing them with healthy ones.

    It harnesses what is already a naturally occurring process, first observed in bacteria fighting off invading viruses by ‘snipping’ the virus DNA strands.

    The first generation of CRISPR lab tools worked in this way, by cutting DNA sequences to disable faulty genes. The second generation allowed researchers to zoom in and correct individual letters in the genetic code. But both approaches involved making cuts to the genetic code, which comes with the risk of unwanted changes that could cause other health problems.

    But the third generation – known as epigenetic editing – looks at the surface of the genes found in the nucleus of every cell in the body. Rather than cutting DNA strands to remove or edit faulty genes, this method removes methyl groups attached to silenced or suppressed genes.

    Sickle Cell diseases

    The researchers say epigenetic editing could be used to treat people affected by Sickle Cell-related diseases, which are genetic mutations that alter the shape and function of red blood cells, leading to chronic pain, organ damage, and reduced life expectancy.

    “Whenever you cut DNA, there’s a risk of cancer. And if you’re doing a gene therapy for a lifelong disease, that’s a bad kind of risk,” Prof. Crossley says.

    “But if we can do gene therapy that doesn’t involve snipping DNA strands, then we avoid these potential pitfalls.”

    Instead of cutting, the new method uses a modified CRISPR system to deliver enzymes that remove methyl groups from DNA — effectively lifting the brakes on silenced genes. The fetal globin gene plays a crucial role in delivering oxygenated blood to a developing fetus in utero, and the researchers say switching it back on following birth could provide a neat workaround for the faulty adult globin gene that has caused Sickle Cell diseases.

    “You can think of the fetal globin gene as the training wheels on a kid’s bike,” says Prof. Crossley. “We believe we can get them working again in people who need new wheels.”

    The big picture

    So far, all work to achieve this has been carried out in a lab on human cells in a test-tube at UNSW and in Memphis.

    Study co-author Professor Kate Quinlan says the discovery is not only promising for people with Sickle Cell disease, but other genetic diseases where turning certain genes on or off by altering the methyl groups avoids having to cut DNA strands.

    “We are excited about the future of epigenetic editing as our study shows that it allows us to boost gene expression without modifying the DNA sequence. Therapies based on this technology are likely to have a reduced risk of unintended negative effects compared to first or second generation CRISPR,” she says.

    In a few years – once testing in animals and clinical trials were complete – doctors using the new method to treat Sickle Cell diseases would start by collecting some of the patient’s blood stem cells that make new red blood cells. In a lab, they would use epigenetic editing to remove the methyl chemical tags from the fetal globin gene to reactivate it. Then, the edited cells would be returned to the patient, where they settle back into the bone marrow and start producing better-functioning blood cells.

    The road ahead

    Next the researchers from UNSW & St Jude will test the efficacy of these approaches in animal models but also try more CRISPR related tools.

    “Perhaps the most important thing is that it is now possible to target molecules to individual genes,” Prof. Crossley says.

    “Here we removed or added methyl groups but that is just the beginning, there are other changes that one could make that would increase our abilities to alter gene output for therapeutic and agricultural purposes. This is the very beginning of a new age.”

    Reference: Bell HW, Feng R, Shah M, et al. Removal of promoter CpG methylation by epigenome editing reverses HBG silencing. Nat Commun. 2025;16(1):6919. doi: 10.1038/s41467-025-62177-z

    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

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  • Virtual seminar: Regional template for clinical trial agreement – PAHO/WHO

    Virtual seminar: Regional template for clinical trial agreement – PAHO/WHO

    The Regional Bioethics Program and the Unit for Quality and Regulation of Medicines and Health Technologies of PAHO invite you to a new seminar in our series on clinical trials, on Tuesday, August 26, 2025, from 12:00 p.m. to 2:00 p.m. (EDT – Washington, D.C. time).

    In this session, the regional template for clinical trial agreement developed by PAHO will be presented, and challenges for its implementation in the region will be discussed.

    English – Spanish translation will be available.

    Register

    The videos from previous seminars are available from PAHO’s Portal of Clinical Trials of the Americas. 


     

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  • Banking Associations Push to Close GENIUS Act Loopholes – Global Regulation Tomorrow

    1. Banking Associations Push to Close GENIUS Act Loopholes  Global Regulation Tomorrow
    2. Closing the Payment of Interest Loophole for Stablecoins  Bank Policy Institute
    3. Retailers Are Creating Their Own Currency—Here’s What It Means for Your Wallet  Investopedia
    4. Trade Groups Urge Congress to Address GENIUS Act Loopholes  The National Law Review
    5. What is the possible benefit in allowing traditional banks to start dealing in Stablecoins?  Daily Kos

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  • China’s Arashi Vision Gains by Limit as Insta360 Camera Maker Takes On DJI With First Drone

    China’s Arashi Vision Gains by Limit as Insta360 Camera Maker Takes On DJI With First Drone

    (Yicai) Aug. 15 — Shares in Arashi Vision surged by the exchange-imposed limit today after the leading Chinese panoramic imaging company, best known for its Insta360 panoramic camera, unveiled the specifications of its first drone, directly challenging industry giants such as DJI Technology with its advanced imaging technology.

    Arashi Vision’s share price [SHA:688775] surged 20 percent to CNY224.42 (USD31.25). Since the firm debuted on Shanghai’s Nasdaq-style Star Market in June, the stock has almost quintupled in value.

    Arashi Vision revealed the design of its first drone, the Antigravity A1, yesterday. The unmanned aerial vehicle will feature a stacked dual panoramic lens design with 360-degree image stitching technology and will be capable of shooting panoramic video in 8k resolution.

    The drone is being co-developed with a third-party partner and is expected to hit the market in January next year, the Shenzhen-based company said. Open testing will start soon, it added.

    On July 23, the firm said it plans to enter the consumer-grade drone market, aiming to tackle issues with existing drones, such as limited shooting angles and operational difficulties. This move puts Arashi Vision in direct competition with Shenzhen-based DJI, the world’s largest drone maker.

    “If the marathon is led by a top runner, you’ll run faster too,” Liu Jingkang, who founded the company in 2015, posted on social media on July 29.

    Arashi Vision focuses on developing cameras with a wide horizontal view for outdoor sports and photography enthusiasts. The Insta360 dominated the global panoramic camera market in 2023 with 67 percent market share, the firm said in its listing prospectus.

    Last year, the company’s net profit soared 20 percent to CNY995 million (USD138.5 million) while revenue jumped 53 percent to CNY5.6 billion (USD779.6 million).

    Editors: Dou Shicong, Kim Taylor

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  • New-look Liverpool kick off Premier League season after spending spree

    New-look Liverpool kick off Premier League season after spending spree

    Liverpool © Getty Images

    Reigning champions Liverpool kick off the Premier League season on Friday with Europe’s richest league strengthened by a remarkable £2 billion ($2.7 billion) spending splurge.

    Liverpool will include £100 million midfield signing Florian Wirtz and new forward Hugo Ekitike in their squad to face Bournemouth at Anfield, among a handful of new recruits.

    They are favourites to retain their crown but the unknown factor is the potential effect of the tragic death of Portuguese forward Diogo Jota in a car crash in Spain in July.

    Arsenal, one club hoping to topple Liverpool, face an immediate test of their title credentials against a revamped Manchester United on Sunday.

    Newcastle are set to be without unsettled star striker Alexander Isak for a tough trip to Aston Villa – the Swede is wanted by Liverpool.

    Here are several issues to watch on the opening weekend:

    Big-spending Liverpool seek harmony

    Liverpool have changed their careful shopping habits and suddenly outspent their rivals, overhauling a squad fresh from winning the league.

    Only once since 2007, when Manchester City did it in 2019, have the Premier League champions been the biggest-spending English club in the market.

    A spree that has already seen Liverpool’s US owners approve £260 million on Wirtz, Ekitike and defenders Jeremie Frimpong and Milos Kerkez, is far from over with Isak and Crystal Palace captain Marc Guehi linked with moves to Anfield.

     

     

    Trent Alexander-Arnold, Luis Diaz and Darwin Nunez have been sold.

    The transition has shown teething problems in pre-season with a slick attack let down by a porous defence.

    Manager Arne Slot is confident his side are ready as they seek to retain the title for the first time since 1984.

    “I think we’ve lost five to six players that played quite a lot of minutes for us last season and we brought in four new ones, so then it’s normal that there’s a little bit of adaptation,” said Slot.

    “But we are definitely ready for the league to start.”

    Sesko and Gyokeres seek scoring start

    Benjamin Sesko and Viktor Gyokeres are set to make their Premier League debuts for United and Arsenal respectively at Old Trafford after a summer that could have seen them line up the other way on Sunday.

    Arsenal were linked with a move to Sesko for over a year before deciding to bet on Gyokeres as the man to fire them to a first Premier League title since 2004 for a fee that could rise to £66 million.

    The Gunners have finished second for the past three seasons, lacking a clinical finisher to take that final step towards being champions

    Gyokeres netted a remarkable 97 times in 102 games in two years at Sporting Lisbon, much of which came under United’s now-manager Ruben Amorim.

    Instead of being reunited with the Swede, Amorim has overhauled his attack with the signings of Sesko, Bryan Mbeumo and Matheus Cunha at a combined cost of over £200 million.

    United, one of the world’s richest clubs, had to spend big after their worst season since being relegated in 1974.

    In Amorim’s first year in charge, the Red Devils finished 15th in the Premier League and failed to qualify for Europe, losing the Europa League final.

    Both clubs desperately need a fast start and the battle between the two new No 9s will go a long way to deciding the outcome.

    Villa and Newcastle chase ‘big six’

    As the Premier League’s traditional “big six” of Liverpool, Manchester City, United, Arsenal, Chelsea and Tottenham have flexed their financial muscle in the transfer market, Villa and Newcastle have been squeezed out.

    Constrained by the need to meet financial sustainability rules, Villa’s only major signing has been Ivorian stiker Evann Guessand from Nice.

    Newcastle boss Eddie Howe has had to field constant questions about Isak, who sat out pre-season preparations in a bid to force through a move to Liverpool.

    Despite having Saudi owners, the Magpies’ attempts to replace the Swede have repeatedly fallen down, with most of their targets going elsewhere.

    But both Villa and Newcastle have consistently outperformed some of the “big six” in recent seasons and will be targeting Champions League qualification again this season.


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