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  • Ancient Rivers in Noachis Terra Reveal Mars’ Long-Lived Wet Past

    Ancient Rivers in Noachis Terra Reveal Mars’ Long-Lived Wet Past

    There’s very little scientific debate about the existence of surface water on Mars in its past. The evidence at this point is overwhelming. Orbiter images clearly show river channels and deltas, and rovers have found ample minerals that only form in the presence of water. Now the scientific debate has moved on. Scientists are trying to learn the extent of Martian surface water, both on the planet’s surface and through time.

    NASA’s Mars Reconnaissance Orbiter (MRO) is a prolific purveyor of images of Mars’ surface. One of its most well-known image shows Jezero Crater, the landing site of the Mars Perseverance rover. Jezero Crater is an ancient paleolake filled by an ancient river that created a delta of sediments. The orbiter also identified clays and carbonate salts, minerals that were altered by water in the planet’s past.

    This image of Jezero Crater is one of the MRO’s most well-known images. It shows clear evidence of flowing water. The colours map the location of different minerals, including water-altered clays and carbonate salts. Image Credit: NASA/ JPL-Caltech/ MSSS/ JHU-APL.

    There are two schools of thought around Mars’ watery past. One says that water was stable on the Martian surface for long periods of time, while the other states that the water channels were carved during geologically brief periods of time when climate shifts caused ice sheets to melt. Call the first one the ‘warm and wet’ theory and the second one the ‘cold and dry’ theory. Both theories are well developed, and make predictions about what scientists will find when they dig deeper.

    Some research into Noachis Terra supports the idea that water features there were carved by ice-related processes during short-lived periods of wetness, the cold and dry theory. This 2016 paper illustrates that point of view. “Our studied valleys’ association with ice-rich material and abundant evidence for erosion caused by downslope flow of ice-rich material are consistent with a cold, wet Mars hypothesis where accumulation, flow, and melting of ice have been dominant factors in eroding crater valleys,” those researchers concluded.

    Not all regions of Mars have been studied equally, and the Noachis Terra is not as well-studied as some other regions. The ‘warm and wet’ climate theory predicts that Noachis Terra would’ve had high levels of precipitation. However, there’s an overall lack of Valley Networks (VNs) in the region. Valley Networks are similar to Earth’s river drainage basins and are compelling evidence of Mars’ watery past.

    This map of Mars shows important surface features, as well as all of the planet's surface regions. Noachis Terra is a southern highland region of heavily cratered ancient terrain. Image Credit: By Jim Secosky modified NASA image. - http://planetarynames.wr.usgs.gov/images/mola_regional_boundaries.pdf, Public Domain, This map of Mars shows important surface features, as well as all of the planet’s surface regions. Noachis Terra is a southern highland region of heavily cratered ancient terrain. Image Credit: By Jim Secosky modified NASA image. – http://planetarynames.wr.usgs.gov/images/mola_regional_boundaries.pdf, Public Domain,

    New research presented at the Royal Astronomical Society’s National Astronomy Meeting presented a different sort of evidence to support the high levels of precipitation predicted in Noachis Terra by the warm and wet theory. It’s titled “The Fluvial History of Noachis Terra, Mars,” and the lead researcher is Adam Losekoot. Losekoot is a PhD student at the Open University, a public research university in the UK.

    “Studying Mars, particularly an underexplored region like Noachis Terra, is really exciting because it’s an environment which has been largely unchanged for billions of years. It’s a time capsule that records fundamental geological processes in a way that just isn’t possible here on Earth,” Losekoot said in a press release.

    The evidence Losekoot and his fellow researchers uncovered is in the form of Fluvial Sinuous Ridges.

    “Noachis Terra, in Mars’ southern highlands, is a region where ‘warm, wet’ climate models predict high rates of precipitation, but is poorly incised by VNs,” Losekoot explained. “We searched instead for Fluvial Sinuous Ridges (FSRs, aka inverted channels) here as they provide alternate evidence to VNs for stable surface water.”

    FSRs are winding, elevated features left behind from Mars’ watery past. They form when water flows across the surface carrying sediment with it. The sediment deposits become harder than the rock in the surrounding terrain due to compaction and mineral precipitation. When Mars’ water disappeared, aeolian erosion ate away at the softer, surrounding rock, leaving the elevated FSRs behind.

    To find the FSRs in Noachis Terra, Losekoot and his co-researchers turned to NASA’s MRO. No other mission has done more to reveal Mars’ past than the MRO. They used data from its HiRISE and other instruments, as well as data from the Mars Orbital Laser Altimeter on the Mars Global Surveyor, to identify FSRs.

    Losekoot and his co-researchers found 15,000 km of FSRs in Noachis Terra. “We find FSRs to be common across Noachis Terra, with a cumulative length of more than 15,000 km. These are often isolated segments, but some systems are hundreds of km in length,” Losekoot writes.

    This HiRISE image shows two branches of an FSR. The river split into two then rejoined outside of the image. The lower branch is heavily eroded and quite spread out, the upper branch is narrower but more clearly preserved. They could've had different exposure times or undergone different geological processes. Or they could be from different periods of water activity. There are remnants of an infilling material within the ridge and a meander where the branch turns back towards the lower trunk. The mesa in between the branches could be a crater that was filled with the same sediment as the FSR. Image Credit: HiRISE Image: ESP_085519_1585 NASA/JPL/University of Arizona. Licence type: Attribution (CC BY 4.0) This HiRISE image shows two branches of an FSR. The river split into two then rejoined outside of the image. The lower branch is heavily eroded and quite spread out, the upper branch is narrower but more clearly preserved. They could’ve had different exposure times or undergone different geological processes. Or they could be from different periods of water activity. There are remnants of an infilling material within the ridge and a meander where the branch turns back towards the lower trunk. The mesa in between the branches could be a crater that was filled with the same sediment as the FSR. Image Credit: HiRISE Image: ESP_085519_1585 NASA/JPL/University of Arizona. Licence type: Attribution (CC BY 4.0)

    The FSRs are broadly distributed across Noachis Terra, and some are tens of meters tall. That means the water flowed for a long time.

    “The broad distribution of FSRs suggests a broadly distributed source of water,” Losekoot writes. “The most likely candidate is precipitation, suggesting a benign surface environment. For FSRs to have formed mature, interconnected systems, up to tens of meters high, these conditions must also have been relatively long-lived.”

    “This suggests that ~3.7 Ga, Noachis Terra experienced warm and wet conditions for a geologically relevant period,” Losekoot explained.

    This HiRISE image shows narrow FSR with a pointed pinnacle ridge. The pointed could indicate that this FSR has suffered heavy erosion for a long time until only a narrow peak remained, or it may be that only a narrow part of the original river infill has been preserved. Image Credit: HiRISE Image: ESP_067439_1505 NASA/JPL/University of Arizona. Licence type: Attribution (CC BY 4.0) This HiRISE image shows narrow FSR with a pointed pinnacle ridge. The pointed could indicate that this FSR has suffered heavy erosion for a long time until only a narrow peak remained, or it may be that only a narrow part of the original river infill has been preserved. Image Credit: HiRISE Image: ESP_067439_1505 NASA/JPL/University of Arizona. Licence type: Attribution (CC BY 4.0)

    The way the FSRs are distributed across Noachis Terra and their extent suggests that precipitation is responsible. They also form large, interconnected systems, which suggests the watery period was long-lived. This work supports the idea that Mars was warm and wet for a long time, rather than just for bursts of time when ice sheets melted.

    This MRO CTX image gives an oblique view of part of a system of FSRs in Noachis Terra. It shows river tributaries that were probably active at the same time. The rivers meandered, and there are areas where the river banks burst and deposited fine layers of sediment. At the top of the image is a really clear example of an area where two FSRs intersect with an infilled crater. This is likely where the river flowed into the crater, filling it up and then breaching the other side to continue through the crater and down to the bottom of the image. CTX image: MurrayLab_V01_E020_N-20_Mosaic. Image Credit: NASA/JPL/MSSS/The Murray Lab. Licence type: Attribution (CC BY 4.0) This MRO CTX image gives an oblique view of part of a system of FSRs in Noachis Terra. It shows river tributaries that were probably active at the same time. The rivers meandered, and there are areas where the river banks burst and deposited fine layers of sediment. At the top of the image is a really clear example of an area where two FSRs intersect with an infilled crater. This is likely where the river flowed into the crater, filling it up and then breaching the other side to continue through the crater and down to the bottom of the image. CTX image: MurrayLab_V01_E020_N-20_Mosaic. Image Credit: NASA/JPL/MSSS/The Murray Lab. Licence type: Attribution (CC BY 4.0)

    “Our work is a new piece of evidence that suggests that Mars was once a much more complex and active planet than it is now, which is such an exciting thing to be involved in,” said Losekoot.

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  • ‘Space ice’ found in comets isn’t much like water on Earth after all

    ‘Space ice’ found in comets isn’t much like water on Earth after all

    Space is cold, and research has shown time and time again that space ice is prevalent throughout the universe. However, despite sharing a similar name to the ice we find in glaciers or even in our freezers here on Earth, new research says that frozen water found on icy planets, comets, and even in the dust that sails through space is very different from the ice you might put your soda over.

    For starters, despite looking like a shapeless solid, ice is actually made up of multiple nanoscopic crystals, all of which are only a few billionths of a meter across, if that. So, what makes Earth ice and space ice so different? Well, according to researchers, Earth ice is made up of orderly lattice crystal designs. These all showcase the six-fold symmetry of snowflakes in the underlying structure.

    But we’ve long believed that space ice has a different structure. Instead, because of the near-vacuum conditions of space, the water frozen there likely lacked the energy needed to form these orderly lattices. Scientists believed they were most likely made up of random arrangements of crystals. But new research is challenging this perspective.

    Instead of being made up entirely of random crystallized structures, the researchers found that in order for the ice they made in their tests to truly resemble that of space ice, they had to give it some structure — roughly 20% of the overall structure. But what is even more intriguing is that when warmed slightly, they found that the crystals retain the structure seen in their original designs.

    This suggests that the ice holds onto some of its memory of the past, which could help greatly in future studies of frozen water in space. It could also fundamentally change our understanding of how life came to Earth, something that researchers have long theorized happened as amino acids hitched rides in the frozen water of comets.

    But if space ice retains some of the structure of its original design, then the empty places for those acids to grow and live would be even more scarce than they was previously thought to be. Of course, the study is far from definitive, and further research will need to be done to confirm these findings. For now, though, they raise some interesting questions about what we think we know about how the universe and space ice actually works.

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  • Psychological Stress and Cancer; H. Pylori Still a Risk; Cancer Lessons from Turtles – MedPage Today

    1. Psychological Stress and Cancer; H. Pylori Still a Risk; Cancer Lessons from Turtles  MedPage Today
    2. More Than a Feeling: How Stress Shapes Cancer and Healing – Sami Mansfield  Oncodaily
    3. Neurologist shares how stress alters brain structure and lists 5 neurological conditions that stress may worsen  Hindustan Times
    4. Chronic stress is costing you your health  San Mateo Daily Journal
    5. Are you always stressed? It can affect your brain, says neurologist; know these 5 tips to manage stress  MSN

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  • ‘Superman’ Thursday previews hit $22.5 million at box office

    ‘Superman’ Thursday previews hit $22.5 million at box office

    David Corenswet stars are Superman in Warner Bros.’ “Superman.”

    Warner Bros. Discovery

    It’s not a bird or a plane that soared into cinemas Thursday night — it was Warner Bros.’ “Superman.”

    The first film in the new era of DC films under James Gunn and Peter Safran snared $22.5 million from preview showings.

    It’s the third-best Thursday performance for a superhero flick under the DC banner ever, just behind “The Dark Knight Rises,” which secured $30.6 million in 2012, and “Batman v. Superman: Dawn of Justice,” which tallied $27.7 million on its first Thursday in 2016, according to data from Comscore.

    It’s also the best preview numbers for a Superman film ever. “Superman: Man of Steel” secured just $9 million in Thursday night preview tickets in 2013.

    “‘With great power comes great responsibility’ may be the mantra of Spider-Man, but Peter Safran and James Gunn have a similar charge and therefore the stakes are incredibly high for the new ‘Superman’ movie to deliver superhero style box office numbers over what will be a highly scrutinized summer movie weekend,” said Paul Dergarabedian, senior media analyst at Comscore.

    “Superman” is expected to tally between $130 million and $140 million at the box office during its full three-day opening weekend. “Man of Steel” generated $116 million during its opening weekend more than a decade ago.

    That range is also on par with the 2022 release of Matt Reeves’ “The Batman,” which took in $134 million. Only three DC films have performed better during their first three days in theaters — “Batman v. Superman” opened to $166 million, “The Dark Knight Rises” captured $160 million and “The Dark Knight” brought in $158.4 million.

    “Premium screens will undoubtedly be a major draw for James Gunn’s hopeful superhero spectacle, and if families turn out to introduce today’s younger generation of kids to Superman, we’ll be looking up to box office staying power through the rest of summer,” said Shawn Robbins, director of analytics at Fandango and founder of Box Office Theory.

    Rachel Brosnahan and David Corenswet star as Lois Lane and Superman in Warner Bros.’ “Superman.”

    Warner Bros. Discovery

    That would be a good sign for the new era of DC under Gunn and Safran.

    The pair took over as co-heads of Warner Bros. Discovery’s DC Comics film and TV unit in late 2022. Since taking the reins for DC Studios they have developed a 10-year plan to reinvigorate its franchises across TV and film, including fresh spins on Superman and Batman.

    Both executives have experience with the superhero genre and have brought heroes from Disney’s Marvel Cinematic Universe and DC Universe to the big and small screens, including “Guardians of the Galaxy,” “The Suicide Squad” and “Peacemaker.”

    While several television projects have already debuted on WBD’s streaming service HBO Max, “Superman” is the first theatrical project to come to fruition from Gunn and Safran.

    Critics seem on board with the reboot, as the film currently holds an 83% “Fresh” rating from more than 300 reviews on Rotten Tomatoes.

    “It’s the start of a new era for DC characters and the return of thematically hopeful stories within that canvas,” said Robbins. “Superman is the perfect archetype to usher in this reboot despite the fact that every iteration of the character has faced headwinds in meeting fan demand while simultaneously courting broader audiences. This film is no different in that regard, but it certainly represents a tonal shift from the brooding era of DC films over the previous decade-plus.”

    Disclosure: Comcast is the parent company of NBCUniversal and CNBC. NBCUniversal owns Fandango and Rotten Tomatoes.

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  • Study confirms high survival rates for men with low-risk prostate cancer

    Study confirms high survival rates for men with low-risk prostate cancer

    New research in the July 2025 issue of JNCCN-Journal of the National Comprehensive Cancer Network finds that for people diagnosed with nonmetastatic low-risk prostate cancer later in life, and treated according to NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), 90% were likely to survive their cancer for their remaining life-expectancy. Of those with nonmetastatic higher-risk cancer and a longer life expectancy, that likelihood was still greater than 65%.

    The researchers studied 62,839 people diagnosed with non-metastatic prostate cancer in Sweden between the years 2000-2020. All were placed within a defined risk category, had a life expectancy of more than three years, and were treated according to evidence-based, expert consensus-driven recommendations from the NCCN Guidelines® for Prostate Cancer. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer. Those with high-risk cancer were still twice as likely to die of other causes.

    Our data support adherence to guideline recommendations for treatment of prostate cancer. If guideline-recommended treatment is used, most people with prostate cancer will live for many years after diagnosis. That includes active surveillance as an excellent treatment strategy for appropriately selected people.”


    Pietro Scilipoti, MD, lead researcher of Uppsala University in Sweden and IRCCS San Raffaele Hospital in Italy

    The Gleason score/Grade Group, clinical TNM stage, treatment data, and other information for the study came from the National Prostate Cancer Register (NPCR) of Sweden. Life expectancy at the time of diagnosis was calculated based on age and comorbidity. Date and cause of death were taken from the Cause of Death Register.

    “This study offers a big sigh of relief for many men facing a prostate cancer diagnosis,” commented Ahmad Shabsigh, MD, The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute, Member of the NCCN Guidelines Panel for Prostate Cancer, who was not involved with this research. “It reveals that with NCCN Guidelines-recommended treatment, you’re significantly more likely to die from something else-up to six times more likely, in fact-even if your cancer is high-risk. This holds true even when looking at data from a different healthcare system, like Sweden’s. What’s truly striking is that for patients with low-risk prostate cancer, many of whom were on active surveillance, the 30-year mortality risk from the cancer itself was only about 11%. It really underscores the power of evidence-based treatment plans and the importance of focusing on a person’s overall health, not just their cancer.”

    Source:

    National Comprehensive Cancer Network

    Journal reference:

    Scilipoti, P., et al. (2025). Long-Term Outcomes After Guideline-Recommended Treatment of Men With Prostate Cancer. Journal of the National Comprehensive Cancer Network. doi.org/10.6004/jnccn.2025.7022.

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  • Study Reveals how Deep Ocean Currents Shape Microbial Life across South Pacific

    Study Reveals how Deep Ocean Currents Shape Microbial Life across South Pacific

    A groundbreaking study in the journal Science, has unveiled how deep ocean currents—known as global overturning circulation—play a pivotal role in shaping the diversity and function of microbial life across the South Pacific Ocean. 

    This research, led by scientists from J. Craig Venter Institute (JCVI), UC San Diego’s Scripps Institution of Oceanography, and University of California Berkeley offers the most detailed genetic map to date of how microbial communities are structured by the physical movement of ocean water.

    Winds and storms only reach to about 500 meters (1,640 feet), about an eighth of the total ocean depth of 4,000 meters (13,125 feet), said study lead author Bethany Kolody, a graduate of Scripps Oceanography who is currently a postdoctoral researcher at Cal. Beyond 500 meters below the surface, currents are driven by differences in water temperature and salinity, which affects its density, forming the global overturning circulation. This circulation acts like a conveyor belt, transporting water—and the microbes within it—across vast distances and depths.

    “Until now, it was unclear whether these water masses also served as distinct microbial ecosystems,” said Kolody. “We can now answer that question with a resounding, ‘yes.’”

    The research team collected over 300 water samples along a transect from Easter Island in the South Pacific Ocean to Antarctica, spanning the full depth of the ocean. Using advanced metagenomic and metabarcoding techniques, they reconstructed the genomes for more than 300 microbes and identified tens of thousands of additional microbial species using a molecular fingerprinting technique that looks at highly conserved genes—the 16S rRNA gene for prokaryotes (which includes both bacteria and archaea) and the 18S rRNA gene for eukaryotes.

    Their findings revealed a striking pattern: microbial diversity increases sharply some 300 meters (1,000 feet) below the ocean surface in a zone they call the “prokaryotic phylocline.” This layer, akin to the pycnocline (a zone of rapid density change), marks a transition from low-diversity surface waters to the rich microbial communities of the deep ocean.

    The study, released July 10, identified six distinct microbial “cohorts,” three of which correspond to depths and the other three aligning with major water masses: Antarctic Bottom Water, Upper Circumpolar Deep Water , and ancient Pacific Deep Water. Each cohort harbors unique microbial species and functional genes, shaped by the temperature, pressure, nutrient levels, and age of the water.

    For example, the Antarctic Bottom Water cohort includes microbes adapted to cold, high-pressure environments, with genes that help maintain membrane fluidity and resist oxidative stress. In contrast, the ancient water cohort—found in slow circulating water that has not seen the surface in 1,000 or more years—hosts microbes with genes enabling life in low oxygen environments and the breakdown of complex, low-energy carbon compounds.

    The voyage to collect water samples began at Easter Island and ended near Antarctica in the South Pacific. Samples were taken at numerous depths to give a complete picture of microbial life at each location and have shed new understanding about how these populations are layered, each employing survival strategies for their specific environments. Image: Bethany Kolody.

    Beyond taxonomy, the researchers also mapped the functional potential of microbial communities. They identified ten “functional zones” based on the presence of key metabolic genes. These zones correspond to oceanographic features such as upwelling regions, nutrient gradients, and oxygen minimum zones.

    Surface zones were rich in genes for light harvesting, iron acquisition, and photoprotection—traits essential for life in the sunlit upper ocean. Deeper zones featured genes for breaking down complex organic molecules, surviving low oxygen, and enduring environmental stress.

    Microbes are the engines of the ocean’s carbon cycle. They convert carbon dioxide into organic compounds (carbon fixing), recycle nutrients, and help trap carbon in the deep sea (carbon sequestration). Understanding how their communities are structured by ocean circulation is crucial for predicting how climate change might alter these processes.

    “The study provides a baseline for how microbial ecosystems are organized under current ocean conditions,” said Andrew Allen, senior author of the study and a microbial oceanographer at JCVI and Scripps Oceanography. “As climate change impacts global overturning circulation, the distribution and function of these microbial communities could shift, with unknown consequences for global carbon cycling.”

    By pairing genomic data with physical and chemical measurements, scientists can build a global, species-resolved atlas of ocean life—essential for understanding and protecting the planet’s largest ecosystem.

    “This study is a reminder that life in ocean ecosystems is, in part, governed by fundamental patterns and processes that are unknown to us,” said Allen. “Seeing and understanding them requires that we examine them more sensitively, carefully, and thoroughly. The breakthroughs reported in this study are the result of a truly interdisciplinary effort involving physical oceanographers, biological oceanographers, and genome biologists all working very closely together. Agencies, such as the National Science Foundation, that support basic interdisciplinary ecological research in life and earth sciences, continue to be essential to our ability to understand factors that control the distribution, diversity, metabolism, and evolution of organisms in nature.”

    The authors advocate for incorporating molecular sampling into global ocean monitoring programs like GO-SHIP. 

    Besides Andrew Allen, Scripps Oceanography researchers affiliated with the study include  Zoltán Füssy, Sarah Purkey and Eric Allen. 

    The complete study, “Overturning circulation structures the microbial functional seascape of the South Pacific,” is published in the journal Science. This research was supported by the National Science Foundation, the Simons Foundation, the National Institutes of Health, the Emerson Collective, the Gordon and Betty Moore Foundation, and the Chan Zuckerberg Initiative.

    Adapted from JCVI

     

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  • HSBC becomes first UK bank to quit industry’s net zero alliance | HSBC

    HSBC becomes first UK bank to quit industry’s net zero alliance | HSBC

    HSBC has become the first UK bank to leave the global banking industry’s net zero target-setting group, as campaigners warned it was a “troubling” sign over the lender’s commitment to tackling the climate crisis.

    The move risks triggering further departures from the Net Zero Banking Alliance (NZBA) by UK banks, in a fresh blow to international climate coordination efforts.

    HSBC’s decision follows a wave of exits by major US banks in the run-up to Donald Trump’s inauguration in January. His return to the White House has spurred a climate backlash as he pushes for higher production of oil and gas.

    HSBC was a founding member of the NZBA at its launch in 2021, with the bank’s then chief executive, Noel Quinn, saying it was vital to “establish a robust and transparent framework for monitoring progress” towards net zero carbon-emission targets.

    “We want to set that standard for the banking industry. Industry-wide collaboration is essential in achieving that goal,” Quinn said.

    Convened by the UN environment programme’s finance initiative but led by banks, the NZBA commits members to aligning their lending, investment and capital markets activities with net zero greenhouse-gas emissions by 2050 or earlier.

    Six of the largest banks in the US – Citigroup, Bank of America, Morgan Stanley, Wells Fargo and Goldman Sachs – left the NZBA after Trump was elected.

    UK lenders including Barclays, Lloyds, NatWest, Standard Chartered and Nationwide were still listed as members as of Friday afternoon.

    HSBC’s decision to leave the alliance comes just months after it announced it was delaying key parts of its climate goals by 20 years and watering down environmental targets in a new long-term bonus plan for its chief executive, Georges Elhedery, who took over last year.

    The climate campaign group ShareAction condemned the move, saying it was “yet another troubling signal around the bank’s commitment to addressing the climate crisis”.

    Jeanne Martin, ShareAction’s co-director of corporate engagement, said: “It sends a counterproductive message to governments and companies, despite the multiplying financial risks of global heating and the heatwaves, floods and extreme weather it will bring.

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    “Investors will be watching closely how this backsliding move will translate into its disclosures and policies.”

    HSBC said in a statement “We recognise the role the Net Zero Banking Alliance has played in developing guiding frameworks to help banks establish their initial target-setting approach.

    “With this foundation in place, we have decided to withdraw from the NZBA as we work towards updating and implementing our own net zero transition plan.

    “We remain resolutely focused on supporting our customers to finance their transition objectives and on making progress towards our net zero by 2050 ambition.”

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  • Nerve pain medication gabapentin possibly tied to dementia, study says

    Nerve pain medication gabapentin possibly tied to dementia, study says

    July 11 (UPI) — A drug used to treat seizures, nerve pain and restless leg syndrome might be linked with increased risk of dementia, a new study says.

    Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment by 85%, researchers reported Thursday in the journal Regional Anesthesia & Pain Medicine.

    What’s more, the risk was more than doubled in people normally considered too young to suffer from brain aging, those 18 to 64, results show.

    “The findings of this study support the need for close monitoring in adult patients prescribed gabapentin to assess for potential cognitive decline,” wrote the research team led by Nafis Eghrari, a medical student at Case Western Reserve University in Cleveland.

    “Moreover, this provides a foundation to further research whether gabapentin plays a causal role in the development of dementia and cognitive decline,” the researchers added.

    Gabapentin has become increasingly popular for the treatment of chronic pain because it’s not nearly as addictive as opioids, researchers said in background notes.

    But concerns have been growing that gabapentin might contribute to cognitive decline, since it works by suppressing communication between nerve cells, researchers said.

    To examine this further, researchers analyzed records for more than 26,400 people who had been prescribed gabapentin for chronic low back pain, and compared them to a similar number of other back pain patients who hadn’t gotten the drug.

    People who’d received six or more gabapentin prescriptions were more likely to be diagnosed with dementia or mild cognitive impairment within 10 years of their initial pain diagnosis, results show.

    Looking at age groups, researchers found that 18- to 64-year-olds prescribed gabapentin were more than twice as likely to develop dementia or MCI.

    This was driven mainly by 35- to 64-year-olds, among whom the risks of dementia more than doubled and MCI more than tripled, researchers said.

    These risks also rose along with prescription frequency, results show. Those with 12 or more gabapentin prescriptions were 40% more likely to develop dementia and 65% more likely to develop MCI than those prescribed the drug three to 11 times.

    Researchers noted that because this is an observational study, it cannot draw a direct cause-and-effect association between gabapentin and brain decline.

    “We hope the current study promotes further research to delineate whether gabapentin plays a causal role in the development of dementia and the underlying mechanisms of this relationship,” the team concluded in their paper.

    More information

    The Cleveland Clinic has more on gabapentin.

    Copyright © 2025 HealthDay. All rights reserved.

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  • New device offers breakthrough for safe drug delivery into the brain

    New device offers breakthrough for safe drug delivery into the brain

    A new device combining ultrasound and advanced imaging to provide crucial information for the safe delivery of drugs into the brain has been developed by University of Queensland researchers.

    Dr. Pranesh Padmanabhan from UQ’s School of Biomedical Sciences and Queensland Brain Institute said the device allows real-time observation of individual cells after ultrasound treatment, which is an emerging technology for the delivery of drugs past the blood-brain barrier.

    The information learned about how treated cells respond and change could ultimately benefit the treatment of neurodegenerative brain disorders such as Alzheimer’s and Parkinson’s disease.

    The blood-brain barrier prevents most drug uptake into the brain.


    Insights from this device will help inform ultrasound treatment protocols and establish a balance where uptake of drugs into the brain is effective, yet still safe.”


    Dr. Pranesh Padmanabhan from UQ’s School of Biomedical Sciences and Queensland Brain Institute 

    The custom-built device will examine sonoporation-based drug delivery.

    Sonoporation is an emerging strategy involving ultrasound-based treatment combined with injected ‘microbubbles’.

    In this process, sound waves interact with the microbubbles causing them to vibrate and exert force on the blood-brain barrier to create a tiny pore at the cell surface.

    Dr. Padmanabhan said the device, developed over 5 years, will allow researchers to identify and map changes in treated cells and observe how they respond and recover.

    “This device will enable scientists to understand how ultrasound-based treatments work at the single-molecule and single-cell levels,” he said.

    “It has the potential to improve treatment of neurodegenerative diseases, where drugs target specific areas of the brain.

    “The goal is really to improve the rate of uptake of drugs into the brain, as currently only about 1-2 per cent of small molecule drugs actually reach it.

    “The results could also help inform treatment in other medical fields where sonoporation shows great promise, including cardiology and oncology.”

    The research is published in Journal of Controlled Release.

    Source:

    The University of Queensland

    Journal reference:

    Lee, J. L. F., et al. (2025). High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells. Journal of Controlled Release. doi.org/10.1016/j.jconrel.2025.113974.

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  • Oasis take over UK charts as reunion tour hits Manchester | Oasis

    Oasis take over UK charts as reunion tour hits Manchester | Oasis

    One week after the first show of their long-awaited reunion tour, and ahead of their first home town shows in Manchester this weekend, Oasis are taking over the UK charts.

    The band have placed three albums in the UK Top 5. Singles compilation Time Flies… 1994–2009 is No 1 for the first time since it was released in June 2010. Their second album, 1995’s (What’s the Story) Morning Glory? rises 12 places to No 2, and their 1994 debut album Definitely Maybe jumps 22 spots to No 4.

    In the singles chart, Acquiesce – originally the B-side to their first No 1 single, 1995’s Some Might Say, peaks at No 17 after making its stand-alone chart debut at No 40 last week.

    Acquiesce is the second song performed in full on their current tour set list, after the instrumental introduction Fuckin’ in the Bushes and Hello. With the lyrics “Because we need one another / We believe in one another”, it has been adopted by fans as an anthem of fraternal love between Liam and Noel Gallagher, despite Noel disagreeing with the interpretation.

    The 1996 No 1 single Don’t Look Back in Anger reaches No 18, though hasn’t yet surpassed its most recent peak of No 9 last September, soon after the reunion was announced.

    It also spent seven weeks in the chart in 2017 after being adopted as the unofficial anthem of Manchester in the wake of the terrorist attack on an Ariana Grande concert in the city that May. When Oasis perform the song on the current tour, the stage visuals feature yellow bumblebees in tribute to the city’s worker bee symbol.

    Live Forever, which also lingered on the chart in the wake of the reunion news, rises to No 19.

    After two nights in Cardiff last weekend, Oasis are set to perform five nights at Heaton Park in Manchester from tonight (11 July). Temperatures are expected to reach 31C on night one, prompting organisers to share a weather warning for the first outdoor show of the tour. Rules on bringing bottles into the ground have been relaxed, with ticketholders now permitted to carry 500ml of water in a sealed bottle and up to 200ml of sun cream.

    Oasis posted: “Wear a (bucket) hat. Where possible stay in shade. Look after yourself and look after each other.”

    Fans without tickets have been warned against attempting to get in for the sold-out shows after TikTok users claimed you could enter the park by swimming.

    As in Cardiff last weekend, the city has been overrun by international visitors, with pubs, shops and even tattoo parlours reporting an uptick in business, while Liam Gallagher has voiced new announcements for the tram route that will take fans to the gig.

    It is unlikely that fans will be disappointed: the first night of Cardiff earned unilateral five-star reviews in the British press. The Guardian’s Alexis Petridis called it “a triumph”.

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