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  • Amnesty calls on governments to reign in Big Tech. But as Trump’s tech threat looms, will they?

    Amnesty calls on governments to reign in Big Tech. But as Trump’s tech threat looms, will they?

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    Human rights group Amnesty International is urging governments worldwide to break up with Big Tech, arguing that “the concentration of power” of a few companies has profound implications on privacy, nondiscrimination, and access to information. 

    A report published on Thursday, called ‘breaking up with Big Tech,’ by the group took aim at Google, Meta, Microsoft, Amazon, and Apple. It urged governments to “rein in Big Tech and put people’s rights first”.

    The report comes as tech relations between the United States and Europe turn fragile after US President Donald Trump threatened to impose “substantial” additional tariffs on countries that implement legislation targeting American tech companies.

    “These few companies act as digital landlords who determine the shape and form of our online interaction,” said Hannah Storey, an advocacy and policy adviser on technology and human rights at Amnesty.

    The report also argued that artificial intelligence (AI) is the “next phase” in tech companies’ “dominance”.

    “Big Tech companies are rapidly building and deploying AI systems, prioritising speed and scale over fairness and accuracy,” the report said, adding that the biased data AI models are trained on is harmful for users and marginalised communities. It said they could be more vulnerable to harms stemming from algorithmic profiling and biometric mass surveillance.

    The Amnesty report alleged that Google and Meta profit from harvesting and monetising vast quantities of our personal data and because of the companies’ market dominance, users have little meaningful choice or control over how their data is used.

    “The more data they collect, the more dominant they become, and the harder it is for competitors to challenge their position,” the report added. 

    Google’s YouTube and Meta’s Facebook and Instagram also use algorithms “optimised for engagement and profit,” which emphasise content meant to provoke strong emotions and outrage from users, the report said. 

    Amnesty alleged that Facebook was instrumental in the Tigray war in Ethiopia (2020-2022), saying that Meta’s algorithms amplified content that incited hatred and violence against Tigrayans as government officials and pro-government activists used Facebook to “dehumanise the entire ethnic group”.

    Amnesty also alleged in 2022 that Facebook prompted violence in the ethnic cleansing of the Rohingya in Myanmar in 2017. 

    Meta responded to Amnesty, saying that the report contained “multiple inaccurate claims,” including the one on Tigray, adding that it takes its role “seriously in keeping abuse off our services” and that “privacy is at the core of everything” the company does. 

    Apple, Amazon, and Microsoft were also highlighted in the report for their market dominance.

    Microsoft responded that it is “firmly committed to respecting human rights,” while Apple and Amazon did not respond to Amnesty’s allegations.

    Euronews Next has reached out to the five companies for their reaction to the report. 

    The recommendations:

    Amnesty made a set of recommendations to policymakers, including states and competition authorities, to use competition laws as part of their “human rights toolbox”.

    It also urged states to investigate Big Tech for human rights harms, break up companies that are found guilty of doing so, and block mergers and acquisitions that risk harming human rights. 

    As for AI, the report said the generative AI sector should be investigated to establish human rights risks and impacts from anticompetitive practices. However, this may be difficult as AI companies notoriously do not share the sources of the data they use to train their models.

    Whether the European Union will respond to Amnesty’s requests will stir anticipation, as calls grow for EU leaders to respond to the US tariff threat on governments that regulate American tech companies.

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  • New FDA-Cleared Product: CGM + AI for Weight Management – Medscape

    1. New FDA-Cleared Product: CGM + AI for Weight Management  Medscape
    2. FDA approves first-ever glucose monitoring system for weight loss from Signos  CNBC
    3. Dexcom Nabs Weight Management Indication For Signos CGM  insights.citeline.com
    4. In a new era, glucose sensors straddle the line between medical device and wellness tool  statnews.com
    5. FDA Clears OTC Glucose Monitor for Weight Management  Drug Topics

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  • Signaling mechanisms driving olfactory neurogenesis in zebrafish

    Signaling mechanisms driving olfactory neurogenesis in zebrafish

    Cellular differentiation of stem cells into specialized cells requires many steps, including division, to create more cells; fate determination, which is a commitment to a specific lineage or developmental path; and migration, to integrate the cell into its final location.

    Previous in vitro work has shown that stem cells can spontaneously self-organize into groups of specialized cell types, yet little is known about how that happens in living animals – where densely populated microenvironments have high degrees of noise in cell-to-cell signaling and variations in gene expression.

    In their study and a featured cover image in a special issue of Stem Cell Reports on Neural Stem Cells, researchers at the University of Alabama at Birmingham and the University of Illinois Chicago describe signaling mechanisms that determine one such example of vertebrate development – the transition from olfactory stem cells into highly regenerative olfactory neurons that are responsible for the sense of smell.

    Applying multiple techniques including high-resolution imaging of live zebrafish embryos, quantitative tracking of cell fate and single-cell RNA sequencing, researchers identified a unique bistable toggle switch that assigns divergent cell fates to progenitor cells and drives their assembly into cellular “neighborhoods.” In doing so, they showed how signaling that guides continuous neural development is integrated at multiple scales – single cells, small clusters of cells and between entire organs.

    The study describes “a previously unknown paradigm of cellular neighborhood assembly through which the olfactory epithelium integrates fluctuating, stochastic signals to streamline fate commitment, differentiation and integration into the olfactory neuronal rosette,” wrote lead author Sriivatsan Govinda Rajan, Ph.D., and corresponding author Ankur Saxena, Ph.D., UAB Department of Cell, Developmental and Integrative Biology. “These findings reveal how stochastic signaling networks spatiotemporally regulate a balance between progenitors and derivatives, driving sustained neurogenesis in an intricate organ system.”

    Remarkably, the human nose turns over its neurons every couple of months or so throughout our lifetimes. Given this unusual neuroregeneration, we wanted to answer a fundamental question: How do stem cells funnel fluctuating signals to make new neurons over and over again? Now, we’re building on our molecular ‘answers’ from the zebrafish model system by asking if the identified molecular pathways can be applied in other contexts to shape the nervous system across vertebrates. Long-term, our hope is to discover new therapeutic avenues for patients with neurodevelopmental or neurodegenerative disorders.”


    Ankur Saxena, Ph.D., corresponding author, UAB Department of Cell, Developmental and Integrative Biology

    Co-authors with Rajan and Saxena in the study, “Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis,” are Lynne M. Nacke, UAB Department of Cell, Developmental and Integrative Biology; and Joseph N. Lombardo, Farid Manuchehrfar, Kaelan Wong, Pinal Kanabar, Elizabeth A. Somodji, Jocelyn Garcia, Mark Maienschein-Cline and Jie Liang, University of Illinois Chicago.

    At UAB, Cell, Developmental and Integrative Biology is a department in the Marnix E. Heersink School of Medicine. More information about the Saxena Lab’s work can be found at www.saxenalab.com. Rajan is now at Memorial Sloan Kettering Cancer Center, New York City, New York.

    Source:

    University of Alabama at Birmingham

    Journal reference:

    Rajan, S. G., et al. (2025). Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis. Stem Cell Reports. doi.org/10.1016/j.stemcr.2025.102575

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  • MHRA Approves First New UTI Antibiotic in Decades – Medscape

    1. MHRA Approves First New UTI Antibiotic in Decades  Medscape
    2. UK approves GSK’s antibiotic for female urinary tract infections  Reuters
    3. GSK Gepotidacin approved in UK for UTIs in females aged 12 years and older  Medical Dialogues
    4. MHRA approves first new UTI antibiotic in 30 years  The Pharmaceutical Journal
    5. British Equities Extend Losses; GSK Bags Approval for Antibiotic  MarketScreener

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  • Tokyo stocks fall on sluggish Japan output data, profit-taking

    Tokyo stocks fall on sluggish Japan output data, profit-taking






    This May 7, 2020 file photo shows the Tokyo Stock Exchange. (Mainichi)


    TOKYO (Kyodo) — Tokyo stocks fell Friday, pressured by weaker-than-expected Japanese industrial output data, while some investors locked in gains following recent advances.


    The 225-issue Nikkei Stock Average ended down 110.32 points, or 0.26 percent, from Thursday at 42,718.47. The broader Topix index finished 14.60 points, or 0.47 percent, lower at 3,075.18.


    On the top-tier Prime Market, notable decliners were real estate, insurance and transportation equipment issues.


    The U.S. dollar mostly traded around the 147 yen line in Tokyo amid deepening uncertainty about the independence of the U.S. central bank, with Federal Reserve Governor Lisa Cook suing President Donald Trump on Thursday after he attempted to fire her over alleged mortgage fraud, dealers said.


    At 5 p.m., the dollar fetched 147.00-02 yen compared with 146.91-147.01 yen in New York and 147.16-18 yen in Tokyo at 5 p.m. Thursday.


    The euro was quoted at $1.1674-1676 and 171.61-65 yen against $1.1678-1688 and 171.61-71 yen in New York and $1.1643-1644 and 171.34-38 yen in Tokyo late Thursday afternoon.


    The yield on the benchmark 10-year Japanese government bond ended at 1.600 percent, down 0.015 percentage point from Thursday’s close, as the debt was bought following a decline in U.S. Treasury yields.


    On the stock market, investor sentiment was negatively affected by government data that showed Japanese industrial output in July declined 1.6 percent from the previous month, weighed down by weakness in the auto sector, brokers said.


    “Although market players seem to have already factored in the impact of U.S. tariffs to some extent, the data showing a decline was a negative trading incentive,” as they grew concerned about an economic downturn, said Maki Sawada, a strategist in the Investment Content Department of Nomura Securities Co.


    The market was also dragged down by profit-taking, while exporter shares were sold on the yen’s appreciation, which decreases overseas profits of exporters when repatriated.

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  • Baker McKenzie Advises Zug Estates Holding AG on Green Bond Placement | Newsroom

    Baker McKenzie Advises Zug Estates Holding AG on Green Bond Placement | Newsroom

    Baker McKenzie advised Zug Estates Holding AG on the successful placement of an additional CHF 100 million green bond in the Swiss market. The Zug Estates Group designs, develops, markets and manages properties in the Zug region.

    The fixed-interest bond carries a coupon of 1.25% and a maturity of seven years. The proceeds will be used to refinance sustainable projects in accordance with Zug Estates’ Green Finance Framework. Application will be made for admission to trading of the bonds on SIX Swiss Exchange.

    Baker McKenzie’s Matthias Courvoisier, Yves Mauchle and Samuel Marbacher advised Zug Estates on the transaction.

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  • Julia Roberts Talks ‘After the Hunt’ and Loss of “Art of Conversation”

    Julia Roberts Talks ‘After the Hunt’ and Loss of “Art of Conversation”

    To give you a sense of the knotty conflicts, character dynamics and power struggles at play in Luca Guadagnino’s new film After the Hunt, during the film’s official Venice Film Festival press conference, Julia Roberts got asked out of the gate to offer her thoughts on whether the film undermines the feminist struggle.

    “Not to be disagreeable because it’s not in my nature,” Roberts said with a grin as she defended the movie by countering that it’s only meant to inspire debate. “There’s a lot of old arguments that get rejuvenated in this movie in a way that does create conversation. The best part of your question is you talking about how you all came out of the theater talking about [the film], and that’s how we wanted it to feel — that everybody comes out with all these different feelings, emotions and points of views. You realize what you believe in strongly and what your convictions are because we stir it all up for you. So, you’re welcome.”

    After the Hunt is described as psychological drama about college professor Alma Imhoff (Roberts) who finds herself at a personal and professional crossroads when star student Maggie (Ayo Edebiri) accuses her colleague Hank (Andrew Garfield) of assault. As events unfold, a dark secret from the professor’s past threatens to be revealed. Guadagnino directed from a script by Nora Garrett.

    Actually, the pointed question was the second of the session, and it followed a journalist asking Roberts and Edebiri what was so attractive about playing such “troubled women.”

    “Trouble is where the juicy stuff is. All that great complexity that Nora wrote for all the characters is what assembled this kind of a group,” Roberts responded, gesturing to the press conference panel that hosted Guadagnino, Edebiri, Garfield, Garrett, Chloë Sevigny and Michael Stuhlbarg. “It’s like dominoes of conflict, once one falls, then suddenly everywhere you turn, there’s some new piece of conflict and challenge. That’s what makes it worth getting up and going to work in the morning.”

    As for Edebiri, she called the gig “a dream” because of the challenges it presented. “That’s how you grow,” she added. “That’s the type of movie I enjoy watching.”

    Roberts and Edebiri in After the Hunt.

    Yannis Drakoulidis, Courtesy of Amazon MGM Studios

    Roberts, who clearly enjoyed her time with Guadagnino as evidenced by her sartorial choice when arriving in Venice, said working on After the Hunt reminded her of Bruce Beresford’s Tender Mercies. The 1982 drama follows a broken-down, middle-aged country singer as he gets a new wife, reaches out to his long-lost daughter and tries to put his troubled life back together.

    “I just thought there was something magical about the idea that a kind of camera just landed in a place and happened to document what was going on where it landed. That’s how I feel about this movie,” Roberts explained. “We’re not making statements. We are portraying these people in this moment in time, and the camera has fallen from the sky in this particular moment and and captures all this. That’s what is sort of incredible about it.”

    Roberts continued: “It’s not so much that we’re making a statement. We’re just sharing these lives for this moment, and then we want everyone to go away and talk to each other. That, to me, is the most exciting bit because we’re kind of losing the art of conversation in humanity right now. If making this movie does anything, getting everybody to talk to each other is the most exciting thing that I feel we could accomplish.”

    Conversations will surely be in full effect when After the Hunt team has its world premiere Friday evening here on the Lido inside Sala Grande. The 82nd edition of the Venice Film Festival runs Aug. 27-Sept. 6.

    Amazon MGM Studios releases After the Hunt on Oct. 17.

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  • Managing risk in procuring CORSIA Eligible Emission Units

    Managing risk in procuring CORSIA Eligible Emission Units


    Carbon credit procurement is no longer a sustainability side-topic in the aviation industry: the Carbon Offsetting and Reduction Scheme for International Aviation (CORSIA) now presents financial and reputational exposure for most airlines.

    Independent forecasters, including MSCI, expect carbon credit prices under CORSIA to rise sharply, surpassing the peaks previously seen in the voluntary market. And with compliance penalties looming; treasury and procurement professionals must adopt a structured risk management approach to sourcing the Eligible Emissions Units that are required under CORSIA.

    In this article, we outline four key risk categories in carbon procurement under CORSIA and share mitigation strategies that airlines can consider as part of their strategy for CORSIA Phase 1.

    Airlines are now exposed to carbon market risk

    Carbon credits are transitioning from discretionary purchases to an obligation for the aviation industry, where non-delivery or pricing missteps can result in cost overruns, audit issues or non-compliance determination from regulators.

    Key drivers include:

    • ICAO’s tightening credit eligibility criteria, including registry and methodology restrictions
    • Finite issuance of CORSIA-eligible units from projects authorised by Article 6
    • Registry delivery bottlenecks, especially during year-end submission periods
    • Growing demand as Phase 1 accelerates and more airlines enter the market

    This is why a passive or reactive approach to credit sourcing can present many risks for airlines.

    Key risk categories in procuring Eligible Emission Units

    1. Volume constraints

    CORSIA’s complex eligibility criteria is likely to limit the supply of Eligible Emissions Units. For example, it only considers reduction projects starting after 2016 and specific vintages. These criteria also specify methodology restrictions and require host-country approval, which affects carbon credit eligibility.

    Airlines that act early are better positioned to lock-in supply and mitigate this risk.

    2. Credit price volatility

    Carbon markets remain fragmented and opaque, with pricing influenced by:

    • Project type and the methodologies that have been used
    • Article 6 authorisation premiums
    • Market sentiment ahead of compliance deadlines

    Small moves in the market can result in price swings.

    3. Counterparty and delivery risk

    Carbon markets involve a complex network of developers, registries, brokers, traders, and various intermediaries. However, their financial standing, operational reliability, and regulatory oversight vary significantly. Large aviation industry participants, with stringent internal compliance and KYC requirements, may find it challenging to onboard a broad spectrum of these counterparties.

    Partnering with financially robust and reputable entities is critical. Counterparts with strong balance sheets, and operations regulated within relevant jurisdictions are more likely to fulfill contractual obligations, mitigating risks of non-delivery or financial default.

    4. Timing and procurement mismatch

    Another risk stems from airlines underestimating the lead times inherent in the carbon market, leading to procurement efforts commencing too close to compliance deadlines. This critical timing mismatch can expose them to registry congestion, spot market illiquidity, and unacceptable delays in credit delivery.

    Successful procurement depends on recognising the time required for all key functions, including credit verification and issuance, registry processing, and contract negotiation.

    Mitigation strategies for airline carbon credit risk

    Work with trusted counterparts

    Finding the right partner can help you turn a compliance obligation into a competitive advantage. Look out for partners that:

    • Have a track-record in carbon markets
    • Can demonstrate balance sheet strength
    • Understand host-country authorisation processes
    • Have skin in the game and have invested in high-quality projects

    Start Early

    Starting procurement in 2025 can maximise your chances of securing favourable terms in a market that is forecast to be under-supplied, and provides a buffer to handle delays.

    Contract Forward

    You can secure future delivery of Eligible Emission Units with trusted counterparts. This might not be your full obligations under CORSIA, but it can provide a significant portion of your obligations.

    Consider deliveries of EEUs on a regular basis, rather than waiting for the tight window before retirements are due.

    Diversify your sourcing

    Consider splitting your required volume between multiple sources, to reduce the risks of a single point of failure.

    Planning for treasury and procurement

    To stay ahead of the curve, treasury and procurement professionals may consider:

    • Beginning credit planning 12–18 months ahead of expected delivery requirements
    • Defining procurement needs by volume, delivery timeframes, and preferences for registries, activities and host countries
    • Considering the multiple different types of procurement structures available
    • Auditing EEU proposals against ICAO’s eligibility and tagging requirements
    • Building supplier relationships that combine registry access, delivery assurance and contractual reliability

    How we help airlines de-risk their carbon procurement

    CSC Commodities, a division of Marex, supports the aviation industry with a dedicated trading desk and origination team that offers:

    • Direct access to a wide range of CORSIA eligible carbon credits via ICAO-approved registries
    • Flexible procurement structures including spot, forward and conditional to suit your specific hedging, timing and budget needs
    • Support for due diligence, documentation and administration

    Whether helping you secure annual compliance needs or building a procurement roadmap for Phase 1 and beyond, at CSC we can help you access this market and provide execution confidence in a volatile market.

    Speak with our team about structuring a CORSIA carbon credit procurement strategy:

    Read our disclaimer

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  • Oil prices fall on expected weaker demand, but set for weekly gain – Reuters

    1. Oil prices fall on expected weaker demand, but set for weekly gain  Reuters
    2. Oil prices fall on demand concerns but head for weekly gain By Reuters  Investing.com
    3. Oil ticks up on US crude stocks drop, impact of US tariffs on India  Reuters
    4. Oil ticks lower as end of driving season looms, Druzhba restarts  Business Recorder
    5. Crude Oil Price Outlook – Crude Oil Continues to Bounce Around  FXEmpire

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  • Destination X winner reveals how she will spend her prize money

    Destination X winner reveals how she will spend her prize money

    Charlie TaylorBBC Radio Somerset and

    Clara BullockBBC News, Somerset

    PA Media Rob Brydon standing in a blue suit in a carriage with blue seats behind him.PA Media

    The series’ grand final aired on Thursday night

    The winner of Rob Brydon’s BBC show Destination X has said she will spend some of the £100,000 prize to go on holiday with her family.

    Judith Magambo, who is from Bristol and works as a nuclear engineer in Somerset, was one of the contestants travelling around on a bus with blacked-out windows, trying to work out where they were.

    The grand final aired on Thursday night and Ms Magambo was crowned the winner after being the first to find presenter Rob Brydon at the Spanish Steps in Rome.

    “It was definitely not what I expected. I did not expect us to be completely in the dark pretty much all the time,” Ms Magambo, 28, said.

    Three people are standing next to each other by a railing overlooking a city. They are looking at each other and smiling while holding champagne flutes.

    Nuclear engineer Judith Magambo (centre) won the BBC TV show

    She added: “You had earmuffs, were blindfolded – completely in the dark.

    “That was when I started to feel a little bit out of my comfort zone. We had to rely only on the clues and the challenges.”

    The contestants were put to the test with challenges throughout their journey, as well as receiving clues about their destination.

    “A lot of the time I did have to rely on myself,” Ms Magambo said.

    Nuclear Engineer who works in Somerset wins Destination X

    “I am a nuclear engineer, I think people got intimidated, thinking I know everything about the world.

    “I had to figure it all out on my own which worked out in my favour.”

    Ms Magambo said she wants to make the prize money last.

    “I’ve got to be sensible,” she said. “At the same time, I need a break, I need some time to myself.

    “I’ve gone straight from sixth form to uni to a graduate job and have been working ever since. So travelling with my family would be nice.”

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