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  • Naseeruddin Shah deletes post supporting Diljit Dosanjh in Sardaar Ji 3 row: ‘It is impossible to carry torch of truth’ | Bollywood

    Naseeruddin Shah deletes post supporting Diljit Dosanjh in Sardaar Ji 3 row: ‘It is impossible to carry torch of truth’ | Bollywood

    Veteran actor Naseeruddin Shah faced backlash on social media after he came forward to defend actor Diljit Dosanjh, supporting his decision to work with Pakistani actor Hania Aamir in Sardaar Ji 3. However, the controversy led to Naseeruddin deleting his Facebook post, seemingly in response to the negative reaction. Also read: Sardaar Ji 3: Diljit Dosanjh shares public response in Pakistan amid row over Hania Aamir’s casting

    Naseeruddin Shah has posted a cryptic note on Facebook after deleting the post.

    Naseeruddin Shah deletes post after backlash

    Naseeruddin posted a supportive message for Diljit on Facebook on Monday, but it appears to have been deleted as it’s no longer visible on his timeline. It seems to be a reaction to the backlash he was getting for his comments.

    The actor has posted a cryptic note on Facebook after deleting the post where he posted a quote by Georg Christoph Lichtenberg.

    Naseeruddin wrote, “It is almost impossible to carry the torch of truth through a crowd without singeing somebody’s beard. -Georg Christoph Lichtenberg, scientist and philosopher.”

    The comments section of Naseeruddin’s latest post reveals a divided opinion, with some users defending his right to free speech and others criticising him for supporting Diljit’s collaboration with a Pakistani actor.

    What did Naseeruddin write on Facebook?

    Earlier this week, Naseeruddin used Facebook to write words to show support to Diljit amid the backlash he is getting for working with Pakistani actor in Sardaar Ji 3.

    Defending Diljit, Naseeruddin wrote, “I STAND FIRMLY WITH DILJIT. The dirty tricks deptt of Jumla Party has been awaiting a chance to attack him. They think they’ve got it at last. He was not responsible for the casting of the film, the director was.”

    He added, “But no one knows who he is whereas Diljit is known the world over, and he agreed to the cast because his mind is not poisoned. What these goons want is to put an end to personal interaction between the people of India and Pakistan. I have close relatives and some dear friends there and no one can stop me from meeting them or sending them love whenever I feel like it. And my response to those who will say “Go to Pakistan” is ‘GO TO KAILASA’.”

    Diljit in spotlight for Sardaar Ji 3

    Over the last few days, Diljit has been getting hate for his latest film Sardaar Ji 3 including Pakistani actor Hania Aamir. The film also stars Neeru Bajwa. Amid the drama, the movie opened overseas on June 27. It didn’t release in India.

    After the launch of the trailer, there have been calls to ban Diljit and his future work in India. The All Indian Cine Workers Association (AICWA) and Federation of Western India Cine Employees (FWICE) have called for a ban on Diljit and all his upcoming projects. Singer Mika Singh has shared that Diljit should apologise. The stir comes in the wake of the recent Pahalgam terror attack on April 22, followed by India’s Operation Sindoor on May 7, in which air strikes were carried out on terror bases in Pakistan and Pakistan-occupied Kashmir.

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  • Joint Statement from the Quad Foreign Ministers’ Meeting in Washington

    Joint Statement from the Quad Foreign Ministers’ Meeting in Washington

    Secretary Marco Rubio meets with Indo-Pacific Quad Foreign Ministers at the Department of State in Washington, D.C., July 1, 2025. From left, Japanese Foreign Minister Iwaya Takeshi, Indian External Affairs Minister Dr. Subrahmanyam Jaishankar, and Australian Foreign Minister Penny Wong.

    Begin text: We, the Secretary of State of the United States, and the Foreign Ministers of Australia, India, and Japan met in Washington, D.C., on July 1, 2025, to reaffirm our steadfast commitment to a free and open Indo-Pacific. We underscore our commitment to defending the rule of law, sovereignty, and territorial integrity. As four leading maritime nations in the Indo-Pacific, we are united in our conviction that peace and stability in the maritime domain underpin the security and prosperity of the region. We are committed to a region where all countries are free from coercion and strongly oppose any unilateral actions that seek to change the status quo by force or coercion.

    We discussed the opportunities and challenges in the Indo-Pacific and how to further harness the strengths and resources of the Quad to advance peace, security, and prosperity, working with our regional partners. To ensure the Quad’s enduring impact, we are pleased to announce today a new, ambitious, and strong agenda focused on four key areas: maritime and transnational security, economic prosperity and security, critical and emerging technology, and humanitarian assistance and emergency response. Through this renewed focus, we will sharpen the Quad’s ability to leverage our resources to address the region’s most pressing challenges.

    As we advance our shared objectives for the region, our cooperation with and support for ASEAN and its centrality and unity, the Pacific Islands Forum and Pacific-led regional groupings, and the Indian Ocean Rim Association (IORA) remain unwavering.

    We remain seriously concerned about the situation in the East China Sea and South China Sea. We reiterate our strong opposition to any unilateral actions that seek to change the status quo by force or coercion. We express our serious concerns regarding dangerous and provocative actions, including interference with offshore resource development, the repeated obstruction of the freedoms of navigation and overflight, and the dangerous maneuvers by military aircraft and coast guard and maritime militia vessels, especially the unsafe use of water cannons and ramming or blocking actions in the South China Sea. These actions threaten peace and stability in the region. We are seriously concerned by the militarization of disputed features. We emphasize the importance of upholding freedom of navigation and overflight, other lawful uses of the sea, and unimpeded commerce consistent with international law, as reflected in the United Nations Convention on the Law of the Sea (UNCLOS). We affirm that maritime disputes must be resolved peacefully and in accordance with international law, and reiterate that the award rendered by the Arbitral Tribunal on July 12, 2016 is a significant milestone and the basis for peacefully resolving disputes between the parties.

    We are deeply concerned about the abrupt constriction and future reliability of key supply chains, specifically for critical minerals. This includes the use of non-market policies and practices for critical minerals, certain derivative products, and mineral processing technology. We underscore the importance of diversified and reliable global supply chains. Reliance on any one country for processing and refining critical minerals and derivative goods production exposes our industries to economic coercion, price manipulation, and supply chain disruptions, which further harms our economic and national security.

    We condemn North Korea’s destabilizing launches using ballistic missile technology and its continued pursuit of nuclear weapons in violation of multiple UN Security Council resolutions (UNSCRs). We reaffirm our commitment to the complete denuclearization of the Korean Peninsula consistent with relevant UNSCRs, and we urge North Korea to abide by all its obligations under the UNSCRs. We also express grave concern over North Korea’s malicious cyber activity, including cryptocurrency theft and use of workers abroad to fund North Korea’s unlawful weapons of mass destruction and ballistic missile programs. We will continue to support efforts to address contraventions of North Korea-related UNSCRs. We urge all UN Member States to abide by their international obligations under the UNSCRs to implement sanctions, including the prohibition on the transfer to North Korea or procurement from North Korea of all arms and related materiel. We express deep concern about countries that are deepening military cooperation with North Korea, which directly undermines the global nonproliferation regime. We reconfirm the necessity of immediate resolution of the abductions issue.

    We remain deeply concerned by the worsening crisis in Myanmar and its impact on the region. We call on the regime to adhere to its commitment to a ceasefire, and call on all parties to implement, extend and broaden ceasefire measures. We reaffirm our strong support for ASEAN’s efforts, including calling for the full and effective implementation of the Five Point Consensus in seeking an inclusive, durable, and peaceful resolution to the crisis. We call on all parties to allow safe and unhindered delivery of humanitarian assistance. We are also concerned about the impact of the crisis on regional security and the spread of transnational crimes. We are committed to fighting cybercrime and online scam operations.

    The Quad unequivocally condemns all acts of terrorism and violent extremism in all its forms and manifestations, including cross-border terrorism, and renews our commitment to counterterrorism cooperation. We condemn in the strongest terms the terrorist attack in Pahalgam, Jammu and Kashmir on April 22, 2025, which claimed the lives of 25 Indian nationals and one Nepali citizen, while injuring several others. We express our deepest condolences to the families of the victims and extend our heartfelt wishes for a swift and full recovery to all those injured. We call for the perpetrators, organizers, and financiers of this reprehensible act to be brought to justice without any delay and urge all UN Member States, in accordance with their obligations under international law and relevant UNSCRs, to cooperate actively with all relevant authorities in this regard.

    In the face of these challenges, we are proud to announce today key initiatives that the Quad is advancing to strengthen maritime and transnational security, economic prosperity and security, critical and emerging technology, and support humanitarian assistance and emergency response across the Indo-Pacific. We are launching today the Quad Critical Minerals Initiative, an ambitious expansion of our partnership to strengthen economic security and collective resilience by collaborating to secure and diversify critical minerals supply chains. We continue to deepen our cooperation on maritime law enforcement cooperation through regional training initiatives, maritime legal dialogues, and Coast Guard cooperation. We plan to host the first Quad Indo-Pacific Logistics Network field training exercise this year to strengthen shared airlift capacity and leverage our collective logistics strengths to respond to natural disasters more rapidly and efficiently, providing support for regional partners. We also plan to launch the Quad Ports of the Future Partnership in Mumbai this year. We continue to coordinate rapid responses to regional disasters and collectively contributed over USD $30 million in humanitarian assistance to support communities affected by the earthquake that struck central Myanmar in March 2025. We will continue to counter foreign efforts to push false narratives and interfere with Quad interests in the Indo-Pacific.

    As the Quad continues to evolve, our four democracies remain committed to deepening our cooperation in support of a free and open Indo-Pacific, and ensuring our cooperation has an enduring impact on the region’s top challenges and opportunities in the 21st century. We look forward to the next Quad Leaders’ Summit hosted by India later this year and the next Quad Foreign Ministers’ Meeting hosted by Australia in 2026.

    End text.


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  • Gold Rates in Pakistan Today, 2 July 2025

    Gold Rates in Pakistan Today, 2 July 2025

    KARACHI – Gold prices in Pakistan registered massive gains in line with upward trend in international markets on July 2, 2025.

    According to the Saraffa Association, the price of 24-karat gold per tola surged to 356,800 after an increase of Rs6,600 while the rate for 10 grams stood at Rs305,898.

    Gold prices hold significant importance in Pakistan due to cultural, economic, and investment reasons. Gold is traditionally used in weddings, festivals, and as a form of savings, especially by women. Fluctuations in gold prices directly impact jewelry demand and the overall retail market.

    Economically, many Pakistanis invest in gold as a hedge against inflation and currency depreciation. In times of financial uncertainty, gold acts as a safe haven. Moreover, changes in international gold rates affect local prices, influencing import costs and trade balance. Therefore, monitoring gold prices is crucial for investors, consumers, and policymakers in Pakistan.

    Today Gold Rate in Pakistan

    City Gold Price Silver Rate
    Karachi 356,800 Rs3,878
    Lahore 356,800 Rs3,878
    Islamabad 356,800 Rs3,878
    Peshawar 356,800 Rs3,878
    Quetta 356,800 Rs3,878
    Sialkot 356,800 Rs3,878
    Hyderabad 356,800 Rs3,878
    Faisalabad 356,800 Rs3,878

    Gold Price Movement This Week

    • May 28: Rs349,300

    • May 27: Rs347,900

    • May 26: Rs351,500

    • May 24: Rs354,100

    • May 23: Rs351,000

    • May 22: Rs347,500

    • May 21: Rs349,400

    Meanwhile, the silver rates remained constant  as one tola priced at Rs3,782.

    Market experts attribute the ongoing volatility to uncertain trends in global bullion trading and the fluctuating value of the Pakistani rupee against the US dollar.

    Gold rally breaks negative streak in Pakistan amid tweaks; Check New Prices

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  • Law & order during Muharram: CM directs action against dissemination of fake news – Pakistan

    Law & order during Muharram: CM directs action against dissemination of fake news – Pakistan

    LAHORE: On the direction of Chief Minister Punjab Maryam Nawaz Sharif, special measures have been taken for the first time to monitor and prevent fake news for establishing law and order during Muharram-ul-Haram.

    A new system has been implemented and a special Control Room has been established in this regard.

    The CM directed to launch strict legal action against the dissemination of fake news on the social media during Muharram-ul-Haram.

    On the direction of Chief Minister Maryam Nawaz, tracing of people who are involved in disseminating controversial contents on the social media accounts has been launched and a strict legal action is being taken. Dozens of controversial social media accounts have been blocked across Punjab on the report of the Special Branch.

    On the direction of Chief Minister Maryam Nawaz, a Cyber Patrol Unit will perform its duties for the first time in the province during Ashura.

    A special portal of PITB has also been activated for monitoring and reporting objectionable social media contents.

    The special cell will monitor 24/7 social media contents pertaining to religious hatred and sectarianism.

    After reporting controversial content on the portal, the account is blocked and the whereabouts of the account holder is traced. The Chief Minister directed to initiate special measures to ensure a complete ban on the promotion and publication of contents based on religious hatred and speeches. She also directed to ensure a complete ban on the usage of drone cameras under any circumstance.

    She directed to carry out the deployment of a Quick Response Force to ensure complete security of Muharram processions and gatherings. Iron pipes will be installed on all sides for security purposes during the Muharram processions. Special cameras will be installed at the entrance gate of every procession during the Ashura so that the visitors can be identified by their faces.

    The CM directed to deploy female police officers and personnel for the security of female mourners in the gatherings and processions. She highlighted, “The Karbala incident imparts us a lesson to adopt peace and tolerance. All possible steps will be taken to ensure peace and order during the Ashura.” She asserted, “In the context of the current global situation, the holy month of Muharram is extremely sensitive and there is absolutely no room for committing negligence by the relevant stakeholders in the performance of their duties.”

    Copyright Business Recorder, 2025

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  • Neopharm’s brands launch new body care catering to seasonal woes

    Neopharm’s brands launch new body care catering to seasonal woes

    Atopalm, a skin care brand specialising in sensitive skin, recently introduced a new product called Mild & Soothing Feminine Cleanser, which is aimed at providing gentle care for the Y-zone in hot and humid weather.

    According to the brand, the summer season is a time when women need to take extra care, as the skin around the intimate area becomes more sensitive and can easily feel uncomfortable.

    The product has completed a gynaecological skin test to ensure that “all women can use it safely” on a daily basis. Based on results of the test, it is suitable for use on the vulva area, with its skin safety grade being rated as “very good”.

    Its key ingredient is AMPamide, Neopharma’s proprietary ingredient that has been proven to soothe and alleviate inflammation, to help manage skin irritated by friction and humidity.

    In addition, it contains plant-based cleansing ingredients derived from coconut and corn, and a synbiotic formula combining probiotics and prebiotics that helps maintain Y-zone skin health.

    “The hypoallergenic, weakly acidic foam gently acts on Y-zone skin without friction, expels 99% of three types of harmful bacteria (Candida, Escherichia coli, and Staphylococcus aureus), and even eliminates unpleasant odours caused by sweat and secretions,” Atopalm said.

    A human application test found that the product has a soothing effect of 70.03% on skin damaged by external stimuli.

    It has also completed a 7-second cleansing power test, where it showed that the ingredients will be washed off cleanly without leaving any residue, if the user rinses the skin under running water for seven seconds after using the product.

    “The Mild & Soothing Feminine Cleanser does not contain any of the ‘10 ingredients harmful to the skin’ and is formulated only with ingredients that have received an EWG Green Grade, so any woman over the age of four can use it safely every day.”

    Derma:B’s Balance FIT range is targeted at improving body swelling and cellulite. (Neopharm)

    Balancing act

    Neopharm’s body care brand Derma:B has released a new range called Balance FIT that claims to help “create a balanced body line” for those concerned about swelling and cellulite, which are difficult to resolve through diet alone.

    The two products, Body Cream and Body Serum, were sold for the first time on a live broadcast by leading Korean fashion store Musinsa on June 5.

    A core ingredient of the Balance FIT line is the patented PPC Complex, consisting of polydeoxyribonucleotide (PDRN), peptide, and collagen.

    “The 99% pure low-molecular vegan PDRN activates collagen synthesis to improve decreased skin elasticity. Similarly, the low-molecular liposome peptide promotes collagen and elastin synthesis, while the ultra-pure nano collagen of 300Da size is effectively absorbed into the skin and helps improve elasticity.”

    Additionally, the Body Cream contains pumpkin extract and mate leaf extract that are said to aid in relieving swelling. Its cream texture allows for smooth application, and it is more effective when gently massaged on areas that often swell, such as the calves.

    In a human application test, it was evaluated to improve calf swelling after just one use, with the effect being ascertained both visually and through a calf circumference reduction test. It was also found that sock marks were less formed and disappeared quickly after application of the product.

    Targeted at ameliorating cellulite, the Body Serum is formulated with garcinia extract, banana leaf extract, and green tea catechins to moisturise the skin and enhance skin texture.

    Its temporary cellulite improvement effect on the thighs as well as elasticity improvement effect on the upper arms were confirmed after eight weeks of use in a human application test.

    Furthermore, the abdominal elasticity of participants had an 11.82% improvement after a one-time use of the product, suggesting its efficacy in body tightening.

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  • Strict monitoring of all routes of Muharram processions ordered – Pakistan

    Strict monitoring of all routes of Muharram processions ordered – Pakistan

    LAHORE: Punjab Information Minister and in-charge of Muharram Arrangements for Faisalabad Division, Azma Bokhari, visited Chiniot to review the administrative and security preparations for the sacred month of Muharram.

    At the Deputy Commissioner’s Office, DC Safiullah Gondal and DPO Abdullah Ahmad briefed the minister on the ongoing arrangements.

    Addressing the officials, Azma Bokhari gave clear directives, stating that providing protection and essential facilities to mourners is the top priority of the Punjab Government. No negligence or loophole will be tolerated under any circumstances.”

    Meeting with procession organizers and license holders, the minister emphasized that the Muharram teaches us patience, harmony, and unity. On the directions of Chief Minister Maryam Nawaz Sharif, we are actively working across all districts to ensure peace and smooth arrangements at every level.”

    She noted that strict monitoring of all routes of processions and religious gatherings is in progress. Flashpoints are on high alert, security agencies are in full coordination, and scholars from Peace Committees are in close contact. She said a zero-tolerance policy is in place for those spreading hate or incitement on social media. A dedicated team is monitoring online activity 24/7, and no miscreant will escape legal action.”

    She also shared that CCTV surveillance is active along procession routes. Facilities such as mobile hospitals, clinics-on-wheels, and water sprinklers are available for the convenience of mourners. “This is not just a religious responsibility; it is a national duty to maintain peace and order, and it requires joint efforts from all segments of society, she said.”

    The minister added that she would remain present in the Faisalabad Division until the conclusion of Ashura processions and gatherings. She appreciated the performance of the Chiniot administration and expressed satisfaction over the arrangements made by local organizers.

    Speaking to the media, Azma highlighted the progress under the Punjab Development Program, stating: “Streets are being built across the province, villages are being turned into model villages, and sewerage systems are being upgraded.” She concluded by saying that with collective efforts, we will promote exemplary peace, tolerance, and unity during the sacred days of Muharram.”

    Copyright Business Recorder, 2025

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  • First Step Towards an Artificial Human Genome Now Underway

    First Step Towards an Artificial Human Genome Now Underway

    As if sequencing a full human genome wasn’t tricky enough, scientists are now attempting to reconstruct our species’ genetic material from the ground up.

    It’s an ambitious and controversial project called the Synthetic Human Genome (SynHG) project, and work has already begun on a proof-of-concept.

    The goal of this crucial first step is to use the human genome blueprint to write the genetic code for a single, enormously long strand of DNA in just one of our chromosomes – making up approximately 2 percent of our total genome.

    The entire DNA content will be digitally designed before it is then built in the lab.

    According to proponents, this project could kickstart a genetic revolution, profoundly changing our understanding of human DNA and possibly enabling designer cell-based therapies and virus-resistant tissue transplantation.

    Related: Scientists Just Achieved a Major Milestone in Creating Synthetic Life

    Emboldened by these futuristic possibilities, the Wellcome Trust – one of the world’s largest scientific research charities – announced this week that it was funding the SynHG initiative with £10 million (approximately US$13.7 million).

    YouTube Thumbnail

    Researchers behind the project, who hail from the Universities of Oxford, Kent, Manchester, Cambridge, and Imperial College London, told the BBC that “the sky is the limit”. They aim to build a fully synthetic human chromosome in the next five to 10 years.

    “The ability to synthesize large genomes, including genomes for human cells, may transform our understanding of genome biology and profoundly alter the horizons of biotechnology and medicine,” says project leader and molecular biologist Jason Chin from the Ellison Institute of Technology and Oxford.

    “With SynHG we are building the tools to make large genome synthesis a reality.”

    Some independent scientists, however, are dubious that the SynHG project can get that far, even with cutting-edge generative AI and advanced robotic assembly technologies.

    Award-winning geneticist Robin Lovell-Badge from the Francis Crick Institute, who is not involved in the SynHG project, says that he is “very enthusiastic” about the initiative, as “you can only truly understand something if you can build it from scratch.”

    But despite all the knowledge we have gained since fully sequencing and reading the human genome in 2003, he says there is still a lot of work to be done before we can actually build a complete one.

    Today, the only human-made genomes fully written from scratch are for single-celled organisms that have, at most, 16 chromosomes made from roughly 12 million base pairs. That accomplishment took roughly a decade of hard work.

    Humans, by comparison, typically possess more than 30 trillion cells with 46 chromosomes and 3 billion base pairs. Who knows how long it will take scientists to untangle that level of complexity?

    YouTube Thumbnail

    YouTube Thumbnail

    “As for synthetic human chromosomes, although the current project is very unlikely to get that far, it may eventually be possible to make synthetic cells that can be grown in the lab with high efficiency,” says Lovell-Badge.

    “However, there is no suggestion to make synthetic humans. We have no idea how to do this, and it is likely to be very unsafe.”

    While the details are hazy, the SynHG team claims to be working with academic, civil society, industry, and policy experts to examine the ethical, legal, and social implications of their research.

    Projects like these are bound to inspire social and ethical debates on the possibilities and consequences of complex health and reproductive issues, from the right to make ‘designer’ babies to the definition of eugenics.

    “We must recognize that this sort of work is not without controversy, and that is vital for researchers and the public to be in communication with one another,” says Sarah Norcross, director of the Progress Educational Trust (PET), which is a charity for people affected by genetic conditions.

    “The public must have a clear understanding of what this research entails, while researchers and funders must have a thoroughgoing understanding of where the public wants to go with this science.”

    Related News

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  • First Step Towards an Artificial Human Genome Now Underway : ScienceAlert

    First Step Towards an Artificial Human Genome Now Underway : ScienceAlert

    As if sequencing a full human genome wasn’t tricky enough, scientists are now attempting to reconstruct our species’ genetic material from the ground up.

    It’s an ambitious and controversial project called the Synthetic Human Genome (SynHG) project, and work has already begun on a proof-of-concept.

    The goal of this crucial first step is to use the human genome blueprint to write the genetic code for a single, enormously long strand of DNA in just one of our chromosomes – making up approximately 2 percent of our total genome.

    The entire DNA content will be digitally designed before it is then built in the lab.

    According to proponents, this project could kickstart a genetic revolution, profoundly changing our understanding of human DNA and possibly enabling designer cell-based therapies and virus-resistant tissue transplantation.

    Related: Scientists Just Achieved a Major Milestone in Creating Synthetic Life

    Emboldened by these futuristic possibilities, the Wellcome Trust – one of the world’s largest scientific research charities – announced this week that it was funding the SynHG initiative with £10 million (approximately US$13.7 million).

    frameborder=”0″ allow=”accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share” referrerpolicy=”strict-origin-when-cross-origin” allowfullscreen>

    Researchers behind the project, who hail from the Universities of Oxford, Kent, Manchester, Cambridge, and Imperial College London, told the BBC that “the sky is the limit”. They aim to build a fully synthetic human chromosome in the next five to 10 years.

    “The ability to synthesize large genomes, including genomes for human cells, may transform our understanding of genome biology and profoundly alter the horizons of biotechnology and medicine,” says project leader and molecular biologist Jason Chin from the Ellison Institute of Technology and Oxford.

    “With SynHG we are building the tools to make large genome synthesis a reality.”

    Some independent scientists, however, are dubious that the SynHG project can get that far, even with cutting-edge generative AI and advanced robotic assembly technologies.

    Award-winning geneticist Robin Lovell-Badge from the Francis Crick Institute, who is not involved in the SynHG project, says that he is “very enthusiastic” about the initiative, as “you can only truly understand something if you can build it from scratch.”

    But despite all the knowledge we have gained since fully sequencing and reading the human genome in 2003, he says there is still a lot of work to be done before we can actually build a complete one.

    Today, the only human-made genomes fully written from scratch are for single-celled organisms that have, at most, 16 chromosomes made from roughly 12 million base pairs. That accomplishment took roughly a decade of hard work.

    Humans, by comparison, typically possess more than 30 trillion cells with 46 chromosomes and 3 billion base pairs. Who knows how long it will take scientists to untangle that level of complexity?

    YouTube Thumbnail frameborder=”0″ allow=”accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share” referrerpolicy=”strict-origin-when-cross-origin” allowfullscreen>

    “As for synthetic human chromosomes, although the current project is very unlikely to get that far, it may eventually be possible to make synthetic cells that can be grown in the lab with high efficiency,” says Lovell-Badge.

    “However, there is no suggestion to make synthetic humans. We have no idea how to do this, and it is likely to be very unsafe.”

    While the details are hazy, the SynHG team claims to be working with academic, civil society, industry, and policy experts to examine the ethical, legal, and social implications of their research.

    Projects like these are bound to inspire social and ethical debates on the possibilities and consequences of complex health and reproductive issues, from the right to make ‘designer’ babies to the definition of eugenics.

    “We must recognize that this sort of work is not without controversy, and that is vital for researchers and the public to be in communication with one another,” says Sarah Norcross, director of the Progress Educational Trust (PET), which is a charity for people affected by genetic conditions.

    “The public must have a clear understanding of what this research entails, while researchers and funders must have a thoroughgoing understanding of where the public wants to go with this science.”

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  • Quad ministers condemn April attack in Indian Kashmir without naming Pakistan – Reuters

    1. Quad ministers condemn April attack in Indian Kashmir without naming Pakistan  Reuters
    2. Quad ministers condemn Pahalgam attack without naming Pakistan  Dawn
    3. ‘Nuclear blackmail can’t stop us from responding’: India in its message to US on Pakistan-sponsored terror  The Economic Times
    4. Straight Talk | Modi’s Playbook For Quad: Shaming Pakistan, Countering China And Dismissing Trump | Opinion News  News18
    5. Time to call out state-sponsored terrorism: Indian EAM’s ‘veiled attack’ on Pakistan at UN  Asia News Network

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  • New cutting-edge software can help uncover hidden features of childhood heart tumors

    New cutting-edge software can help uncover hidden features of childhood heart tumors

    New cutting-edge software developed in Melbourne can help uncover how the most common heart tumor in children forms and changes. And the technology has the potential to further our understanding of other childhood diseases, according to a new study.

    The research, led by Murdoch Children’s Research Institute (MCRI) and published in Genome Biology, found the software, VR-Omics, can identify previously undetected cell activities of cardiac rhabdomyoma, a type of benign heart tumor.

    Developed by MCRI’s Professor Mirana Ramialison, VR-Omics is the first tool capable of analysing and visualising data in both 2D and 3D virtual reality environments. The innovative technology aims to analyse the spatial genetic makeup of human tissue to better understand a specific disease.

    Cardiac rhabdomyoma, usually detected during pregnancy or infancy, doesn’t cause health problems in most cases. But in some babies and children the tumors can grow and block blood flow to vital organs, causing respiratory distress, irregular heartbeat, obstructions and heart failure.

    When the tumors cause severe health complications, treatment options are limited and include surgically removing part of the heart, which may lead to further complications and death. Unfortunately, it’s not well understood why these tumors form.”


    Professor Mirana Ramialison, MCRI

    To challenge her new software, Professor Ramialison and her team, including Denis Bienroth and Natalie Charitakis, analysed heart tissue from three children in Melbourne with cardiac rhabdomyoma. In a breakthrough, the research uncovered specific underlying features of the tumor that hadn’t been identified previously.

    Professor Ramialison said the VR-Omics tool would help researchers to gain a better insight into the disease.

    “VR-Omics generates 3D visualisations of the cells within human tissue based on large collections of patient data,” she said. This could allow for greater analysis of human tissue compared to other methods.”

    Professor Ramialison also benchmarked the software against existing state-of-the-art methods, finding it performed better in all analysis steps.

    “VR-Omics has a unique capacity to analyze large datasets, which allows it to explore new biological mechanisms in rare tissue sections, like those from cardiac rhabdomyoma,” she said. The technology will enable more biological discoveries that could help better understand many childhood conditions.”

    Researchers from the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen), the University of Konstanz in Germany, Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of Melbourne and Monash University also contributed to the findings.

    Source:

    Murdoch Childrens Research Institute

    Journal reference:

    Bienroth, D., et al. (2025). Automated integration of multi-slice spatial transcriptomics data in 2D and 3D using VR-Omics. Genome Biology. doi.org/10.1186/s13059-025-03630-6.

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