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  • Manipulating Light at the Nanoscale Improves Biosensing

    Manipulating Light at the Nanoscale Improves Biosensing

    Traditional medical tests often require clinical samples to be sent off-site for analysis in a time-intensive and expensive process. Point-of-care diagnostics are instead low cost, easy-to-use, and rapid tests performed at the site of patient care. Recently, researchers at the Carl R. Woese Institute for Genomic Biology reported new and optimized techniques to develop better biosensors for the early detection of disease biomarkers.

    People have long been fascinated with iridescence of peacock feathers, appearing to change color as light hits them from different angles. With no pigments present in the feathers, these colors are a result of light interactions with nanoscopic structures, called photonic crystals, patterned across the surface of the feathers. 

    Inspired by biology, scientists have harnessed the power of these photonic crystals for biosensing technologies due to their ability to manipulate how light is absorbed and reflected. Because their properties are a result of their nanostructure, photonic crystals can be precisely engineered for different purposes.

    The Nanosensors Group at the University of Illinois Urbana-Champaign, led by Professor of Electrical and Computer Engineering Brian Cunningham (CGD leader), previously developed photonic crystal-based biosensors that amplify the fluorescence using gold nanoparticles, which act as tags for sensing various molecular biomarkers. But while this innovative technology enables low-level detection of biomarker molecules, it still has room for further improvement.

    “Traditionally, metal nanoparticles, especially gold, offer the potential for fluorescence enhancement, but suffer from a fundamental flaw at close range,” said Seemesh Bhaskar, an IGB fellow in the CGD research theme and lead author of the study. “These nanoparticles can quench— or decrease—the very fluorescence signals they aim to amplify. This creates a dead zone of detection, limiting the sensitivity of biosensors.”

    In a paper published in MRS Bulletin, the research team aimed to overcome this limitation by introducing a new class of cryosoret nanoassemblies; these organized structures comprised of gold nanoparticle subunits are formed via rapid cryogenic freezing. 

    “Self-assembly is a fundamental principle of nature, whether it’s the formation of planetary systems in cosmology or the precise organization of nucleotides in DNA,” Bhaskar said. “What individual nanoparticles cannot accomplish alone becomes possible through their collective organization. At its core, it’s about engineering optical behavior—both structurally and functionally—through deliberate design.”

    By integrating these cryosoret nanoassemblies with specially designed photonic crystals, the fluorescence demonstrated a 200-fold signal enhancement compared to the photonic crystal alone. This showed that fluorescence quenching was effectively minimized, making this technology a promising avenue for detecting low concentrations of biomarkers.

    Building upon this work, the team next sought to introduce magnetic tunability into the nanoassemblies, with the long-term goal of developing intelligent, responsive biosensors.

    Light is a specific frequency range of electromagnetic radiation; other examples include radio waves, microwaves, and X-rays. Electromagnetic radiation travels through space in the form of waves, and as its name suggests, consists of both electrical and magnetic components. While many biosensing systems take advantage of the electrical component of light, the magnetic component is largely overlooked.

    In a study reported in the journal APL Materials, Bhaskar and his colleagues designed magneto-plasmonic cryosoret nanoassemblies. They integrated these nanoassemblies onto a photonic crystal interface and found that it successfully harnessed both the electric and magnetic components of light. They tested their platform using a common fluorophore, which resulted in ultra-sensitive detection in the attomolar range, while still minimizing fluorescence quenching. 

    Overall, this dual-mode interaction allows for enhanced control over light-matter interactions at the nanoscale, offering a new method to design highly sensitive and tunable biosensing platforms.

    “This work represents a hybrid optical platform where photons are not merely emitted—they are orchestrated,” Cunningham said. “This convergence of photonic-plasmonic simulations, advanced nanofabrication, and chemical engineering principles has far-reaching implications, particularly in the realm of medical diagnostics.”

    Moving forward, the researchers plan to continue optimizing the cryosoret nanoassemblies to target specific biomarkers, like microRNAs, circulating tumor DNA, and viral particles, for early detection of cancer and infectious disease. They hope that with further improvement, point-of-care technologies can meet the pressing need for sensitive, accessible, and deployable biosensing systems.

    Reference: Bhaskar S, Liu L, Liu W, et al. Photonic crystal band edge coupled enhanced fluorescence from magneto-plasmonic cryosoret nano-assemblies for ultra-sensitive detection. APL Materials. 2025;13(4):041103. doi: 10.1063/5.0251312

    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

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  • The 2025 British Grand Prix – presented by OKX

    The 2025 British Grand Prix – presented by OKX

    Why we love the British Grand Prix

    The fans, of course. This weekend’s race in Silverstone is one of the most hotly anticipated, well-attended races of the entire season. No circuit has more grandstands than Silverstone, and this year, there’s even one dedicated solely to Lando fans, aptly named ‘Landostand’. Around 480,000 of you joined us at the home of British racing, last year.

    At Silverstone, it’s quality as well as quantity. By now, Britain’s beloved summer of sport, which this year will include the upcoming Women’s Rugby World Cup, The Hundred cricket tournament, and of course the already-underway Wimbledon tennis Championships, is in full swing. At Silverstone, fans never fail to create a racket, generating a party-like atmosphere.

    We’re always well-represented at the British Grand Prix, but increasingly so in recent years, with our Castore, Reiss, and Abercrombie & Fitch ranges all well sported by fans throughout the circuit, along with plenty of New Era caps and SunGod shades.

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  • DLA Piper advises Ping An Insurance on HKD11.765 billion convertible bond issuance

    DLA Piper has advised its long-standing client Ping An Insurance (Group) Company of China, Ltd. (Ping An) on its successful issuance of HKD11.765 billion (approximately USD1.53 billion) in convertible bonds. This deal is the biggest convertible bond issuance denominated in US dollars or Hong Kong dollars by a Chinese company this year.

    Ping An is one of the largest and most innovative insurance and financial services companies in the world. These convertible bonds, which are due in 2030, carry a zero coupon, and will be listed on the Open Market of the Frankfurt Stock Exchange and convertible into the H shares listed in Hong Kong. The proceeds from this issuance will be used to further develop Ping An’s core business and strengthen its capital position, support new strategic initiatives in the healthcare and elderly care sectors, and for general corporate purposes.

    The deal follows DLA Piper’s earlier advisory role in Ping An’s landmark USD3.5 billion convertible bonds issuance in July 2024, which set multiple records as the largest Reg-S-only convertible bond, the largest convertible bond in the insurance sector, and the first offshore convertible bond ever issued by a Chinese insurance company. The deal was recognized as “Deal of the Year” by China Business Law Journal.  Together, these deals highlight Ping An’s agility in leveraging diverse funding avenues and DLA Piper’s expertise in advising complex, record-setting transactions.

    The DLA Piper team was led by Roy Chan, Senior Partner and Co-Country Managing Partner in China; Philip Lee, Head of Capital Markets, Asia Pacific and Regional Head of DLA Piper’s Financial Services sector in Asia; and Vivian Liu, Head of Capital Market Compliance for Greater China. They were supported by senior associates Yingshi Pan and Le Jing Ong and consultants Daina Wang and Ivy Zou.

    Roy Chan commented: “We are delighted to have supported Ping An on another significant transaction. This issuance not only underscores Ping An’s strong market position but also highlights the growing importance of convertible bonds as a financing tool for leading companies in the region.”

    Vivian Liu added: “Our cross-border team worked seamlessly to ensure the successful execution of this complex transaction, demonstrating our firm’s capability to handle high-profile deals across multiple jurisdictions.”

    Philip Lee stated: “This transaction reflects our commitment to providing top-tier legal services to our clients in the financial sector. We look forward to continuing our support for Ping An as they pursue their strategic objectives.”

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  • More than 400 media figures urge BBC board to remove Robbie Gibb over Gaza | BBC

    More than 400 media figures urge BBC board to remove Robbie Gibb over Gaza | BBC

    More than 400 stars and media figures including Miriam Margolyes, Alexei Sayle, Juliet Stevenson and Mike Leigh have signed a letter to BBC management calling for the removal of a board member, Robbie Gibb, over claims of conflict of interest regarding the Middle East.

    The signatories also include 111 BBC journalists and Zawe Ashton, Khalid Abdalla, Shola Mos-Shogbamimu and the historian William Dalrymple, who express “concerns over opaque editorial decisions and censorship at the BBC on the reporting of Israel/Palestine”.

    Delivered on the eve of Channel 4’s airing of the documentary Gaza: Doctors Under Attack, which the BBC commissioned but shelved as it said it “risked creating a perception of partiality”, the letter alleges the decision to drop the film “demonstrates, once again, that the BBC is not reporting ‘without fear or favour’ when it comes to Israel”.

    The letter accuses Robbie Gibb of having a conflict of interest on Gaza. Photograph: James Veysey/Rex/Shutterstock

    It also accuses the BBC of being “crippled by the fear of being perceived as critical of the Israeli government” and claims the “inconsistent manner in which guidance is applied draws into focus the role of Gibb, on the BBC Board and BBC’s editorial standards committee” as “we are concerned that an individual with close ties to the Jewish Chronicle … has a say in the BBC’s editorial decisions in any capacity, including the decision not to broadcast Gaza: Medics Under Fire”.

    Gibb, Theresa May’s former spin doctor and a former head of the BBC’s Westminster political team, led the consortium that bought the Jewish Chronicle in 2020 and, up until August 2024, was a director of Jewish Chronicle Media.

    The letter, organised by a group of BBC insiders, says: “For many of us, our efforts have been frustrated by opaque decisions made at senior levels of the BBC without discussion or explanation. Our failures impact audiences.

    “As an organisation we have not offered any significant analysis of the UK government’s involvement in the war on Palestinians. We have failed to report on weapons sales or their legal implications. These stories have instead been broken by the BBC’s competitors.”

    The statement alleges Gibb has a “conflict of interest” which “highlights a double standard for BBC content makers who have themselves experienced censorship in the name of ‘impartiality’.”

    It adds: “In some instances staff have been accused of having an agenda because they have posted news articles critical of the Israeli government on their social media. By comparison, Gibb remains in an influential post with little transparency regarding his decisions despite his ideological leanings being well known. We can no longer ask licence fee payers to overlook Gibbs’s ideological allegiances.”

    The letter concludes: “We, the undersigned BBC staff, freelancers and industry figures are extremely concerned that the BBC’s reporting on Israel and Palestine continues to fall short of the standards our audiences expect. We believe the role of Robbie Gibb, both on the board, and as part of the editorial standards committee, is untenable. We call on the BBC to do better for our audiences and recommit to our values of impartiality, honesty and reporting without fear or favour.”

    Owing to their fear of repercussions, the 111 BBC journalists signed anonymously.

    A BBC spokesperson said: “Robust discussions amongst our editorial teams about our journalism are an essential part of the editorial process. We have ongoing discussions about coverage and listen to feedback from staff and we think these conversations are best had internally.

    “Regarding our coverage of Gaza, the BBC is fully committed to covering the conflict impartially and has produced powerful coverage from the region. Alongside breaking news, ongoing analysis, and investigations, we have produced award winning documentaries such as Life and Death in Gaza, and Gaza 101.”

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  • Nikon Z9 Mirrorless Flagship with FTZ II Adapter Now $4,600 on Amazon Renewed

    Nikon Z9 Mirrorless Flagship with FTZ II Adapter Now $4,600 on Amazon Renewed

    The Nikon Z9 for $4,600? That’s a Pro-Level Steal. If you’ve been waiting for the right moment to invest in Nikon’s flagship mirrorless beast, the moment has arrived. The Nikon Z9 Mirrorless Camera with the FTZ II Adapter Kit is now available on Amazon Renewed for only $4,600 — a major drop for a camera that continues to push the boundaries of hybrid cinematography and professional stills. Grab it here on Amazon Renewed. This price isn’t just attractive. It’s a golden opportunity for filmmakers and photographers looking to step into Nikon’s most advanced system without the premium price tag.

    Filmmaking with the Nikon Z9. 8K N-RAW. Picture: Nikon
    Filmmaking with the Nikon Z9. 8K N-RAW. Picture: Nikon

    See the Nikon Z9 on Amazon Renewed

    Even in the face of upcoming successors like the Z9 Mark II (explored in The Nikon Z9 Mark II: What to Expect from Nikon’s Next Mirrorless Flagship), the original Z9 remains an industry powerhouse.

    It delivers:

    • Full-frame 8K video at up to 60p

    • No mechanical shutter for silent operation and fewer moving parts

    • Advanced AF tracking powered by deep learning

    • Dual CFexpress card slots for robust workflows

    • Superb build quality trusted by pros in the field

    The inclusion of the FTZ II Adapter means users can seamlessly use Nikon’s legacy F-mount lenses with full autofocus capabilities — perfect for hybrid shooters with a legacy lens collection.

    Nikon Z9Nikon Z9
    Nikon Z9

    Buying from Amazon Renewed means the gear has been professionally inspected, tested, and cleaned by qualified vendors. Plus, it’s backed by Amazon’s satisfaction guarantee, so there’s peace of mind with that savings. In a similar spotlight, we previously covered a gem of a deal in The Canon EOS-1D X Mark II for Just $1,800 on Amazon Renewed: showing that renewed gear is becoming a serious option for serious creatives.

    Nikon Z9Nikon Z9
    Nikon Z9

    With the Nikon Z9 still dominating the field and the price of entry now dramatically lower, this deal is too good to ignore. Whether you’re a cinematographer looking for 8K RAW power or a photographer seeking uncompromising autofocus and speed, this is your chance to level up your kit without draining your wallet. Check the Nikon Z9 Renewed deal now

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  • The inside story of the wildest shoot in film history

    The inside story of the wildest shoot in film history

    Alamy A still of Martin Sheen wearing an army hat in Apocalypse Now (Credit: Alamy)Alamy

    No production has been as troubled as the 1979 war epic. As behind-the-scenes documentary Hearts of Darkness is re-released, its director, and two of those who were on set, reveal all.

    “The way we made it was very much like the way the Americans were in Vietnam,” explained Francis Ford Coppola, after the Cannes Film Festival screening of Apocalypse Now in 1979. “We were in the jungle. There were too many of us. We had access to too much money, too much equipment, and, little by little, we went insane.”

    While the troubled production of Coppola’s epic, brutal, psychedelic war film had been well documented in the press while it was being made – from finance issues to actors being re-cast, and health problems to extreme weather – it would not be until 1991 that the true extent of the chaos would become clear via Hearts of Darkness: A Filmmaker’s Apocalypse.

    Alamy The shoot was meant to last five months – but ended up taking over a year (Credit: Alamy)Alamy

    The shoot was meant to last five months – but ended up taking over a year (Credit: Alamy)

    The documentary was assembled from extensive footage that Coppola’s wife Eleanor shot while on set, depicting a film production that while breathtaking in scope, ambition and vision, was equally messy, drug-addled, and riddled with seemingly insurmountable setbacks. Fax Bahr and the late George Hickenlooper were the two young directors tasked with combing through reel after reel to piece together the madness and tell the gripping story of the film’s making. Now that film, having undergone a 4K restoration, is back in US and UK cinemas from this weekend.

    Bahr still recalls the first day he saw Coppola’s footage, which had been sitting, largely untouched, for over a decade. “Some of the reports had been, ‘Oh, there’s a lot of out-of-focus stuff,’” he tells the BBC. “But the reels we looked at were extraordinary. Just beautiful footage. Clearly, she had been copiously recording everything that was happening. It was absolute gold.”

    The long list of troubles

    Apocalypse Now, loosely based on the 1899 novella Heart of Darkness by Joseph Conrad, is considered one of the greatest works in cinematic history. However, it nearly fell apart at various stages. With filming starting in the Philippines in March 1976, it was initially set to be a five-month shoot – but in the end would last over a year. Coppola fired his leading man, Harvey Keitel, a few weeks in, and replaced him with Martin Sheen, who then suffered a near-fatal heart attack on location. Expensive sets were totally destroyed by a typhoon, and some actors were infected with hookworm parasites, while others leaned into heavy partying and drug-taking on set.

    Then Marlon Brando, who was playing the AWOL Colonel Kurtz, showed up on set heavily overweight and completely unprepared, which forced Coppola to re-write and shoot the ending of the film to suit him. As time went on, the film was so drastically over budget that Coppola took on the role of financing it himself, which would have ruined him had it not made its money back. According to Eleanor Coppola’s book, Notes, even after the shoot had wrapped, during post-production, Coppola only gave himself a 20% likelihood that he could pull out a credible film from the wreckage.

    Every day it would rain. It would rain like it was mad at you. It would rain sheets like I had never seen before – Damien Leake

    The documentary paints a picture of a production that sets out to recreate the Vietnam war and, in many ways, ends up mirroring many of the same patterns of behaviour that took place among soldiers. One person suitably placed to make such a comparison is Chas Gerretsen, the Dutch war photographer and photojournalist who was brought onto the set for six months (the results were collected in the 2021 book Apocalypse Now: The Lost Photo Archive.) “Vietnam was insane, Apocalypse Now only slightly less so,” Gerretsen tells the BBC. 

    The harsh conditions were totally alien to most people there. “The crew complained a lot about the heat, humidity, hotel rooms, bugs, mosquitoes,” he says. “The mud – sometimes knee-deep – was a real challenge.” Damien Leake, who played a machine gunner in the film, was on set for three weeks and similarly remembers the physical as being unlike anything he had encountered. “The first thing I remember is getting off the plane and the humidity hits you like a wet mop,” he tells the BBC. “Having been from New York, I know humidity, but this was unbelievable.” The water was not safe to drink, geckos climbed the walls of the hut he stayed in, and the weather was biblical. “Every day it would rain,” he says. “It would rain like it was mad at you. It would rain sheets like I had never seen before.”

    STUDIOCANAL Francis Ford Coppola on set with his wife Eleanor, whose footage forms the core of Hearts of Darkness (Credit: STUDIOCANAL)STUDIOCANAL

    Francis Ford Coppola on set with his wife Eleanor, whose footage forms the core of Hearts of Darkness (Credit: STUDIOCANAL)

    As the production dragged on, it became tough for the cast and crew, who started to miss life back home. “They were pretty much like the soldiers in Vietnam, who had never been further away from home than Canada,” recalls Gerretsen. “There was a lot of homesickness. One member of the crew went nearly every weekend to Manila – a three-to-four-hour trip, each way, over a bad road – and rented a hotel room overlooking the airport, just watching planes take off for the USA.”

    It was such a unique film in film-making history. I don’t think anybody will ever be able to do anything like that again – Fax Bahr

    Coppola’s vision was crumbling more and more as time went on. In particular, he couldn’t nail the ending of the film which, to this day, varies in several different edits and versions of the film. “I call this whole movie the Idiodyssey,” Coppola said at the time, as recorded in Hearts of Darkness. “None of my tools, none of my tricks, none of my ways of doing things works for this ending. I have tried so many times that I know I can’t do it. It might be a big victory to know that I can’t do it. I can’t write the ending to this movie.” However, his cast seemingly stayed loyal and committed. “Actors would walk through fire for Francis,” says Leake, “because he gives them such leeway and such a sense of them being able to make this [scene/character] their own. Then he then shapes it into what he wants. You can’t ask for more than that.”

    While homesickness plagued many, Leake had a different experience. He calls his time on the shoot “the most glorious three weeks of my life. I would go hang out with Filipino people, which I adored. I thought they were wonderful. I fell in love with a beautiful girl and if I had had a bigger part in the film, I’d probably still be there. I loved it that much.”

    Telling the behind-the-scenes story 

    Once Bahr began to work through all the footage, it was only then that it sunk in just how miraculous it was that this film existed at all. “I knew that it was an extremely challenging film to pull off, but until you get into the nitty gritty of the footage, you couldn’t really understand the horrendous obstacles that they kept facing.”

    As such, the task Bahr had in telling the story behind the story was a challenge itself, requiring him to dig through around 80 hours of footage. “The first cut of the documentary was four and a half hours,” he explains. “Because Ellie (Coppola) kept shooting after the production was over, we had a whole post-production section [in the original cut].” And of course, there was plenty of drama during that process, even when Coppola and his team were out of the jungle and back in the comfort of a studio. “One of the editors absconded with the print and holed up in a hotel room,” Bahr recalls. “Nobody could find him and they thought that the whole thing was stolen. Then he would send back burned celluloid in envelopes saying, ‘I’m getting rid of the film, scene by scene’. They were just freaking out.” Thankfully, the creative differences that had caused the rift and theft were resolved before any serious damage was done.

    Alamy Marlon Brando, who played Colonel Kurtz, was notoriously erratic during filming (Credit: Alamy)Alamy

    Marlon Brando, who played Colonel Kurtz, was notoriously erratic during filming (Credit: Alamy)

    Bahr recalls the moment when he knew that the documentary had uncovered something foundational. “The discovery of the audio tapes that Ellie made of Francis was revelatory,” he says of the audio recordings that play out over scenes in the film. “Ellie was the only person on Earth who was capable of capturing Francis like that – up close and personal. This was putting you right here with an American master in his most private moments and it was a real glimpse into the very centre of creativity: its doubt, worry, angst, and working out these ideas. That was incredibly special.”

    Coppola gave Bahr and Hickenlooper his blessing to do what they wanted with the footage. His only instruction was: be honest. “He said, ‘There’s some ugly things that happened here, but as long as you tell the story honestly, I’ll support it.’” The only request he made was that the narration, which had been done by a voice actor, was re-recorded by his wife, given that the material was hers and, in many ways, this was a story seen through her eyes. It was a final masterstroke move that made the documentary feel like even more of a raw insider’s look at the film shoot. 

    “The nicest thing that anyone says to me about the documentary is that it’s a necessary accessory to understanding Apocalypse Now,” says Bahr. “People say, ‘Well, I saw Apocalypse Now and loved it, but after I saw your documentary, I understood it in a more comprehensive way.’ That’s the highest compliment possible.”

    For Bahr, Apocalypse Now exists as a total one-off. “It was such a unique film in film-making history,” he says. “I don’t think anybody will ever be able to do anything like that again. Not just because Francis was willing to stake his whole fortune on it, but also just because of the ambition. I mean, he intended to go to the Philippines and recreate Vietnam for the crew and have everybody in the company go through that experience. It was such a brilliant vision.”

    For Gerretsen, his experiences have become almost impossible to distinguish from his memories of actual war zones. “The explosions, the coloured smoke, the hours of waiting for the scene to be set up – everything is mixed,” he says. When he did watch the finished film, its impact was significant. “It was incredible in the way it brought it all back. It was a masterpiece, no doubt, but it would be several years before I could watch it again. Both the Vietnam and Cambodian wars, and Apocalypse Now, continue to be with me because the insanity of war is still with us.”

    Hearts of Darkness: A Filmmaker’s Apocalypse is in UK cinemas from 4 July, and will play at New York’s Film Forum from 4 July, and other US cinemas nationally from 18 July. A 4k Blu-ray collector’s edition will be available to buy in the UK from 28 July.

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  • Baker McKenzie Advises Bain Capital on the formation of a leading European Digital Transaction Management software platform | Newsroom

    Baker McKenzie Advises Bain Capital on the formation of a leading European Digital Transaction Management software platform | Newsroom

    Leading global law firm, Baker McKenzie, has advised Bain Capital on the entry into of exclusive negotiations for Signaturit to join the Namirial Group.

    The transaction remains subject to customary regulatory approvals and employee representative consultation.

    Namirial, which Bain Capital announced it was acquiring from Ambienta in March 2025 (closing expected in July 2025), is a leading provider of DTM software solutions. Signaturit is one of the leading providers of cloud-based DTM services in Southern Europe, offering solutions across digital identity management, Digital Signature, KYC & fraud prevention, and eID wallet. The combination of Namirial with Signaturit will create a leading Pan-European DTM provider with a leading position across Italy, Spain, France, and Germany with ~1,400 employees and serving ~240,000 customers worldwide.

    The Baker McKenzie team was led by Private Equity Partners Alex Lewis and David Allen (London) with support from Partners Michael Doumet (Paris) and Juanjo Corral (Madrid), Senior Associates Grace Blackburn and Oliver Feslier-Holmes (London) and Associates Kirstie Trup and Patrick Sharkey (London).

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  • Orthopedic surgeon says ‘even modest weight loss’ can reduce osteoarthritis risk: Here’s everything women should know | Health

    Orthopedic surgeon says ‘even modest weight loss’ can reduce osteoarthritis risk: Here’s everything women should know | Health

    According to the World Health Organisation (WHO), more than 60 percent of the 528 million people with osteoarthritis (OA) globally are women, and 73 percent of those affected are over the age of 55. The WHO reports that the knee is the most commonly affected joint, followed by the hip and hand. Also read | Nearly one billion people globally will have osteoarthritis by 2050: Lancet study

    Osteoarthritis (OA) is a common joint disorder that affects many women. (Freepik)

    In an interview with HT Lifestyle, Dr Sharmila Tulpule, orthopaedic surgeon, regenerative medicine specialist, and founder and director of Orthobiologix Biotech Pvt Ltd, said that osteoarthritis, long thought of as a ‘wear-and-tear’ disease, has become incredibly complex, especially for women.

    The prevalence of osteoarthritis, a type of joint disorder that occurs due to cartilage breakdown in the joints, is expected to increase with ageing populations and rising rates of obesity and injuries. By understanding the causes, symptoms, and treatment options for OA, you can take steps to manage the condition and improve your quality of life. 

    According to Dr Tulpule, below are the factors concerning osteoarthritis in women:

    Hormonal changes and menopause

    ● Estrogen decline during menopause accelerates cartilage degradation, increasing OA risk.

    ● Hormone replacement therapy (HRT) may offer some benefits but requires careful consideration due to potential risks.

    Obesity and metabolic factors

    ● Obesity is a significant risk factor for OA, particularly in weight-bearing joints like the knees.

    ● Excess weight increases joint stress and systemic inflammation, exacerbating OA symptoms.

    ● Even modest weight loss can reduce OA risk and improve joint function.

    Physical activity and joint health

    ● Regular, moderate physical activity strengthens muscles around joints, enhancing mobility and reducing pain.

    ● Conversely, sedentary lifestyles contribute to joint stiffness and muscle weakness.

    Mental health and quality of life

    ● OA can lead to depression and anxiety, particularly in women, affecting overall well-being.

    ● Addressing mental health is crucial for effective OA management and improving quality of life.

    By understanding the risk factors, symptoms, and treatment options for OA, women can take steps to manage the condition and improve their quality of life. (Freepik)
    By understanding the risk factors, symptoms, and treatment options for OA, women can take steps to manage the condition and improve their quality of life. (Freepik)

    What to know about regenerative therapies

    Dr Tulpule said, “Regenerative therapies offer a more holistic approach by addressing the underlying causes of OA rather than merely alleviating symptoms. They are particularly beneficial for women seeking alternatives to invasive surgeries and medications.”

    According to Dr Tulpule, stem cell therapy holds promise as a regenerative treatment for knee osteoarthritis, offering potential benefits in pain reduction and functional improvement. 

    Explaining platelet-rich plasma (PRP) therapy, Dr Tulpule said it utilises growth factors from the patient’s own blood to stimulate tissue repair and reduce inflammation. “Studies indicate that PRP can provide longer-term pain relief and functional improvement compared to traditional treatments like hyaluronic acid (HA) injections,” she said.

    Dr Tulpule added that gold-induced cytokine therapy is a novel regenerative treatment that involves incubating the patient’s own blood with gold particles, enhancing the anti-inflammatory and reparative properties of platelets. Studies have shown that it can lead to significant improvements in pain and function in patients with knee OA, with minimal adverse effects, she said.

    Management and prevention

    “For women, osteoarthritis is not just a joint issue — it intertwines with hormonal health, body weight, lifestyle, mental wellness, and occupational context,” Dr Tulpule said. 

    According to her, a nuanced approach means:

    1. Advocating early detection especially during menopause.

    2. Promoting preventive strategies combining diet, weight management, and exercise.

    3. Considering hormone-based therapies for symptomatic relief when appropriate.

    4. Supporting women’s mental health alongside physical care.

    5. Raising community awareness on how everyday activities shape OA risk.

    Dr Tulpule concluded, “By addressing the unique facets of OA in women, clinicians can shift from reactive interventions to proactive, personalised care. This not only delays disease progression, but preserves mobility, dignity, and quality of life for millions of women worldwide.”

    Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.

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  • Man with Rare Bat Virus in Critical Condition After Being ‘Bitten Several Months Ago,’ Say Authorities

    Man with Rare Bat Virus in Critical Condition After Being ‘Bitten Several Months Ago,’ Say Authorities

    NEED TO KNOW

    • A man in his 50s has been hospitalized in critical condition after contracting the Australian bat lyssavirus (ABLV) in New South Wales, Australia

    • This is the first confirmed case of the virus in the state and fourth overall in Australia, NSW Health announced

    • NSW Health Protection director Keira Glasgow called this case “a very tragic situation” in a statement following the diagnosis

    A man is in critical condition after contracting a rare bat virus in Australia.

    The first confirmed case of Australian bat lyssavirus (ABLV) has been reported in the state of New South Wales, involving a man in his 50s. He fell ill after being “bitten by a bat several months ago,” New South Wales Health announced in a release on Wednesday, July 2.

    “This is a very tragic situation. The man had been bitten by a bat several months ago and received treatment following the injury,” said NSW Health Protection director Keira Glasgow. “Further investigation is underway to understand whether other exposures or factors played a role in his illness.”

    ABLV is closely related to the rabies virus and is found in flying foxes, fruit bats and microbats. It is transmitted by bites from bats to humans, causing a potentially fatal illness that affects the central nervous system, according to NSW Health. The symptoms are flu-like, including a fever, headache and fatigue, which can develop into delirium, paralysis and death.

    In 2024, 118 people required medical assessment after being bitten or scratched by bats. ABLV was first identified in 1996 and there have since been four confirmed cases in Australia, NSW Health reported.

    Getty Rabies virus under a microscope

    Getty

    Rabies virus under a microscope

    NSW Heath is urging Australians not to handle or touch any bats after the first confirmed case of ABLV in the state in order to prevent the spread of the virus, as there is currently no cure.

    “It is incredibly rare for the virus to transmit to humans, but once symptoms of lyssavirus start in people who are scratched or bitten by an infected bat, sadly there is no effective treatment,” said Glasgow, per the release.

    The NSW Health director advises that if anyone is bitten or scratched by a bat to seek urgent medical assessment.

    “You will need to wash the wound thoroughly for 15 minutes right away with soap and water and apply an antiseptic with anti-virus action, such as betadine, and allow it to dry,” said Glasgow. “You will then require treatment with rabies immunoglobulin and rabies vaccine.”

    NSW Health said that if a bat appears to be in distress, injured or trapped “do not try to rescue it [and] instead, contact trained experts WIRES or your local wildlife rescue group.”

    Getty Flying fruit batGetty Flying fruit bat

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    This update comes as twenty new bat viruses have been discovered in China, posing serious risk to humans.

    According to a study published by the Public Library of Science (PLOS), researchers tested ten different species of 142 bats in China’s Yunnan province and discovered 20 new viruses, a new species of bacteria and a new type of parasite.

    Two of the viruses are similar to the deadly Hendra and Nipah viruses, the former of which causes a rare, flu-like reaction that can be fatal in humans and horses, according to the World Health Organization.

    Read the original article on People

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  • Bees’ secret to learning may transform how robots recognize patterns

    Bees’ secret to learning may transform how robots recognize patterns

    A tiny brain no bigger than a sesame seed may hold the key to transforming artificial intelligence (AI) and robotics, thanks to groundbreaking research revealing how bees use their flight movements to enhance learning and recognition.

    Scientists at the University of Sheffield have uncovered that bees don’t just passively see the world – they actively shape their visual perception through body movements during flight.

    By building a computational model that mimics a bee’s brain, researchers have demonstrated how the insect’s unique flight patterns generate distinct neural signals, enabling it to identify complex visual patterns, such as flowers or even human faces, with remarkable accuracy.

    “In this study we’ve successfully demonstrated that even the tiniest of brains can leverage movement to perceive and understand the world around them,’ said Professor James Marshall, a senior author on the study.

    “This shows us that a small, efficient system – albeit the result of millions of years of evolution – can perform computations vastly more complex than we previously thought possible,” he added.

    A comparison to the previous experiment

    The current experiment is an upgrade on the team’s previous attempts to understand how bees use active vision to collect and process information.

    Their earlier experiment dealt with studying how bees fly around and inspect certain patterns, while the current one sheds light on the underlying brain mechanisms driving that behavior.

    “In our previous work, we were fascinated to discover that bees employ a clever scanning shortcut to solve visual puzzles. But that just told us what they do; for this study, we wanted to understand how,” said Dr. HaDi MaBouDi, a researcher at the University of Sheffield.

    “Our model of a bee’s brain demonstrates that its neural circuits are optimised to process visual information not in isolation, but through active interaction with its flight movements in the natural environment, supporting the theory that intelligence comes from how the brain, bodies, and the environment work together,” he continued.

    Does brain size matter for intelligence?

    This question has sparked the interest of scientists for ages. Professor Lars Chittka from the University of London finally answered this question, courtesy to this experiment.

    “Scientists have been fascinated by the question of whether brain size predicts intelligence in animals. But such speculations make no sense unless one knows the neural computations that underpin a given task,” he revealed.

    “Here we determine the minimum number of neurons required for difficult visual discrimination tasks and find that the numbers are staggeringly small, even for complex tasks such as human face recognition. Thus, insect microbrains are capable of advanced computations,” he stated.

    This study, a collaboration with Queen Mary University of London, was published in the journal eLife.

    Can bees show the future path of AI?

    Inspired by the agility and endurance of bees, researchers at MIT have developed robotic insects designed to assist artificial pollination – an innovation that could transform agriculture.

    Weighing less than a paperclip, these robotic insects can also perform double aerial flips and complete acrobatic maneuvers while flying.

    The main aim is to have these robotic insects perform precise pollination that can help farmers grow fruits and vegetables inside multilevel warehouses. This could also help boost yields and mitigate some of agriculture’s harmful effects on the environment.

    By studying insect brains and behavior, researchers uncover intelligence principles inspiring new technologies. Building on this, MIT’s robotic pollinators mimic natural flight to improve agriculture, showcasing how biology guides advancements in AI and robotics for real-world solutions.

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