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  • Everton hoping to sign England winger Katie Robinson from Aston Villa

    Everton hoping to sign England winger Katie Robinson from Aston Villa

    Everton are closing in on an agreement to sign England winger Katie Robinson on loan from Aston Villa this summer, with an option to buy clause.

    The deal is not yet finalised but all parties are confident of an agreement with Robinson planning to carry out a medical at Everton on Wednesday.

    Robinson joined Villa on a free transfer from Brighton in 2024 and has a year remaining on her current contract.

    The 22-year-old was the youngest member of Sarina Wiegman’s Lionesses squad that reached the Women’s World Cup final in 2023.

    She made 16 appearances in all competitions for Villa last season but only started five matches under new manager Natalia Arroyo between January and May.

    Robinson impressed during her time at Brighton and is considered a young forward with high potential.

    Everton manager Brian Sorensen has worked with young English talent before, enjoying success with Chelsea’s Aggie Beever-Jones and Manchester City’s Jess Park in loan spells at the club.

    The Toffees are ambitious in this summer’s transfer window following the arrival of new owners The Friedkin Group and fresh investment.

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  • US SEC's guidance is first step toward rules governing crypto ETFs – Reuters

    1. US SEC’s guidance is first step toward rules governing crypto ETFs  Reuters
    2. SEC considers allowing crypto ETFs to launch without 19b-4 filing  Crypto Briefing
    3. SEC ETF Breakthrough: Simplifying the Token-Based ETF Listing Process  Bitget
    4. SEC Staff Shares Disclosure Guidance For Crypto ETPs  Law360
    5. Why The Pro-Crypto SEC Is Exploring Tokenized IPOs  Forbes

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  • South Africa’s Wiaan Mulder hits 367 … and declares 33 runs short of Lara’s Test record | South Africa cricket team

    South Africa’s Wiaan Mulder hits 367 … and declares 33 runs short of Lara’s Test record | South Africa cricket team

    South Africa’s Wiaan Mulder scored an unbeaten 367 against Zimbabwe before the stand-in captain remarkably declared 33 runs shy of Brian Lara’s Test record.

    In his first match as South Africa captain in place of the injured Keshav Maharaj, all-rounder Mulder reached the stunning total – the highest by a player in his first Test innings as captain – as he arrived at lunch with the team on 626 for five.

    But with Lara’s record in sight the captain declared. Mulder had been bowled when on 247 but was saved by a no-ball as Tanaka Chivanga overstepped.

    Lara’s 400 not out came against England at St John’s in 2004. Lara’s feat, which has stood for 21 years, is one of sport’s great records, beating the previous record of 380, set by Australia’s Matthew Hayden in 2003, who himself had beaten Lara’s record of 375, set in 1994.

    In June 1994 Lara also hit 501 for Warwickshire against Durham, which remains the highest first-class score of all time.

    Mulder reached his triple century in just 297 balls, making it the second-fastest 300 in Test history, behind Virender Sehwag’s famous 278-ball effort against South Africa in Chennai in 2008.

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    Mulder’s score also represents the highest by a South African, passing Hashim Amla’s 311 not out against England at the Oval in 2012.

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  • Jofra Archer poised to make England Test comeback against India at Lord’s | England v India 2025

    Jofra Archer poised to make England Test comeback against India at Lord’s | England v India 2025

    Jofra Archer is poised to make his long-awaited comeback in the third Test against India this week, with Brendon McCullum, the England head coach, calling for Lord’s to deliver a pitch that has pace, bounce and sideways movement.

    Archer, 30, joined the England squad at Edgbaston last week but was held back from what became a crushing 336-run defeat by Shubman Gill’s tourists. And now at one-all in the series, England’s seam attack seems likely to be refreshed amid a strong hint from McCullum that this means Archer’s return.

    McCullum said: “He will certainly be available for selection, and if you look at it, our seamers have gone two Tests on the spin and we have got a short turnaround before we head down to HQ. We’ll let the dust settle on this one, but Jofra is looking fit, he’s looking strong, he’s looking ready to go, and he’ll come into calculations.”

    As the scene of Archer’s electric debut during the 2019 Ashes – five wickets and a fearsome battle with Steve Smith that saw Australia’s master batter subbed out of the match with concussion – Lord’s represents a poignant setting for his Test career to resume.

    But after a four-year absence triggered by elbow and lower back stress fractures, the great unknown is whether the bowler will be the same again. Since the last of his 13 Test caps in 2021, Archer has lived a diet of limited-overs cricket and has played just one first-class match for Sussex this season.

    McCullum added: “We all know what he’s capable of achieving in Test cricket and we hope that when the opportunity does arrive for him, he’s able to recapture that and also improve on what he’s been able to do already in that form of the game.”

    The seamer to make way is another question here, with arguably all three of England’s incumbent quicks – Chris Woakes, Brydon Carse and Josh Tongue – in need of a breather after being out-bowled by Akash Deep and Mohammed Siraj. India have also confirmed that Jasprit Bumrah will “definitely” return, ramping up the challenge.

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    Whoever steps aside for Archer – and Jamie Overton and Gus Atkinson being part of the squad means that more than one change is possible – McCullum is hopeful that Karl McDermott, head groundsman at Lord’s, produces a pitch “with a bit more pace, a bit more bounce, and maybe a little bit of sideways, hopefully.”

    The subtext here was some disappointment with the pitch at Edgbaston, even if McCullum admitted he and captain Ben Stokes “got it wrong” when deciding to bowl first. “What we won’t do is react too strongly to it,” the New Zealander added. “We’re a team that likes to stay really level and we know we’ve got a big challenge in a few days’ [time].”

    Away from the Anderson-Tendulkar Trophy, the International Cricket Council has confirmed the appointment of Sanjog Gupta as its new chief executive. As first revealed by the Guardian two months ago, the head of cricket at ICC rights holders JioStar has replaced the outgoing Geoff Allardice after nearly four years in the role.

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  • Amazon Prime Day set to lift US online sales to $23.8 billion, Adobe estimates – Reuters

    1. Amazon Prime Day set to lift US online sales to $23.8 billion, Adobe estimates  Reuters
    2. Amazon Prime Day 2025: We found the best deals to shop before the sale officially kicks off  Yahoo
    3. Companies from Walmart to TikTok Shop are stretching out sales and sweetening deals to compete with Amazon Prime Day  Modern Retail
    4. Amazon Prime Day 2025: Big discounts on Galaxy S24 Ultra, iPhone 15 and more confirmed  Hindustan Times
    5. 4 Trends Marketers Should Keep in Mind Heading Into Prime Day  Adweek

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  • The Problem of Endometriosis in the UK

    The Problem of Endometriosis in the UK

    pharmafile | July 7, 2025 | Feature | Research and Development |  NHS, Obstetrics & Gynaecology, Pain, Reproductive health, Theramex, endometriosis, gynaecology 

    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

    By Tina Backhouse, General Manager, Theramex 

    When did we decide it was an acceptable condition of womanhood in the UK to live with chronic pain? 1

    Endometriosis is a condition which causes cells that line the uterus to grow elsewhere and often causes complications, such as fertility issues. Most notably, women with endometriosis can experience excruciating pains around their menstrual cycle.2

    There are 1.5 million women in the UK affected by endometriosis3 and yet too often it seems that healthcare professionals see severe period pain as a natural part of a woman’s cycle, rather than as an indication that something might not be right.4

    There are currently three-quarters of a million women’s health appointments waiting to happen in the UK.5 How many of these are linked to women suffering from chronic pain, still waiting for answers?

    Waiting for the ‘right’ GP

    While public awareness of these once-taboo gynaecological conditions is growing, there is still room for greater engagement and understanding within the healthcare community.

    The average wait for an endometriosis diagnosis is eight years,6 during which, women too often face misunderstanding and dismissal from medical professionals,1 leading to delays in treatment and multiple visits to A&E.7 Additionally, Black women are 50% less likely to be diagnosed with endometriosis than White women, and those who are diagnosed wait on average two and a half years longer than White women for their diagnosis.8

    The workload of GPs is undeniably heavy, but it is crucial that time is taken, and training is completed to shift the perception of women’s pain. Misdiagnosing women’s pain as anxiety, or dismissing it as normal, must stop being a default response from so many GPs.1

    The advice and guidance scheme, which connects GPs with hospital doctors to bypass lengthy waiting lists, is making progress by directing women towards specialist support via services such as women’s health hubs – local centres which integrate services to support women with gynaecological concerns. From July – December 2024, the scheme diverted 660,000 treatments (of all kinds, not just women’s health) from hospitals into the community.9

    However, the advice and guidance scheme is only as good as the specialist support services that it has access to, and women’s health targets for Integrated Care Boards have since been scrapped.This means that that funding for these hubs could be redirected, leaving access to specialist endometriosis care in an even worse predicament.

    It’s worrying that the gynaecological care waiting list backlog hasn’t had the necessary reaction; with these funding targets removed, it could lead to women continuing to wait on lengthy lists for appointments and relying more on the non-specialist, secondary care advice from GPs, who have no required training in women’s health.1

    Paywalls to treatment

    For many women experiencing debilitating endometriosis symptoms, the alternate ending to their stories is turning to private healthcare for diagnosis or treatment and, in some cases, even crowdfunding their treatments.10 Access to women’s health hubs is already a postcode lottery;11 we cannot allow this to be exacerbated by waiting lists creating a paywall to treatment.

    The importance of women living without pain must not be sidelined by an overstretched NHS. Gynaecological conditions are often forgotten at the bottom of the pile; when living with endometriosis, the pain that many women experience is important, and the NHS must be better at attending to these significant cases with the same urgency that they provide to other conditions.1

    Now is the time for doctors to recognise and address the severe pain many women endure during their periods.

    Addressing these issues is not only vital for women’s health but also for the broader economic impact. The economic cost of absenteeism due to severe period pain and heavy periods alongside endometriosis costs the economy £11 billion due to absenteeism from work.12 Additionally, Endometriosis UK estimates that one in six women with endometriosis leave the workplace due to their symptoms.13 Ensuring women receive timely and effective care for conditions like endometriosis is crucial, not only for their well-being, but also to prevent the personal and economic toll that results from inadequate support.

    GPs, as the first point of care, must understand women’s pain better. They need access to information and training around recognising gynaecological conditions, such as endometriosis, that can heavily impact the quality of women’s lives.1

    For too long, women’s pain has been ignored

    We shouldn’t leave it to chance whether a patient seeking support will be directed towards a GP with an understanding of endometriosis or not. It must become a government priority to ensure that GPs know what is and isn’t ‘normal’ for women to experience during their period, so that pain is no longer dismissed as part of the female experience.

    References

    1 Women and Equalities Committee. ‘Women’s reproductive health conditions.’ House of Commons Available at: https://committees.parliament.uk/publications/45909/documents/228040/default/ [Accessed May 2025]

    2 Endometriosis UK, What is endometriosis?, Available at: https://www.endometriosis-uk.org/what-is-endometriosis. [Accessed May 2025]

    3 Endometriosis UK, Endometriosis Facts and Figures, Available at: https://www.endometriosis-uk.org/endometriosis-facts-and-figures. [Accessed May 2025]

    4 Wiggleton-Little Ja (2024), ‘Just” a painful period: A philosophical perspective review of the dismissal of menstrual pain,’ Women’s Health Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11113068/. [Accessed May 2025]

    5 Mundasad Sm et al (2024), ‘Gynaecology waiting lists double, leaving women in pain.’ BBC News Available at: https://www.bbc.co.uk/news/articles/clyvg2157mvo#:~:text=Waiting%20lists%20for%20gynaecology%20appointments%20across%20the%20UK,-%20up%20from%20360%2C400%20just%20before%20the%20pandemic. [Accessed May 2025]

    6 Rajesh Sh et al (2025), ‘Diagnosis and management of endometriosis.’, BMJ 2025;388:q2782 doi:10.1136/bmj.q2782

    7 Endometriosis UK (2024), ‘“Dismissed, ignored and belittled” The long road to endometriosis diagnosis in the UK’  Available at: https://www.endometriosis-uk.org/sites/default/files/2024-03/Endometriosis%20UK%20diagnosis%20survey%202023%20report%20March.pdf [Accessed May 2025]

    8 Griffith Ve et al (2023), ‘Endometriosis: black women continue to receive poorer care for the condition’ The Conversation Available at: https://theconversation.com/endometriosis-black-women-continue-to-receive-poorer-care-for-the-condition-200663 [Accessed May 2025]

    9 Department of Health and Social Care (2024), ‘Patients get care closer to home as GP scheme expanded.’ Gov.uk Available at:https://www.gov.uk/government/news/patients-get-care-closer-to-home-as-gp-scheme-expanded [Accessed May 2025]

    10 McCarron Sa (2025), ‘Health service ‘failing’ endometriosis sufferers, says Northern Ireland mum fund raising for surgery.’ ITV News Available at: https://www.itv.com/news/utv/2025-01-20/mum-no-choice-but-to-head-abroad-for-surgery [Accessed May 2025]

    11 Dimsdale Co (2024), ‘The six NHS regions without a women’s health hub, mapped.’ INews Available at:

    https://inews.co.uk/news/nhs-regions-womens-health-hub-3439518#:~:text=Women%20face%20a%20postcode%20lottery%20of%20access%20to,England%20lacking%20a%20single%20dedicated%20women%E2%80%99s%20health%20hub. [Accessed May 2025]

    12 NHS Confederation (2024), ‘Women’s health economics: investing in the 51 per cent.’ Available at: https://www.nhsconfed.org/publications/womens-health-economics[Accessed May 2025]

    13 Endometriosis UK. ‘Endometriosis in the workplace.’ Available at: https://www.endometriosis-uk.org/endometriosis-workplace [Accessed May 2025]

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  • “We Got It All Wrong”: New Study Reveals Dinosaur Speeds Were Vastly Overestimated by Decades of Fossil Trackway Data

    “We Got It All Wrong”: New Study Reveals Dinosaur Speeds Were Vastly Overestimated by Decades of Fossil Trackway Data

    IN A NUTSHELL
    • 🦖 Fossil trackways have been crucial in studying dinosaur locomotion, but new research suggests they’ve led to overestimations of speed.
    • 🔍 Researchers at Liverpool John Moores University analyzed modern birds, specifically helmeted guineafowl, to understand how muddy substrates affect trackway interpretations.
    • 📉 Findings indicate that previous calculations of dinosaur speed, based on Alexander’s formula, may be significantly overstated when applied to soft surfaces.
    • 🧩 The study calls for more comprehensive research to refine our understanding of dinosaur movement, urging caution in speed-based behavioral reconstructions.

    The fascinating world of dinosaurs has always captured our imagination, painting vivid pictures of these magnificent creatures roaming the Earth. Recent research challenges some of our long-held beliefs about dinosaur speed. A study from Liverpool John Moores University provides new insights into how these ancient giants might have moved. By analyzing fossil trackways and comparing them with modern birds, scientists have unveiled surprising findings about dinosaur locomotion that could reshape our understanding of their behavior and lifestyle.

    Fossil Trackways: A Window into Dinosaur Movement

    Fossil trackways have long been a vital tool in understanding the behavior and locomotion of extinct animals. These preserved footprints offer a glimpse into how dinosaurs might have moved across varied landscapes. However, new research suggests that our previous interpretations of these trackways might have been flawed. Traditionally, calculations of dinosaur speeds were based on equations derived from mammalian data. This approach failed to account for the unique conditions under which these tracks were made.

    The Liverpool research team focused on theropods, one of the three major dinosaur groups. They discovered that trackways made in soft, muddied surfaces could significantly distort recorded speeds. In fact, the original equation by R. McNeill Alexander, used for decades to estimate dinosaur speed, was based on data from living animals moving on hard surfaces. The study reveals that speeds calculated from trackways on softer substrates might be dramatically overestimated.

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    Modern Birds Reveal the Secrets of Dinosaur Locomotion

    To test their hypothesis, researchers turned to modern birds, specifically the helmeted guineafowl. This bird was chosen because of its similarities to non-avian theropods like Velociraptor. By observing the guineafowl moving across different types of mud, scientists gained valuable insights into how substrate consistency affects trackway formation and perceived speed.

    High-speed video recordings of the guineafowl’s movements provided a wealth of data. The researchers found that the bird’s trackways, when analyzed using Alexander’s formula, significantly overstated their actual speed. This finding suggests that many dinosaur trackways might have been misinterpreted, leading to erroneous conclusions about their pace and behavior. The study emphasizes the need to consider the substrate’s role in trackway analysis, which could lead to more accurate reconstructions of dinosaur movement.

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    Reconsidering Dinosaur Speeds and Behavior

    The implications of this research are far-reaching. If dinosaur speeds have been overestimated, it could alter our understanding of their behavior, including predator-prey dynamics and migration patterns. For example, a theropod trackway previously thought to indicate running might actually represent a walking pace. Similarly, a large ornithopod moving leisurely could have been mistakenly classified as running.

    This new perspective encourages scientists to reassess previous speed-based behavioral reconstructions. The research suggests that while some dinosaurs likely did run, the speeds at which they did so might have been much slower than previously believed. The team advocates for using trackway data to make broad comparisons of relative speeds rather than specific velocity estimates. This approach could lead to a more nuanced understanding of dinosaur ecology and their interactions with the environment.

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    The Future of Dinosaur Locomotion Studies

    While this study sheds new light on dinosaur locomotion, it also highlights the limitations of current research methods. The researchers acknowledge that their guineafowl model might not fully represent the dynamics of larger dinosaurs moving on different substrates. They call for further studies across a range of body sizes and sediment types to refine our understanding of dinosaur movement.

    Without additional research on modern animals moving on compliant substrates, calculating precise speeds from fossil trackways remains challenging. The study concludes with a call for more comprehensive investigations, emphasizing the importance of integrating data from extant taxa to enhance our interpretations of extinct species. Such efforts could pave the way for more accurate reconstructions of dinosaur locomotion and contribute to our broader understanding of ancient ecosystems.

    As we continue to unravel the mysteries of these ancient creatures, one thing remains certain: our quest to understand dinosaurs is far from over. This study is a reminder that science is ever-evolving, and each new discovery brings us closer to the truth. How will future research reshape our perception of these magnificent giants? What other surprises lie hidden in the fossil record, waiting to be uncovered?

    Our author used artificial intelligence to enhance this article.

    Did you like it? 4.4/5 (25)

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  • Five facts about UV exposure and sun safety – Pharmafile

    Five facts about UV exposure and sun safety – Pharmafile

    1. Five facts about UV exposure and sun safety  Pharmafile
    2. A Dermatologist Shares the Ideal SPF to Use This Summer  CNET
    3. Everything you need to know about skin cancer and sunscreen  INDIA New England News
    4. Dermatologist urges sun safety as temperatures heat up during UV Awareness Month  5newsonline.com
    5. Sunscreen and skin cancer: Brown University dermatologist answers the burning questions  Brown University

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  • Why does Mars show shades of yellow, orange in ESA’s dramatic new satellite image?

    Why does Mars show shades of yellow, orange in ESA’s dramatic new satellite image?



    The image shows planet Mars. — ESA/File

    Mars is commonly known as the Red Planet, but a recent satellite image from the European Space Agency (ESA) displays a vibrant blend of yellows, oranges, and browns. The striking view also highlights an impact crater and four dust devils moving across the terrain.

    Taken by the high-resolution camera on ESA’s Mars Express orbiter, the image features Arcadia Planitia — a key region for understanding Mars’ geological past and assessing its potential for future human habitation, reported Space.com.

    Located northwest of the solar system’s tallest volcanoes, Arcadia Planitia is notable for its ancient solidified lava flows, estimated to be up to 3 billion years old. Scientists also believe the area contains water ice just beneath the surface, making it a key target for upcoming Mars missions, according to ESA.

    The region frequently hosts “dust devils,” which are short-lived, whirlwind-like phenomena formed when warm surface air rises and lifts dust. In the image, four dust devils appear as faint white streaks, crossing from the darker to lighter regions of the plain.

    In the lower right corner of the photo, a large impact crater measuring about 9 miles (15 kilometres) wide is visible. The layered patterns surrounding the crater suggest that the ground contained significant water ice at the time of impact. The crater’s relatively intact appearance also indicates it formed recently in geological terms.

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  • Synthetic DNA nanoparticles for gene therapy

    Synthetic DNA nanoparticles for gene therapy

    Case Western Reserve University researcher receives prestigious NSF Award for ‘programmable’ nanoparticles

    Case Western Reserve University chemist Divita Mathur was awarded a National Science Foundation (NSF) Faculty Early Career Development Program (CAREER) grant for her research in synthetic DNA nanoparticles, which have potential applications in gene therapy.

    Divita Mathur

    The grant will support Mathur’s work in synthesizing nanoparticles and studying how they behave inside cells in a laboratory. She will use single-cell injections and a microscope to track the nanoparticles and watch what happens to them over time inside individual cells.

    The CAREER award is considered the agency’s most prestigious grant to junior faculty members “who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization.”

    Mathur, Frank Hovorka Assistant Professor of Chemistry in the College of Arts and Sciences, is among three CWRU faculty members awarded CAREER grants this year.

    “This groundbreaking work is a great example of fundamental science that could lead to new life-saving treatments,” said David Gerdes, dean of the college. “The CAREER award shows that she is a rising star, not only on our campus, but also in our national scientific community.”

    Mathur’s DNA nanoparticles are highly programmable and could be designed to encode a gene that replaces a missing or malfunctioning gene, instructing a cell to produce a needed protein or correct a genetic error.

    In many genetic diseases, scientists know the gene that needs to be corrected, Mathur said.

    “The problem is the delivery,” she said. “It’s easy to deliver things to the liver, so liver-based therapies are in clinical trials. Converting this to another area of the body is difficult, which is one of the things that motivates us to pursue this research.” 

    Mathur said that eventually these DNA nanoparticles could also be designed with an attachment that functions like a barcode on an envelope, sending it to a particular address, or in this case, targeting a particular kind of cell.

    The CAREER Award grant allows Mathur to delve into the basic question of how these manufactured DNA structures behave once they get inside a cell. To study that, she will attach a molecule to the DNA that fluoresces so the particles can be observed by microscope inside a living cell. 

    “We don’t know how these nanoparticles act when they are inside the cell; how they interact with the proteins that are inside,” Mathur said. “We have to understand that fundamentally before we can imagine how to design therapeutics.”

    Divita Mathur with 3D DNA helix

    The CAREER award also provides funding for Mathur to engage high school students in summertime chemistry research projects and for building mixed-reality, three-dimensional models of chemical and biochemical molecules.

    “We want to show students how molecules are three-dimensional, how they occupy space and how they have a specific orientation in space, like right or left-handedness,” she said.

    Earlier this year, Mathur received the university’s John S. Dieckhoff Award for Excellence in Graduate Mentoring. One of the undergraduates working in her lab, Sara Desai, received the prestigious Barry Goldwater scholarship, a highly competitive national scholarship that provides tuition assistance for students who intend to pursue research careers in science, mathematics or engineering.

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