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  • “It’s Its Own New Thing” – Scientists Discover New State of Quantum Matter

    “It’s Its Own New Thing” – Scientists Discover New State of Quantum Matter

    UC Irvine physicists have discovered a new phase of quantum matter with unusual electron-hole pairings. The material’s resilience to radiation hints at breakthroughs in quantum technologies and future space-ready computers. (Artist’s concept). Credit: SciTechDaily.com

    UC Irvine scientists identified a novel quantum state with potential for energy-efficient devices. Its radiation resistance makes it particularly valuable for space missions.

    Researchers at the University of California, Irvine have identified a previously unknown state of quantum matter. According to the team, this discovery could pave the way for computers that recharge themselves and withstand the extreme conditions of deep space exploration.

    “It’s a new phase of matter, similar to how water can exist as liquid, ice, or vapor,” said Luis A. Jauregui, professor of physics & astronomy at UC Irvine and corresponding author of the new Physical Review Letters. “It’s only been theoretically predicted – no one has ever measured it until now.”

    The phase behaves like a fluid formed by electrons and their counterparts, known as “holes,” which spontaneously pair together to create exotic structures called excitons. In a surprising twist, both electrons and holes rotate in the same direction. “It’s its own new thing,” Jauregui said. “If we could hold it in our hands, it would glow a bright, high-frequency light.”

    Materials and experimental conditions

    The phase was detected in a material engineered at UC Irvine by postdoctoral researcher Jinyu Liu, the study’s first author. Jauregui and his colleagues confirmed its existence using powerful magnetic fields at the Los Alamos National Laboratory (LANL) in New Mexico.

    Luis A. Jauregui
    “If you want computers in space that are going to last, this is one way to make that happen,” Luis Jauregui says. Credit: Steve Zylius / UC Irvine

    To generate this unusual quantum state, the researchers exposed the material—hafnium pentatelluride—to an intense magnetic field of up to 70 Teslas. (For comparison, a strong refrigerator magnet produces about 0.1 Teslas.) Under these conditions, the material revealed its transformation into the new quantum phase.

    Implications for future technology

    Jauregui explained that, as his team applied the magnetic field, the “material’s ability to carry electricity suddenly drops, showing that it has transformed into this exotic state,” he said. “This discovery is important because it may allow signals to be carried by spin rather than electrical charge, offering a new path toward energy-efficient technologies like spin-based electronics or quantum devices.”

    Unlike conventional materials used in electronics, this new quantum matter isn’t affected by any form of radiation, which makes it an ideal candidate for space travel.

    “It could be useful for space missions,” Jauregui said. “If you want computers in space that are going to last, this is one way to make that happen.”

    Companies like SpaceX are planning human-piloted space flight to Mars, and to do that effectively, you need computers that can withstand prolonged periods of exposure to radiation.

    “We don’t know yet what possibilities will open as a result,” Jauregui said.

    Reference: “Possible Spin-Triplet Excitonic Insulator in the Ultraquantum Limit of HfTe5” by Jinyu Liu, Varsha Subramanyan, Robert Welser, Timothy McSorley, Triet Ho, David Graf, Michael T. Pettes, Avadh Saxena, Laurel E. Winter, Shi-Zeng Lin and Luis A. Jauregui, 22 July 2025, Physical Review Letters.
    DOI: 10.1103/bj2n-4k2w

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  • Select groups of myocardial infarction patients benefit from Helicobacter pylori screening

    Select groups of myocardial infarction patients benefit from Helicobacter pylori screening

    Not all acute myocardial infarction patients should be offered routine screening for the stomach ulcer bacterium Helicobacter pylori. However, it is possible that some patient groups with an elevated risk of post-infarction gastrointestinal bleeding benefit from such a test, concludes a large-scale study from Karolinska Institutet and Södersjukhuset in Sweden published in the journal JAMA.

    Upper gastrointestinal bleeding is a serious complication that affects approximately two per cent of patients within a year of a myocardial infarction.

    It’s associated with increased mortality and the risk of recurring cardiovascular events. We therefore wanted to examine if screening for the common Helicobacter pylori bacterium, which causes gastritis and gastric ulcers, can reduce the risk of bleeding. This is currently not routine practice.”


    Robin Hofmann, study’s lead author, senior consultant at the Department of Cardiology, Södersjukhuset, and associate professor at the Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet

    The randomized study included almost 18,500 myocardial infarction patients at 35 hospitals in Sweden. Half the group was tested for the bacterium and treated with antibiotics and protein pump inhibitors by their doctors if testing positive, while the other half received routine care without an extra test or treatment.

    Effective in patients with anemia

    After almost two years’ follow-up, the researchers found that there were slightly fewer individuals in the screening programme who had suffered gastrointestinal bleeding, but not enough to make the difference statistically significant. However, they found a positive effect of the screening when studying specific sub-groups of patients, such as those with anaemia or kidney failure. A particularly positive effect was observed in patients with moderate to severe anaemia, who suffered gastrointestinal bleeding at roughly half the rate if they underwent screening.

    “Our results suggest that screening for Helicobacter pylori does not need to be done routinely for all individuals following a heart attack,” says Dr Hofmann. “On the other hand, testing and treatment could be a meaningful complement for selected patient groups with an elevated risk of bleeding.”

    The researchers will now go on to study the long-term effects and try to identify which groups will benefit most from screening.

    The study was conducted in collaboration with Södersjukhuset, Region Stockholm and the Uppsala Clinical Research Centre (UCR), and was financed primarily by the Swedish Research Council, the Swedish Heart Lung Foundation and Region Stockholm. 

     

    Source:

    Journal reference:

    Hofmann, R., et al. (2025). Helicobacter pylori Screening After Acute Myocardial Infarction. JAMA. doi.org/10.1001/jama.2025.15047

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  • Navigating biometrics under PIPEDA: OPC’s new guidance raises the bar

    The Office of the Privacy Commissioner of Canada (“OPC”) has released its anticipated final “Guidance for Processing Biometrics – For Businesses” (the “Guidance”). This Guidance does not change the law under the Personal Information Protection and Electronic Documents Act (“PIPEDA”), but clarifies the OPC’s interpretation and enforcement stance.  Unlike Quebec, where the legislative requirements relating to biometrics expressly arise from applicable law, as a “principles-based” law, what is required by PIPEDA may change over time, requiring every business in Canada, particularly those in the tech and gaming sectors, to carefully consider the OPC’s new higher bar for compliance. Taking a deliberate, privacy-first approach is required before implementing any system implicating individuals’ biometric information, particularly because informed consent remains a cornerstone of Canada’s privacy law.

    The Guidance defines “biometrics” as the quantification of human characteristics into measurable terms for use by two categories of technologies: “physiological biometrics”, which involve morphological (body shape or structure) or biological characteristics of an individual that are relatively stable over time (e.g., fingerprints, iris patterns, facial geometry, and DNA), and “behavioural biometrics”, which involve distinctive characteristics of individuals’ movements, gestures, or motor skills (e.g. keystroke patterns, gait, voice, and eye movement).  Photographs, video recordings, and behaviour observations are not, on their own, necessarily biometric information unless they are quantified into measurable data. The Guidance acknowledges that organizations are using biometrics in multiple systems (which it defines as “biometric systems”) by inputting them manually or automatically, for purposes including for recognition (verification or identification of an individual) or classification (estimation of personal attributes based on biometrics).

    Ten key takeaways

    Biometrics are (almost) always sensitive: Treat biometric data uniquely identifying individuals as sensitive by default, raising the bar for consent, safeguards, and reporting—even if retained briefly. To determine sensitivity for non-identifying biometric data, one must assess the relevant context for risks of harm or whether the biometric data could reveal other types of information considered sensitive.

    Avoid “no-go zones”: Uses like mass surveillance, discriminatory profiling, or unlawful collections that cause significant harm, even with consent, are generally inappropriate per OPC precedents.

    Justification is non-negotiable: A four-part test (legitimate need, effectiveness, minimal intrusiveness, proportionality) must be passed before deployment. Do not rely on biometrics for convenience if alternatives exist.

    Express consent is the default: Obtain explicit, informed consent specific to biometrics (in other words, consent to take a photo is not the same as consent to generate a face embedding), integrated into user flows, and renewable. Businesses must avoid vague policies, ensure opt-out options when practicable, and provide alternatives to biometrics, especially when biometrics aren’t essential to their product or service.

    Minimize collection and retention: Limit to essential data (favour verification over identification), store templates under user control (e.g. on the user’s device) where possible, and destroy records promptly after purpose fulfillment. When designing a biometric system, businesses should not implement additional features that enable the broader collection of personal information than is required to fulfill their specific purposes.

    Delete upon request: If an individual withdraws consent to the processing of biometric information, a business should delete all the biometric information it has collected or created about them; subject to legal or contractual restrictions. This requirement extends to third parties with whom biometric information has been shared.

    Prioritize safeguards: Implement privacy protective by design features (e.g., encryption, cancellable templates), report breaches if they pose real harm risks, test and monitor systems access and vulnerability regularly.

    Accuracy and bias: The OPC expects a business to choose technology with error rates suitable to the stakes, to test for biases and errors on operationally relevant data before launch and on an ongoing basis, and to ensure that the use of biometrics does not discriminate against human rights. Biometric systems need to have procedures for handling corrections and false matches and mitigating harm to individuals.

    Embrace accountability and openness: Build governance with human oversight, regularly review and update privacy policies, audit third parties and formalize business relationships with them; develop robust breach response plans, and transparently detail the biometrics under a business’s control and program-level explanations about their use. Having a contractual right to audit service providers is essential.

    Fact-specific application: Remember, nothing in PIPEDA has changed; this is interpretive guidance of principles-based legislation. So, tailor responses to context, but heed OPC expectations to avoid enforcement scrutiny.

    Detailed analysis

    Sensitivity

    One of the core messages of the Guidance is that organizations must justify not only how they use biometrics, but whether they should be using biometrics at all. In particular, the Guidance establishes a high standard for biometric data that is capable of uniquely identifying a person—like a fingerprint, faceprint, or voiceprint—as sensitive regardless of context, due to its intimate link to an individual’s body, its uniqueness, stability over time, and difficulty to alter.

    For other biometric data that is not uniquely identifying, such as general age markers or eye color, sensitivity depends on context, including whether it could be combined with other data to identify someone, pose a high risk of harm if misused, or reveal sensitive details like health or medical conditions. Notably, per the Guidance, even brief retention does not diminish this sensitivity.

    Appropriate purpose

    The purpose for the collection of biometric information must always be appropriate. Organizations should avoid OPC-identified “no-go zones” where uses are generally inappropriate, such as otherwise unlawful collections, profiling leading to unfair or discriminatory treatment contrary to human rights law, or purposes likely to cause significant harm, or surveillance via an individual’s own device. Beyond these zones, businesses must demonstrate legitimacy through a four-part test: (i) assessing legitimate need (tied to a bona fide business interest, not speculation), (ii) effectiveness (with proven reliability and low error rates), (iii) minimal intrusiveness (favouring less invasive alternatives over convenience), and (iv) proportionality (ensuring privacy impacts align with benefits, preferring narrow scopes). To illustrate, the Guidance references past findings where a telecommunications company’s voiceprint authentication was deemed appropriate for addressing security needs with strong safeguards, while an internet-scraping operation creating a facial recognition database was rejected as mass surveillance posing undue harm, and where fingerprint use for exam security was found disproportionate to its benefits.

    Valid consent

    Once an appropriate purpose is established, obtaining valid consent becomes essential, as it is a cornerstone of PIPEDA for collecting, using, or disclosing biometric information, with limited exceptions, such as in the employment relationship. Consent must be meaningful, ensuring individuals reasonably understand the nature, purpose, and consequences of the processing. For sensitive biometrics, express consent is the default, requiring explicit agreement with clear explanations of the biometric type, purposes, third-party disclosures, and residual risks of harm. A description of a business’s practices in privacy policies will not suffice, and consent must be renewed when extending the use of the biometric information. Individuals must also be provided with alternative options to biometrics and clear and easy-to-effect opt-outs where practicable. If a business is taking the position that consenting to the collection and processing of biometric information is required for the use of its products or services, it must be prepared to demonstrate full compliance with the principles outlined in the Guidance.

    Unless biometrics are integral to service delivery, they can’t be mandatory under PIPEDA, so organizations should also provide customers accessible non-biometric alternatives without barriers whenever possible. When collecting biometric information from third parties, organizations should verify lawful compliance at every stage, including obtaining consent. Public observability does not necessarily create an exemption from the consent requirements.

    Limiting collection, use, disclosure, and retention

    From there, the Guidance emphasizes limiting collection, use, disclosure, and retention to what’s strictly necessary, starting with minimizing collection by using only the essential biometric characteristics. This favours verification (one-to-one matching) over identification (one-to-many) to reduce data needs. For example, allowing gamers to opt out of optional behavioral biometrics and erase templates without gameplay disruption. This was the subject of an OPC investigation where an exam board agreed to limit fingerprint data to secure digital templates.

    Businesses deploying technologies such as facial recognition for age verification, or voice analysis for authentication, should consider storing templates under user control (e.g., on personal devices) to avoid centralized databases and designing systems with constrained capabilities to prevent over-collection. The extraction and use of secondary information, such as that related to health, ethnicity, or biological relationships is prohibited, unless separate and specific consent is obtained that is consistent with the purposes of the collection.

    Retention must end promptly after the purpose or legal needs are met, with permanent destruction across all systems. To meet this obligation, organizations should maintain tight disclosure circles, de-link data across systems, and use separate retention schedules for biometrics versus other personal information the biometrics may be linked to. They must also deploy systems to promptly delete data upon consent withdrawal, subject only to legal or contractual restrictions. Organizations must ensure that such practices extend to relevant third parties as well.

    Safeguards

    Given biometrics’ high-risk nature, robust safeguards to prevent data breaches, theft, or unauthorized access are non-negotiable, and must be proportional to the level of sensitivity. This includes deploying and routinely testing, auditing and improving physical, organizational, and technical measures against breaches or spoofing (e.g., via deepfakes).

    Organizations are encouraged to adopt privacy-by-design, such as cancellable templates for revocability, homomorphic encryption for secure matching, and end-to-end encryption.

    As the capstone of PIPEDA compliance, organizations remain fully responsible for biometric information under their control, including when outsourced to third parties, which must be contractually bound to equivalent protections regardless of location. Businesses should control and monitor access strictly, granting it only to essential personnel and logging activities for anomaly detection. Regular testing, including annual penetration assessments by independent experts, is advised for systems handling large volumes of biometrics, as seen in OPC recommendations for government entities. For tech firms integrating biometrics into apps or hardware, this means building in audit trails and opting for systems that cannot be repurposed beyond the intended use, ensuring compliance even as threats evolve.

    Regular reviews should address evolving threats, such as spoofing via deepfakes or voice synthesis, which could compromise systems like those used for secure logins. Any breaches should be promptly reported to the OPC and the affected individuals in accordance with PIPEDA or other applicable law; such as provincial privacy laws.

    Accuracy and bias

    When designing and deploying biometric systems that are used to make decisions about an individual, organizations must take steps to ensure that such systems are accurate and free of bias. Errors by this technology can result in serious harm to individuals and severe consequences for organizations, for example, when it is used to determine who is selected for an interview, review loan or lease applications, or determine insurance coverage. Faulty and inaccurate biometric systems can not only breach privacy laws, but human rights and consumer laws. Therefore, it is essential to ensure that biometric systems do not discriminate on the basis of protected grounds such as race, gender, or age.

    In order to comply with Principle 6 of PIPEDA, organizations must ensure that personal information is maintained with a level of accuracy, completeness, and currency commensurate with the purposes for which it is used in order to reduce the risk offlawed or inappropriate information influencing their decisions. rOrganizations must also test and monitor their biometric systems before deployment and during use to ensure that they are accurate and free of bias and develop a procedure for responding to and correcting inaccurate results.

    Accountability

    Accountability is a key principle of PIPEDA. Organizations remain responsible for all processing of biometric data, including by third-party service providers. Any contracts should ensure third parties provide protections equivalent to those of the principal organization. For global tech companies, audit rights over contractors are crucial, ensuring biometric data in cloud-based gaming services is not mishandled abroad.

    A robust governance structure, integrated into a privacy management program, supports compliance through internal audits, and defined pause conditions for underperforming systems.

    The Guidance requires organizations to provide adequate training and supervision to employees responsible for managing biometric data, to develop robust mechanisms for reporting and remedying privacy violations, and to be prepared to demonstrate compliance with privacy legislation to regulators. When using biometric systems to assist in making important decisions about an individual, organizations should ensure that they are manually reviewing and approving these decisions. Businesses need to be able to explain and support all decisions in the event they are challenged under privacy, human rights, consumer protection, or other laws.

    Openness

    Finally, transparency builds trust and is required by PIPEDA and other privacy laws. Organizations are required to make privacy policies on biometrics readily accessible, detailing data types, uses, and related entities like subsidiaries. Organizations must provide contact details for the officer or organization representative responsible for privacy compliance. Transparent organizations go further by explaining retention practices, legal deletion limits, service provider involvements (including foreign transfers and associated risks like law enforcement access), and the mechanics of any automated biometric decisions.

    In the fast-paced world of video games and tech, this openness not only complies with PIPEDA but signals to users that their biometric data is handled with the care its sensitivity demands.

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  • Oil Drifts Higher With OPEC+ and US Policy on Russia in Focus

    Oil Drifts Higher With OPEC+ and US Policy on Russia in Focus

    A pumpjack near Crane, Texas. Photographer: Justin Hamel/Bloomberg

    Oil drifted higher as traders waited for fresh catalysts to move prices out of what’s been a relatively narrow band, with attention on an upcoming OPEC+ meeting and US moves on Russian supplies.

    Brent rose toward $69 a barrel, after the November contract gained 1% in the previous session, while West Texas Intermediate was near $65. OPEC+ will hold a meeting this weekend to decide on output for October, and most market watchers expect that the group will opt to keep supply steady.

    Most Read from Bloomberg

    Russian flows are also in focus amid US efforts to pressure Moscow to make peace in Ukraine by targeting India, a top importer of its crude. New Delhi rejected that initiative, with a cordial meeting between Prime Minister Narendra Modi and President Vladimir Putin on Monday. Separately, Treasury Secretary Scott Bessent said Washington would look at sanctions this week.

    Global crude benchmark Brent has largely been confined between $65 and $70 a barrel in recent weeks, with prices about 8% lower this year. There are widespread concerns about a looming surplus after OPEC+ opted at earlier meetings to relax supply curbs in a bid to reclaim market share, and as the US-led trade war risks crimping energy demand.

    “Crude is likely to remain rangebound,” said Vandana Hari, founder of market analysis firm Vanda Insights, adding that Ukrainian attacks on Russian oil facilities were providing a floor for prices, while chances of tighter US sanctions had receded. “Expectations of a looming glut are capping gains,” she said.

    On the Indian standoff, President Donald Trump said New Delhi had offered to cut its tariff rates to zero following the US imposition last week of 50% levies as punishment for the purchases of Moscow’s oil. Still, it wasn’t clear when the offer was made, or whether the White House plans to reopen talks. Later Tuesday, the US leader is due to make an announcement at 2 p.m. Washington time, although the topic of his address is unclear.

    Most Read from Bloomberg Businessweek

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  • Australian fast bowler Starc retires from T20 international cricket – France 24

    1. Australian fast bowler Starc retires from T20 international cricket  France 24
    2. Mitchell Starc announces retirement from T20Is to focus on Tests, 2027 ODI World Cup  ESPNcricinfo
    3. Fast bowler announces T20I retirement as Australia name squad  ICC
    4. Mitchell Starc retires from T20Is with an eye on prolonging international career  Cricbuzz.com
    5. Australia pace great Mitchell Starc retires from T20 international cricket  Dawn

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  • Androgen deprivation therapy lowers satisfaction after penile prosthesis surgery

    Androgen deprivation therapy lowers satisfaction after penile prosthesis surgery

    Prostate cancer is the most common malignancy among men, with over 160,000 new cases diagnosed annually in the United States. Although advances in surgery, radiotherapy, and hormone therapy have extended survival, these treatments often result in complications that impact quality of life. Erectile dysfunction, reduced libido, and changes in intimacy remain common and distressing, affecting both patients and their partners. Androgen deprivation therapy, in particular, has been shown to triple the risk of erectile dysfunction and significantly reduce sexual satisfaction. While penile prosthesis surgery provides a restorative option, little is known about its effectiveness in men previously treated with hormone therapy. Based on these challenges, there is a need for in-depth research on inflatable penile prosthesis (IPP) outcomes in the context of androgen deprivation therapy (ADT).

    Researchers from the University of Texas McGovern Medical School, Hamad Medical Corporation, and MD Anderson Cancer Center published their study (DOI: 10.1002/uro2.116) on February 19, 2025, in UroPrecision. The research focused on whether androgen deprivation therapy (ADT)—commonly prescribed alongside surgery or radiotherapy for prostate cancer—affects patient satisfaction after inflatable penile prosthesis (IPP) surgery. By comparing satisfaction scores between men who had undergone ADT and those who had not, the study provides important new insights into how hormonal therapy shapes long-term sexual outcomes for prostate cancer survivors.

    The team conducted a retrospective review of 529 cases treated between 2017 and 2022, identifying 96 prostate cancer survivors who had received IPP surgery and completed the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire. Patients were divided into two groups: those with prior ADT and those without. Findings showed that men with ADT reported significantly lower satisfaction scores (p = 0.0344). Independent of hormone therapy, men treated with radical prostatectomy generally reported higher satisfaction than those treated with radiation therapy. Coronary artery disease was also linked to lower satisfaction, suggesting comorbidities further influence outcomes. Researchers propose that ADT reduces satisfaction by suppressing testosterone, which not only targets prostate cancer cells but also weakens penile tissue, leading to atrophy and diminished elasticity. This physiological impact likely explains lower scores among ADT patients. Radiation therapy patients also had poorer results due to progressive vascular damage, while radical prostatectomy patients tended to benefit more from prosthesis surgery. These results underscore the importance of considering treatment history, comorbidities, and hormonal status when evaluating erectile dysfunction solutions.

    Our study demonstrates that hormone therapy can leave a lasting imprint on sexual health, even after advanced treatments like penile prosthesis surgery. These findings are vital for clinicians when counseling prostate cancer patients, as they show that expectations and treatment choices must be carefully managed. While penile implants remain effective for restoring function, patients who have undergone hormonal therapy may require additional support and strategies to achieve satisfactory outcomes”.


    Dr. Kareim Khalafalla, senior author of the study

    This study carries important implications for prostate cancer care. It highlights the need for pre-treatment counseling that fully explains the long-term effects of androgen deprivation therapy on sexual health and the effectiveness of prosthesis surgery. Integrating urologists, oncologists, and mental health professionals into patient care can ensure a more comprehensive approach to survivorship. As survival rates continue to improve, addressing quality-of-life concerns such as intimacy and sexual satisfaction becomes increasingly critical. Future research should focus on multicenter studies and explore strategies to counteract ADT-related dysfunction, paving the way for more personalized treatments that improve both physical and emotional recovery.

    Source:

    Chinese Academy of Sciences

    Journal reference:

    Jacob, J., et al. (2025). Effect of hormonal therapy on satisfaction rates after penile prosthesis surgery in prostate cancer survivors. UroPrecision. doi.org/10.1002/uro2.116

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  • BOJ must keep raising rates but focus on global uncertainty, deputy gov says – Reuters

    1. BOJ must keep raising rates but focus on global uncertainty, deputy gov says  Reuters
    2. BOJ’s Himino: Appropriate to Keep Raising Rates in Line with Economic, Price Trends  Forex Factory
    3. Recap: BOJ’s Nakagawa warns on tariff risks, says Tankan survey key for outlook  investingLive
    4. BOJ’s Deputy Chief Steers Clear of Hinting at Rate Hike Timing  Bloomberg.com
    5. BOJ board member reaffirms stance on raising interest rates  The Japan Times

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  • Exploring testosterone’s influence on cardiovascular, metabolic, reproductive, and mental health

    Exploring testosterone’s influence on cardiovascular, metabolic, reproductive, and mental health

    For decades, testosterone has been recognized as the primary driver of male reproductive development and secondary sex characteristics. Yet its influence extends beyond fertility and sexual function, touching nearly every system in the body. Declines in testosterone, particularly in aging men, are associated with osteoporosis, metabolic syndrome, cardiovascular disease, and depression. At the same time, excessive levels carry risks, including infertility or aggressive cancers. Traditional treatment approaches, such as testosterone replacement therapy (TRT), often struggled with balancing benefits against potential harms. Due to these challenges, there is a growing need for in-depth research on testosterone’s multifaceted mechanisms, associated disease risks, and personalized therapeutic strategies.

    A new comprehensive review (DOI: 10.1002/uro2.115), published February 18, 2025, in UroPrecision, examines the complex relationship between testosterone and men’s health. Conducted by researchers from institutions in Germany, Qatar, Jordan, and Hungary, the study explores testosterone’s influence on cardiovascular, metabolic, reproductive, and mental health. It also evaluates how precision medicine and artificial intelligence are reshaping diagnosis and therapy for testosterone-related disorders. By integrating clinical evidence with biomarker advances, the paper provides a roadmap for more personalized and effective treatment strategies, particularly for conditions such as hypogonadism, infertility, and age-related decline.

    The review details how testosterone production is tightly regulated through the hypothalamic-pituitary-gonadal axis, influencing libido, muscle growth, fat distribution, bone density, and mood. Imbalances manifest as hypogonadism, with symptoms ranging from erectile dysfunction to osteoporosis, or hypergonadism, characterized by excess hair growth, mood changes, and infertility. Treatments include TRT via injections, gels, or implants, alongside emerging alternatives like clomiphene citrate or gonadotropin therapy. However, concerns remain about cardiovascular safety, prostate health, and long-term outcomes.

    Biomarker research is revolutionizing testosterone management. Traditional measures such as free testosterone and sex hormone-binding globulin are now complemented by advanced tools like liquid chromatography-mass spectrometry and novel indicators such as insulin-like factor 3. Genomic and proteomic profiling further identify patient-specific variations in testosterone metabolism and androgen receptor sensitivity. Artificial intelligence is emerging as a powerful aid, integrating clinical and genetic data to optimize TRT dosing, predict outcomes, and minimize risks. The authors emphasize that combining biomarkers, precision medicine, and AI may finally resolve long-standing debates over testosterone therapy’s safety and efficacy.

    Testosterone is not merely a hormone of reproduction—it is a hormone of life. Our review shows how precision medicine and advanced diagnostics can move treatment beyond the ‘one-size-fits-all’ model. By considering genetic, hormonal, and lifestyle factors, we can tailor testosterone therapies that maximize benefits while minimizing risks. This personalized approach is especially critical for aging men, who face rising risks of cardiovascular disease, metabolic disorders, and cognitive decline. The future of men’s health lies in individualized, data-driven strategies.”


    Dr. Aksam Yassin, lead author 

    The findings hold broad clinical significance. Personalized testosterone therapy could transform care for millions of men worldwide, offering safer management of hypogonadism, improved fertility support, and enhanced protection against age-related conditions such as osteoporosis, heart disease, and Alzheimer’s disease. In reproductive health, testosterone is even being investigated as a potential male contraceptive. Integration of biomarkers, genetic testing, and AI will allow clinicians to better predict who will benefit most from therapy and who may face adverse effects. These innovations highlight a future where testosterone treatment is not only about restoring levels but about optimizing lifelong health outcomes.

    Source:

    Chinese Academy of Sciences

    Journal reference:

    Yassin, A., et al. (2025). Testosterone and men’s health: An in‐depth exploration of their relationship. UroPrecision. doi.org/10.1002/uro2.115

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  • Starc announces retirement from T20Is to focus on Tests, 2027 ODI World Cup

    Starc announces retirement from T20Is to focus on Tests, 2027 ODI World Cup

    Mitchell Starc has announced his retirement from T20Is in order to prioritise Australia’s heavy Test schedule from late next year and the 2027 ODI World Cup.

    Starc, 35, played 65 T20Is and was part of the Australia side that won the 2021 T20 World Cup in the UAE. He last featured in the format at the 2024 World Cup in the Caribbean. His 79 T20I wickets currently puts him second for Australia with his best of 4 for 20 coming against West Indies in 2022.

    “Test cricket is and has always been my highest priority,” Starc said. “I have loved every minute of every T20 game I have played for Australia, particularly the 2021 World Cup, not just because we won but the incredible group and the fun along the way.

    From mid-2026 Australia face a hectic run in Test cricket including a home series against Bangladesh, a tour of South Africa, a four-match series against New Zealand, five Tests away in India in January 2027, the one-off 150th anniversary match against England at the MCG and then an away Ashes in mid-2027.

    The ODI World Cup, which will be staged in South Africa, Zimbabwe and Namibia, will be held in October and November 2027 with Australia the defending champions.

    “Looking ahead to an away Indian Test tour, the Ashes and an ODI World Cup in 2027, I feel this is my best way forward to remain fresh, fit and at my best for those campaigns,” Starc said. “It also gives the bowling group time to prepare for the T20 World Cup in the matches leading into that tournament.”

    Chair of selectors George Bailey said: “Mitch should be incredibly proud of his T20 career for Australia. He was an integral member of the 2021 World Cup winning side and, as across all his cricket, had a great skill for blowing games open with his wicket taking ability.

    “We will acknowledge and celebrate his T20 career at the right time, but pleasingly he remains focussed on continuing to play Test and ODI cricket for as long as possible.”

    Starc’s announcement comes as Australia name their latest T20I squad for the three-match series against New Zealand in early October. Cameron Green will miss the trip across the Tasman so he can play the opening round of the Sheffield Shield for Western Australia which could see him return to bowling.

    Nathan Ellis will also be absent for the birth of his and wife Connie’s first child. Matt Short, who missed both recent series against West Indies and South Africa due to a side injury, returns as does Mitchell Owen who suffered a concussion in Darwin last month. Marcus Stoinis, who came to an agreement with the selectors over his availability, is back in the squad after not being selected for the last two series and playing in the Hundred.

    Australia T20I squad vs New Zealand

    Mitchell Marsh (capt), Sean Abbott, Xavier Bartlett, Tim David, Ben Dwarshuis, Josh Hazlewood, Travis Head, Josh Inglis, Matt Kuhnemann, Glenn Maxwell, Mitchell Owen, Matthew Short, Marcus Stoinis, Adam Zampa

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  • Another case surfaces in KP as polio drive kicks off in Balochistan – Pakistan

    Another case surfaces in KP as polio drive kicks off in Balochistan – Pakistan

    ISLAMABAD/QUE­TTA: As a new polio case was found in Tank district of Khyber Pakhtunkhwa, taking the total number of cases detected this year to 24, a week-long special anti-polio campaign was launched in 26 of the 36 districts of Balochistan on Monday amid tight security.

    The latest polio case involved a 20-month-old girl from Ping union coun­cil of Tank district, an official of NIH confirmed.

    “This is the 14th polio case from southern Khyber Pakhtunkhwa province this year. With this detection, the total number of polio cases found in the country in 2025 reached 24. The break-up of the polio cases is: 16 in Khyber Pakhtunkhwa, six in Sindh, and one each in Punjab and Gilgit-Balti­stan,” the official said.

    He said the victim belo­nged to ​Bettani tribe, adding that the case belonged to highly security compromised area not accessible for vaccination and no travel history was found.

    Meanwhile, a week-long special polio campaign was launched in 26 of the 36 districts in Balochistan amid tight security. Provi­ncial authorities have made strict security arran­g­eme­nts to ensure safety of the polio workers in view of the recent target killing of a supervisor of the Polio Pro­g­ramme in Chaman, a town bordering Afghan­istan.

    He was targeted by armed men in Roghani area of Chaman while taking part in creating awareness among the parents along with polio workers before launching the campaign in the area.

    “We are providing tight security to our polio workers in all the 26 districts where polio staff was administering polio drops and vaccination,” a senior official told Dawn, adding that during the week-long campaign more than 2.18 million children under the age of five will be administered anti-polio drops.

    The Emergency Operations Centre (EOC) Balochistan Coordinator Inam-ul-Haq while announcing the campaign programme said that during the drive in the province more than 2.18 million children under the age of five will be administered anti-polio drops.

    Calling the campaign, a crucial step in the fight against poliovirus, Mr Haq urged parents to ensure their children receive the vaccine, warning that failure to do so could result in lifelong disability.

    “All preparations have been finalised, and vaccination teams have been fully mobilised in both urban and remote areas of the province,” he said.

    The campaign was launched in Quetta, Pishin, Qilla Abdullah, Chaman, Barkhan, Dera Bugti, Hub, Jaffarabad, Jhal Magsi, Kalat, Khuzdar, Qilla Saifullah, Loralai, Mastung, Noshki, Nasirabad, Sherani, Sibi, Sohbatpur, Usta Mohammad, Zhob, Musakhail, Chagai, Duki, Lasbela, and Ziarat.

    A total of 11,659 teams will take part in the drive, including 9,129 mobile teams, 958 fixed-site teams, and 586 transit teams deployed at bus terminals, railway stations, and other key locations. Mr Haq stressed that the success of the campaign depends heavily on the community support. He appealed to civil society members, teachers and religious leaders to help raise awareness about polio among the masses and encourage families to get their children vaccinated.

    Alongside the polio campaign, he also reminded parents of the importance of routine immunisation, which protects children against 12 vaccine-preventable diseases such as measles, tuberculosis, hepatitis B, and diphtheria.

    He urged families to visit their nearest health centers to ensure their children receive all scheduled vaccines on time.

    Published in Dawn, September 2nd, 2025

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