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  • Justin Verboomen’s golden debut and Germany’s team triumph in Crozet

    Justin Verboomen’s golden debut and Germany’s team triumph in Crozet

    Justin Verboomen: Belgium’s new golden boy

    The story that captured everyone’s hearts in Crozet, and perhaps the wider equestrian world, belonged to a newcomer in black, yellow and red.

    Belgium’s Justin Verboomen, making his European Championship debut, paired with the nine-year-old stallion Zonik Plus to deliver not just one, but two golden rides.

    The first came on Friday (29 August) in the Grand Prix Special, where their 82.371 per cent score marked them instantly as contenders.

    Then, on Sunday (31 August), beneath a clearing sky and before a sold-out crowd, Verboomen stepped into the theatre of the Freestyle to music.

    Much like in figure skating’s free skate, riders here craft their own stories, stitching compulsory movements to melody, blurring technique and storytelling.

    The Belgian duo did just that, the crowd clapping in time with the stallion’s hooves, as if the arena itself had found its pulse.

    There was a wobble in the half pass, a moment where it could all have slipped away, yet Verboomen’s composure and Zonik Plus’ focus pulled the performance back into harmony. Their score, a personal best 89.964 per cent, secured Belgium’s second-ever medal at a European Championship, and with it, the arrival of a new name to reckon with.

    “I can’t believe it,” Verboomen admitted to FEI.org. “The second victory is really a surprise for me. I’m very proud of my horse again. He’s so young. He’s always attentive to me. I think it’s his greatest quality.”

    By toppling riders such as Denmark’s Laudrup-Dufour and Germany’s Werth, the most decorated in the sport’s history, Verboomen’s star was unmistakably born.

    Great Britain’s Paris 2024 bronze medallist Becky Moody finished just outside the podium in fourth.

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  • Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

    Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

    Researchers from Renji Hospital, School of Medicine, Shanghai Jiao Tong University, et al. have conducted a study entitled “Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions”. This study was published in Frontiers of Medicine, Volume 17, Issue 3.

    Immunoglobulin (IgG) glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases, including systemic lupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation aberration in autoimmunity. This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy. Relative to that in serum samples from the control cohort, IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages (from preconception to the third trimester of pregnancy) and was significantly associated with lupus activity and fetal loss during lupus pregnancy. The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation. The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells (pDCs). RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase (SYK) signaling pathway significantly differed between IgG- and deSia-IgG-treated pDCs. This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG. Finally, the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG. The results suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner.

    This study was supported by grants from the National Natural Science Foundation of China, the Science and Technology Commission of Shanghai Municipality, the Medical-Engineering Joint Funds of Shanghai Jiao Tong University, the Shanghai Key Laboratory of Gynecologic Oncology, Shanghai Health Commission and the Clinical Scientific Research Innovation Cultivation Fund of Renji Hospital. For more detailed information, the full paper is available at: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-022-0965-7.


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  • Older Africans Overlooked in Care and Research

    Older Africans Overlooked in Care and Research

    For decades, public health efforts across sub-Saharan Africa have focused on HIV prevention, testing and treatment campaigns on children and women of reproductive age, overlooking the population at older ages.

    At present, the high success of antiretroviral therapy (ART) campaigns, together with the continuous efforts to achieve — that 95 per cent of people with HIV know their status, 95 per cent of those are on treatment and 95 per cent of those have suppressed viral loads — have the HIV treatment gap in many African countries. In turn this has dramatically the life expectancy of people living with HIV.

    One consequence of this is that the HIV epidemic is increasingly affecting older people. Due to this increase in life expectancy in the population living with HIV, the HIV epidemic has experienced an ageing process.

    However, most HIV programmes and studies still the population over 50 years of age. The immediate consequence is that older adults, especially women past childbearing age, are often invisible in surveillance data, overlooked in prevention messaging and under-represented in care strategies.

    Few HIV interventions are tailored to this group, even though they face unique risks. This blind spot has serious consequences for the health and well-being of a growing and vulnerable population.

    We have worked in the past years to better understand the ageing process of the HIV epidemic, not only on the growing number of people living with HIV, but also on explaining the risks of new HIV infections in the older population.

    In response to this dearth of data, the changes in the HIV epidemic in a group of older people over two waves of data collection (2013-16 Wave 1; 2019-22 Wave 2) and across nearly a decade.

    The study, a sub-study of the , followed over 7,000 adults aged 40 and older in four locations. Three were in South Africa — the urban setting of Soweto in the country’s industrial heartland and the rural setting of Bushbuckridge in the north-east of the country and Dikagale, Mamabolo and Mothiba in the north — and one in Nairobi slums in Kenya.

    These settings allow for comparison of east and southern Africa, the two African regions with higher prevalence of HIV. At the same time, it permits a comparison between rural and urban settings.

    We were able to assess the number of people living with HIV, the number of new infections and the social factors driving the HIV transmission. We did this by doing HIV tests and asking participants if they’d ever been tested for HIV, whether they knew their HIV status and whether they were receiving ART.

    We found that one in five adults (22 per cent) in the study were living with HIV (that is, they were infected with HIV). This rate stayed high across both time points. We also observed that new infections were happening in this older population, especially in widows, rural residents and those with no formal education.

    This shows that, even as treatment access improved, major disparities persisted. And older adults are still acquiring HIV, often because the public campaigns for HIV leave them out.

    The conclusion that can be drawn from our findings is that the world needs to stop seeing HIV as only a “young person’s disease”. The narrative needs to change, as must the response. Ageing with HIV is now a global public health reality — especially in sub-Saharan Africa — and the HIV response must evolve to reflect that.

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  • Microsoft (MSFT) Integrates Copilot AI into Samsung TVs

    Microsoft (MSFT) Integrates Copilot AI into Samsung TVs

    Microsoft Corporation (NASDAQ:MSFT) is one of the top tech stocks to buy now according to Goldman Sachs. On August 27, the company integrated its Copilot AI assistant into select 2025 Samsung TVs and monitors. The service is free to use and will be available on models including Micro RGB, Neo QLED, OLED, The Frame Pro, The Frame, as well as the M7, M8, and M9 Smart Monitors. Microsoft plans to expand the availability to more models and regions in the future.

    Microsoft (MSFT) Integrates Copilot AI into Samsung TVs

    Ken Wolter / Shutterstock.com

    The AI assistant is a voice-powered tool featuring a friendly on-screen character with expressive features that match the tone of the conversation. It responds with both voice and “rich, glanceable cards” that display information like movie ratings and photos. Copilot is designed to be a “personal and helpful companion” in the living room. It can assist with a variety of tasks, including finding content to watch, answering everyday help questions, and performing post-watch deep dives.

    This Copilot integration is part of a continuing partnership between Microsoft and Samsung, which has previously included bringing features like Windows and Office to Galaxy devices.

    Microsoft Corporation (NASDAQ:MSFT) develops software, hardware, and cloud services used by businesses and consumers worldwide. Its core products include the Windows operating system, the Microsoft Office suite, and the Azure cloud platform, alongside LinkedIn, Xbox, and various enterprise solutions.

    While we acknowledge the potential of MSFT as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

    READ NEXT: 10 Must-Buy Penny Stocks to Invest In and 6 Best Railroad Stocks to Buy Right Now.

    Disclosure: None. This article is originally published at Insider Monkey.

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  • Ireland man relied on ChatGPT for months, later diagnosed with Stage 4 Cancer

    Ireland man relied on ChatGPT for months, later diagnosed with Stage 4 Cancer

    Dublin-based Warren Tierney, a 37-year-old father and former psychologist, is warning people against using AI chatbots as a substitute for medical care after his alarming experience with ChatGPT.

    Tierney had been struggling with a persistent sore throat and difficulty swallowing but turned to ChatGPT instead of visiting a doctor. For months, the AI tool reassured him that his symptoms were “highly unlikely” to be cancer, even offering comforting messages such as “I will walk with you through every result that comes. If this is cancer — we’ll face it. If it’s not — we’ll breathe again.”

    But when his condition worsened, Tierney finally sought emergency care. Doctors diagnosed him with stage-four esophageal adenocarcinoma, a rare and aggressive throat cancer with a survival rate of just 5–10% over five years.

    “I know that probably cost me a couple of months,” Tierney admitted, reflecting on how the false sense of assurance delayed his treatment. “That’s where we have to be super careful when using AI. I maybe relied on it too much.”

    OpenAI, the maker of ChatGPT, has consistently emphasized that the chatbot is not designed to provide medical advice or treatment. Health professionals stress that AI-generated responses can never replace proper diagnosis and early intervention, which, in Tierney’s case, could have altered the trajectory of his illness.

    Now, Tierney is using his story to raise awareness about the dangers of over-reliance on AI for health concerns, urging others to seek medical help first, not chatbot reassurance.

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  • Wigan girl’s nut allergy sparks row on flight to Disney

    Wigan girl’s nut allergy sparks row on flight to Disney

    Sarah Spina-MatthewsBBC News, Manchester

    Sarah Bacon A close-up of Savannah. She is smiling while holding the handle of her suitcase. She is wearing a pink and white bow and a white vest with a heart pattern on it.Sarah Bacon

    Savannah was heading to Disneyland Paris to take part in a dance show

    A mother is calling for better training for airline staff after feeling like she had to “beg for assistance” with her daughter’s severe airborne peanut allergy on board an Air France flight.

    Sarah Bacon, from Wigan, said she notified the crew of her seven-year-old daughter Savannah’s allergy – which means even particles of peanuts in the air can cause a potentially life-threatening reaction – months before the Manchester to Paris flight last month.

    But she said staff were “reluctant” to make an announcement asking passengers not to consume peanuts, as was normal procedure on all the flights Ms Bacon had previously taken with her daughter.

    Air France has been approached for comment.

    Savannah is looking down at her arm. She has blonde hair tied back and she is wearing a white T-shirt.

    Savannah was diagnosed with multiple allergies at the age of six months

    Ms Bacon said she and her daughter were on the way to Paris so that Savannah could take part in a dance performance at Disneyland.

    She said a flight attendant notified the people in the seats around Savannah but she had to “push” for the general announcement to be made.

    However, she said on the way home the flight attendant initially refused to make an announcement at all, forcing her to notify the passengers around her herself, before a “muffled” announcement was eventually made after several requests.

    “I felt like I had to beg for assistance,” Ms Bacon said.

    She said she wanted airline staff to have better training, given passengers were at higher risk in confined places like planes.

    Ms Bacon said: “We always carry two EpiPens but there’s never a guarantee that they will work.”

    ‘Life or death’

    She said the incident had made her anxious about flying in future, including for a booked holiday to Florida later this year.

    “It makes me so anxious, it has affected me mentally,” she said.

    “All we can do is trust other passengers and staff to keep us safe. We want more knowledge and training.

    “I don’t think people understand when they hear the message that for some people it is life or death.”

    Ms Bacon said she had travelled with Savannah about 10 times before on various airlines and “never had an issue previously”.

    But it is not the first time the family have faced complications over Savannah’s allergies, which were diagnosed when she was six months old.

    In April Ms Bacon highlighted the “sighing” reaction of shop staff after she asked them to check for allergens in a pick-and-mix selection.

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  • ‘Scarlet’ Director Mamoru Hosoda Bridges East and West

    ‘Scarlet’ Director Mamoru Hosoda Bridges East and West

    In anime master Mamoru Hosoda’s latest feature, “Scarlet,” the innovative Japanese filmmaker looks West for inspiration: to Shakespearean themes, classic European fantasy and the tradition of Walt Disney princesses.

    In a sense, that makes it the mirror image of what’s fueling the headline-grabbing success of “KPop Demon Hunters,” the American-made, Asian-culture-imbued animated hit that just became Netflix’s most-watched original film. (It’s probably not a coincidence that both “KPop” and “Scarlet” were developed with Sony’s support. While “KPop” was produced in-house, “Scarlet” is the first of Studio Chizu’s projects to be co-financed by the Japanese powerhouse.)

    Beyond hinting that “Scarlet” is “very relevant to kind of our current social climate,” Hosoda has been fairly secretive about this new project, which premieres out of competition at the Venice Film Festival Sept. 4.

    “Simply put, this is a story of vengeance,” he confides. “Our protagonist Scarlet is a princess from this kind of Middle Ages society who failed to exact revenge on her sworn enemy. She then gets transported to a different world, where she doesn’t give up on her quest for revenge.”

    From “The Boy and the Beast” to “Belle,” nearly all Hosoda’s films straddle two separate time periods or worlds — real life and escapist virtual realms, past and present, modernity and myth — in a strategy that tests his protagonists’ capacity to face the challenges in their daily lives. “Scarlet” is no exception, introducing its eponymous princess to a modern-day nurse in Hosoda’s unique spin on the buddy-movie formula.

    “Doing that with this transportation to a different world allows the exchange of really unique ideas,” explains Hosoda, who remains coy about where Scarlet comes from. “Which two worlds are being contrasted is really the core essence of what makes this movie unique.”

    This meeting of cultures mirrors a more overarching phenomenon Hosoda has observed in the medium of animation. Until roughly 10 years ago, he observes, there was little overlap between the toons being produced in America, Europe and Japan. “That all changed with the rise of the streaming platforms,” he explains.

    Suddenly, “audiences from around the world got to consume and understand different types of animation expression, and these big walls that separated those three styles have really come down,” enabling the artistic fusion reflected in “Spider-Man: Into the Spider-Verse” and “KPop Demon Hunters.”

    “Whatever we create, there is an audience internationally that can relate to it, and who now has the literacy to understand the nuance of what these different types of animation are trying to convey,” he says.

    “I’m actually a huge fan of the American 2D hand-drawn animation style, from which I’ve drawn a lot of influence. I look at ‘Beauty and the Beast’ and what Glen Keane was able to establish as this benchmark of character and performance,” adds Hosoda. “I have so much respect for what he has done, and now perhaps Japanese anime is influencing other people.”

    “Scarlet,” which took four and a half years to produce (almost 50% longer than the three-year timeframe Hosoda’s previous features required), boasts a richer, more detailed aesthetic, including a range of facial types and expression rarely seen in anime. Though Hosoda began his career practicing a traditional Japanese 2D hand-drawn approach, he has progressively incorporated digital techniques along the way (most significantly in “Belle,” on which Hosoda tapped Disney veteran Jin Kim to do some of the character designs).

    Kim returns on “Scarlet,” this time joined by “Big Hero 6” collaborator Tadahiro Uesugi (a set designer with a distinctive eye). “Several of the collaborators on this film have a lot of big credits under their belt, and that has allowed me to expand our horizon of expression,” says Hosoda, who used CG to enhance the hand-drawn feel. “The detail on a lot of the characters and models is something that would be extremely challenging to do with 2D, if not impossible.”

    Another key factor in Hosoda’s growth as a storyteller has been the way international festival exposure has brought a wider audience to his work. That began when “The Girl Who Leapt Through Time” was invited to screen at Busan in South Korea, followed by the Berlin premiere of “Summer Wars” and “Mirai” debuting in Cannes.

    “With each film, I’m able to directly interact with new audiences, which has expanded my own horizon for different types of themes and forms of expression,” he says. “The fact that I’m able to take these almost Shakespearean elements and apply them to animation is something that I never imagined would have happened when I rewind the clock 20 years.

    “For me, this idea of revenge is more relevant now than ever. The world is very unstable. It’s kind of scary. There’s a lot of conflict,” he says. “But as a creator and filmmaker, I think we all strive to communicate on this different plane or artistic level, and I hope that that can kind of bring us into a different world, so to speak.”

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  • The Sky Today on Tuesday, September 2: Mercury meets Regulus

    The Sky Today on Tuesday, September 2: Mercury meets Regulus

    The bright planet Mercury passes the star Regulus in Leo just before sunrise — if you’re quick, you can spot them.

    • At 6 A.M. EDT, Mercury will pass 1.2° north of Regulus, observable in the east before sunrise from locations with clear eastern horizons.
    • Mercury, with a magnitude of –1.3, will reach an altitude of 4° approximately 30 minutes before sunrise, appearing to the lower left of Venus (magnitude not specified). Regulus (magnitude 1.4) will be located just over a degree to Mercury’s lower right and may require binoculars or a telescope for observation.
    • Telescopic observation of Mercury will reveal its 5” apparent width, 90% illumination, and smaller size compared to Venus (85% illumination and larger disk size).
    • Provided local sunrise, sunset, moonrise, moonset times, and moon phase (73% waxing gibbous) for 40° N 90° W, with the caveat that these times might differ slightly based on location. Observation with optical instruments should cease several minutes before sunrise.

    Mercury passes 1.2° north of Regulus at 6 A.M. EDT; the pair is visible in the east just before sunrise, but it might be a challenging observation. You’ll want to get to a location above the surrounding terrain if possible, with an eastern horizon free of tall trees or buildings. 

    Rising around 5:30 A.M. local daylight time, Mercury reaches an altitude of 4° roughly half an hour before sunrise. It’s now magnitude –1.3, which should help it stand out against the brightening sky, although binoculars can also help you locate it to the far lower left of blazing Venus, which stands some 20° high at this time. Magnitude 1.4 Regulus will be more challenging and may only be visible with binoculars or a telescope, just over a degree to the lower right of Mercury in the sky as they are rising. The star should be just within the same field of view as the planet with a telescope, and definitely within a single binocular field. 

    If you’re using a telescope, take a moment to focus on Mercury as well. The tiny planet appears 5” wide — nearly 2.5 times smaller than Venus’ disk, currently — and is 90 percent lit, slightly more than Venus’ 85 percent. The latter, brighter planet hangs  2° directly below M44 this morning, so if you’d like to catch a binocular view of the two, you can look for them a little earlier, while the sky is still dark — try some 60 to 90 minutes before sunrise. 

    Note that you should always put away any binoculars or telescope at least a few minutes before sunrise occurs from your location, which may differ slightly from the times listed below. 

    Sunrise: 6:29 A.M.
    Sunset: 7:30 P.M.
    Moonrise: 4:44 P.M.
    Moonset: 12:33 A.M. 
    Moon Phase: Waxing gibbous (73%)
    *Times for sunrise, sunset, moonrise, and moonset are given in local time from 40° N 90° W. The Moon’s illumination is given at 12 P.M. local time from the same location.

    For a look ahead at more upcoming sky events, check out our full Sky This Week column. 

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  • Key Starbucks supplier in Switzerland tastes bitter harvest of Trump tariffs – Reuters

    1. Key Starbucks supplier in Switzerland tastes bitter harvest of Trump tariffs  Reuters
    2. Swiss Outlook for 2026 Is Cut by UBS Amid Concern on Tariff Hit  Bloomberg.com
    3. Switzerland’s Quarterly GDP Up 0.1% in Q2, Final Data Confirms  富途牛牛
    4. Worse to come for Swiss GDP, French yields to rise  Capital Economics
    5. Swiss economy set to slow due to US tariffs  Bloomer Advance Newspaper

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  • Non-profit music collective launches festival in ‘rescue plan’ for UK gig circuit | Festivals

    Non-profit music collective launches festival in ‘rescue plan’ for UK gig circuit | Festivals

    A group of festival organisers and grassroots venues have launched a “pioneering, gamechanging music collective” to counter what they say is the slow collapse of the UK’s alternative live circuit.

    Blaming soaring costs and corporate dominance for pushing dozens of smaller events to close, the not-for-profit festival will bring together independent festivals, venues and collectives to share resources, cut costs and pool audiences.

    Led by Si Chai, the founder of Chai Wallahs, the Where It All Began festival – scheduled for next spring – has been backed by the Music Venue Trust. Freddie Fellowes, the founder of the Secret Garden Party festival, has offered to host the event on his family’s farm in Cambridgeshire.

    “The current independent festival model has become unsustainable, pressured and too financially stressful for most organisers since Covid, which means a wealth of incredible grassroots artists are being denied a fair opportunity to perform and carve out their own careers,” said Chai. “I’ve got a plan to save it that will work, but it needs everybody to get involved.”

    The cooperative will operate as a Community Benefit Society, with participants co-owning and co-programming the festival. A public crowdfunding campaign will launch later this year, offering members a stake in how the event is run.

    “This is a rescue plan,” Chai said. “We’re not here to compete with the independent scene. We’re here to help.”

    The model, organisers say, is designed to reduce production and transport costs by up to 40%, while marketing will rely on shared databases rather than expensive commercial campaigns. The aim is to create a replicable blueprint that could stabilise parts of the sector most vulnerable to market shocks.

    Those shocks have already been severe. According to the Association of Independent Festivals (AIF), 78 UK festivals were cancelled or closed in 2024 – more than twice the number lost the year before. The AIF blames a combination of rising insurance premiums, energy costs, licensing fees and exclusive supplier deals as the main culprits.

    More worrying, said John Rostron, the chief executive of the AIF, was a cultural shift that would heavily impact the future of the UK’s music scene. “Where small festivals once served as testing grounds for emerging artists, they are now struggling to survive in an industry increasingly skewed towards multinational operators like Live Nation,” he said.

    Live Nation Entertainment, which helped launch the careers of stars including Adele, Ed Sheeran and Stormzy, was formed in 2010 after a merger with Ticketmaster. It was a controversial launch, initially opposed by the UK’s competition watchdog. Now the US-based company runs all but one of the UK’s major festivals and collectively sells a quarter – or 880,000 – of all festival tickets.

    A Live Nation spokesperson agreed that “pressures on festivals are felt from top to bottom, with costs rising significantly”. But, they added: “Independent festivals are where many artists take their first steps and where fans discover music they love for life. Thanks to the popularity and success of some of our established festivals, we’re able to partner with and invest in independent festivals and events such as the Great Escape, First Fifty and the BBC Introducing stages at Reading and Leeds.”

    Chai said Where It All Began was not attempting to scale up or rival that dominance. Instead, it is designed to protect what remains.

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    Already, nine independent venues and collectives have signed on to take part in the first edition. More are expected to join before the public campaign opens.

    Rostron believes that Chai’s model is “pioneering and gamechanging”. He added: “It is an interesting and creative potential solution to the current crisis that might just get us over the line by sharing the risk of holding a festival that is now too great to be shouldered by any one organiser on their own.”

    Fellowes said the new model was “necessary, hopeful and long overdue”.

    “It fills a vital role in the development, patronage and support of artists, without which the growth of creativity will be stunted,” he said.

    But Chai said the collective was not dealing in hope. It was, he said, focused on survival. “If this works, it won’t just be a festival,” he said. “It will be proof that independents still have power when they act together.”

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