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  • New study maps bacterial communication to fight MRSA infections

    New study maps bacterial communication to fight MRSA infections

    Imagine two people talking over a walkie-talkie set. Successful communication depends on them being tuned to the same frequency. If others try to communicate nearby, interference can occur, and important messages may be lost.

    Something similar happens in the world of bacteria. Bacteria communicate on their own “frequencies” when, for example, they coordinate an attack on a host by infecting a wound. However, other bacterial species can disrupt this communication, which, in turn, weakens the ability to coordinate and attack.

    Now, researchers from the University of Copenhagen have conducted the largest mapping to date of the frequencies – or signaling molecules – that Staphylococcus bacteria use to communicate.

    Staphylococci are a family of bacteria that, among other places, live on our skin. One species, Staphylococcus aureus, also exists in antibiotic-resistant variants known as methicillin-resistant S. aureus (MRSA). MRSA strains are therefore more difficult to treat than regular staphylococci.

    The researchers then used their new knowledge to effectively treat an MRSA infection.

    With our mapping, we can identify which signaling molecules are most effective against MRSA. We found that a signal from another Staphylococcus variant, Staphylococcus simulans, was very potent against S. aureus. Originally, the signaling molecule was isolated from a bacterial strain from a cow, but it is also present on goats, horses and humans.”


    Christian Adam Olsen, professor at the Department of Drug Design and Pharmacology at the University of Copenhagen and one of the authors of the new study

    The researchers tested, in a mouse model, whether the signaling molecule from S. simulans could also disrupt MRSA signals and prevent infection. It could.

    “In the experiment, we showed that with a single dose of this signaling molecule, the mice could overcome an MRSA skin infection just as effectively as mice treated daily with an antibiotic ointment, which is a current option for treating staphylococcal skin infections,” says postdoc Benjamin Svejdal Sereika-Bejder, who also contributed to the new study.

    A new weapon against antibiotic resistance?

    Antibiotic resistance is an increasing problem in society, which is why there is great interest in finding alternative treatments for bacterial infections. Therefore, the researchers also investigated whether bacteria would develop resistance towards treatment with the signaling molecule.

    “No one has previously tested whether staphylococci develop resistance towards treatment with these signaling molecules, as we see with antibiotics. In our experiments, we observed that under laboratory conditions, the bacteria did not develop resistance even after 15 days. This is very promising but will require further testing in animal models,” says postdoc Benjamin Svejdal Sereika-Bejder.

    This alternative technique weakens the bacteria’s ability to communicate effectively but does not kill them, as is the case with antibiotics. The bacteria are allowed to live but have a harder time coordinating an attack on the host’s immune system.

    “The explanation is likely that there is no evolutionary pressure on the bacteria to develop resistance, as they do not perceive the signaling molecules as being lethal to them. They are also encountering the signaling molecules from other bacteria in their natural environment,” says Christian Adam Olsen.

    Source:

    University of Copenhagen – The Faculty of Health and Medical Sciences

    Journal reference:

    Gless, B. H., et al. (2025) Mapping of quorum sensing interaction network of commensal and pathogenic staphylococci. mBio. doi.org/10.1128/mbio.00967-25.

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  • ‘You can’t settle for average!’ – Luka Modric still feels ‘the fire inside me’ as he explains why he picked AC Milan over other offers after leaving Real Madrid

    ‘You can’t settle for average!’ – Luka Modric still feels ‘the fire inside me’ as he explains why he picked AC Milan over other offers after leaving Real Madrid

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    • Modric explains why he joined Milan
    • Speaks about his hunger and desire to win titles with new club
    • Croatian left Madrid after spending 13 years

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  • Mac graphics settings for Cyberpunk 2077 aim for console-like simplicity

    Mac graphics settings for Cyberpunk 2077 aim for console-like simplicity

    PC-like power, console-like benefits

    Cyberpunk is a big get for the Mac’s gaming team, as it’s an enduringly popular open-world game with a distinctive look, but it’s also of a piece with all of the AAA gaming launches the Mac has seen in the last couple of years. It’s a popular and graphically impressive game from a major studio, but it’s also coming to the Mac years after it initially arrived on PCs and consoles.

    Cyberpunk’s graphics settings show where the Mac could have advantages as a gaming platform, though. Like PCs, Apple Silicon Macs are available at all kinds of price and performance levels, from the low-end fanless MacBook Air to the top-tier M3 Ultra Mac Studio. But unlike PCs, where developers can’t account for all of the possible CPU, GPU, motherboard, storage, and RAM configurations, Windows versions, and graphics driver updates, the Mac comes in a more finite number of configurations with more tightly controlled software. This makes it easier for developers to target and tune for specific hardware.

    Case in point, Cyberpunk’s “For this Mac” preset. Unlike the PC game’s Steam Deck preset, this isn’t a fixed collection of specific settings made with one particular hardware configuration in mind. Rather, it’s a dynamic preset that chooses different settings based on which specific Mac hardware you’re running the game on. An M1 Mac using this preset would get different settings than an M4 Max Mac using the same preset, and players can choose it knowing that they ought to get reasonably smooth and consistent performance with the best settings that their individual Mac can reasonably handle. (The one setting “For this Mac” doesn’t touch is ray-tracing, which can be manually enabled on M3- and M4-series Macs with the GPU hardware to support it but which won’t be turned on automatically.)

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  • What We Saw When NASA Sent A Probe To Explore Kuiper Belt Object Arrokoth

    What We Saw When NASA Sent A Probe To Explore Kuiper Belt Object Arrokoth

    In 2006, NASA launched New Horizons on a long journey to study dwarf planet Pluto over 5 billion kilometers (3.1 billion miles) from Earth. 

    The spacecraft first headed to gas giant Jupiter for a gravity assist in 2007, in a maneuver which would increase its velocity by around 14,000 kilometers per hour (9,000 miles per hour). As it did so, it imaged Jupiter’s moons Io, Europa, and Ganymede, before heading towards Pluto at its new zippy speed of around 300 million miles per year.

    Arriving at its primary target in 2015, the spacecraft collected data on Pluto and its moons Charon, Nix, Hydra, Kerberos, and Styx. 

    “Data from New Horizons clearly indicated that Pluto and its satellites were far more complex than imagined, and scientists were particularly surprised by the degree of current activity on Pluto’s surface,” NASA explained of the mission. “The atmospheric haze and lower than predicted atmospheric escape rate forced scientists to fundamentally revise earlier models of the system.”

    But the spacecraft was not done yet. Following the Pluto flyby, NASA redirected it towards an object in the Kuiper belt, around 6.4 billion kilometers (4 billion miles) from Earth. When it arrived in 2019, the object became the most distant object ever visited by a spacecraft.

    The object was officially named Arrokoth in 2019 after the word for “sky” in the Powhatan/Algonquian language.

    “The name ‘Arrokoth’ reflects the inspiration of looking to the skies and wondering about the stars and worlds beyond our own,” Alan Stern, New Horizons principal investigator from Southwest Research Institute, Boulder, Colorado, said in a statement at the time. “That desire to learn is at the heart of the New Horizons mission, and we’re honored to join with the Powhatan community and people of Maryland in this celebration of discovery.”

    Arrokoth is a contact binary, with one lobe in contact with a smaller lobe, resembling a space snowman. The two lobes are believed to have clumped together under the force of gravity, but this closeup view of the asteroid revealed a few mysteries.

    “What we’ve learned after sitting down and scratching our heads a little bit is that it’s what we call a ‘cold classical Kuiper Belt’ object,” New Horizons mission scientist Carey Lisse told the BBC’s Sky at Night magazine.

    “It’s not cold because it’s far from the Sun; it’s dynamically cold. Its orbit has been pretty much the same for the entire history of the Solar System.”

    These “cold” objects make up around a third of the Kuiper belt, with their circular orbits indicating that they haven’t been disturbed too much by the giant planets of the Solar System.

    The team believes that Arrokoth is a “primordial” object, being largely unaffected by other objects in the past 4.6 billon years. That makes it pretty useful for studying the early Solar System, though heating can still affect the object at its surface, and perhaps as much as 10 meters (32 feet) deep.

    One interesting aspect of the object, studied since New Horizon’s brief visit, is how the two lobes came together. 

    “They are just touching each other, it’s like they are kissing, or if they were spacecraft they would be docking,” New Horizons co-investigator William McKinnon explained to Sky and Telescope. “There is no evidence that the merger of these two lobes was at all violent.”

    According to that team, the two objects must have come together very slowly indeed, impacting at relative speeds of less than 3 meters per second. Others have put the velocity of impact at even lower. 

    “We find that the individual mapped mounds on Arrokoth’s larger lobe, Wenu, are consistent with the merger or assembly of discrete, similarly sized multi-km-scale planetesimals from Arrokoth’s natal collapse cloud,” another recent team, which looked closely at mounds on the object, explained in their paper. 

    “Our numerical calculations of collisional mergers of precursor bodies indicate that normal impact speeds ≲1 m/s are necessary to preserve the shapes of the individual subunits, using gravel friction parameters.”

    Further study of such objects could tell us a lot about the formation of the Solar System. While no further trips are planned to Arrokoth, New Horizons is still operational.

    “The New Horizons mission has a unique position in our solar system to answer important questions about our heliosphere and provide extraordinary opportunities for multidisciplinary science for NASA and the scientific community,” Nicola Fox, associate administrator for NASA’s Science Mission Directorate in Washington, said in a 2023 statement. “The agency decided that it was best to extend operations for New Horizons until the spacecraft exits the Kuiper Belt, which is expected in 2028 through 2029.” 

    If another suitable target can be identified soon, New Horizons may be able to take a closer look at it, revealing further details of the Kuiper belt.

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  • Microsoft’s July Patch Might Be to Blame If Azure VM Isn’t Loading – TechRepublic

    1. Microsoft’s July Patch Might Be to Blame If Azure VM Isn’t Loading  TechRepublic
    2. Windows KB5064489 emergency update fixes Azure VM launch issues  BleepingComputer
    3. Windows 11 24H2/Windows Server 2025: VM hangs after July 2025 update; fix with OOB update KB5064489  BornCity
    4. Microsoft releases emergency fix for Azure Virtual Machines issue caused by Windows 11 update  BetaNews

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  • How an “ocean of fire” shaped early Earth’s core

    How an “ocean of fire” shaped early Earth’s core

    Earth’s deepest layers were not always solid rock blanketing a molten core. New simulations show a hidden sea of magma pooled above the core during the planet’s chaotic youth and how it still shapes the underground landscape today.

    Charles‑Édouard Boukaré, a planetary physicist at York University, guided the work and argues that the ancient melt layer, or basal magma ocean, was an unavoidable consequence of early cooling. 


    “Another way to say this is there is a memory,” Boukaré said, explaining that the planet’s interior still remembers its fiery beginnings.

    Modeling the infant Earth

    The research team combined isotope data from ancient rocks with modern seismic images to build a three‑dimensional model of a newborn planet.

    Their code tracked how iron‑rich liquid separated from lighter crystal mush and trickled to the bottom of the mantle.

    Even when they forced crystallization to start in mid‑mantle zones, dense melt still slid downward, proving that the deep pool forms, no matter where solidification begins.

    The result overturns earlier one‑directional models that made the mantle freeze from the core upward.

    The simulations reproduced present‑day mantle temperatures and predicted a lingering layer of melt up to 60 miles (96 kilometers) thick.

    That prediction matches tiny signals in seismic data that hint at pockets of extraordinary heat above the core.

    Heat flow kept Earth’s core liquid

    Cooling crust near the surface formed the first minerals, but their extra weight made them plunge back into the mantle.

    Most solidified crystals remelted on the trip down, yet some carried shallow chemical signatures that are now buried nearly 1,800 miles (2,900 kilometers) deep.

    Iron oxide lowered the melting point of these sinking masses and helped them merge into the basal ocean. Heat flowing out of Earth’s core kept the iron‑rich mixture liquid long after the rest of the mantle stiffened into rock.

    Because the melt is denser than the surrounding solids, it refuses to rise and cool.

    That quirk sealed in a reservoir of incompatible elements such as neodymium and tungsten, explaining why modern lava sometimes carries ancient isotopic fingerprints.

    Clues from mantle blobs

    Seismologists have mapped two continent‑sized zones beneath Africa and the Pacific where earthquake waves slow sharply.

    These large, low‑shear velocity provinces might be the frozen rims of the primeval ocean, dating back more than 4.4 billion years.

    Alternative theories say the blobs are piles of sunken ocean crust recycled by plate tectonics. Yet the volume and dense, iron‑enriched makeup of the blobs fit the basal magma ocean story far better than crustal recycling alone.

    If the blobs truly are relics of early melt, they could act as anchors that pin mantle plumes in place, explaining the long‑lived volcanic tracks that dot the Pacific seafloor.

    Their presence also helps seismologists interpret odd, low‑velocity patches found near Earth’s core–mantle boundary worldwide.

    Earth’s core drives convection

    Heat leaving the core drives convection that powers the geodynamo, the engine behind Earth’s magnetic field. A thick, insulating sheet of iron‑rich melt alters that heat flow and could modulate magnetic strength over tens of millions of years.

    “Continent drift might affect the location of tectonic plates,” notes Boukaré, hinting that the drift could partially reflect the deep ocean’s rhythm of currents. Changes in melt thickness also tweak how stiff slabs sink and how buoyant plumes rise. 

    Isolated melt pockets may even lubricate slab edges, letting plates slide with less friction. That effect could explain why subduction zones sometimes shift along straight lines rather than wandering like rivers.

    Chemical prints in ancient rocks

    Isotopic ratios of samarium–neodymium and lutetium–hafnium vary subtly in rocks that are older than 3 billion years.

    The variations match the signature expected when shallow crystals rain into a deep, iron‑saturated melt, then remix into later lavas.

    Some Archean basalts in western Greenland preserve these signals, confirming that early differentiation products were never fully erased by later convection.

    The model reconciles that evidence with the fact that most upper mantle rocks look chemically uniform today.

    Geochemists once limited the amount of bridgmanite crystallization because they feared it would skew surface isotopes, but the new work shows that shallow and deep processes can cancel each other’s signals. This finding opens room for more extensive early mantle stratification than previously thought.

    Echoes on other worlds

    It is theorized that Mars lost its magnetic shield early, and Venus never developed plate tectonics, outcomes that may reflect how long their own basal oceans survived.

    Running Boukaré’s code with Martian gravity produces a melt layer that freezes quickly, starving the core of heat and ending dynamo action.

    Super‑Earth exoplanets, with stronger gravity and thicker mantles, may hold basal oceans far longer.

    That persistence could dampen surface volcanism and help the planets retain atmospheres, parameters that astronomers use when ranking habitability.

    Future questions about Earth’s core

    Laboratory experiments that squeeze minerals to core pressures are planned to test how truly dense molten iron‑silicate mixtures become. Those results will refine melt‑mobility numbers in the next generation of mantle models.

    Seismologists are also hunting for ultrasonic echoes that bounce off the melt’s upper surface, a signal that would prove the ocean still exists today. Any detection would transform theories about mantle convection and core cooling in one stroke.

    Looking ahead, the team plans to fold more trace elements into the model and simulate mantle overturn events triggered by giant impacts.

    Those runs could reveal whether the basal ocean ever mixed completely or still hides a liquid heart.

    Success in either search would ripple into planetary science, informing models of exoplanets and guiding missions that probe the deep interiors of rocky worlds.

    The next decade of experiments and observations could turn the idea of a lasting magma sea from theory into accepted geology.

    The study is published in Nature.

    Photo credits: @Sylvain Petitgirard/University of Bayreuth.

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  • CUE-101 Plus Pembrolizumab Yields 50% ORR in HPV+ HNSCC With Low PD-L1 Expression

    CUE-101 Plus Pembrolizumab Yields 50% ORR in HPV+ HNSCC With Low PD-L1 Expression

    Head and Neck Cancer | Image credit:

    © G.Go – stock.adobe.com

    First-line treatment with CUE-101 at the recommended phase 2 dose (RP2D) of 4 mg/kg in combination with pembrolizumab (Keytruda) produced a confirmed overall response rate (cORR) of 50%, including complete responses (CRs), in patients with human papillomavirus (HPV)–positive, recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) with a PD-L1 combined positive score (CPS) of at least 1, according to updated data from the expansion portion of the phase 1 CUE-101-01 trial (NCT03978689).1

    At a data cutoff of July 14, 2025, 2 patients had achieved a CR and 10 had achieved a partial response (PR); an additional CR was reported in a patient with multiple tumors. Responders included patients with a low PD-L1 CPS (between 1 to 19). The 12-month overall survival (OS) rate with CUE-101 plus pembrolizumab was 88% and the median OS was 32 months.

    “We are excited to report an additional CR in a patient that had recurrent metastatic HPV-positive HNSCC treated with CUE-101 in combination with pembrolizumab,” Matteo Levisetti, chief medical officer of Cue Biopharma, stated in a news release. “This patient had durable stable disease for close to 2 years and more recently demonstrated significant tumor reductions and now a CR. Notably, the patient had multiple sites of disease, including the lungs that cleared prior to the CR observed in the target lesion. We believe the kinetics of tumor reduction and disease eradication in this patient is due to the repeated stimulation and expansion of tumor-specific T cells given the mechanism of action of CUE-101. It also serves as a clear example of the differences in timing of the clinical activity often observed with immunotherapy compared to traditional cytotoxic therapies and supports the prolonged median OS observed in this trial.”

    According to the drug’s developer, Cue Biopharma, these results are favorable compared with historical data from the phase 3 KEYNOTE-048 trial (NCT02358031). Treatment with pembrolizumab monotherapy in this trial produced an ORR of 19%, a 12-month OS rate of 57%, and a median OS of 12.3 months.

    Dan Passeri, chief executive officer of Cue Biopharma, added that, “The culmination of maturing data further support our conviction that CUE-101, representative of our approach with the CUE-100 series, demonstrates a potential breakthrough therapeutic approach for establishing a new standard of care. With this maturing data, we are further emboldened in our conviction that our Immuno-STAT platform represents transformative potential for selectively modulating the patient’s immune system.”

    CUE-101 is a modular T-cell engager designed to selectively activate HPV16-specific CD8-positive T cells through targeted delivery of attenuated IL-2.1,2 It consists of an HLA-A*0201 molecule presenting an HPV16 E7–derived peptide, fused to 4 reduced-affinity IL-2 molecules.

    CUE-101 is currently being evaluated as monotherapy and in combination with pembrolizumab for the treatment of patients with recurrent/metastatic HNSCC in CUE-101-01.2

    CUE-101-01 Trial Overview and Additional Data

    This phase 1, open-label, dose-escalation and -expansion study requires patients to have the HLA-A*0201 genotype and HPV16-positive disease confirmed by P16 immunohistochemistry and HPV16 mRNA in situ hybridization. Patients in the monotherapy cohort were also required to have disease progression following platinum-based chemotherapy or checkpoint inhibitor therapy and received CUE-101 every 3 weeks. Patients in the combination cohort were treatment-naive for recurrent/metastatic disease and received CUE-101 with pembrolizumab 200 mg every 3 weeks. Notably, eligibility for the combination arm required a PD-L1 CPS of 1 or higher.

    Enrollment in both the monotherapy and combination therapy arms of the study is now complete. As of the data cutoff of September 7, 2023, 49 and 27 patients were enrolled onto the first-line monotherapy and second-line combination cohorts, respectively.

    Previously reported data from the study showed that the Kaplan-Meier estimate for median OS among patients treated with CUE-101 monotherapy in the second line (n = 20) was 20.8 months (95% CI, 11.0-not applicable); the landmark 12-month OS rate was 59% in this patient population.

    Twenty of the 22 patients who received the second-line combination of CUE-101 and pembrolizumab were alive at the data cutoff, with 8 patients surviving for at least 12 months and 13 remaining on treatment. The disease control rate among newly diagnosed patients receiving the combination was 65%.

    In terms of safety, adverse effects (AEs) were consistent with the mechanism of action of CUE-101, known profile of pembrolizumab, and underlying disease biology. The risk of grade 3 or higher treatment-related AEs was low; most were no higher than grade 2, reversible, and easily managed with appropriate medical care.

    References

    1. Cue Biopharma reports new complete response and confirmed 50% overall response rate in ongoing phase 1 trial of CUE-101 and pembrolizumab in recurrent/metastatic HPV+ head and neck cancer. News release. Cue Biopharma. July 16, 2025. Accessed July 16, 2025. https://cuebiopharma.gcs-web.com/news-releases/news-release-details/cue-biopharma-reports-new-complete-response-and-confirmed-50
    2. Chung CH, Adkins D, Colevas D, et al. A phase 1 dose-escalation and expansion study of CUE-101, given as monotherapy in 3L and in combination with pembrolizumab in 1L recurrent/metastatic HPV16+ head and neck cancer patients. J ImmunoTher Cancer. 2023;11(suppl 1):674. doi:10.1136/jitc-2023-SITC2023.0674

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  • Excise deptt recovers over Rs 67,000 in taxes

    Excise deptt recovers over Rs 67,000 in taxes

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    ISLAMABAD, Jul 16 (APP): The Islamabad Excise Department has intensified vehicle inspections along major roads to enforce traffic and tax regulations and in a recent operation, officials inspected a total of 42 vehicles and imposes fine of  Rs 67,700 to violators.

    The inspection teams specifically targeted vehicles with dark tinted windows and non-standard number plates, both of which are prohibited under local laws due to security and identification concerns, said the spokesman of ICT administration here.

    As a result of the inspection, fines amounting to Rs50,000 were imposed on drivers found using unauthorized tinted windows. Additionally, a separate penalty was enforced against the use of non-compliant number plates, leading to 10 fines issued to motorists who had installed plates that did not match the officially approved format.

    Beyond traffic-related violations, the Excise Department also recovered outstanding vehicle token taxes during the operation.

    A total of Rs67,700 was collected from motorists who had not cleared their token tax dues, which are mandatory annual payments required for all registered vehicles.

    Officials emphasized that such actions are part of a broader campaign to ensure compliance with vehicle regulations in Islamabad. The crackdown aims to improve road safety, aid law enforcement in vehicle identification, and ensure tax collection from vehicle owners.

    Authorities have reiterated that inspections and enforcement will continue across various parts of the capital. The Excise Department has urged citizens to abide by the rules, remove unauthorized window tints, replace non-standard number plates, and pay their token taxes on time to avoid fines and legal action.

    According to the Excise Department spokesman, the drive also helps address broader security concerns in the region, where tinted windows and obscure number plates can hinder law enforcement’s ability to monitor vehicle movements effectively.

    The Islamabad administration plans to maintain a strict check on vehicles circulating within the city, particularly on main highways and entry points. Officials warned that further operations will be carried out unannounced, with heavy penalties for repeat offenders.

    Motorists have been advised to ensure their vehicles meet all regulatory standards, including the proper display of number plates, removal of dark window tints, and clearance of pending taxes. Authorities believe that these steps are essential to streamline road monitoring and promote a culture of accountability among vehicle owners.

    The administration has called on residents to cooperate with the ongoing campaign and ensure their vehicles comply with all legal requirements. Failure to do so may lead to fines, impoundment of vehicles, or other legal consequences.

    The Assistant Commissioner Nilore, who oversaw the recent inspection on Express Highway, stated that the operation was conducted smoothly, with most motorists cooperating with the inspection teams. He added that such initiatives are necessary to uphold traffic discipline and ensure public safety.

    The authorities have pledged to continue their vigilance in ensuring that all vehicles operating in the city are in compliance with the law.

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  • Can’t sleep, can’t focus, can’t thrive? ADHD and insomnia may be a vicious cycle

    Can’t sleep, can’t focus, can’t thrive? ADHD and insomnia may be a vicious cycle

    Insomnia could explain why adults with ADHD traits report having a lower quality of life, according to new research led by the University of Southampton and the Netherlands Institute of Neuroscience.

    A study published on July 15 in BMJ Mental Health found that having higher ADHD traits was associated with a lower quality of life and that insomnia could be part of the reason why.

    At least one in four people with attention deficit hyperactivity disorder (ADHD) report having a sleep disorder, with insomnia being the most common of these.

    “Our findings show a link between ADHD traits, insomnia severity, and reduced life satisfaction,” says Dr Sarah L. Chellappa, Associate Professor in Psychology at the University of Southampton and senior author on the research paper.

    “We know that sleep disruption can impact neurobehavioral and cognitive systems, including attention and emotional regulation. At the same time, sleep disruption may arise from ADHD-related impulsivity and hyperactivity, suggesting a reinforcing cycle between sleep disorders and ADHD.”

    Researchers from the University of Southampton and the Netherlands Institute for Neuroscience (Prof Eus Van Someren) examined data from the Netherlands Sleep Registry, an online survey with more than ten thousand adult participants.

    The team analysed responses from 1,364 participants who had answered questions about ADHD traits, sleep disturbances, circadian factors, depression, and quality of life.

    They found ADHD traits were associated with worse depression, more severe insomnia, lower sleep quality, and a preference for going to bed and waking up later.

    ADHD and insomnia severity both predicted a lower quality of life, with analysis suggesting insomnia was the potential link in this association.

    “Adults with ADHD traits may be more likely to have low sleep quality, insomnia complaints, and low mood levels, all of which lead to reduced life satisfaction,” says Professor Samuele Cortese, a co-author on the paper, also from the University of Southampton.

    “There needs to be more research to understand this complex interplay. By improving our understanding, we could uncover treatment options that improve the quality of life of people with ADHD. For instance, targeting insomnia complaints in individuals with higher ADHD traits, with Cognitive Behavioural Therapy for Insomnia or Sleep Restriction therapy may help improve their quality of life.”

    The paper Associations of ADHD symptom severity, sleep/circadian factors, depression, and quality of life is published in BMJ Mental Health and is available online.

    The research was supported by the Netherlands Organisation for Scientific Research and the European Research Council.

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  • Insta360 now offers filters and a larger battery for its 360-degree X5

    Insta360 now offers filters and a larger battery for its 360-degree X5

    It’s been less than three months since Insta360 released its X5 360-degree action camera, but the company is already introducing new accessories and a major firmware update. Improvements include a new AdaptiveTone feature delivering “better color and detail in both bright and dark areas” when filming with both lenses, and a larger battery you can swap in that boosts recording time to just under four hours.

    AdaptiveTone is the most compelling reason to install the free update. It addresses the challenges of adjusting and balancing exposure on dual lens cameras when both are potentially capturing scenes with different lighting conditions. The new feature records ”more comprehensive lighting information from the environment” for each lens, which the company says is then used in post-processing to adjust the exposure of footage and deliver more “natural-looking results” based on the perspective, angle, or specific footage you choose to export.

    The update also makes the X5’s PureVideo mode, designed to reduce the noise in footage captured in low-light conditions using AI and “dynamic range optimization,” available when shooting with just a single lens. To better deal with bright lighting conditions where creators want to use slower shutter speeds to capture motion blur, Insta360 is also introducing three neutral density filters (ND16, ND32, and ND64 all priced at $59.99 each) that can be attached using the X5’s user-replaceable lens system.

    The X5’s battery life is getting a boost with Endurance Mode now available while shooting in 8K/30 fps mode to extend recording time to just under two hours. Dropping the camera’s resolution to 5.7K/24 fps also increases the camera’s runtime from 185 to 208 minutes, but if that’s still not enough a new $49.99 2,800mAh Ultra Battery is about 17 percent larger than the X5’s standard 2,400mAh power pack.

    Insta360 has even introduced a handful of upgrades designed for motorcyclists. Immersive Shake Stabilization will smooth out footage while still preserving a bit of natural shake to impart a feeling of speed, and the X5 can now automatically blur and obscure license plates. There’s also a new $159.99 remote control accessory that can be strapped to a bike’s handlebars or worn like a watch that features an LCD live preview screen, GPS data like speed and direction, and a built-in noise canceling microphone with a wind screen.

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