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  • Nepal Eliminates Rubella, But Battles Japanese Encephalitis — Vax-Before-Travel

    Nepal Eliminates Rubella, But Battles Japanese Encephalitis — Vax-Before-Travel

    (Vax-Before-Travel News)

    The World Health Organization (WHO) recently announced that the Federal Democratic Republic of Nepal, a country located high in the Himalaya Mountains in southeast Asia, has eliminated rubella as a public health problem.

    Rubella, or German measles, is a vaccine-preventable disease that is a highly contagious viral infection. It is severe for pregnant women as infection can lead to a range of lifelong and debilitating congenital disabilities, says the WHO.

    “Nepal’s success reflects the unwavering commitment of its leadership, persistent efforts of the health care workers and volunteers, and unstinting support of engaged and informed communities, for a healthy start for babies and a future free of rubella disease,” said Dr Catharina Boehme, Officer-In-Charge WHO Southeast Asia, in a press release on August 18, 2025.

    Unfortunately, this disease eradication success has not translated to the Japanese Encephalitis (JE), a flavivirus transmitted by mosquitoes that is often contracted from infected pigs and sheep.

    As of August 2025, JE infections are the leading cause of viral encephalitis in 24 countries in the WHO Southeast Asia and Western Pacific/Oceania Regions, exposing more than 3 billion people to infection risks.

    In Nepal, Japanese Encephalitis has been a significant public health concern since 1978, especially in the Terai region, an area that borders India.

    JE is also a vaccine-preventable disease. The WHO indicated in August 2025 that Nepal’s national JE vaccination coverage surpasses 95%. The government integrated JY vaccinations beginning in 2015.

    However, as of August 19, 2025, the Health Ministry’s data show 33 JE cases and three fatalities this year.

    In 2024, 23 people died, and 80 others were infected with the JE virus.

    The WHO and the U.S. CDC recommend that international travelers visiting Nepal consider vaccination. Proven JE vaccines are available in the United States, commercially offered at various travel clinics and pharmacies in 2025.

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  • Marvel’s All-New True Believers Blind Bags Debut with ‘Ultimate Endgame’ #1

    Marvel’s All-New True Believers Blind Bags Debut with ‘Ultimate Endgame’ #1

    ULTIMATE ENDGAME #1 (OF 5)

    Written by DENIZ CAMP

    Art by TERRY DODSON & JONAS SCHARF

    Cover by MARK BROOKS

    ULTIMATE ENDGAME will be written by current ULTIMATES (2024) scribe, Deniz Camp, and feature artwork by Jonas Scharf (ULTIMATE SPIDER-MAN: INCURSION) and, announced today, superstar artist Terry Dodson! The five-issue series delivers the moment every reader has been waiting for—the return of the Maker! Imprisoned for the last two years—both in real time and in-universe—the Maker is set to emerge and finally confront the heroes who have brought hope and freedom to a world he once held in his tight grip!

    Bringing the characters of all five titles together for the first time, the Ultimate fate of this captivating new universe is decided in an epic, multi-front conflict with the Maker and his powerful allies. Under the direction of visionary writer Jonathan Hickman, the Ultimate Universe has been an industry sensation and captivated fans won’t want to miss this critical chapter of its sprawling, interconnected saga.

    Preorder ULTIMATE ENDGAME #1 at your local comic shop today and inquire about the availability of the ULTIMATE ENDGAME TRUE BELIEVERS BLIND BAGS later this year.

    Grab these comics and more at your local comic book shop! Or redeem then read your digital copy on the Marvel Unlimited app by using the code found in your print comic. Find and support your local comic book shop at ComicShopLocator.com.

    To read your Marvel comics digitally, download the Marvel Unlimited app for iOS and Android devices. Gain an expansive catalog of 30,000+ comics spanning Marvel Comics history, plus access your entire digital library including comics redeemed from print.

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  • Gaza: Looming offensive and restrictions on humanitarians – UN News

    1. Gaza: Looming offensive and restrictions on humanitarians  UN News
    2. In Gaza City, we are saying goodbye  Al Jazeera
    3. Thousands of Palestinians leave Gaza City fearing Israeli offensive  Dawn
    4. Katz meets with IDF brass to approve military’s plans for takeover of Gaza City  The Times of Israel
    5. Statement by the Humanitarian Country Team of the Occupied Palestinian Territory* (18 August 2025) [EN/AR/HE]  OCHA

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  • Silent Hill f Gamescom Trailer Reveals Suzie Yeung as Hinako

    Silent Hill f Gamescom Trailer Reveals Suzie Yeung as Hinako

    Silent Hill f made an appearance at Gamescom Opening Night Live this evening with a brand new trailer, and our first listen at the English actor portraying main character Hinako, Suzie Yeung.

    The new trailer opens with Hinako waking up in a dark room, seemingly confused. As she wanders, it seems she’s in some kind of shrine, and ends up following a figure with a blue lamp deeper in. She’s then attacked by those freaky dolls we’ve seen in past trailers, and we see shots of a number of other unsettling rooms in the shrine.

    The trailer cuts to another scene at an old house on a rainy day, which Hinako seems to recognize as her own. We see her with her clothes torn and bloody, and a creepy woman’s voice giving instructions to kill everyone, and then Hinako confronting one of her classmates. All-in-all, not nearly as gory as the last trailer, but still plenty unnerving.

    Silent Hill f is set in 1960s Japan, with a story written by Ryukishi07 intended to contrast beauty and horror. First announced in 2022, we’ve since learned that it’s standalone from the other Silent Hill games, and that it’s Japan’s first M-rated Silent Hill game, and comes with some frankly disgusting content warnings. We’ve also recently learned it’s expected to be combat-heavy, with series producer Motoi Okamoto saying, “Challenging action games are gaining popularity among younger players nowadays, so I believed that if we implemented such elements into the game, it would resonate well even with people who are new to the series.”

    Silent Hill f will be out shortly, on September 25 of this year, on Xbox, PlayStation, and PC. We played it for five hours earlier this month, and you can read our preview right here.

    You can catch up on everything announced at Gamescom Opening Night Live right here.

    Rebekah Valentine is a senior reporter for IGN. You can find her posting on BlueSky @duckvalentine.bsky.social. Got a story tip? Send it to rvalentine@ign.com.

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  • Amylin Breakthrough May Spark New Weight Loss Drugs

    Amylin Breakthrough May Spark New Weight Loss Drugs

    OKLAHOMA CITY – Amylin, a hormone that controls appetite and blood sugar by activating three different receptors in the brain, could be the basis for the next blockbuster obesity drugs. A University of Oklahoma study published today in the journal Science Signaling reveals a new understanding of how amylin receptors react upon being activated, an advancement that will be crucial to the field of drug development.

    “This paper shows the new biochemical and pharmacological methods we developed that will enable the field, for the first time, to understand exactly what drugs in development do at each of the three amylin receptors,” said the paper’s senior author, Augen Pioszak, Ph.D., an associate professor of biochemistry and physiology at the University of Oklahoma College of Medicine. “Amylin receptors are very complicated, and each has very different and unique properties. What we have discovered has eluded researchers for many years, and we believe our findings will advance drug development.”

    Amylin is secreted from the pancreas, along with insulin, after a person eats. Amylin receptors in the brain are in the same family as GLP-1 receptors, which are targeted by pioneering drugs like semaglutide (Ozempic and Wegovy).

    “There has been a lot of interest in the pharmaceutical industry for developing new obesity drugs,” said Sandra Gostynska, a doctoral student in Pioszak’s lab who is the lead author of the paper and made the seminal findings. “What we have done is given the field new tools for understanding how a drug can affect amylin receptors.”

    Their findings are two-fold:

    • The three amylin receptors share a core component but have differing accessory subunits, as if they wear common attire but dress it up with different accessories to make each a distinct fashion. Understanding how to target that distinctiveness may be important for creating a drug that best controls appetite and brings about the most weight loss with the fewest side effects. Gostynska developed a laboratory procedure to arrive at that understanding.
    • Drugs have the potential to pull the subunits together or push them apart. This, too, could be important for drug development because the drugs may act differently depending on whether they push or pull.

    Pharmaceutical companies are already developing drugs based on amylin. Pioszak said his lab’s research provides clarity for what occurs when a drug targets a complicated set of receptors.

    “We believe our findings will further the study of drugs because what pharmaceutical and biotech companies want to know is what their drug does at each amylin receptor,” Pioszak said. “Now we have a method of answering those questions that were previously unanswerable.”

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

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  • Inside Pakistan’s strikingly successful Washington charm offensive – The Washington Post

    1. Inside Pakistan’s strikingly successful Washington charm offensive  The Washington Post
    2. How and why Trump brought Pakistan in from the cold  The Times of India
    3. Pakistan-US Relations: Why Army’s New Strategy with Trump May Backfire  Deccan Herald
    4. No Air Force One yet; optics secured  The Express Tribune
    5. Navigating the U.S. Strategic Interests in South Asia Amid Global Shifts: Critical Appraisal of Second Tenure of Donald Trump  Institute of Strategic Studies Islamabad (ISSI)

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  • Calvin Harris Explains Why Miley Cyrus Collab Was Scrapped: ‘My Bad’

    Calvin Harris Explains Why Miley Cyrus Collab Was Scrapped: ‘My Bad’

    No, Calvin Harris isn’t going to release his previously teased collaboration with Miley Cyrus — but that doesn’t mean he’s on the outs with the pop star, despite a few comments he made that some fans interpreted as shade against her.

    More than a year after he first shared a snippet of an ocean-themed EDM song featuring Cyrus’ vocals, the DJ has caused a stir online by sharing a new teaser for the same project in a recent TikTok, this time with Jessie Reyez singing on the track. At first not addressing the three-time Grammy winner’s absence, Harris simply captioned the post, “Yes I love it #newmusic #ocean.”

    Fans, however, were immediately confused. It wasn’t long before his comment section filled up with questions about where the version with the “Flowers” singer had gone — and some of his replies to those queries quickly led some viewers to believe that there must be bad blood between the two artists that had caused the song’s release to be blocked.

    “Awwwwww where’s Miley!!!!!” one person wrote, to which Harris replied, “I do not know.”

    “I like this better than the Miley version,” another fan commented, with the electronic hitmaker agreeing, “And it is !!!”

    “We only want Miley,” a third person wrote, to which Harris responded, “Off you pop then.”

    But, fear not. As followers clamored for answers, Harris eventually clarified that he doesn’t have anything against Cyrus. When someone questioned why he was directing “hate” at the Hannah Montana alum, he corrected, “I love Miley,” later writing that the vocalist has “an amazing voice.”

    “It was my bad … crossed wires,” he also responded to someone asking whether it had been Cyrus’ “fault” that the collab had been shelved.

    To another fan who asked if there was “any issue between” Harris and Cyrus, he answered, “Absolutely not!!”

    The debacle comes just a few months after Harris dropped new single “Blessings” with Clementine Douglas, which followed March’s solo release “Smoke the Pain Away.” Though he hasn’t yet shared when the Reyez-assisted ocean song will drop, Harris appears to finally be gearing up to release it after first sharing a portion of Cyrus’ abandoned version in May 2024.

    “We were dancing, we were wild in the ocean,” Cyrus sang at the time over the uptempo club-ready beat. “When the crowd is all around me, you’re still all I see.”

    In the comments of his new TikTok teasing the piece, Harris also explained that Reyez — despite Cyrus’ previous involvement — has always been a part of the upcoming song. Noting that the Canadian singer-songwriter had penned its lyrics, the DJ responded to one fan who’d asked, “Wasn’t this one the one with Miley Cyrus?” by writing, “Kind of but it was with Jessie first.”

    He also emphasized that Cyrus’ version will likely never see the light of day. To one person who questioned if there was “any chance Miley’s version could still be released,” Harris wrote frankly, “I’m afraid not.”

    And to another fan who implored, “Please release it with Miley’s vocals,” the producer said, “Not possible.”

    Check out Harris’ song teaser — featuring Reyez, not Cyrus — below.


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  • Taylor Swift Talks About Caring for Her Father

    Taylor Swift Talks About Caring for Her Father

    Add family caregiver to Taylor Swift’s long résumé.

    The global pop star recently shared her caregiving experience with her father, Scott Swift, 73. He required quintuple bypass surgery this summer after doctors found five blocked arteries during a resting stress test.

    Appearing on the New Heights podcast hosted by Jason and Travis Kelce, Taylor, who was sitting next to Travis, her NFL star boyfriend, said she, mother Andrea Swift, 67, and brother Austin Swift, 33, were by her father’s side after the surgery. 

    “My brother, my mom and I were each taking shifts in the ICU and staying with him 24/7,” she said.

    A quintuple bypass surgery involves taking blood vessels from another part of the body and transplanting them onto the affected heart vessels to reroute blood flow around the blockages, according to Verywell Health.

    The Grammy-winning artist noted that taking care of her dad felt like a “parent-child reversal in a lot of ways.” She compared her dad to a teenager because her brother told her he was Facetiming his friends all night and needed his phone taken away so he could recover. 

    The “Shake It Off” singer said she remembers her dad building “play sets and swing sets and cribs” for her when she was young, but now she is responsible for assembling his medical equipment.

     “I’m building his shower chair and his walker and his bed,” Taylor said. “It’s just surreal, man. We just all moved in with him the whole summer, pretty much.”

     She was also helping her father walk “on his harness,” a device used to support his chest after surgery. She called him “the loveliest patient ever” and said he’s doing “incredibly well.”

     “He just kept saying ‘thank you’ over and over again,” she added.

    The caregiving didn’t stop there. Swift also mentioned that Andrea recently got a “new knee” and is “doing great.”

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  • Climate change fuels chikungunya surge globally – Deccan Herald

    Climate change fuels chikungunya surge globally – Deccan Herald

    1. Climate change fuels chikungunya surge globally  Deccan Herald
    2. Cases of Mosquito-Borne Chikungunya Virus Are Surging Globally: What to Know  The New York Times
    3. Glacial Lake Outburst in Alaska and Discovery of a New Human Ancestor  Scientific American
    4. World Health Organization warns of epidemic threat as dangerous virus spreads: ‘We are seeing history repeating itself’  The Cool Down
    5. Experts: Chikungunya fever cases drop in South China, no after-effects reported  chinadailyasia.com

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  • Fatal Lead Toxicity From Ayurvedic Supplements in a Patient With Parkinson’s Disease

    Fatal Lead Toxicity From Ayurvedic Supplements in a Patient With Parkinson’s Disease


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