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By Stuart Condie

  SYDNEY--Australia's ANZ Group scrapped its share buyback and plans to invest in mortgage and commercial bankers as its new CEO tries to boost productivity and returns. 

  ANZ on Monday said it would halt its ongoing share buyback, which has about 800 million Australian dollars, or US$518 million, remaining. This will allow it to return about A$1 billion in surplus capital to the bank, it said. 

  ANZ, which is Australia's fourth-largest bank by market capitalization, will invest heavily in its in-house mortgage sales force with the aim of increasing the number of lenders in its branches by up to 50%. 

  It also wants to increase the number of commercial bankers servicing its business and private customers by up to 50%. It plans to develop its own pipeline of bankers in a new Commercial Bankers Academy. 

  "Our people will deliver our strategy, and we must focus on a culture of customers, performance and talent," said Chief Executive Nuno Matos, who took charge this year. 

  Write to Stuart Condie at stuart.condie@wsj.com 

  (END) Dow Jones Newswires

  October 12, 2025 19:08 ET (23:08 GMT)
Copyright (c) 2025 Dow Jones & Company, Inc.

If you want to take a real-time sample of the global economy in action at any one moment, then the Cathay Cargo Hub at Hong Kong International Airport (HKG) is a particularly fascinating node. 
 
HKG is the world’s busiest air-cargo hub and no airline moves more freight through it – more than 1.7 million tonnes annually – than Cathay Pacific. Founded in 1946 as a cargo operator between Australia and China, Cathay now manages a sprawling 246,000 sq m hub and the constant hum of palletised and shrink-wrapped goods. In just one section of the warehouse, the inventory ranges from huge cases of Château d’Arche wine to Golden Lily mangoes from the Philippines, alongside priceless artworks packed in Cadogan Tate crates – all destined for the holds of windowless cargo freighters.
 
Air cargo accounts for less than one per cent of all goods shipped by tonnage globally but it makes up some 35 per cent of the total value. It carries all the things the world needs or wants in a hurry, from the latest iPhone and cold-chain pharma to Italian supercars and oil-drilling machinery. This urgency is just one of the reasons why air cargo is worth paying attention to: when people stop buying the things they need, it’s often a reliable signal that a recession might be on the horizon.

On a recent weekday morning, the warehouse was particularly active, catching up from the two-day stoppage enforced by Super Typhoon Ragasa, a level-10 storm that sideswiped Hong Kong. But the air-cargo world faces headwinds beyond the weather, including the unpredictable currents of geopolitics. 

Not long ago, air cargo prices were being driven upwards as a result of “fast fashion” purchases and other inexpensive goods from Chinese companies such as Shein and Temu. But after the Trump administration eliminated de minimis exemptions on goods worth less than $800 (€688) – precisely what Shein and Temu had exploited – US-bound air cargo from China – a key, typically one-way route – fell by at least 25 per cent.

“Supply chains don’t change overnight,” says Tom Owen, cargo director at Cathay Cargo. “But there has been a recalibration.” One benefit for air-cargo companies such as Cathay is that they don’t own factories – they own planes. This agility can work in their favour, as Cathay Group CEO Ronald Lam noted at the Routes World conference in Hong Kong, the day after the typhoon blew through. The uncertainty of tariffs, he said, created a “rush” to place orders. Air cargo, with its far shorter lead times compared with ocean shipping, “is really well positioned to capture that rush.” Hong Kong’s position as a global hub means that Cathay Group can adjust its routes swiftly. “We are getting more cargo from India and Southeast Asia, routed via Hong Kong to the US, to replenish the slowdown on US-bound cargo from China.”

During a week when the Trump administration threatened yet again to escalate the trade war that it began, air-cargo companies such as Cathay find themselves in the eye of the storm. But this is an industry in which agility and flexibility are key. During the coronavirus pandemic, cargo kept many airlines afloat as they quickly converted their passenger fleet into impromptu freighters, loading cargo where passengers normally sat. The latest disruptions present a new challenge but also a lesson. While long-term planning is crucial to success in business, the best strategies leave room to adapt. Take it from Cathay, which has dealt with its fair share of turbulence: be ready to change course quickly, even while mid-air.

Tom Vanderbilt is a regular Monocle contributor. For more opinion, analysis and insight, subscribe to Monocle today.

Perth, Australia (ABN Newswire) – OTC Markets Group Inc. (OTCMKTS:OTCM), operator of regulated markets for 12,000 U.S. and international securities, today announced that Locksley Resources Ltd (ASX:LKY,OTC:LKYRF) (FRA:X5L) (OTCMKTS:LKYRF), an exploration and development company focused on rare earths and antimony critical minerals, has qualified to trade on the OTCQX Best Market.

Highlights

– Locksley Resources Limited has qualified to trade on the OTCQX(R) Best Market, upgrading from the OTCQB(R) Venture Market

– Trading on OTCQX enhances Locksley’s visibility and accessibility to U.S. investors, supporting its U.S. focused critical minerals strategy

– Locksley’s flagship Mojave Project in California is strategically located adjacent to MP Materials’ Mountain Pass Mine, targeting rare earth elements (REEs) and antimony as part of a fully integrated mine-tomarket strategy

– The Company’s downstream technology partnerships underpin its role in re-establishing U.S. domestic supply chains for critical materials, with a particular focus on antimony

– Rare earths and Antimony are front and center in the global race to secure critical materials, with Locksley’s Mojave Project positioned at the heart of America’s efforts to restore domestic supply independence through a 100% U.S. mine-to-market strategy

Locksley has upgraded to OTCQX from the OTCQB Venture Market, and the symbol remains as “LKYRF.” U.S. investors can find current financial disclosure and Real-Time Level 2 quotes for the company on www.otcmarkets.com.

The OTCQX Market is designed for established, investor focused U.S. and international companies. To qualify for OTCQX, companies must meet high financial standards, follow best practice corporate governance, and demonstrate compliance with applicable securities laws. Graduating to the OTCQX Market marks an important milestone for companies, enabling them to demonstrate their qualifications and build visibility among U.S. investors.

Rare Earths & Antimony – Front and Centre in a Shifting Global Landscape

Locksley’s progression to the OTCQX comes amid escalating global focus on rare earth security, following new export restrictions and rising trade tensions. As nations move to safeguard access to critical materials, Locksley’s Mojave Project stands at the center of America’s effort to restore domestic supply independence. With a fully integrated mine-to-market strategy across antimony and rare earths, the Company is advancing a 100% American made approach that aligns directly with U.S. national policy priorities and the reshoring of strategic materials.

Nathan Lude – Head of Strategy, Capital Markets & Commercialisation commented

“Graduating to the OTCQX Market in record time since our initial listing just over three months ago, is a significant milestone for Locksley as we broaden our visibility and accessibility to U.S. investors. Our Mojave Rare Earths and Antimony Critical Minerals Project are strategically located in a tier-one jurisdiction adjacent to MP Materials’ Mountain Pass Mine. Locksley is positioned to play a pivotal role in re-establishing domestic supply chains through its mine-to-market strategy for critical materials, with a particular focus on antimony.”

About Locksley Resources Limited:

Locksley Resources Limited (ASX:LKY,OTC:LKYRF) (FRA:X5L) (OTCMKTS:LKYRF) is an ASX listed explorer focused on critical minerals in the United States of America. The Company is actively advancing exploration across two key assets: the Mojave Project in California, targeting rare earth elements (REEs) and antimony. Locksley Resources aims to generate shareholder value through strategic exploration, discovery and development in this highly prospective mineral region.

Mojave Project

Located in the Mojave Desert, California, the Mojave Project comprises over 250 claims across two contiguous prospect areas, namely, the North Block/Northeast Block and the El Campo Prospect. The North Block directly abuts claims held by MP Materials, while El Campo lies along strike of the Mountain Pass Mine and is enveloped by MP Materials’ claims, highlighting the strong geological continuity and exploration potential of the project area.

In addition to rare earths, the Mojave Project hosts the historic “Desert Antimony Mine”, which last operated in 1937. Despite the United States currently having no domestic antimony production, demand for the metal remains high due to its essential role in defense systems, semiconductors, and metal alloys. With significant surface sample results, the Desert Mine prospect represents one of the highest-grade known antimony occurrences in the U.S.

Locksley’s North American position is further strengthened by rising geopolitical urgency to diversify supply chains away from China, the global leader in both REE & antimony production. With its maiden drilling program planned, the Mojave Project is uniquely positioned to align with U.S. strategic objectives around critical mineral independence and economic security.

Tottenham Project

Locksley’s Australian portfolio comprises the advanced Tottenham Copper-Gold Project in New South Wales, focused on VMS-style mineralisation

About OTC Markets Group Inc.:

OTC Markets Group Inc. (OTCQX:OTCM) operates regulated markets for trading 12,000 U.S. and international securities. Our data-driven disclosure standards form the foundation of our public markets: OTCQX(R) Best Market, OTCQB(R) Venture Market, OTCID(TM) Basic Market and Pink Limited(TM) Market. Our OTC Link(R) Alternative Trading Systems (ATSs) provide critical market infrastructure that broker-dealers rely on to facilitate trading.

Our innovative model offers companies more efficient access to the U.S. financial markets.

OTC Link ATS, OTC Link ECN, OTC Link NQB, and MOON ATS(TM) are each SEC regulated ATS, operated by OTC Link LLC, a FINRA and SEC registered broker-dealer, member SIPC.

Source:
Locksley Resources Limited OTC Markets Group Inc.

Contact:
Locksley Resources Limited
T: +61 8 9481 0389
E: info@locksleyresources.com.au

1. The Activities overview page is all grown up

When the Activities overview page first appeared in LMS 5.0, we were thrilled to have a place to go to easily see all course activities — and their due dates, etc. — all in one place. When the Activities overview page debuted, only the Assignment activity was fully supported (teachers could easily see what they needed to grade, and learners could easily see what they needed to do).

But in LMS 5.1, this gets even better. Now the Activities overview page works across all the major activities — forums, quizzes, H5P, wikis, lessons, glossaries, even BigBlueButton sessions.

Why this matters: Instead of being just a tidy list, this page now acts like a real command centre. Teachers can see what needs grading or follow-up without digging around. Learners see their progress laid out clearly: what’s done, what’s next. That’s a big deal for reducing confusion.

PRINCETON, N.J. and CAMBRIDGE, Mass., Oct. 12, 2025 /PRNewswire/ — Taiho Oncology, Inc., and Cullinan Therapeutics, Inc., today announced new data from the central nervous system (CNS) involvement cohort of the REZILIENT2 study of zipalertinib, an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in patients with advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations (ex20ins) or uncommon non-ex20ins EGFR mutations and CNS involvement. Data will be presented at the European Society for Medical Oncology (ESMO) Congress 2025, as a mini oral presentation on October 19 during the “NSCLC metastatic” session from 8:30 to 10 a.m. CEST.

The mini oral presentation will highlight preliminary efficacy and safety data from the CNS involvement cohort of the ongoing parallel cohort Phase 2b REZILIENT2 trial of zipalertinib.¹

Patients with locally advanced or metastatic NSCLC harboring EGFR ex20ins mutations represent a significant unmet medical need. An incidence of baseline brain metastases in EGFR ex20ins NSCLC patients ranging from 23% to 39% has been reported.² Patients with lung cancer with CNS involvement have a worse prognosis and require more aggressive therapy, including surgery and radiotherapy.

“Treatment options are limited for patients with NSCLC with EGFR mutations and active brain metastases,” said Helena A. Yu, MD, Thoracic Medical Oncologist, Memorial Sloan Kettering Cancer. “We are pleased to see that in approximately one-third of patients exposed to zipalertinib, a decrease in CNS lesions was observed. These preliminary results suggest the potential for zipalertinib to treat these patients, warranting future investigation.”

Authors will report results from the REZILIENT2 study of zipalertinib against active CNS metastases in patients with NSCLC harboring EGFR ex20ins or other uncommon mutations¹:

Summary of Preliminary Efficacy – by Investigator

As of the February 2025 data cutoff, 32 patients were enrolled in the CNS involvement cohort of the ongoing parallel cohort Phase 2b REZILIENT2 trial and received zipalertinib 100 mg orally twice daily. Patients received a median of 2 prior lines of therapy, and of all patients enrolled, 21 patients had ex20ins mutations and 13 patients had other uncommon mutations.

 As of the data cutoff, zipalertinib demonstrated:

• In the Response Assessment in Neuro-Oncology for Brain Metastases (RANO-BM) criteria evaluable population with measurable CNS disease (n=16, including 3 patients with leptomeningeal disease (LMD), intracranial objective response rate was 31.3% including 1 intracranial complete response.
• In the same population, the intracranial disease control rate (iDCR) was 68.8% and the median intracranial duration of response (DOR) was 8.1 months.
• Measured in 29 of the cohort’s patients, preliminary systemic objective response rate (ORR) was 27.6% and median DOR was 7.6 months.
• Intracranial antitumor activity was found to be similar to its overall systemic anticancer activity in this cohort of patients.

Summary of Preliminary Safety and Tolerability

Administered at 100 mg orally twice daily, zipalertinib was found to be well tolerated, with no new safety signals observed.

Treatment-related adverse events of grade 3 or higher occurred in 8 patients (25%) and included anemia (n=3) and interstitial lung disease (n=2). There was one death due to interstitial lung disease.

About REZILIENT2
REZILIENT2 is a Phase 2b clinical trial (NCT05967689), evaluating the safety and efficacy of zipalertinib in patients with locally advanced or metastatic NSCLC harboring ex20ins mutations or other uncommon/single or compound EGFR mutations. Patients are enrolled into one of four cohorts: Cohort A (“prior ex20ins treatment”), Cohort B (“first-line”), Cohort C (“active brain metastases”), and Cohort D (“other uncommon EGFR mutations”). Cohort C includes patients harboring EFGR ex20ins or other uncommon/single or compound EGFR mutations and CNS involvement. In this cohort, patients may or may not have had prior treatment for advanced disease. Patients are treated with oral zipalertinib 100 mg twice daily. The primary endpoint is ORR and confirmed per investigator-assessed Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 and the secondary endpoints include DOR, DCR, PFS, OS, intracranial efficacy by RANO-BM criteria, PK and safety.

About Zipalertinib
Zipalertinib (development code: CLN-081/TAS6417) is an orally available small molecule designed to target activating mutations in EGFR. The molecule was selected because of its ability to inhibit EGFR variants with ex20ins mutations, while sparing wild-type EGFR. Zipalertinib is designed as a next generation, irreversible EGFR inhibitor for the treatment of a genetically defined subset of patients with non-small cell lung cancer. Zipalertinib has received Breakthrough Therapy Designation from the FDA. Zipalertinib is investigational and has not been approved by any health authority.

Zipalertinib is being developed by Taiho Oncology, Inc., its parent company, Taiho Pharmaceutical Co., Ltd., and in collaboration with Cullinan Therapeutics, Inc. in the U.S.

About Taiho Oncology, Inc.
The mission of Taiho Oncology, Inc. is to improve the lives of patients with cancer, their families and their caregivers. The company specializes in the development and commercialization of orally administered anti-cancer agents for various tumor types. Taiho Oncology has a robust pipeline of small-molecule clinical candidates targeting solid-tumor and hematological malignancies, with additional candidates in pre-clinical development. Taiho Oncology is a subsidiary of Taiho Pharmaceutical Co., Ltd. which is part of Otsuka Holdings Co., Ltd. Taiho Oncology is headquartered in Princeton, New Jersey and oversees its parent company’s European and Canadian operations, which are located in Baar, Switzerland and Oakville, Ontario, Canada.

For more information, visit https://www.taihooncology.com/, and follow us on LinkedIn and X.

Taiho Oncology and the Taiho Oncology logo are registered trademarks of Taiho Pharmaceutical Co., Ltd.

About Cullinan Therapeutics
Cullinan Therapeutics, Inc. (Nasdaq: CGEM) is a biopharmaceutical company dedicated to creating new standards of care for patients. Cullinan has strategically built a diversified portfolio of clinical-stage assets that inhibit key drivers of disease or harness the immune system to eliminate diseased cells in both autoimmune diseases and cancer. Cullinan’s portfolio encompasses a wide range of modalities, each with the potential to be best and/or first in class. Anchored in a deep understanding of oncology, immunology, and translational medicine, we create differentiated ideas, identify the most appropriate targets, and select the optimal modality to develop transformative therapeutics across a wide variety of autoimmune and cancer indications. We push conventional boundaries from candidate selection to differentiated therapeutic, applying rigorous go/no go criteria at each stage of development to fast-track only the most promising molecules to the clinic and, ultimately, commercialization. With deep scientific expertise, our teams exercise creativity and urgency to deliver on our promise to bring new therapeutic solutions to patients. Learn more about Cullinan at https://cullinantherapeutics.com/, and follow us on LinkedIn and X.

Forward Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, express or implied statements regarding the company’s beliefs and expectations regarding our plans regarding future data presentations, the clinical development and regulatory filing plan and timeline of zipalertinib, the safety and efficacy profile of zipalertinib and its potential to address unmet medical need, and other statements that are not historical facts. The words “believe,” “continue,” “could,” “estimate,” “expect,” “intends,” “may,” “plan,” “potential,” “project,” “pursue,” “will,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words.

Any forward-looking statements in this press release are based on management’s current expectations and beliefs of future events and are subject to known and unknown risks and uncertainties that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These risks include, but are not limited to, the following: uncertainty regarding the timing and results of regulatory submissions; the risk that any NDA or other regulatory submissions we may file with the United States Food and Drug Administration or other global regulatory agencies are not cleared on our expected timelines, or at all; the success of our clinical trials and preclinical studies; the risks related to our ability to protect and maintain our intellectual property position; the risks related to manufacturing, supply, and distribution of our product candidates; the risk that any one or more of our product candidates, including those that are co-developed, will not be successfully developed and commercialized; the risk that the results of preclinical studies or clinical studies will not be predictive of future results in connection with future studies; and the success of any collaboration, partnership, license or similar agreements. These and other important risks and uncertainties discussed in our filings with the Securities and Exchange Commission, including under the caption “Risk Factors” in our most recent Annual Report on Form 10-K and subsequent filings with the SEC, could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change, except to the extent required by law. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release. Moreover, except as required by law, neither the company nor any other person assumes responsibility for the accuracy and completeness of the forward-looking statements included in this press release. Any forward-looking statement included in this press release speaks only as of the date on which it was made.

Contacts

Taiho Oncology

Leigh Labrie
(609) 664-9878
[email protected]

Cullinan Therapeutics

Investors 
Nick Smith
+1 401.241.3516
[email protected]

Media
Rose Weldon
+1 215.801.7644
[email protected]

References

1. K. Ohashi et al. Activity of Zipalertinib Against Active Central Nervous System (CNS) Metastases in Patients With Non-Small Cell Lung Cancer (NSCLC) Harboring EGFR Exon 20 Insertion (Ex20ins)/Other Uncommon Mutations.
2. Remon J. et al. EGFR exon 20 insertions in advanced non-small cell lung cancer: A new history begins. Cancer Treatment Review. Volume 90, November 2020, 102105.

SOURCE Taiho Oncology