Aggression isn’t just a behavioral issue—it has deep neurobiological roots, especially when shaped by early-life trauma. New research is investigating how childhood adversity rewires brain circuits that control emotion, memory, and attention, increasing the risk of impulsive and pathological aggression.
A key focus is the thalamic nucleus reuniens, a brain region connecting the prefrontal cortex and hippocampus, which appears to act as a hub for trauma-related behavioral changes.
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Sora Shin, a neuroscientist at the Fralin Biomedical Research Institute at VTC, received a … grant from the National Institutes of Health to study how early-life trauma alters brain circuits that control aggression and attention.
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The nucleus reuniens is involved in memory, emotion, and decision-making, and its dysfunction is implicated in anxiety-related behaviors and clinical disorders such as schizophrenia.
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Using advanced technologies such as CRISPR gene editing, optogenetics, and real-time brain recordings in mice, Shin will examine how trauma-related changes in these circuits influence aggressive behavior.
“We want to better understand how brain circuits contribute to aggressive behavior, especially when thinking and memory start to decline after experiencing trauma,” said Shin ….
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