High prevalence of penicillin-resistant group B Streptococcus among pregnant women in Northwest Ethiopia

  • Mohammed, M., Asrat, D., Woldeamanuel, Y. & Demissie, A. Prevalence of group B Streptococcus colonization among pregnant women attending antenatal clinic of Hawassa Health Center, Hawassa, Ethiopia. Ethiop. J. Health Dev. 26(1), 36–42 (2012).

    Google Scholar 

  • Morgan, J. A., Zafar, N. & Cooper, D. B. Group B Streptococcus and Pregnancy. Treasure Island (FL) ineligible companies. Disclosure: Nowera Zafar declares no relevant financial relationships with ineligible companies. Disclosure: Danielle Cooper declares no relevant financial relationships with ineligible companies.: StatPearls Publishing.

  • Melin, P. Neonatal group B streptococcal disease: From pathogenesis to preventive strategies. Clin. Microbiol. Infect. 17(9), 1294–1303 (2011).

    CAS 
    PubMed 

    Google Scholar 

  • Jannati, E. et al. Capsular serotype and antibiotic resistance of group B streptococci isolated from pregnant women in Ardabil, Iran. Iran. J. Microbiol. 4(3), 130 (2012).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ueno, H. et al. Characterization of group B streptococcus isolated from women in Saitama City, Japan. Jpn. J. Infect. Dis. 65(6), 516–521 (2012).

    PubMed 

    Google Scholar 

  • Hanna, M. & Noor, A. Streptococcus Group B. Treasure Island (FL) ineligible companies. Disclosure: Asif Noor declares no relevant financial relationships with ineligible companies.: StatPearls Publishing.

  • Mengist, A., Kannan, H. & Abdissa, A. Prevalence and antimicrobial susceptibility pattern of anorectal and vaginal group B Streptococci isolates among pregnant women in Jimma, Ethiopia. BMC Res. Notes 9(1), 351 (2016).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Borghesi, A., Stronati, M. & Fellay, J. Neonatal group B streptococcal disease in otherwise healthy infants: Failure of specific neonatal immune responses. Front. Immunol. 8, 215 (2017).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Shiferawu, S., Mekonen, M., Baza, D. & Lera, T. Prevalence of group b streptococcus, its associated factors and antimicrobial susceptibility pattern among pregnant women attending antenatal care at Arbaminch Hospital, South Ethiopia. Am. J. Health Res. 7(6), 104–115 (2019).

    Google Scholar 

  • Miselli, F. et al. Transmission of group B Streptococcus in late-onset neonatal disease: A narrative review of current evidence. Ther. Adv. Infect. Dis. 9, 1–14 (2022).

    Google Scholar 

  • Shirazi, M. et al. The prevalence of group B streptococcus colonization in Iranian pregnant women and its subsequent outcome. Int. J. Fertil. Steril. 7(4), 267–270 (2014).

    PubMed 

    Google Scholar 

  • Jin, G. et al. Maternal and neonatal outcomes of Group B Streptococcus colonization: A retrospective study. BMC Infect. Dis. 25(1), 94 (2025).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Husen, O. et al. Prevalence, antimicrobial susceptibility pattern and associated factors of group B Streptococcus among pregnant women attending antenatal Care at Bule Hora University Teaching Hospital, Southern Ethiopia. Infect. Drug Resist. 16, 4421–4433 (2023).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ying, Q., Wang, S., Lou, X., Ding, J. & Ding, J. Burden and risk factors of invasive group B Streptococcus disease among neonates in a Chinese maternity hospital. BMC Infect. Dis. 19(1), 123 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Serra, G. et al. Group B streptococcus colonization in pregnancy and neonatal outcomes: A three-year monocentric retrospective study during and after the COVID-19 pandemic. Ital. J. Pediatr. 50(1), 175 (2024).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Fairlie, T., Zell, E. R. & Schrag, S. Effectiveness of intrapartum antibiotic prophylaxis for prevention of early-onset group B streptococcal disease. Obstet. Gynecol. 121(3), 570–577 (2013).

    CAS 
    PubMed 

    Google Scholar 

  • Le Doare, K. et al. Intrapartum antibiotic chemoprophylaxis policies for the prevention of group B streptococcal disease worldwide: Systematic review. Clin. Infect. Dis. 65(suppl_2), S143–S151 (2017).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Costa HdPF, BRITO A: Prevenção da doença perinatal pelo estreptococo do grupo B. Manual da Sociedade Brasileira de Pediatria, 1–18 (2011).

  • Kimura, K. et al. High frequency of fluoroquinolone-and macrolide-resistant streptococci among clinically isolated group B streptococci with reduced penicillin susceptibility. J. Antimicrob. Chemother. 68(3), 539–542 (2013).

    CAS 
    PubMed 

    Google Scholar 

  • Desravines, N. et al. Intrapartum group B streptococcus antibiotic prophylaxis in penicillin allergic pregnant women. AJP Rep. 9(3), e238–e243 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • De Francesco, M. A., Caracciolo, S., Gargiulo, F. & Manca, N. Phenotypes, genotypes, serotypes and molecular epidemiology of erythromycin-resistant Streptococcus agalactiae in Italy. Eur. J. Clin. Microbiol. Infect. Dis. 31(8), 1741–1747 (2012).

    CAS 
    PubMed 

    Google Scholar 

  • Fröhlicher, S. et al. Serotype distribution and antimicrobial susceptibility of group B streptococci in pregnant women: results from a Swiss tertiary centre. Swiss Med. Wkl. 144(1112), w13935 (2014).

    Google Scholar 

  • Khan, M. A., Faiz, A. & Ashshi, A. M. Maternal colonization of group B streptococcus: Prevalence, associated factors and antimicrobial resistance. Ann. Saudi Med. 35(6), 423–427 (2015).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Back, E. E., O’Grady, E. J. & Back, J. D. High rates of perinatal group B Streptococcus clindamycin and erythromycin resistance in an upstate New York Hospital. Antimicrob. Agents Chemother. 56(2), 739–742 (2012).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Abarzúa, F. et al. Prevalencia de portación vaginal-anal de Streptococcus agalactiae en el tercer trimestre de gestación y susceptibilidad a macrólidos y lincosamidas, en mujeres embarazadas de Clínica Alemana Temuco, Chile. Rev. Chilena Infectol. 31(3), 305–308 (2014).

    PubMed 

    Google Scholar 

  • Dutra, V. G. et al. Streptococcus agalactiae in Brazil: Serotype distribution, virulence determinants and antimicrobial susceptibility. BMC Infect. Dis. 14(1), 323 (2014).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Melo, S. C. et al. Antimicrobial susceptibility of Streptococcus agalactiae isolated from pregnant women. Rev. Inst. Med. Trop. Sao Paulo 58, 83 (2016).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Girma, W., Yimer, N., Kassa, T. & Yesuf, E. Group B Streptococcus recto-vaginal colonization in near-term pregnant women, Southwest Ethiopia. Ethiop. J. Health Sci. 30(5), 687–696 (2020).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Wayne, P. Performance standards for antimicrobial susceptibility testing. In CLSI Supplements M00130th ed Clinical and Laboratory Standards Institute (2020).

  • Zhang, Z. Model building strategy for logistic regression: purposeful selection. Ann. Transl. Med. 4(6), 111 (2016).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Alemseged, G. et al. Isolation and anti-microbial susceptibility pattern of group B Streptococcus among pregnant women attending antenatal clinics in Ayder Referral Hospital and Mekelle Health Center, Mekelle, Northern Ethiopia. BMC. Res. Notes 8(1), 518 (2015).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Assefa, S., Desta, K. & Lema, T. Group B streptococci vaginal colonization and drug susceptibility pattern among pregnant women attending in selected public antenatal care centers in Addis Ababa, Ethiopia. BMC Pregnancy Childbirth 18(1), 1–9 (2018).

    Google Scholar 

  • Gizachew, M. et al. Streptococcus agalactiae from Ethiopian pregnant women; prevalence, associated factors and antimicrobial resistance: Alarming for prophylaxis. Ann. Clin. Microbiol. Antimicrob. 18(1), 3 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Mengist, H. M., Zewdie, O., Belew, A. & Dabsu, R. Prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women attending antenatal care (ANC) in Nekemte Referral Hospital (NRH), Nekemte, Ethiopia. BMC Res. Notes 10(1), 1–6 (2017).

    Google Scholar 

  • Anosike, I., Ebana, R., Edet, U., Egbomuche, R. & Victory, A. Prevalence of Streptococcus agalactiae among women resident in Calabar, Cross River State, Nigeria. Asian J. Res. Med. Pharm. Sci. 2, 1–7 (2017).

    Google Scholar 

  • Sadaka, S. M., Aly, H. A., Meheissen, M. A., Orief, Y. I. & Arafa, B. M. Group B streptococcal carriage, antimicrobial susceptibility, and virulence related genes among pregnant women in Alexandria, Egypt. Alex. J. Med. 54(1), 69–76 (2018).

    Google Scholar 

  • Wang, P. et al. Serotypes, antibiotic susceptibilities, and multi-locus sequence type profiles of Streptococcus agalactiae isolates circulating in Beijing, China. PLoS ONE 10(3), e0120035 (2015).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Shin, A. et al. Group B Streptococcus detection rate and clindamycin resistance among reproductive-age women in Korea during 2003–2022. J. Korean Med. Sci. 40(15), e29 (2025).

    CAS 
    PubMed 

    Google Scholar 

  • Scheftelowitz Cohen, R., Chodik, G. & Eisenberg, V. H. Re-evaluating Perinatal Group B Streptococcal screening in Israel—Is it time for a change in policy?. Prev. Med. 153, 106716 (2021).

    PubMed 

    Google Scholar 

  • Islam, N., Furuya-Kanamori, L., Mahmood, S. & Thalib, L. Prophylactic antibiotics for preventing genital tract infection in women undergoing surgical procedures for incomplete abortion: A systematic review and meta-analysis of randomised controlled trials. BJOG Int. J. Obst. Gynaecol. 128(8), 1273–1281 (2021).

    CAS 

    Google Scholar 

  • Esmaon, R., Lim, B. K., Gan, F., Hamdan, M. & Tan, P. C. Sexual activity, vaginal symptoms, maternal perineal hygiene behavior, and constipation on ano-vaginal colonization of group B streptococcus in near term pregnancy. BMC Pregnancy Childbirth 24(1), 461 (2024).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Brokaw, A., Furuta, A., Dacanay, M., Rajagopal, L. & Adams Waldorf, K. M. Bacterial and host determinants of group B streptococcal vaginal colonization and ascending infection in pregnancy. Front. Cell. Infect. Microbiol. 11, 720789 (2021).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sri-Budayanti, N. & Hariyasa-Sanjaya, N. Group-B streptococcus in pregnant women: Prevalence of colonization and sensitivity pattern in denpasar during June 2007 May 2008. Bali Med. J. 2(1), 17–20 (2013).

    Google Scholar 

  • Dashtizade, M., Zolfaghari, M. R., Yousefi, M. & Nazari-Alam, A. Antibiotic susceptibility patterns and prevalence of Streptococcus agalactiae rectovaginal colonization among pregnant women in Iran. Rev. Bras. Ginecol. Obstet. 42(8), 454–459 (2020).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Bolukaoto, J. Y. et al. Antibiotic resistance of Streptococcus agalactiae isolated from pregnant women in Garankuwa, South Africa. BMC Res. Notes 8(1), 364 (2015).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Nabil, A., Esleem, S. E. & Elmanama, A. A. Prevalence of group B streptococcus colonization among pregnant women in Gaza strip, Palestine. IUG J. Nat. Stud. 25(3), 1–12 (2017).

    Google Scholar 

  • Fantahun, Y., Sebre, S., Seman, A. & Kumbi, S. Magnitude of maternal vaginal colonization of Group B streptococcus and neonatal transmission in pregnant women during labor and delivery at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Ethiop. Med. J. 58, 105–113 (2020).

    Google Scholar 

  • Mudzana, R., Mavenyengwa, R. T. & Gudza-Mugabe, M. Analysis of virulence factors and antibiotic resistance genes in group B streptococcus from clinical samples. BMC Infect. Dis. 21(1), 125 (2021).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gebretekle, G. B. et al. Half of prescribed antibiotics are not needed: A pharmacist-led antimicrobial stewardship intervention and clinical outcomes in a referral hospital in Ethiopia. Front. Public Health 8, 109 (2020).

    PubMed 
    PubMed Central 

    Google Scholar 

  • MaHAaCA EF: A practical guide to antimicrobial stewardship program in Ethiopian hospitals. Addis Ababa, Ethiopia (2018).

  • Ibrahim, R. A. et al. Antimicrobial resistance surveillance in Ethiopia: Implementation experiences and lessons learned. Afr. J. Lab. Med. 7(2), 770 (2018).

    PubMed 
    PubMed Central 

    Google Scholar 

  • World Health Organization. Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report 2022 (World Health Organization, 2022).

    Google Scholar 

  • Gebremeskel, T. K., Zeleke, T. A., Mihret, A. & Tikue, M. D. Prevalence and antibiotic susceptibility pattern of Streptococcus agalactiae among pregnant women at Adigrat Zonal Hospital and Adigrat Health Center, Tigray, Ethiopia. J. Gynecol. Obstet. 3(2), 29–35 (2015).

    Google Scholar 

  • Jisuvei, S. C., Osoti, A. & Njeri, M. A. Prevalence, antimicrobial susceptibility patterns, serotypes and risk factors for group B streptococcus rectovaginal isolates among pregnant women at Kenyatta National Hospital, Kenya; A cross-sectional study. BMC Infect. Dis. 20, 1–9 (2020).

    Google Scholar 

  • Ayenew, W. et al. Prevalence and predictors of self-medication with antibiotics in Ethiopia: A systematic review and meta-analysis. Antimicrob. Resist. Infect. Control 13(1), 61 (2024).

    PubMed 
    PubMed Central 

    Google Scholar 

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