Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239–42.
Google Scholar
Kaeuffer C, Le Hyaric C, Fabacher T, Mootien J, Dervieux B, Ruch Y, Hugerot A, Zhu YJ, Pointurier V, Clere-Jehl R, Greigert V, Kassegne L, Lefebvre N, Gallais F, Covid Alsace Study Group, Meyer N, Hansmann Y, Hinschberger O, Danion F, COVID Alsace Study Group. Clinical characteristics and risk factors associated with severe COVID-19: prospective analysis of 1,045 hospitalised cases in North-Eastern france, March 2020. Euro Surveill. 2020;25(48):2000895. https://doi.org/10.2807/1560-7917.ES.2020.25.48.2000895. PMID: 33272355; PMCID: PMC7716399.
Google Scholar
Government of Ireland. Ireland COVID19 Data Hub. Ireland: Government of Ireland. 2023. Available at: https://covid19ireland-geohive.hub.arcgis.com/ Accessed 02 February 2025.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506.
Google Scholar
Cai Q, Chen F, Wang T, Luo F, Liu X, Wu Q, He Q, Wang Z, Liu Y, Liu L, Chen J, Xu L. Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Diabetes Care. 2020;43(7):1392–8. https://doi.org/10.2337/dc20-0576. Epub 2020 May 14. PMID: 32409502.
Google Scholar
Simonnet A, Chetboun M, Poissy J, Raverdy V, Noulette J, Duhamel A, et al. High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS‐CoV‐2) requiring invasive mechanical ventilation. Obesity. 2020;28(7):1195–9.
Google Scholar
Petrilli CM, Jones SA, Yang J, Rajagopalan H, O’Donnell L, Chernyak Y, Tobin KA, Cerfolio RJ, Francois F, Horwitz LI. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369:m1966. https://doi.org/10.1136/bmj.m1966. PMID: 32444366; PMCID: PMC7243801.
Huang Y, Lu Y, Huang Y-M, Wang M, Ling W, Sui Y, et al. Obesity in patients with COVID-19: a systematic review and meta-analysis. Metabolism. 2020;113:154378.
Google Scholar
Strausz S, Kiiskinen T, Broberg M, Ruotsalainen S, Koskela J, Bachour A, et al. Sleep Apnoea is a risk factor for severe COVID-19. Bmj Open Respiratory Res. 2021;8(1):e000845.
Liu Y, Pan Y, Yin Y, Chen W, Li X. Association of dyslipidemia with the severity and mortality of coronavirus disease 2019 (COVID-19): a meta-analysis. Virol J. 2021;18:1–11.
Khairy Y, Naghibi D, Moosavi A, Sardareh M, Azami-Aghdash S. Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients. Syst Reviews. 2022;11(1):242.
Dissanayake H. COVID-19 and metabolic syndrome. Best Pract Res Clin Endocrinol Metab. 2023;37(4): 101753. https://doi.org/10.1016/j.beem.2023.101753.
Google Scholar
Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep. 2018;20(2):1–8.
Elliott J, Bodinier B, Whitaker M, Delpierre C, Vermeulen R, Tzoulaki I, et al. COVID-19 mortality in the UK biobank cohort: revisiting and evaluating risk factors. Eur J Epidemiol. 2021;36:299–309.
Google Scholar
Gallus S, Scala M, Possenti I, Jarach CM, Clancy L, Fernandez E, Gorini G, Carreras G, Malevolti MC, Commar A, Fayokun R, Gouda HN, Prasad VM, Lugo A. The role of smoking in COVID-19 progression: a comprehensive meta-analysis. Eur Respir Rev. 2023;32(167):220191. PMID: 36889786; PMCID: PMC10032583.
Google Scholar
Carter C, Notter J. COVID-19 disease: a critical care perspective. Clinics in Integrated Care. 2020;1: 100003.
Google Scholar
Organisation for Economic Co-operation and Development (OECD). Health at a glance: Europe 2022. Available at: https://www.oecd.org/en/publications/health-at-a-glance-europe-2022_507433b0-en.html.
Health Research Consent Declaration Committee. HRCDC 2023 Available from: https://hrcdc.ie/about-us/
Government of Ireland. Healthy Ireland Survey 2023. Available from: https://www.gov.ie/en/healthy-ireland/publications/healthy-ireland-survey-2023/#smoking
Bennett KE, Mullooly M, O’Loughlin M, Fitzgerald M, O’Donnell J, O’Connor L, Oza A, Cuddihy J. Underlying conditions and risk of hospitalisation, ICU admission and mortality among those with COVID-19 in ireland: A National surveillance study. Lancet Reg Health Eur. 2021;5:100097. Epub 2021 Apr 15. PMID: 33880459; PMCID: PMC8049357.
Google Scholar
Aboueshia M, Hussein MH, Attia AS, Swinford A, Miller P, Omar M, et al. Cancer and COVID-19: analysis of patient outcomes. Future Oncol. 2021;17(26):3499–510.
Google Scholar
Morales DR, Ostropolets A, Lai L, Sena A, Duvall S, Suchard M, et al. Characteristics and outcomes of COVID-19 patients with and without asthma from the United States, South Korea, and Europe. J Asthma. 2023;60(1):76–86.
Google Scholar
Kartsonaki C, Baillie JK, Barrio NG, Baruch J, Beane A, Blumberg L, et al. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19. Int J Epidemiol. 2023;52(2):355–76.
Google Scholar
Kouhpayeh H. Clinical features predicting COVID-19 mortality risk. Eur J Translational Myology. 2022;32(2):10268. https://doi.org/10.4081/ejtm.2022.10268. PMID: 35421918; PMCID: PMC9295175.
Google Scholar
Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P, et al. Comorbidity and its impact on patients with COVID-19. SN Compr Clin Med. 2020;2:1069–76.
Google Scholar
Boudou M, ÓhAiseadha C, Garvey P, O’Dwyer J, Hynds P, Modelling. COVID-19 severity in the Republic of Ireland using patient co-morbidities, socioeconomic profile and geographic location, February to November 2020. Sci Rep. 2021;11:18474. https://doi.org/10.1038/s41598-021-98008-6.
Google Scholar
Longmore DK, Miller JE, Bekkering S, Saner C, Mifsud E, Zhu Y, et al. Diabetes and overweight/obesity are independent, nonadditive risk factors for in-hospital severity of COVID-19: an international, multicenter retrospective meta-analysis. Diabetes Care. 2021;44(6):1281–90.
Google Scholar
Bienvenu LA, Noonan J, Wang X, Peter K. Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities. Cardiovasc Res. 2020;116(14):2197–206.
Google Scholar
Abu-Farha M, Al-Mulla F, Thanaraj TA, Kavalakatt S, Ali H, Abdul Ghani M, Abubaker J. Impact of diabetes in patients diagnosed with COVID-19. Front Immunol. 2020;11:576818. https://doi.org/10.3389/fimmu.2020.576818. PMID: 33335527; PMCID: PMC7736089.
Google Scholar
Farrell RJ, O’Regan R, O’Neill E, Bowens G, Maclellan A, Gileece A, et al. Sociodemographic variables as predictors of adverse outcome in SARS-CoV-2 infection: an Irish hospital experience. Ir J Med Sci. 2021;190:893–903.
Google Scholar
Sanchis-Gomar F, Lavie CJ, Mehra MR, Henry BM, Lippi G. Obesity and outcomes in COVID-19: when an epidemic and pandemic collide. Mayo Clin Proc. 2020;95(7):1445–53. https://doi.org/10.1016/j.mayocp.2020.05.006.
Google Scholar
Yu W, Rohli KE, Yang S, Jia P. Impact of obesity on COVID-19 patients. J Diabetes Complications. 2021;35(3): 107817. https://doi.org/10.1016/j.jdiacomp.2020.107817.
Google Scholar
López-Reyes A, Martinez-Armenta C, Espinosa-Velázquez R, Vázquez-Cárdenas P, Cruz-Ramos M, Palacios-Gonzalez B, Gomez-Quiroz LE, Martínez-Nava GA. NLRP3 inflammasome: the stormy link between obesity and COVID-19. Front Immunol. 2020;11:570251. PMID: 33193349; PMCID: PMC7662564.
Google Scholar
Boehmer TK. Changing age distribution of the COVID-19 pandemic—United States, May–August 2020. MMWR Morbidity and Mortality Weekly Report. 2020;69(39):1404–9.
Google Scholar
Gupta S, Hayek SS, Wang W, Chan L, Mathews KS, Melamed ML, et al. Factors associated with death in critically ill patients with coronavirus disease 2019 in the US. JAMA Intern Med. 2020;180(11):1436–47.
Google Scholar
Biscarini S, Colaneri M, Ludovisi S, Seminari E, Pieri TC, Valsecchi P, et al. The obesity paradox: analysis from the SMAtteo COvid-19 registry (SMACORE) cohort. Nutr Metabolism Cardiovasc Dis. 2020;30(11):1920–5.
Google Scholar
Abate BB, Kassie AM, Kassaw MW, Aragie TG, Masresha SA. Sex difference in coronavirus disease (COVID-19): a systematic review and meta-analysis. BMJ Open. 2020;10(10): e040129. https://doi.org/10.1136/bmjopen-2020-040129.
Google Scholar
Department of Health. All Ireland Traveller Health Study: Our Geels – Summary of Findings: Government of Ireland. 2020. Available from: https://www.gov.ie/en/publication/b9c48a-all-ireland-traveller-health-study/. Accessed 02 February 2025.
Bwire GM. Coronavirus: why men are more vulnerable to Covid-19 than women? SN Compr Clin Med. 2020;2(7):874–6.
Google Scholar
Haitao T, Vermunt JV, Abeykoon J, Ghamrawi R, Gunaratne M, Jayachandran M, Narang K, Parashuram S, Suvakov S, Garovic VD. COVID-19 and Sex Differences: Mechanisms and Biomarkers. Mayo Clinic Proceedings. 2020;95(10):2189–2203. https://doi.org/10.1016/j.mayocp.2020.07.024. Epub 2020 Aug 4. PMID: 33012349; PMCID: PMC7402208.
Palaiodimos L, Kokkinidis DG, Li W, Karamanis D, Ognibene J, Arora S, Southern WN, Mantzoros CS. Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx. New York Metabolism. 2020;108:154262. Epub 2020 May 16. PMID: 32422233; PMCID: PMC7228874.
Google Scholar
Giacomelli A, Ridolfo AL, Milazzo L, Oreni L, Bernacchia D, Siano M, et al. 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study. Pharmacol Res. 2020;158: 104931.
Google Scholar
Bornstein SR, Dalan R, Hopkins D, Mingrone G, Boehm BO. Endocrine and metabolic link to coronavirus infection. Nat Reviews Endocrinol. 2020;16(6):297–8.
Google Scholar
Jia X, Yin C, Lu S et al. Two things about COVID-19 might need attention. Preprints.org; 2020. https://doi.org/10.20944/preprints202002.0315.v1
Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63:364–74.
Google Scholar
Lippi G, Henry BM. Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19). Eur J Intern Med. 2020;75:107–8.
Google Scholar
Vardavas CI, Nikitara K. COVID-19 and smoking: A systematic review of the evidence. Tob Induc Dis. 2020;18:20. https://doi.org/10.18332/tid/119324. PMID: 32206052; PMCID: PMC7083240.
Google Scholar
Guo FR. Active smoking is associated with severity of coronavirus disease 2019 (COVID-19): an update of a meta-analysis. Tob Induc Dis. 2020;18:37. https://doi.org/10.18332/tid/121915.
Google Scholar
Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Lian N, et al. The impact of COPD and smoking history on the severity of COVID-19: a systemic review and meta‐analysis. J Med Virol. 2020;92(10):1915–21.
Google Scholar
Usman MS, Siddiqi TJ, Khan MS, Patel UK, Shahid I, Ahmed J, et al. Is there a smoker’s paradox in COVID-19? BMJ Evidence-Based Medicine. 2021;26(6):279–84.
Google Scholar
Health Protection Surveillance Centre. Report on COVID-19 deaths reported in Ireland: Health Protection Surveillance Centre. 2024 Available from: https://www.hpsc.ie/a-z/respiratory/coronavirus/novelcoronavirus/surveillance/covid-19deathsreportedinireland/. Accessed 02 February 2025.
Department of Health. COVID-19 Nursing Homes Expert Panel: Final Report Ireland: Government of Ireland. 2020 Available from: https://www.gov.ie/en/publication/3af5a-covid-19-nursing-homes-expert-panel-final-report/. Accessed 02 February 2025.
Government of Ireland. Statement from the National Public Health Emergency Team – Tuesday 29 December Ireland: Gov.ie. 2020 Available from: https://www.gov.ie/en/press-release/86f64-statement-from-the-national-public-health-emergency-team-tuesday-29-december/. Accessed 02 February 2025.
Patel JA, Nielsen F, Badiani AA, Assi S, Unadkat V, Patel B, et al. Poverty, inequality and COVID-19: the forgotten vulnerable. Public Health. 2020;183:110.
Google Scholar
Health Protection Surveillance Centre (HPSC). Summary of COVID-19 virus variants in Ireland Ireland: HPSC. 2022 Available from: https://www.hpsc.ie/a-z/respiratory/coronavirus/novelcoronavirus/surveillance/summaryofcovid-19virusvariantsinireland. Accessed 02 February 2025.