Long-term weight change among breast cancer patients treated with chemotherapy: a longitudinal study over 13 years | Breast Cancer Research

  • Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

    Article 
    PubMed 

    Google Scholar 

  • Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšić M, et al. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391:1023–75.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight gain after breast Cancer diagnosis and All-Cause mortality: systematic review and Meta-Analysis. J Natl Cancer Inst. 2015;107:djv275.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chan DSM, Vieira R, Abar L, Aune D, Balducci K, Cariolou M, et al. Postdiagnosis body fatness, weight change and breast cancer prognosis: global Cancer update program (CUP global) systematic literature review and meta-analysis. Int J Cancer. 2022. https://doi.org/10.1002/ijc.34322.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jung W, Park SH, Park Y-MM, Song Y-M, Park JH, Yu J, et al. Weight change and cardiovascular disease incidence in breast cancer survivors: a nationwide cohort study. Breast Cancer Res Treat. 2025. https://doi.org/10.1007/s10549-024-07594-2.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Vance V, Mourtzakis M, McCargar L, Hanning R. Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev Off J Int Assoc Study Obes. 2011;12:282–94.

    Article 
    CAS 

    Google Scholar 

  • Lambert LK, Balneaves LG, Howard AF, Gotay CC. Patient-reported factors associated with adherence to adjuvant endocrine therapy after breast cancer: an integrative review. Breast Cancer Res Treat. 2018;167:615–33.

    Article 
    PubMed 

    Google Scholar 

  • Wells KJ, Pan TM, Vázquez-Otero C, Ung D, Ustjanauskas AE, Muñoz D, et al. Barriers and facilitators to endocrine therapy adherence among underserved hormone-receptor-positive breast cancer survivors: a qualitative study. Support Care Cancer Off J Multinatl Assoc Support Care Cancer. 2016;24:4123–30.

    Google Scholar 

  • van den Berg MMGA, Winkels RM, de Kruif JTCM, van Laarhoven HWM, Visser M, de Vries JHM et al. Weight change during chemotherapy in breast cancer patients: a meta-analysis. BMC Cancer. 2017;17.

  • Bhimani J, O’Connell K, Ergas IJ, Foley M, Gallagher GB, Griggs JJ, et al. Trends in chemotherapy use for early-stage breast cancer from 2006 to 2019. Breast Cancer Res BCR. 2024;26:101.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Vaz-Luis I, Cottu P, Mesleard C, Martin AL, Dumas A, Dauchy S, et al. UNICANCER: French prospective cohort study of treatment-related chronic toxicity in women with localised breast cancer (CANTO). ESMO Open. 2019;4:e000562.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pedersen B, Delmar C, Lörincz T, Falkmer U, Grønkjær M. Investigating changes in weight and body composition among women in adjuvant treatment for breast cancer: A scoping review. Cancer Nurs. 2019;42:91–105.

    Article 
    PubMed 

    Google Scholar 

  • Heideman WH, Russell NS, Gundy C, Rookus MA, Voskuil DW. The frequency, magnitude and timing of post-diagnosis body weight gain in Dutch breast cancer survivors. Eur J Cancer Oxf Engl 1990. 2009;45:119–26.

    CAS 

    Google Scholar 

  • Trédan O, Bajard A, Meunier A, Roux P, Fiorletta I, Gargi T, et al. Body weight change in women receiving adjuvant chemotherapy for breast cancer: A French prospective study. Clin Nutr. 2010;29:187–91.

    Article 
    PubMed 

    Google Scholar 

  • Puklin LS, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, et al. Post-diagnosis weight trajectories and mortality among women with breast cancer. NPJ Breast Cancer. 2023;9:98.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fukui J, White K, Frankland TB, Oshiro C, Wilkens L. Weight changes according to treatment in a diverse cohort of breast cancer patients. BMC Cancer. 2021;21:1005.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nyrop KA, Williams GR, Muss HB, Shachar SS. Weight gain during adjuvant endocrine treatment for early-stage breast cancer: what is the evidence? Breast Cancer Res Treat. 2016;158:203–17.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sadim M, Xu Y, Selig K, Paulus J, Uthe R, Agarwl S, et al. A prospective evaluation of clinical and genetic predictors of weight changes in breast cancer survivors. Cancer. 2017;123:2413–21.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Reddy SM, Sadim M, Li J, Yi N, Agarwal S, Mantzoros CS, et al. Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer. Br J Cancer. 2013;109:872–81.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Shang L, Hattori M, Fleming G, Jaskowiak N, Hedeker D, Olopade OI, et al. Impact of post-diagnosis weight change on survival outcomes in black and white breast cancer patients. Breast Cancer Res BCR. 2021;23:18.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Rey D, Touzani R, Bouhnik A-D, Rousseau F, Monet A, Préau M, et al. Evolution of physical activity and body weight changes in breast cancer survivors five years after diagnosis– VICAN 2 & 5 French National surveys. Breast. 2021;59:248–55.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lei Y-Y, Ho SC, Kwok C, Cheng A, Cheung KL, Lee R, et al. Weight and waist-to-hip ratio change pattern during the first five years of survival: data from a longitudinal observational Chinese breast cancer cohort. BMC Cancer. 2021;21:839.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nyrop KA, Deal AM, Shachar SS, Park J, Choi SK, Lee JT, et al. Weight trajectories in women receiving systemic adjuvant therapy for breast cancer. Breast Cancer Res Treat. 2020;179:709–20.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Uhelski A-CR, Blackford AL, Sheng JY, Snyder C, Lehman J, Visvanathan K, et al. Factors associated with weight gain in pre- and post-menopausal women receiving adjuvant endocrine therapy for breast cancer. J Cancer Surviv Res Pract. 2023. https://doi.org/10.1007/s11764-023-01408-y.

    Article 

    Google Scholar 

  • Raghavendra A, Sinha AK, Valle-Goffin J, Shen Y, Tripathy D, Barcenas CH. Determinants of weight gain during adjuvant endocrine therapy and association of such weight gain with recurrence in Long-term breast Cancer survivors. Clin Breast Cancer. 2018;18:e7–13.

    Article 
    PubMed 

    Google Scholar 

  • Nyrop KA, Deal AM, Lee JT, Muss HB, Choi SK, Wheless A, et al. Weight gain in hormone receptor-positive (HR+) early-stage breast cancer: is it menopausal status or something else? Breast Cancer Res Treat. 2018;167:235–48.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Anbari AB, Deroche CB, Armer JM. Body mass index trends and quality of life from breast cancer diagnosis through seven years’ survivorship. World J Clin Oncol. 2019;10:382–90.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Qin B, Kim K, Goldman N, Rundle AG, Chanumolu D, Zeinomar N, et al. Multilevel factors for adiposity change in a Population-Based prospective study of black breast Cancer survivors. J Clin Oncol. 2022;40:2213–23.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pedersini R, Laganà M, Bosio S, Zanini B, Cosentini D, di Mauro P, et al. Is weight gain preventable in women with early breast cancer undergoing chemotherapy? A real-world study on dietary pattern, physical activity, and body weight before and after chemotherapy. Breast Cancer Res Treat. 2023;202:461–71.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Irwin ML, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Gilliland FD, et al. Changes in body fat and weight after a breast Cancer diagnosis: influence of demographic, prognostic, and lifestyle factors. J Clin Oncol. 2005;23:774–82.

    Article 
    PubMed 

    Google Scholar 

  • Sella T, Zheng Y, Tan-Wasielewski Z, Rosenberg SM, Poorvu PD, Tayob N, et al. Body weight changes and associated predictors in a prospective cohort of young breast cancer survivors. Cancer. 2022;128:3158–69.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Liu L-N, Wen F-H, Miaskowski C, Lin Y-C, Wang J-S, Jeng C, et al. Weight change trajectory in women with breast cancer receiving chemotherapy and the effect of different regimens. J Clin Nurs. 2014;23:2757–68.

    Article 
    PubMed 

    Google Scholar 

  • Saquib N, Flatt SW, Natarajan L, Thomson CA, Bardwell WA, Caan B, et al. Weight gain and recovery of pre-cancer weight after breast cancer treatments: evidence from the women’s healthy eating and living (WHEL) study. Breast Cancer Res Treat. 2007;105:177–86.

    Article 
    PubMed 

    Google Scholar 

  • Hurtado MD, Saadedine M, Kapoor E, Shufelt CL, Faubion SS. Weight gain in midlife women. Curr Obes Rep. 2024;13:352–63.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ekenga CC, Wang X, Pérez M, Schootman M, Jeffe DB. A prospective study of weight gain in women diagnosed with Early-Stage invasive breast cancer, ductal carcinoma In Situ, and women without breast Cancer. J Womens Health. 2020;29:524–33.

    Article 

    Google Scholar 

  • Gross AL, May BJ, Axilbund JE, Armstrong DK, Roden RB, Visvanathan K. Weight change in breast cancer survivors compared to cancer-free women: a prospective study in women at Familial risk of breast cancer. Cancer Epidemiol Biomark Prev. 2015;24:1262–9.

    Article 
    CAS 

    Google Scholar 

  • Freedman RJ, Aziz N, Albanes D, Hartman T, Danforth D, Hill S, et al. Weight and body composition changes during and after adjuvant chemotherapy in women with breast cancer. J Clin Endocrinol Metab. 2004;89:2248–53.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sedjo RL, Hines LM, Byers T, Giuliano AR, Marcus A, Vadaparampil S, et al. Long-term weight gain among Hispanic and non-Hispanic white women with and without breast cancer. Nutr Cancer. 2013;65:34–42.

    Article 
    PubMed 

    Google Scholar 

  • Sternfeld B. Physical activity and changes in weight and waist circumference in midlife women: findings from the study of women’s health across the Nation. Am J Epidemiol. 2004;160:912–22.

    Article 
    PubMed 

    Google Scholar 

  • Banack HR, Bea JW, Chen Z, Blew RM, Nicholas S, Stefanick M, et al. Longitudinal patterns of abdominal visceral and subcutaneous adipose tissue, total body composition, and anthropometric measures in postmenopausal women: results from the women’s health initiative. Int J Obes. 2023;47:288–96.

    Article 

    Google Scholar 

  • Greendale GA, Sternfeld B, Huang M, Han W, Karvonen-Gutierrez C, Ruppert K, et al. Changes in body composition and weight during the menopause transition. JCI Insight. 2019;4:e124865.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Purcell SA, Marker RJ, Cornier M-A, Melanson EL. Dietary intake and energy expenditure in breast Cancer survivors: A review. Nutrients. 2021;13:3394.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Van Soom T, El Bakkali S, Gebruers N, Verbelen H, Tjalma W, van Breda E. The effects of chemotherapy on energy metabolic aspects in cancer patients: A systematic review. Clin Nutr. 2020;39:1863–77.

    Article 
    PubMed 

    Google Scholar 

  • Buttiron Webber T, Briata IM, DeCensi A, Cevasco I, Paleari L. Taste and smell disorders in Cancer treatment: results from an integrative rapid systematic review. Int J Mol Sci. 2023;24:2538.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Walker J, Joy AA, Vos LJ, Stenson TH, Mackey JR, Jovel J, et al. Chemotherapy-induced weight gain in early-stage breast cancer: a prospective matched cohort study reveals associations with inflammation and gut dysbiosis. BMC Med. 2023;21:178.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pistilli B, Lohrisch C, Sheade J, Fleming GF. Personalizing adjuvant endocrine therapy for Early-Stage hormone Receptor–Positive breast Cancer. Am Soc Clin Oncol Educ Book. 2022;:60–72.

  • Connolly RM, Miller KD. Back to the beginning: the role of ovarian suppression in management of hormone sensitive breast Cancer in premenopausal women. J Clin Oncol. 2023;41:1339–41.

    Article 
    PubMed 

    Google Scholar 

  • Dahl AK, Reynolds CA. Accuracy of recalled body weight–a study with 20-years of follow-up. Obes Silver Spring Md. 2013;21:1293–8.

    Article 

    Google Scholar 

  • Kyulo NL, Knutsen SF, Tonstad S, Fraser GE, Singh PN. Validation of recall of body weight over a 26-year period in cohort members of the adventist health study 2. Ann Epidemiol. 2012;22:744–6.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tehard B, van Liere MJ, Com NC, Clavel-Chapelon F. Anthropometric measurements and body silhouette of women: validity and perception. J Am Diet Assoc. 2002;102:1779–84.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Burke MA, Carman KG. You can be too thin (but not too tall): social desirability bias in self-reports of weight and height. Econ Hum Biol. 2017;27:198–222.

    Article 
    PubMed 

    Google Scholar 

  • Marell PS, Vierkant RA, Olson JE, Herrmann J, Larson NL, Lebrasseur NK, et al. Changes in amount and intensity of physical activity over time in breast cancer survivors. JNCI Cancer Spectr. 2023;7:pkad056.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Brown JC, Caan BJ, Cespedes Feliciano EM, Xiao J, Weltzien E, Prado CM, et al. Weight stability masks changes in body composition in colorectal cancer: a retrospective cohort study. Am J Clin Nutr. 2021;113:1482–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Brown JC, Cespedes Feliciano EM, Caan BJ. The evolution of body composition in oncology-epidemiology, clinical trials, and the future of patient care: facts and numbers. J Cachexia Sarcopenia Muscle. 2018;9:1200–8.

    Article 
    PubMed 

    Google Scholar 

  • Delrieu L, Blanc D, Bouhamama A, Reyal F, Pilleul F, Racine V, et al. Automatic deep learning method for third lumbar selection and body composition evaluation on CT scans of cancer patients. Front Nucl Med. 2024;3:1292676.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Continue Reading