Independent and combined relationships between light at night, air pollutants, PM2.5 components and risk of cardiovascular-kidney-metabolic syndrome: a cohort study | BMC Public Health

Marassi M, Fadini GP. The cardio-renal-metabolic connection: a review of the evidence. Cardiovasc Diabetol. 2023;22:195.

Google Scholar 

Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, Mathew RO, Khan SS, et al. A synopsis of the evidence for the science and clinical management of Cardiovascular-Kidney-Metabolic (CKM) syndrome: a scientific statement from the American heart association. Circulation. 2023;148:1636–64.

Google Scholar 

Sebastian SA, Padda I, Johal G. Cardiovascular-Kidney-Metabolic (CKM) syndrome: a state-of-the-art review. Curr Probl Cardiol. 2024;49: 102344.

Google Scholar 

Roth S, M’Pembele R, Matute P, Kotfis K, Larmann J, Lurati Buse G. Cardiovascular-Kidney-Metabolic syndrome: association with adverse events after major noncardiac surgery. Anesth Analgesia. 2024;139:679–81.

Google Scholar 

Huang Q, Li Y, Zhou X, Zou X, Ji L. Prevalence of the cardiovascular-kidney-metabolic syndrome in 3 Chinese cohorts. JACC: Asia. 2025;5:116–8.

Google Scholar 

Li J, Lei L, Wang W, Ding W, Yu Y, Pu B, et al. Social risk profile and cardiovascular‐kidney‐metabolic syndrome in US adults. JAHA J Am Heart Assoc. 2024;13: e034996.

Google Scholar 

Zhou W, Wang Q, Li R, Kadier A, Wang W, Zhou F, et al. Combined effects of heatwaves and air pollution, green space and blue space on the incidence of hypertension: a national cohort study. Sci Total Environ. 2023;867: 161560.

Google Scholar 

Cai M, Lin X, Wang X, Zhang S, Wang C, Zhang Z, et al. Long-term exposure to ambient fine particulate matter chemical composition and in-hospital case fatality among patients with stroke in China. Lancet Reg Health – Western Pac. 2023;32:100679.

Google Scholar 

Raza W, Krachler B, Forsberg B, Sommar JN. Air pollution, physical activity and ischaemic heart disease: a prospective cohort study of interaction effects. BMJ Open. 2021;11:e040912.

Google Scholar 

Dong Y, Cao W, Wei J, Chen Y, Zhang Y, Sun S, et al. Health effect of multiple air pollutant mixture on sarcopenia among middle-aged and older adults in China. Ecotoxicol Environ Saf. 2024;281: 116634.

Google Scholar 

Yu Z, Feng Y, Chen Y, Zhang X, Zhao X, Chang H, et al. Green space, air pollution and gestational diabetes mellitus: a retrospective cohort study in central China. Ecotoxicol Environ Saf. 2023;249: 114457.

Google Scholar 

Wang X, Ran S, Xia H, Shi H, Wu G, Zhang Z, et al. Ambient air pollution associated with incident asthma, subsequent cardiovascular disease and death: a trajectory analysis of a national cohort. J Hazard Mater. 2023;460: 132372.

Google Scholar 

Zhang S, Qian ZM, Chen L, Zhao X, Cai M, Wang C, et al. Exposure to air pollution during pre-hypertension and subsequent hypertension, cardiovascular disease, and death: a trajectory analysis of the UK biobank cohort. Environ Health Perspect. 2023;131:017008.

Google Scholar 

Sun Q, Ye F, Liu J, Yang Y, Hui Q, Chen Y, et al. Outdoor artificial light at night exposure and gestational diabetes mellitus: a case–control study. Front Public Health. 2024;12:1396198.

Google Scholar 

Li S, Guo B, Jiang Y, Wang X, Chen L, Wang X, et al. Long-term exposure to ambient PM2.5 and its components associated with diabetes: evidence from a large population-based cohort from China. Diabetes Care. 2023;46:111–9.

Google Scholar 

Li D, Shi Y, Feng Q, Tian F, Zhang Y, Zhang X, et al. The PM2.5 component, benzo[b]fluoranthene, may contribute to the pathogenesis of membranous nephropathy by activating phosphoinositide 3-kinase/protein kinase B pathway and causing podocyte pyroptosis. Int Immunopharmacol. 2025;152: 114383.

Google Scholar 

Wang T, Kaida N, Kaida K. Effects of outdoor artificial light at night on human health and behavior: a literature review. Environ Pollut. 2023;323: 121321.

Google Scholar 

Wu Y, Jiao Y, Shen P, Qiu J, Wang Y, Xu L, et al. Outdoor light at night, air pollution and risk of incident type 2 diabetes. Environ Res. 2024;263: 120055.

Google Scholar 

Helbich M, Browning MHEM, Huss A. Outdoor light at night, air pollution and depressive symptoms: a cross-sectional study in the Netherlands. Sci Total Environ. 2020;744: 140914.

Google Scholar 

Hu X, Wang L-B, Jalaludin B, Knibbs LD, Yim SHL, Lao XQ, et al. Outdoor artificial light at night and incident cardiovascular disease in adults: a national cohort study across China. Sci Total Environ. 2024;918: 170685.

Google Scholar 

Wu Y, Shen P, Yang Z, Yu L, Xu L, Zhu Z, et al. Outdoor light at night, air pollution, and risk of cerebrovascular disease: a cohort study in China. Stroke. 2024;55:990–8.

Google Scholar 

Melbourne CA, Mesut Erzurumluoglu A, Shrine N, Chen J, Tobin MD, Hansell AL, et al. Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals. Environ Int. 2022;159:107041.

Google Scholar 

Liang Z, Wang W, Wang Y, Ma L, Liang C, Li P, et al. Urbanization, ambient air pollution, and prevalence of chronic kidney disease: a nationwide cross-sectional study. Environ Int. 2021;156: 106752.

Google Scholar 

Zhao Y, Hu Y, Smith JP, Strauss J, Yang G. Cohort profile: the China health and retirement longitudinal study (CHARLS). Int J Epidemiol. 2014;43:61–8.

Google Scholar 

Geng G, Xiao Q, Liu S, Liu X, Cheng J, Zheng Y, et al. Tracking air pollution in China: near real-time PM_2.5 retrievals from multisource data fusion. Environ Sci Technol. 2021;55:12106–15.

Google Scholar 

Xue T, Zheng Y, Geng G, Xiao Q, Meng X, Wang M, et al. Estimating spatiotemporal variation in ambient ozone exposure during 2013–2017 using a data-fusion model. Environ Sci Technol. 2020;54:14877–88.

Google Scholar 

Yang B-Y, Guo Y, Markevych I, Qian Z (Min), Bloom MS, Heinrich J Association of Long-term Exposure to Ambient Air Pollutants With Risk Factors for Cardiovascular Disease in China, et al. editors. JAMA Netw Open. 2019;2:e190318.

Tian Y, Ma Y, Wu J, Wu Y, Wu T, Hu Y et al. Ambient PM2.5 chemical composition and cardiovascular disease hospitalizations in China. Environ Sci. 2024;58(37):16327–35.

Wei J, Liu S, Li Z, Liu C, Qin K, Liu X, et al. Ground-level NO₂ surveillance from space across China for high resolution using interpretable spatiotemporally weighted artificial intelligence. Environ Sci Technol. 2022;56:9988–98.

Google Scholar 

Wei J, Li Z, Guo J, Sun L, Huang W, Xue W, et al. Satellite-derived 1-km-resolution PM₁ concentrations from 2014 to 2018 across China. Environ Sci Technol. 2019;53:13265–74.

Google Scholar 

Wei J, Li Z, Cribb M, Huang W, Xue W, Sun L, et al. Improved 1 km resolution PM_2.5 estimates across China using enhanced space–time extremely randomized trees. Atmos Chem Phys. 2020;20:3273–89.

Google Scholar 

Zhao C, Cao X, Chen X, Cui X. A consistent and corrected nighttime light dataset (CCNL 1992–2013) from DMSP-OLS data. Sci Data. 2022;9:424.

Google Scholar 

Zhu N. Spatio-temporal dynamics and influencing factors of carbon emissions (1997–2019) at county level in Mainland China based on DMSP-OLS and NPP-VIIRS nighttime light datasets. Heliyon. 2024. https://doi.org/10.1016/j.heliyon.2024.e37245.

Google Scholar 

Douglas S, Ye W, Zuoqi C, Ying J. Spatiotemporal evolution of West africa’s urban landscape Charac- teristics applying harmonized DMSP-OLS and NPP-VIIRS nighttime light (NTL) data. Chin Geogr Sci. 2022;32(6):933–45.

Ou J, Liu X, Li X, Li M, Li W. Evaluation of NPP-VIIRS nighttime light data for mapping global fossil fuel combustion CO2 emissions: A Comparison with DMSP-OLS Nighttime Light Data. PLoS One. 2015;10(9):e0138310.

Khan SS, Coresh J, Pencina MJ, Ndumele CE, Rangaswami J, Chow SL, et al. Novel prediction equations for absolute risk assessment of total cardiovascular disease incorporating cardiovascular-kidney-metabolic health: a scientific statement from the American Heart Association. Circulation. 2023;148:1982–2004.

Google Scholar 

Zhou B, Fine J, Laird G. Goodness-of-fit test for proportional subdistribution hazards model. Stat Med. 2013;32:3804–11.

Google Scholar 

Liu C, Cao G, Li J, Lian S, Zhao K, Zhong Y, et al. Effect of long-term exposure to PM2.5 on the risk of type 2 diabetes and arthritis in type 2 diabetes patients: evidence from a national cohort in China. Environ Int. 2023;171: 107741.

Google Scholar 

Bożejko M, Tarski I, Małodobra-Mazur M. Outdoor artificial light at night and human health: a review of epidemiological studies. Environ Res. 2023;218: 115049.

Google Scholar 

Mitsui K, Saeki K, Tone N, Suzuki S, Takamiya S, Tai Y, et al. Short-wavelength light exposure at night and sleep disturbances accompanied by decreased melatonin secretion in real-life settings: a cross-sectional study of the HEIJO-KYO cohort. Sleep Med. 2022;90:192–8.

Google Scholar 

Baek J-H, Zhu Y, Jackson CL, Park Y-MM. Artificial Light at Night and Type 2 Diabetes Mellitus. Diabetes Metab J. 2024;48(5):847–63.

Garcia-Saenz A, De Miguel AS, Espinosa A, Costas L, Aragonés N, Tonne C, et al. Association between outdoor light-at-night exposure and colorectal cancer in Spain. Epidemiology. 2020;31:718–27.

Google Scholar 

Sun S, Cao W, Ge Y, Ran J, Sun F, Zeng Q, et al. Outdoor light at night and risk of coronary heart disease among older adults: a prospective cohort study. Eur Heart J. 2021;42:822–30.

Google Scholar 

Kim M, Vu T-H, Maas MB, Braun RI, Wolf MS, Roenneberg T, et al. Light at night in older age is associated with obesity, diabetes, and hypertension. Sleep. 2023;46:zsac130.

Google Scholar 

Xu Y, Zhang J, Tao F, Sun Y. Association between exposure to light at night (LAN) and sleep problems: a systematic review and meta-analysis of observational studies. Sci Total Environ. 2023;857: 159303.

Google Scholar 

Wang R, Hu X, Ou Y, Chen G, Wang L, Qian Z, et al. Association between outdoor light at night and hypertension and high-normal blood pressure: a nationwide cross‐sectional study among Chinese adults. J Clin Hypertens. 2024;26:134–44.

Google Scholar 

Meléndez-Fernández OH, Liu JA, Nelson RJ. Circadian rhythms disrupted by light at night and mistimed food intake alter hormonal rhythms and metabolism. IJMS. 2023;24:3392.

Google Scholar 

Costello HM, Gumz ML. Circadian rhythm, clock genes, and hypertension: recent advances in hypertension. Hypertension. 2021;78:1185–96.

Google Scholar 

Khraishah H, Rajagopalan S. Inhaling poor health: the impact of air pollution on cardiovascular kidney metabolic syndrome. Methodist Debakey Cardiovasc J. 2024;20:47–58.

Google Scholar 

Liang F, Liu F, Huang K, Yang X, Li J, Xiao Q, et al. Long-term exposure to fine particulate matter and cardiovascular disease in China. J Am Coll Cardiol. 2020;75:707–17.

Google Scholar 

De Vieira PR, Cotton A, Elgudin YE, Virani S, Nasir K, Neeland I, et al. Social and environmental determinants of health and cardio-kidney-metabolic syndrome–related mortality. JAMA Netw Open. 2024;7:e2435783.

Google Scholar 

Li G, Huang J, Wang J, Zhao M, Liu Y, Guo X, et al. Long-term exposure to ambient PM2.5 and increased risk of CKD prevalence in China. JASN. 2021;32:448–58.

Google Scholar 

Wu G, Cai M, Wang C, Zou H, Wang X, Hua J, et al. Ambient air pollution and incidence, progression to multimorbidity and death of hypertension, diabetes, and chronic kidney disease: a national prospective cohort. Sci Total Environ. 2023;881: 163406.

Google Scholar 

Sanches TR, Parra AC, Sun P, Graner MP, Itto LYU, Butter LM, et al. Air pollution aggravates renal ischaemia–reperfusion-induced acute kidney injury. J Pathol. 2024;263:496–507.

Google Scholar 

Cao Y, Wang W, Xie S, Xu Y, Lin Z. Joint association of the inflammatory marker and cardiovascular-kidney-metabolic syndrome stages with all-cause and cardiovascular disease mortality: a national prospective study. BMC Public Health. 2025;25:10.

Google Scholar 

Gao C, Gao S, Zhao R, Shen P, Zhu X, Yang Y, et al. Association between systemic immune-inflammation index and cardiovascular-kidney-metabolic syndrome. Sci Rep. 2024;14:19151.

Google Scholar