The association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, red blood cell distribution width, and physical function in elderly non-dialysis patients with chronic kidney disease | BMC Geriatrics

  • Matsushita K, Ballew SH, Wang AY, Kalyesubula R, Schaeffner E, Agarwal R. Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease. Nat Rev Nephrol. 2022;18:696–707.

    Google Scholar 

  • Hsu CY, Chen LR, Chen KH. Osteoporosis in patients with chronic kidney diseases: a systemic review. Int J Mol Sci. 2020. https://doi.org/10.3390/ijms21186846.

  • Hu M, Wang Q, Liu B, Ma Q, Zhang T, Huang T, et al. Chronic kidney disease and cancer: inter-relationships and mechanisms. Front Cell Dev Biol. 2022;10:868715.

    Google Scholar 

  • Wilkinson TJ, Miksza J, Zaccardi F, Lawson C, Nixon AC, Young HML, et al. Associations between frailty trajectories and cardiovascular, renal, and mortality outcomes in chronic kidney disease. J Cachexia Sarcopenia Muscle. 2022;13:2426–35.

    Google Scholar 

  • Yu MD, Zhang HZ, Zhang Y, Yang SP, Lin M, Zhang YM, et al. Relationship between chronic kidney disease and sarcopenia. Sci Rep. 2021;11: 20523.

    Google Scholar 

  • MacKinnon HJ, Wilkinson TJ, Clarke AL, Gould DW, O’Sullivan TF, Xenophontos S, et al. The association of physical function and physical activity with all-cause mortality and adverse clinical outcomes in nondialysis chronic kidney disease: a systematic review. Ther Adv Chronic Dis. 2018;9:209–26.

    Google Scholar 

  • Iman Y, Harasemiw O, Tangri N. Assessing physical function in chronic kidney disease. Curr Opin Nephrol Hypertens. 2020;29:346–50.

    Google Scholar 

  • Li J, Wang Z, Zhang Q, Zhang H, Shen Y, Zhang Q, et al. Association between disability in activities of daily living and phase angle in hemodialysis patients. BMC Nephrol. 2023;24:350.

    Google Scholar 

  • Ruiz-Ortega M, Rayego-Mateos S, Lamas S, Ortiz A, Rodrigues-Diez RR. Targeting the progression of chronic kidney disease. Nat Rev Nephrol. 2020;16:269–88.

    Google Scholar 

  • Cai Y, Zhou H, Zhu Y, Sun Q, Ji Y, Xue A, et al. Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res. 2020;30:574–89.

    Google Scholar 

  • Barbé-Tuana F, Funchal G, Schmitz CRR, Maurmann RM, Bauer ME. The interplay between immunosenescence and age-related diseases. Semin Immunopathol. 2020;42:545–57.

    Google Scholar 

  • Fülöp T, Larbi A, Witkowski JM. Hum Inflammaging Gerontol. 2019;65:495–504.

    Google Scholar 

  • Marzetti E, Picca A, Marini F, Biancolillo A, Coelho-Junior HJ, Gervasoni J, et al. Inflammatory signatures in older persons with physical frailty and sarcopenia: the frailty cytokinome at its core. Exp Gerontol. 2019;122:129–38.

    Google Scholar 

  • Pan Y, Ma L. Inflammatory markers and physical frailty: towards clinical application. Immun Ageing. 2024;21:4.

    Google Scholar 

  • Watson EL, Baker LA, Wilkinson TJ, Gould DW, Xenophontos S, Graham-Brown M, et al. Inflammation and physical dysfunction: responses to moderate intensity exercise in chronic kidney disease. Nephrol Dial Transpl. 2022;37:860–68.

    Google Scholar 

  • Kamper RS, Alcazar J, Andersen LL, Haddock B, Jørgensen NR, Hovind P, et al. Associations between inflammatory markers, body composition, and physical function: the Copenhagen sarcopenia study. J Cachexia Sarcopenia Muscle. 2021;12:1641–52.

    Google Scholar 

  • Buonacera A, Stancanelli B, Colaci M, Malatino L. Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23073636.

  • Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med. 2019;39:345–57.

    Google Scholar 

  • Hong N, Kim CO, Youm Y, Choi JY, Kim HC, Rhee Y. Elevated red blood cell distribution width is associated with morphometric vertebral fracture in community-dwelling older adults, independent of anemia, inflammation, and nutritional status: the Korean urban rural elderly (KURE) study. Calcif Tissue Int. 2019;104:26–33.

    Google Scholar 

  • Zhao WY, Zhang Y, Hou LS, Xia X, Ge ML, Liu XL, et al. The association between systemic inflammatory markers and sarcopenia: results from the West China health and aging trend study (WCHAT). Arch Gerontol Geriatr. 2021;92: 104262.

    Google Scholar 

  • Gilmore N, Mohile S, Lei L, Culakova E, Mohamed M, Magnuson A, et al. The longitudinal relationship between immune cell profiles and frailty in patients with breast cancer receiving chemotherapy. Breast Cancer Res. 2021;23:19.

    Google Scholar 

  • Jiang Z, Han X, Wang Y, Hou T, Dong Y, Han X, et al. Red cell distribution width, anemia, and lower-extremity physical function among rural-dwelling older adults. Aging Clin Exp Res. 2022;34:2483–91.

    Google Scholar 

  • Li CM, Chao CT, Chen SI, Han DS, Huang KC. Elevated red cell distribution width is independently associated with a higher frailty risk among 2,932 Community-Dwelling older adults. Front Med (Lausanne). 2020;7:470.

    Google Scholar 

  • Kim J, Song SH, Oh TR, Suh SH, Choi HS, Kim CS, et al. Prognostic role of the neutrophil-to-lymphocyte ratio in patients with chronic kidney disease. Korean J Intern Med. 2023;38:725–33.

    Google Scholar 

  • Ao G, Wang Y, Qi X, Wang F, Wen H. Association of neutrophil-to-lymphocyte ratio and risk of cardiovascular or all-cause mortality in chronic kidney disease: a meta-analysis. Clin Exp Nephrol. 2021;25:157–65.

    Google Scholar 

  • Chen T, Yang M. Platelet-to-lymphocyte ratio is associated with cardiovascular disease in continuous ambulatory peritoneal dialysis patients. Int Immunopharmacol. 2020;78: 106063.

    Google Scholar 

  • Sági B, Vas T, Csiky B, Nagy J, Kovács TJ. Are Platelet-Related parameters prognostic predictors of renal and cardiovascular outcomes in IgA nephropathy?? J Clin Med. 2024;13(4):991.

  • Roumeliotis S, Neofytou IE, Maassen C, Lux P, Kantartzi K, Papachristou E et al. Association of red blood cell distribution width and Neutrophil-to-Lymphocyte ratio with calcification and cardiovascular markers in chronic kidney disease. Metabolites. 2023;13(2):303.

  • Yilmaz F, Sozel H. Red blood cell distribution width is a predictor of chronic kidney disease progression and all-cause mortality. Bratisl Lek Listy. 2021;122:49–55.

    Google Scholar 

  • Stevens PE, Levin A. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158:825–30.

    Google Scholar 

  • Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604–12.

    Google Scholar 

  • Dos Santos Barros V, Bassi-Dibai D, Guedes CLR, Morais DN, Coutinho SM, de Oliveira Simões G, et al. Barthel index is a valid and reliable tool to measure the functional independence of cancer patients in palliative care. BMC Palliat Care. 2022;21(1): 124.

    Google Scholar 

  • Suárez-Dono J, Cervantes-Pérez E, Pena-Seijo M, Formigo-Couceiro F, Ferrón-Vidán F, Novo-Veleiro I, et al. CRONIGAL: prognostic index for chronic patients after hospital admission. Eur J Intern Med. 2016;36:25–31.

    Google Scholar 

  • Fukui S, Kawakami M, Otaka Y, Ishikawa A, Yashima F, Hayashida K, et al. Activities of daily living among elderly persons with severe aortic stenosis. Disabil Rehabil. 2021;43(3):338–44.

    Google Scholar 

  • Uemura Y, Shibata R, Takemoto K, Koyasu M, Ishikawa S, Murohara T, et al. Prognostic impact of the preservation of activities of daily living on post-discharge outcomes in patients with acute heart failure. Circ J. 2018;82:2793–9.

    Google Scholar 

  • Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173:676–82.

    Google Scholar 

  • Wang J, Xu MC, Huang LJ, Li B, Yang L, Deng X. Value of neutrophil-to-lymphocyte ratio for diagnosing sarcopenia in patients undergoing maintenance hemodialysis and efficacy of Baduanjin exercise combined with nutritional support. Front Neurol. 2023;14: 1072986.

    Google Scholar 

  • Lima-Costa MF, Mambrini JVM, Torres KCL, Peixoto SV, Andrade FB, De Oliveira C, et al. Multiple inflammatory markers and 15-year incident ADL disability in admixed older adults: the Bambui-Epigen study. Arch Gerontol Geriatr. 2017;72:103–7.

    Google Scholar 

  • Lassale C, Batty GD, Steptoe A, Cadar D, Akbaraly TN, Kivimäki M, et al. Association of 10-year C-reactive protein trajectories with markers of healthy aging: findings from the English longitudinal study of aging. The Journals of Gerontology: Series A. 2019;74:195–203.

    Google Scholar 

  • Duarte MP, Almeida LS, Neri SGR, Oliveira JS, Wilkinson TJ, Ribeiro HS, et al. Prevalence of sarcopenia in patients with chronic kidney disease: a global systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2024;15(2):501–12.

    Google Scholar 

  • Pan L, Xie W, Fu X, Lu W, Jin H, Lai J, et al. Inflammation and sarcopenia: a focus on circulating inflammatory cytokines. Exp Gerontol. 2021;154: 111544.

    Google Scholar 

  • Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000;908:244–54.

    Google Scholar 

  • Qin K, Lin L, Lu C, Chen W, Guo VY. Association between systemic inflammation and activities of daily living disability among Chinese elderly individuals: the mediating role of handgrip strength. Aging Clin Exp Res. 2022;34:767–74.

    Google Scholar 

  • Enersen CC, Egelund GB, Petersen PT, Andersen S, Ravn P, Rohde G, et al. The ratio of neutrophil-to-lymphocyte and platelet-to-lymphocyte and association with mortality in community-acquired pneumonia: a derivation-validation cohort study. Infection. 2023;51:1339–47.

    Google Scholar 

  • Platini H, Ferdinand E, Kohar K, Prayogo SA, Amirah S, Komariah M et al. Neutrophil-to-Lymphocyte ratio and Platelet-to-Lymphocyte ratio as prognostic markers for advanced Non-Small-Cell lung Cancer treated with immunotherapy: A systematic review and Meta-Analysis. Med (Kaunas). 2022;58(8):1069.

  • Yoshida Y, Iwasa H, Kim H, Suzuki T. Association between neutrophil-to-lymphocyte ratio and physical function in older adults: a community-based cross-sectional study in Japan. Int J Environ Res Public Health. 2022. https://doi.org/10.3390/ijerph19158996.

  • Hu Q, Mao W, Wu T, Xu Z, Yu J, Wang C, et al. High neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are associated with sarcopenia risk in hospitalized renal cell carcinoma patients. Front Oncol. 2021;11: 736640.

    Google Scholar 

  • Santos HO, Limirio LS, Dos Reis AS, Nehme R, Floriano JP, Gomes GK, et al. Neutrophil-lymphocyte ratio and C-reactive protein levels are not associated with strength, muscle mass, and functional capacity in kidney transplant patients. Inflammation. 2022;45:2465–76.

    Google Scholar 

  • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–23.

    Google Scholar 

  • Sakai Y, Wakao N, Matsui H, Watanabe T, Iida H, Katsumi A. Elevated red blood cell distribution width is associated with poor outcome in osteoporotic vertebral fracture. J Bone Min Metab. 2021;39:1048–57.

    Google Scholar 

  • Continue Reading