Infections GBDLR, Antimicrobial Resistance C. Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990–2021: a systematic analysis from the global burden of disease study 2021. Lancet Infect Dis. 2024;24(9):974–1002.
Wang S, Tang J, Tan Y, Song Z, Qin L. Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis. BMJ Open. 2023;13(4):e066721.
Google Scholar
Ma Y, Sun J, Che G, Cheng H. Systematic infection of Chlamydia Pneumoniae. Clin Lab 2022;68(8). https://doi.org/10.7754/Clin.Lab.2021.210908.
Smith-Norowitz TA, Chotikanatis K, Erstein DP, Perlman J, Norowitz YM, Joks R, Durkin HG, Hammerschlag MR, Kohlhoff S. Chlamydia pneumoniae enhances the Th2 profile of stimulated peripheral blood mononuclear cells from asthmatic patients. Hum Immunol. 2016;77(5):382–8.
Google Scholar
Hansbro PM, Beagley KW, Horvat JC, Gibson PG. Role of atypical bacterial infection of the lung in predisposition/protection of asthma. Pharmacol Ther. 2004;101(3):193–210.
Google Scholar
Thom DH, Grayston JT. Infections with Chlamydia pneumoniae strain TWAR. Clin Chest Med. 1991;12(2):245–56.
Google Scholar
Choroszy-Krol I, Frej-Madrzak M, Jama-Kmiecik A, Sarowska J, Gosciniak G, Pirogowicz I. Incidence of Chlamydophila pneumoniae infection in children during 2007–2010. Adv Exp Med Biol. 2013;788:83–7.
Google Scholar
Del Valle-Mendoza J, Orellana-Peralta F, Marcelo-Rodriguez A, Verne E, Esquivel-Vizcarra M, Silva-Caso W, Aguilar-Luis MA, Weilg P, Casabona-Ore V, Ugarte C, et al. High prevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with acute respiratory infections from lima, Peru. PLoS ONE. 2017;12(1):e0170787.
Google Scholar
Subspecialty Group of Respiratory, tSoPC, Medical A, Editorial Board CJP, China Medicine Education Association Committee on P. Guidelines for the management of community-acquired pneumonia in children (2024 revision). Zhonghua Er Ke Za zhi = Chin J Pediatr. 2024;62(10):920–30.
Experts Group of Pediatric Respiratory Endoscopy TES, Center of National, Health C, Endoscopy Committee PSoCMD, Association, Pediatric Respiratory Endoscopy Committee ESo, Chinese Medical Doctor A, Pediatric Interventional Respirology Group M, Pediatric, Minimally Invasive Section of Chinese M, Child H, et al. Guideline of pediatric flexible bronchoscopy in China(2018 version). Chinese Journal of Applied Clinical Pediatrics. 2018;33(13):983–9.
Yang R, Xu H, Zhang Z, Liu Q, Zhao R, Zheng G, Wu X. The epidemiology of pathogens in Community-Acquired pneumonia among children in Southwest China before, during and after COVID-19 Non-pharmaceutical interventions: A Cross-Sectional study. Influenza Other Respir Viruses. 2024;18(8):e13361.
Google Scholar
Cohen R, Ashman M, Taha MK, Varon E, Angoulvant F, Levy C, Rybak A, Ouldali N, Guiso N, Grimprel E. Pediatric infectious disease group (GPIP) position paper on the immune debt of the COVID-19 pandemic in childhood, how can we fill the immunity gap? Infect Dis now. 2021;51(5):418–23.
Google Scholar
Cai F, Shou X, Ye Q. Epidemiological study on Mycoplasma pneumoniae and Chlamydia pneumoniae infection of hospitalized children in a single center during the COVID-19 pandemic. Front Cell Infect Microbiol. 2022;12:843463.
Google Scholar
Fujita J, Kinjo T. Where is Chlamydophila pneumoniae pneumonia? Respir Investig. 2020;58(5):336–43.
Google Scholar
Han HY, Moon JU, Rhim JW, Kang HM, Lee SJ, Yang EA. Surge of Chlamydia pneumoniae pneumonia in children hospitalized with community-acquired pneumonia at a single center in Korea in 2016. J Infect Chemother. 2023;29(5):453–7.
Google Scholar
Balsamo G, Maxted AM, Midla JW, Murphy JM, Wohrle R, Edling TM, Fish PH, Flammer K, Hyde D, Kutty PK, et al. Compendium of measures to control Chlamydia psittaci infection among humans (Psittacosis) and pet birds (Avian Chlamydiosis), 2017. J Avian Med Surg. 2017;31(3):262–82.
Google Scholar
Miyashita N, Akaike H, Teranishi H, Kawai Y, Ouchi K, Kato T, Hayashi T, Okimoto N. Atypical pathogen study G: Chlamydophila pneumoniae serology: cross-reaction with Mycoplasma pneumoniae infection. J Infect Chemother. 2013;19(2):256–60.
Google Scholar
Conklin L, Adjemian J, Loo J, Mandal S, Davis C, Parks S, Parsons T, McDonough B, Partida J, Thurman K, et al. Investigation of a Chlamydia pneumoniae outbreak in a federal correctional facility in Texas. Clin Infect Diseases: Official Publication Infect Dis Soc Am. 2013;57(5):639–47.
Blasi F, Aliberti S, Allegra L, Piatti G, Tarsia P, Ossewaarde JM, Verweij V, Nijkamp FP, Folkerts G. Chlamydophila pneumoniae induces a sustained airway hyperresponsiveness and inflammation in mice. Respir Res. 2007;8(1):83.
Google Scholar
Wen XH, Li HM, Zhang XY, Liu H, Tang XL, Wu XH, Xu WH, Zhao SY, Yang HM. Clinical features of Chlamydia pneumoniae pneumonia in 10 children. Zhonghua Er Ke Za Zhi. 2025;63(4):362–6.
Google Scholar
Garin N, Marti C, Skali Lami A, Prendki V. Atypical pathogens in adult community-acquired pneumonia and implications for empiric antibiotic treatment: a narrative review. Microorganisms. 2022. https://doi.org/10.3390/microorganisms10122326.
Google Scholar
Crother TR, Schroder NW, Karlin J, Chen S, Shimada K, Slepenkin A, Alsabeh R, Peterson E, Arditi M. Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells. PLoS One. 2011;6(6): e20784.
Google Scholar
Hussain M, Liu G. Eosinophilic asthma: pathophysiology and therapeutic horizons. Cells. 2024. https://doi.org/10.3390/cells13050384.
Google Scholar
Ferreira DS, Annoni R, Silva LF, Buttignol M, Santos AB, Medeiros MC, Andrade LN, Yick CY, Sterk PJ, Sampaio JL, et al. Toll-like receptors 2, 3 and 4 and thymic stromal lymphopoietin expression in fatal asthma. Clin Exp Allergy. 2012;42(10):1459–71.
Google Scholar
Jackson DJ, Akuthota P, Roufosse F. Eosinophils and eosinophilic immune dysfunction in health and disease. Eur Respiratory Review: Official J Eur Respiratory Soc. 2022;31(163).
Zaitsu M. Does Chlamydia pneumoniae infection trigger to development of asthma in wheezy infants? J Asthma. 2009;46(9):967–8.
Google Scholar
Iramain R, De Jesús R, Spitters C, Jara A, Jimenez J, Bogado N, Cardozo L. Chlamydia pneumoniae, and mycoplasma pneumoniae: are they related to severe asthma in childhood? J Asthma: Official J Association Care Asthma. 2016;53(6):618–21.
Google Scholar
Darveaux JI, Lemanske RF. Infection-related asthma. The Journal of Allergy and Clinical Immunology: In Practice. 2014;2(6):658–63.
Google Scholar
Cunningham AF, Johnston SL, Julious SA, Lampe FC, Ward ME. Chronic Chlamydia pneumoniae infection and asthma exacerbations in children. Eur Respir J. 1998;11(2):345–9.
Google Scholar
Smith-Norowitz TA, Shulman A, Abdelmajid H, Hammerschlag MR, Joks R, Weaver D, Kohlhoff S. Chlamydia pneumoniae-immunoglobulin E antibody responses in serum from children with asthma. Pathog Dis. 2023;81. https://doi.org/10.1093/femspd/ftad015.
Hahn DL. Chlamydia pneumoniae and chronic asthma: updated systematic review and meta-analysis of population attributable risk. PLoS One. 2021;16(4):e0250034.
Google Scholar
Yu J, Xu L, Han A, Xie M. The epidemiology of asthma in mainland China: a systematic review and meta-analysis. BMC Public Health. 2024;24(1):2888.
Google Scholar
Feng C, Xu M, Kang J, Wen F, Chen Y, Zhang J, Xiao W, Zhang Z, Yang L, Huo J, et al. Atypical pathogen distribution in Chinese hospitalized AECOPD patients: A multicenter Cross-Sectional study. Int J Chron Obstruct Pulmon Dis. 2021;16:1699–708.
Google Scholar
Calmes D, Huynen P, Paulus V, Henket M, Guissard F, Moermans C, Louis R, Schleich F. Chronic infection with Chlamydia pneumoniae in asthma: a type-2 low infection related phenotype. Respir Res. 2021;22(1):72.
Google Scholar