The burden of malaria in East Africa: prevalence, risk factors, and control strategies | Malaria Journal

  • Namuganga JF, Nankabirwa JI, Maiteki-Ssebuguzi C, Gonahasa S, Opigo J, Staedke SG, et al. East Africa International Center of Excellence for Malaria Research: impact on malaria policy in Uganda. Am J Trop Med Hyg. 2022;107:33–9.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Oladipo HJ, Tajudeen YA, Oladunjoye IO, Yusuff SI, Yusuf RO, Oluwaseyi EM, et al. Increasing challenges of malaria control in sub-Saharan Africa: priorities for public health research and policymakers. Ann Med Surg. 2022;81: 104366.

    Google Scholar 

  • Nyakairu DG. The burden of malaria in east Africa: epidemiology and health impact. INOSR Appl Sci. 2024;12:20–3.

    Google Scholar 

  • ReliefWeb. Guidelines for the diagnosis and treatment of malaria in the Somali context ReliefWeb. 2023. https://reliefweb.int/report/somalia/guidelines-diagnosis-and-treatment-malaria-somalia-2016. Accessed 5 Apr 2025

  • Sisay M, Kebede M, Goshu A. Prevalence of malaria and associated factors among pregnant women in East Dembia District Northwest Ethiopia. BMC Pregnancy Childbirth. 2024;24:866.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Woyessa A, Siebert A, Owusu A, Cousin R, Dinku T, Thomson MC. El Niño and other climatic drivers of epidemic malaria in Ethiopia: new tools for national health adaptation plans. Malar J. 2023;22:195.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Li J, Docile HJ, Fisher D, Pronyuk K, Zhao L. Current status of malaria control and elimination in Africa: epidemiology, diagnosis, treatment, progress and challenges. J Epidemiol Glob Health. 2024. https://doi.org/10.1007/s44197-024-00228-2.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ototo EN, Ogutu JO, Githeko A, Said MY, Kamau L, Namanya D, et al. Forecasting the potential effects of climate change on malaria in the Lake Victoria basin using regionalized climate projections. Acta Parasitol. 2022;67:1535–63.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Nosten F, Richard-Lenoble D, Danis M. A brief history of malaria. Presse Med. 2022;51(3): 104130.

    PubMed 

    Google Scholar 

  • Mawejje HD, Kilama M, Kigozi SP, Musiime AK, Kamya M, Lines J, et al. Impact of seasonality and malaria control interventions on Anopheles density and species composition from three areas of Uganda with differing malaria endemicity. Malar J. 2021;20:138.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lacey H, Jain N, Sugimoto M, Shimato M, Reine I, Oria K. Combating malaria in Kenya through collaborative population health education: a systematic review and pilot case study. Infect Dis. 2023;55:664–83.

    Google Scholar 

  • Nyambura AM. Imported malaria cases and fatality in East Africa: a review. Res Invent J Public Health Pharm. 2024;3:16–21.

    Google Scholar 

  • Yamba EI, Fink AH, Badu K, Asare EO, Tompkins AM, Amekudzi LK. Climate drivers of malaria transmission seasonality and their relative importance in sub-Saharan Africa. Geohealth. 2023. https://doi.org/10.1029/2022GH000698.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Msugupakulya BJ, Urio NH, Jumanne M, Ngowo HS, Selvaraj P, Okumu FO, et al. Changes in contributions of different Anopheles vector species to malaria transmission in east and southern Africa from 2000 to 2022. Parasit Vectors. 2023;16:408.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Tabuti JRS, Obakiro SB, Nabatanzi A, Anywar G, Nambejja C, Mutyaba MR, et al. Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda. Trop Med Health. 2023;51:34.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Ogieuhi IJ, Ajekiigbe VO, Kolo-Manma K, Akingbola A, Odeniyi TA, Soyemi TS, et al. A narrative review of the RTS S AS01 malaria vaccine and its implementation in Africa to reduce the global malaria burden. Discover Public Health. 2024;21:152.

    Google Scholar 

  • Al-Awadhi M, Ahmad S, Iqbal J. Current status and the epidemiology of malaria in the Middle East region and beyond. Microorganisms. 2021;9:338.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kassam NA, Kaaya RD, Damian DJ, Schmiegelow C, Kavishe RA, Alifrangis M, et al. Ten years of monitoring malaria trend and factors associated with malaria test positivity rates in Lower Moshi. Malar J. 2021;20:193.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • WHO. Regional data & trends briefing kit: World malaria report 2024. 2024. https://cdn.who.int/media/docs/default-source/malaria/world-malaria-reports/world-malaria-report-2024-regional-briefing-kit-eng.pdf?sfvrsn=bceac4ae_9&download=true. Accessed 15 May 2025.

  • Severe malaria observatory malaria in Uganda: statistics & facts. https://www.severemalaria.org/countries/uganda. Accessed 16 May 2025.

  • Uganda launches 2024–2025 malaria survey. ChimpReports. https://chimpreports.com/uganda-launches-2024-2025-malaria-survey/. Accessed 16 May 2025.

  • Progress on malaria control in countries. https://www.afro.who.int/sites/default/files/2023-04/033_WHO-AFRO_Era-of-Transformation_Malaria_A4_P.pdf. Accessed 16 May 2025.

  • Malaria – Ethiopia. https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON542. Accessed 15 May 2025.

  • Unprecedented surge of malaria cases in Ethiopia – Ethiopia. ReliefWeb. https://reliefweb.int/report/ethiopia/unprecedented-surge-malaria-cases-ethiopia. Accessed 16 May 2025.

  • Kołodziej D, Ammi HZ, Richert W, Marchelek-Myśliwiec M, Korzeniewski K. Prevalence of malaria in Arusha Region in the northern Tanzania. Int Marit Health. 2024;75:103–8.

    PubMed 

    Google Scholar 

  • WHO EMRO. Somalia’s tangible progress on malaria, even in the face of new strains. Somalia site. https://www.emro.who.int/somalia/news/somalias-tangible-progress-on-malaria-even-in-the-face-of-new-strains.html. Accessed 15 May 2025.

  • Kahamba NF, Finda M, Ngowo HS, Msugupakulya BJ, Baldini F, Koekemoer LL, et al. Using ecological observations to improve malaria control in areas where Anopheles funestus is the dominant vector. Malar J. 2022;21:158.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Alegana VA, Macharia PM, Muchiri S, Mumo E, Oyugi E, Kamau A, et al. Plasmodium falciparum parasite prevalence in East Africa: updating data for malaria stratification. PLoS Glob Public Health. 2021;1(12): 1:e0000014.

    PubMed 

    Google Scholar 

  • Mafwele BJ, Lee JW. Relationships between transmission of malaria in Africa and climate factors. Sci Rep. 2022;12:14392.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mukala J, Mogere D, Kirira P, Kanoi BN, Akisa V, Kobia F, et al. Predictors of birth weight in pregnant women with malaria: a prospective cohort facility-based study in Webuye-Kenya. BMC Pregnancy Childbirth. 2024;24:187.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Seyoum TF, Andualem Z, Yalew HF. Insecticide-treated bed net use and associated factors among households having under-five children in East Africa: a multilevel binary logistic regression analysis. Malar J. 2023;22:10.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kamau A, Paton RS, Akech S, Mpimbaza A, Khazenzi C, Ogero M, et al. Malaria hospitalisation in East Africa: age, phenotype and transmission intensity. BMC Med. 2022;20:28.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Conrad MD, Asua V, Garg S, Giesbrecht D, Niaré K, Smith S, et al. Evolution of partial resistance to artemisinins in malaria parasites in Uganda. N Engl J Med. 2023;389:722–32.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • White NJ. Emergence of artemisinin-resistant Plasmodium falciparum in East Africa. N Engl J Med. 2021;385:1231–2.

    CAS 
    PubMed 

    Google Scholar 

  • Balikagala B, Fukuda N, Ikeda M, Katuro OT, Tachibana S-I, Yamauchi M, et al. Evidence of artemisinin-resistant malaria in Africa. N Engl J Med. 2021;385:1163–71.

    CAS 
    PubMed 

    Google Scholar 

  • Hancock PA, Lynd A, Wiebe A, Devine M, Essandoh J, Wat’senga F, et al. Modelling spatiotemporal trends in the frequency of genetic mutations conferring insecticide target-site resistance in African mosquito malaria vector species. BMC Biol. 2022;20:46.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wangrawa DW, Odero JO, Baldini F, Okumu F, Badolo A. Distribution and insecticide resistance profile of the major malaria vector Anopheles funestus group across the African continent. Med Vet Entomol. 2024;38:119–37.

    CAS 
    PubMed 

    Google Scholar 

  • Camponovo F, Jeandron A, Skrip LA, Golumbeanu M, Champagne C, Symons TL, et al. Malaria treatment for prevention: a modelling study of the impact of routine case management on malaria prevalence and burden. BMC Infect Dis. 2024;24:1267.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Stokes BH, Ward KE, Fidock DA. Evidence of artemisinin-resistant malaria in Africa. N Engl J Med. 2022;386:1385–6.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Rosenthal PJ, Asua V, Bailey JA, Conrad MD, Ishengoma DS, Kamya MR, et al. The emergence of artemisinin partial resistance in Africa: how do we respond? Lancet Infect Dis. 2024;24:e591-600.

    CAS 
    PubMed 

    Google Scholar 

  • Ministry of Health, National malaria control programme. Kenya malaria strategy. 2023. https://www.afro.who.int/sites/default/files/2025-03/Kenya%20Malaria%20Strategy%20%7C%202023-2027.pdf. Accessed 13 Jun 2025.

  • Mihreteab S, Platon L, Berhane A, Stokes BH, Warsame M, Campagne P, et al. Increasing prevalence of artemisinin-resistant HRP2-negative malaria in Eritrea. N Engl J Med. 2023;389:1191–202.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Assefa A, Fola AA, Tasew G. Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic? Malar J. 2024;23:34.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Abebe W, Mekuanint A, Asmare Z, Woldesenbet D, Mihret Y, Setegn A, et al. Prevalence of molecular markers of chloroquine resistance in malaria parasites in East Africa: a systematic review and meta-analysis. J Glob Antimicrob Resist. 2025;41:117–37.

    CAS 
    PubMed 

    Google Scholar 

  • Bridging the funding gap to defeat malaria in Africa. WHO regional office for Africa. https://www.afro.who.int/news/bridging-funding-gap-defeat-malaria-africa. Accessed 11 May 2025.

  • Funding gaps and climate change hinder malaria elimination in Africa: report. https://www.downtoearth.org.in/health/funding-gaps-climate-change-stall-malaria-elimination-in-africa-report. Accessed 11 May 2025.

  • Malaria: artemisinin partial resistance. https://www.who.int/news-room/questions-and-answers/item/artemisinin-resistance. Accessed 11 May 2025.

  • Urgent action needed as malaria evolves resistance to key drug. https://www.bbc.com/news/articles/cxe25v5d8l9o. Accessed 11 May 2025.

  • Nankabirwa JI, Rek J, Arinaitwe E, Namuganga JF, Nsobya SL, Asua V, et al. East Africa international center of excellence for malaria research: summary of key research findings. Am J Trop Med Hyg. 2022;107:21–32.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Climate change aided malaria expansion into highland east Africa | PreventionWeb. https://www.preventionweb.net/news/climate-change-aided-malaria-expansion-highland-east-africa-and-towards-cape-100-years-study.Accessed 11 May 2025.

  • Zero malaria starts with me toolkit module 5: community engagement. https://healthcommcapacity.org/malaria-evidence. Accessed 11 May 2025.

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