Category: 3. Business

Among pregnant women with HIV infection, oral rilpivirine-based antiretroviral regimens were associated with similar rates of adverse pregnancy and birth outcomes as nonrilpivirine regimens. The prevalence of overall birth defects was lower in the rilpivirine group and did not vary by timing of exposure.

METHODOLOGY:

• Researchers analyzed data from the Antiretroviral Pregnancy Registry to compare adverse pregnancy and birth outcomes among pregnant women with HIV infection who received oral rilpivirine-containing antiretroviral regimens and those who did not.
• They analyzed 4617 pregnancies from the US between 2011 to 2023 (median maternal age, 29 years); 781 received oral tablets or oral fixed-dose combinations of rilpivirine, and 3836 received regimens without rilpivirine.
• Outcomes included reported stillbirth, induced abortion, and live birth outcomes such as low birth weight (< 2500 g), very low birth weight (< 1500 g), premature birth (< 37 weeks’ gestation), and birth defects.

TAKEAWAY:

• The oral rilpivirine and nonrilpivirine groups had similar prevalence for induced abortion (age-adjusted prevalence ratio [aPR], 1.1), stillbirth (aPR, 0.6), premature birth (aPR, 0.8), and very low birth weight (aPR, 0.7; P > .05 for all).
• The prevalence of overall birth defects was lower in the oral rilpivirine group than in the nonrilpivirine group (aPR, 0.4; P = .0054). Similarly, rates of low birth weight were significantly lower in the oral rilpivirine group (aPR, 0.7; P = .0046).
• No significant difference was observed in the prevalence of overall birth defects between offspring of women exposed to oral rilpivirine in the first trimester and offspring of women exposed in the second and/or third trimester.

IN PRACTICE:

“These findings on the safety of oral RPV [rilpivirine]-containing ARV [antiretroviral] regimens in pregnant women and their offspring are reassuring for patients and HCPs [healthcare providers] and further support the use of oral RPV as per the current guidelines for the treatment of HIV infection during pregnancy,” the authors wrote.

SOURCE:

This study was led by William R. Short, Perelman School of Medicine, University of Pennsylvania, Philadelphia. It was published online on September 11, 2025, in HIV Medicine.

LIMITATIONS:

The registry relied on voluntary reports of cases from healthcare providers, which may have led to differential reporting. It was primarily designed to detect teratogenic effects, limiting the robustness of data on pregnancy outcomes. Enrollment of women after negative prenatal testing could have lowered the observed prevalence of birth defects. Moreover, this study could not distinguish the individual effects of other antiretroviral drugs on birth outcomes.

DISCLOSURES:

This study was supported byJohnson & Johnson. Six authors reported being employees of the funder and disclosed that they may be holding company stock or stock options. Other authors disclosed receiving consultancy fees or honoraria or having other financial ties with pharmaceutical companies.

By Devyani Gholap

 

Oct 8 (Reuters) – French authorities on Wednesday denied an important maritime concession for the Aquind electricity interconnector project, effectively halting progress on the planned high-voltage link between France and the United Kingdom.

While the project received environmental approval in July, the concession required a national-level recognition of public interest, which was not validated, the Seine-Maritime prefecture said in a statement on Wednesday.

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“We are surprised by this decision, given the growing need for interconnection identified at the European level, particularly between France and Great Britain, and the policies implemented in this respect,” said Martin Dubourg, Aquind director for France.

While presenting a risk for the project, the decision does not call into question its relevance or eventual completion, he added.

With a capacity of 2 gigawatts, the interconnector is expected to transmit over 17 TWh of electricity annually between France and Great Britain, according to the project’s website.

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Good afternoon. Thank you for the invitation to be here to help mark the 10th anniversary of the Center for Indian Country Development (CICD) and to further the goal of advancing development through better data.¹ It’s a privilege to be in the presence of so many tribal leaders, Federal Reserve colleagues, policymakers, researchers, and practitioners all working to advance Native economies. My experiences traveling with CICD and engaging in CICD’s work have been a meaningful part of my time at the Federal Reserve.

At the Board of Governors, I serve as the oversight governor for our Division of Consumer and Community Affairs, which supports the community development function across the Federal Reserve System. It’s a role that means a great deal to me. Community development has been a cornerstone of my career—as a governor, banking regulator, and earlier in my career as a scholar, university leader, and the Treasury Department’s point person on community development in the 1990s.

I’d like to focus my remarks today on why I think the work you all are doing is critical to the prosperity of Native nations and Indigenous communities, and why that success matters for our country.

Two years ago, I traveled to western Montana with CICD staff. We visited the Blackfeet Indian Reservation, which is home to the Blackfeet Nation, and the Flathead Indian Reservation, which is home to the Confederated Salish and Kootenai Tribes.

On our visit, I saw examples of tribal leaders diversifying their economies through tribally owned enterprises—and then leveraging revenues from those enterprises to reinvest in their communities. I heard from business leaders struggling with supply chain challenges and community members pulling together to address housing supply and affordability issues.² At a community roundtable, financial leaders talked about credit needs in their regions including challenges with limited credit and access to financial services and distance from banks.

These issues take center stage in CICD’s research. And in our conversations, research served as a springboard for a variety of community members and leaders to come together to explore solutions. This is why community engagement is a critical part of community development, and a huge value add for the Federal Reserve as we seek to understand how people are experiencing the economy.

I see this same spirit of working together on behalf of a better future—grounded in research—on display here today.

Economic Gaps and Data Needs in Indian Country

There remain persistent economic gaps in Indian Country based on many metrics. Native Americans have lower household income, and poverty is a significant problem on reservations.³ According to the Federal Reserve’s Survey of Household Economics and Decisionmaking (SHED Survey), Native American households consistently report a lower likelihood of having the cash to pay for a $400 emergency expense, which is a common measure of financial security.⁴ Looking at the labor force, unemployment is higher for Native American workers than for workers overall. Research has also documented a lack of financial institutions near reservations, which restricts capital and credit availability. A recent study showed that Native-owned small businesses were less likely to receive the financing they applied for, even though they were much more likely to apply for small amounts of credit.⁵ Native Americans also face a higher cost of homeownership.

Economic downturns can exacerbate gaps, such as when social-distancing measures during the COVID-19 pandemic disproportionately harmed sectors such as gaming and entertainment in which many tribally owned businesses are concentrated.

Addressing these persistent challenges requires coordination with local leaders to achieve progress. During my first stint at the Treasury in the 1990s, I co-chaired a working group whose objective was to reduce barriers to mortgage lenders and expand access to credit in Indian Country, with pilot programs in the Navajo Nation and Oglala Sioux Pine Ridge Reservation. The working group helped map out a clearer process for residents to obtain mortgages by coordinating tribal governmental, federal, and lender roles.⁶ I see this as an example of potential progress that can be made when national and local leaders and the private sector leverage research and come together to find solutions, but also as a reminder that these are long-standing problems that are still with us today.

In other ways, tribal governments have been proactive in diversifying their revenue streams and innovating in their use of economic data to make evidence-based decisions. Native Community Development Financial Institutions (CDFIs) are addressing credit gaps in their communities with culturally informed lending practices and financial services. There are many examples of initiatives targeting specific economic challenges. We see signs of progress, including positive trends in Native American employment and household income. But we’ll only know whether we’re making economic gains in Indian Country over time if we have timely, high-quality data disaggregated for Native peoples and geographies. Data dashboards are not just for researchers. They help tribal nations and decisionmakers in many capacities make informed decisions about how to allocate resources, design interventions, and monitor economic growth.

We know that Indian Country has sometimes been referred to as the “asterisk nation” as a result of insufficient sample sizes of Native Americans in national datasets. Experiences in which external researchers used data in ways that were harmful to tribal communities have also contributed to mistrust of research and data in Indian Country. At the same time, many tribal governments have limited resources to allocate toward their own data collection.

Research and Data Advancements

Research and data advancements in Indian Country are changing this narrative. Over the past decade, CICD’s research has advanced our understanding of the pillars of tribal economies and potential interventions.⁷ We’ve learned more about the role of tribal governments and tribal enterprises in local and regional economies, and the ways tribal treasuries are distinctive from those of local and state governments. CICD’s research has helped us understand how infrastructure gaps such as broadband access can impede economic growth and leave communities more vulnerable to economic shocks. And it’s provided research insights on strategies for increasing access to capital and credit in Native communities.

Much of this research has taken place in collaboration with Native organizations, tribal governments, and economic development practitioners. In some of these areas, such as research on the practices and outcomes of Native CDFIs, CICD and its collaborators have provided some of the first systematic quantitative analysis in the field.

CICD has also developed a suite of data tools that empower community members and decisionmakers to explore economic conditions at local to national levels and monitor trends over time.

Indian Country’s Relevance to the Broader Economy

This work to advance economic research and data in Indian Country matters to the overall economy. The Federal Reserve promotes a healthy economy and a stable financial system for everyone, and that simply cannot be done without supporting strong and sustainable communities in Indian Country. Research tells us that Native economies are closely intertwined with local and regional economies. Examples include tribal casinos attracting visitors to surrounding businesses and Native enterprises subcontracting with non-Native-owned businesses.

CICD’s mission supports the Federal Reserve’s community development function, which works to promote access to credit, investment, and financial services in low- and moderate-income communities, and foster a better understanding of their economic conditions. This happens in a few ways.

As members of the Federal Open Market Committee, my colleagues and I decide on the appropriate setting for monetary policy. In this role, it’s vital that we understand how a variety of individuals, institutions, and communities experience the economy. Research from CICD and community development teams here in Minneapolis and across the Federal Reserve System sheds light on economic circumstances in our communities.

As important as it is, monetary policy isn’t the main thing that matters to a healthy economy. Businesses, financial practitioners, nonprofits, community leaders, and decisionmakers at many levels all need research and data to make evidence-based decisions and promote thriving and economically resilient communities. The community development function provides this research and convening power to advance our collective understanding of local financial needs.

Our community development work also provides timely, on-the-ground insights on developments in the financial system. A prime example of this is the series of surveys CICD conducted during the COVID-19 pandemic. These surveys provided real-time glimpses of the challenges that tribal governments, businesses, and community leaders were facing as a result of the pandemic.

In addition, under the Community Reinvestment Act, the Federal Reserve has a statutory obligation to supervise how banks meet the credit needs of the communities they serve, consistent with safe and sound lending practices. And that very much includes communities in Indian Country. And we need good data and analysis to fulfill our statutory obligations.

What it comes down to is that the Federal Reserve does our best work when we understand what’s happening in communities, and that includes the rich variety of communities across Indian Country.

Learning from Indian Country

As we look to the future, decisionmakers inside and outside of Indian Country can learn from the ways tribal governments have served their communities and guided their economies through many challenges. In my visits with tribal leaders, I have been inspired by their long-range vision—considering how decisions today will affect their ability to care for their communities for generations into the future.

I’ve also come to appreciate their grit and creativity in meeting community needs, whether it be through starting a tribal bank to meet local financial service needs, leveraging tribal enterprises to create employment opportunities, or innovating in their use of economic data to tailor public services to their communities.

Much has been said about the economic challenges in Indian Country, but perhaps what has impressed me the most in my visits is the sense of optimism for the future from so many people I have met, despite these challenges.

Thank you for the important ways you are coming together to use research and data to propel your communities forward. It’s an honor to be here with you.

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1. The views expressed here are my own and are not necessarily those of my colleagues on the Federal Reserve Board or the Federal Open Market Committee. Return to text

2. See the Federal Reserve of Minneapolis website at https://www.minneapolisfed.org/speeches/2021/us-senate-testimony-housing-for-native-americans-review-of-federal-programs-barriers-and-opportunities and https://www.minneapolisfed.org/article/2024/native-americans-pay-more-to-finance-home-purchases-than-white-borrowers. Return to text

3. Federal Reserve Bank of Minneapolis, Native Community Data Profiles. Return to text

4. Board of Governors of the Federal Reserve System, Economic Well-Being of U.S. Households in 2024 (Washington: Board of Governors, May 2025). Return to text

5. See the Federal Reserve of Minneapolis website at https://www.minneapolisfed.org/article/2024/native-entrepreneurs-face-credit-access-challenges. Return to text

6. U.S. Department of Housing and Urban Development and U.S. Department of the Treasury, One-Stop Mortgage Center Initiative in Indian Country: A Report to the President (PDF) (Washington, DC: HUD, 1999). Return to text

7. Casey Lozar, Caryn Mohr, and Ryan Nunn, “Insights from a Decade of Economic Research in Indian Country,” article (Federal Reserve Bank of Minneapolis: April 3, 2025). Return to text

 

Main Takeaway

Budget 2027 maintains a fiscally prudent stance with no
broad personal income tax rate cuts, while enhancing
targeted supports for households, business investment
incentives, housing supply and climate action.

The below provides a brief overview of the more relevant
changes that may be of interest to corporate entities followed
by a table providing a general overview of the more significant
tax changes brought in by Budget 2027, across all taxes.

Corporate Tax, Research and Development
(R&D) and Capital Markets

Measures aimed at the corporate sector strategically
reinforce Ireland’s reputation as an innovative base, providing
enhanced incentives for research and supporting capital
market participation for indigenous enterprises.

Impact on Corporate Taxpayers

A central component of the budget’s innovation strategy is
the substantial enhancement of the R&D tax credit. The rate
is being increased from 30% to 35%. This enhancement
provides significant encouragement for both multinational
corporations (MNCs) and indigenous companies to base their
high-value innovation activities in Ireland.

Furthermore, the measure includes vital liquidity and
compliance improvements for smaller claimants.The first-year
payment minimum threshold is being raised from €75,000
to €87,500. This adjustment directly enhances cash flow for
Small and Medium Enterprises (SMEs) engaged in R&D,
accelerating their access to state funding.

Implications for Investors and Investment
Funds

In the financial services sector, stability and technical clarity
are prioritised. The exit tax rate applied to payments made
from Irish funds and equivalent offshore funds to Irish
individual investors has been reduced from 41% to 38%. This
adjustment aims to improve retail participation in investment
funds, as it enhances net returns for non-resident and
domestic investors.

Combined with the unchanged 9% value-added tax (VAT) on
property-related services, Ireland’s fund ecosystem retains
competitive cost structures.

In support of capital markets, a new market cap exemption
threshold of €1 billion is introduced for Irish SMEs and startups
trading on regulated markets. For companies falling below
this threshold, the standard 1% stamp duty charge paid on
share transactions will no longer apply. The SME marketcap
threshold stamp duty exemption is aimed at attracting
increased equity financing for growth companies listed on
regulated markets, bolstering liquidity and investor appetite.

Entrepreneurial Incentives and Capital
Gains

To stimulate entrepreneurial activity and reward risk-takers,
the Capital Gains Tax (CGT) Revised Entrepreneur Relief has
been significantly strengthened. The overall lifetime limit on
gains eligible for the reduced 10% CGT rate is increased
from €1 million to €1.5 million. This 50% increase applies to
qualifying disposals made on or after 1 January 2026. This
policy signals a strong commitment to supporting successful
founders and incentivises them to reinvest their capital within
the Irish economy, thereby promoting further start-up creation
and economic dynamism.

In support of capital markets, a new market cap exemption
threshold of €1 billion is introduced for Irish SMEs and startups
trading on regulated markets. For companies falling below
this threshold, the standard 1% stamp duty charge paid on
share transactions will no longer apply.

This measure is positioned as essential for enhancing the
growth prospects of homegrown businesses, particularly
those seeking to secure funding or scale internationally. The
Key Employee Engagement Programme (KEEP) has also been
extended until the end of 2028.

Conclusion

Although from a personal income tax perspective Budget
2027 has a much more targeted and measured approach
to what we’ve seen in previous years, the enhancements
to R&D incentives, fund taxation and SME reliefs should
hopefully lower effective tax burdens for corporates and
investors, foster greater deal activity in growth sectors
and prop up Ireland’s positioning as a tax-efficient hub for
innovation finance.

The below table provides a brief summary of the pertinent
tax changes brought in by Budget 2027. We now wait for
the publication of Finance Bill 2026, to see exactly how
these measures will be implemented.

Tax Area	Measure	Key Change/Rate	Effective Date (or Period)	Potential Impact / Client Action
Corporate & SME Tax	Directly or indirectly, individually or in aggregate	Treated as if itself on the Entity List	Same restrictions as parent entity apply	Same restrictions as parent entity apply
	Unlisted foreign entity owned ≥ 50% by MEU List party	Directly or indirectly, individually or in aggregate	Treated as if itself is an MEU	Same restrictions as parent MEU entity apply
	Unlisted foreign entity owned ≥ 50% by an SDN*	Directly or indirectly, individually or in aggregate	Treated as if itself an SDN*	Same restrictions as the SDN owner
Financial Services	Exit Tax (Investment Funds)	Reduced rate on fund payments to individuals	41% to 38%	Aims to encourage greater retail participation by Irish individuals in domestic investment funds.
	SME/Start-up Stamp Duty Exemption	New Market Cap Threshold in respect of shares traded on regulated markets.	Up to €1 billion (Exemption applies)	Supports capital market liquidity and growth for indigenous SMEs and start-ups.
Indirect Taxes (VAT & Excise)	VAT on Hospitality/Hairdressing	Reduced rate introduced	13.5% to 9% (from 1 July 2026)	Significant support for the services sector, aiding more than 150,000 jobs facing cost pressures.
	VAT on Gas and Electricity	Reduced rate extension	9% extended until 31 Dec 2030	Provides long-term certainty and relief on essential energy costs for households and businesses.
	Carbon Tax (Auto-Fuels)	Increased rate per tonne of CO2	€63.50 to €71.00 (from 8 Oct 2025)	Immediate increase in the cost of petrol and diesel; future cost increases for home heating fuels (May 2026).
	Tobacco Excise Duty	Increase per packet of 20 cigarettes	+50 cent (from 7 Oct 2025)	Will push the cost of a popular packet of 20 cigarettes towards €19.
Housing Supply & Development	VAT on New Apartments	Reduced sales rate	13.5% to 9%	Direct reduction in construction costs, intended to lower the final price of new apartment units.
	Derelict Property Tax (DPT)	New tax to replace Derelict Sites Levy	Rate not < 7%=”” of=”” market=”” value=”” (implementation=”” />	Allows Revenue to enforce a minimum 7% annual charge on the market value of vacant land.
Employment & Global Mobility	SARP Minimum Income Threshold	Increased threshold	€125,000 (from 2026)	Requires review of all current/planned expatriate assignments; employees below €125k will cease to qualify for the relief.
	Foreign Earnings Deduction (FED)	Increased maximum relief; Scope widened	€50,000 (from 2026) and now includes Philippines & Turkey	Improves competitiveness for deploying employees to/from expanded market list (Philippines, Turkey).
	Company Car BIK Relief (€10k OMV reduction)	Relief Tapering Schedule	€10,000 (2026); €5,000 (2027); €2,500 (2028); Abolished (2029)	Requires immediate review of corporate fleet policies due to rapid BIK relief withdrawal starting in 2027.
Personal Tax (Income & USC)	USC 2% Rate Band Ceiling	Increased by €1,318 (to €28,700)	1 January 2026	Provides marginal tax relief for middle-income earners; protects minimum wage earners from moving into the top USC rate band.
	Rent Tax Credit	Extended (Value remains €1,000 p.a.)	Extended to end of 2028	Confirms continued cost-of-living support for eligible tenants for three additional years.
	Mortgage Interest Relief	Extended (reduced value in final year)	Extended for 2 years (2025 and 2026)	Provides temporary support for homeowners but note the relief value diminishes in 2026.

The waning hours of Amazon Prime Day—or Prime Big Deal Days—are the star of the show right now, but maybe you want to go shopping somewhere else. Whatever your reasoning, fear not! Plenty of other stores, big and small, are hosting sales alongside Amazon through the end of today. Everything below is hand-tested by WIRED, and doesn’t have to be bought on Amazon. You do you.

If you want to take a gander at the rest of our Amazon Prime Day coverage, updated through the end of the event tonight at 11:59 am ET, you can find it all right here.

Updated October 8, 2025: We’ve added new deals from Slumber Cloud and The Company Store.

WIRED Featured Deals:

Cozy Earth: Up to 25 Percent Off Sitewide—Use Code WIRED

Ask almost anyone on the WIRED Reviews team about their opinion on Cozy Earth, and it’ll be positive. The company makes supremely soft, silky, and comfortable bamboo products, ranging from bedding and linens to pajamas and hoodies. The Cozy Days sale means you can save up to 25 percent off nearly everything on the website.

Backcountry 70 Percent Off Flash Sale

Backcountry is offering up to 70 percent off select outdoor gear and apparel. The sale includes biking, skiing, and climbing gear.

Best Buy’s Techtober Sale

Want some great deals on tech gear but are avoiding Jeff Bezos? Best Buy might not be much better, spiritually, but the retailer is offering a few deals during its Techtober sale that we haven’t seen elsewhere. Techtober lasts until Sunday.

Bookshop.org Anti-Prime Sale: Free Shipping

It’s easy to buy books from big-box stores, but Bookshop.org helps support authors and local bookstores. Right now, you can get free shipping on all orders during its Anti-Prime Sale. You can check out popular books here, or might I recommend Everything Is Tuberculosis by John Green? (I just started it and I had to force myself to put it down until the weekend.)

Solo Stove Two-Day Sale

Solo Stove makes a lot of solid gear, including pizza ovens and its well-known fire pits. Right now, nearly everything is on sale, and it’s a great time to pick something up ahead of the colder and cozier months.

Chirp Wheel XR (3-pack) for $104 ($26 off)

The Chirp Wheel XR helped our tester Hannah Singleton with her tech neck woes. You’ll get multiple different sizes with the three- or four-pack, which are specially designed to help work out kinks and tension in various points of your body. It’s important to start slowly, ease into it, and only use the wheel for small amounts of time to start. But now that she’s had practice, Singleton says she can’t imagine living life without her Chirp wheels.

Lelo: Up to 40 Percent Off + Free Gift

We like a lot of Lelo sex toys here at WIRED, and many of them are discounted for the store’s “Prime Time for Pleasure” sale. There are options for all sorts of bodies and partner situations, and purchases over $199 get a free Sona 2 Travel vibrator.

Brooklinen Big Deals: 15 Percent Off Sitewide

Brooklinen makes darn fine bedding and linens, and right now the whole site is 15 percent off. Similar to Cozy Earth, everyone on the WIRED Reviews team has great things to say about the Brooklinen gear they’ve tested. Here are some of our faves.

Slumber Cloud Fall Sale: 20 Percent Off

Slumber Cloud makes some of my all-time favorite cooling bedding, including fantastic cooling sheets and even a cooling travel pillow. You can shop up to 20 percent off the site right now for its fall sale.

The Company Store Comfort Days Sale: 25 to 40 Percent Off Sitewide

The Company Store makes a ton of fantastic bedding, from sheets for every season to luxe down comforters and even a great Serene Foam mattress topper. (Serene foam is like memory foam, but traps less heat, so you’ll love this if you want a softer bed.) The shop is running a sitewide sale of 25 percent off orders over $100 (use code COMFORT25), and some items, like the fantastic linen sheets, are 40 percent off.

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Elon Musk has agreed to settle a $128m (£100m) lawsuit brought by four former top executives at Twitter, now X, over unpaid severance when he took over the company.

The executives, who include former chief Parag Agrawal, argued that Mr Musk fired them “without reason” after he bought Twitter in 2022 and denied them severance payments.

“The parties have reached a settlement and the settlement requires certain conditions to be met in the near term,” attorneys for the plaintiffs wrote in a court filing last week. They did not disclose the terms of the settlement.

The suit, filed last year, is one of several legal challenges over unpaid severance for workers who were laid off after Musk took over.

Lawyers for the former Twitter executives, and for Mr Musk and X, did not immediately respond to requests for comment on the settlement.

The former top brass – Mr Agrawal, former chief financial officer Ned Segal, former chief legal officer Vijaya Gadde and former general counsel Sean Edgett – contended in their lawsuit that they are owed one year’s salary and stock awards, under a years-old severance plan.

They also said Musk’s move was part of a pattern of refusing to pay former staff what they were due.

In August, Mr Musk and X agreed to settle a separate lawsuit filed by roughly 6,000 former rank-and-file Twitter employees who argued they were owed $500m in severance pay.

Mr Musk purchased Twitter in 2022 for $44bn, after initially trying to back out of his offer. After the acquisition closed, he immediately moved to fire top leaders at the company, including the four executives. Mr Musk slashed Twitter’s workforce by more than half.

In their lawsuit, the former top officials contend that Mr Musk was frustrated about being forced to complete the purchase and that the billionaire falsely accused them of misconduct to push them out.