Ford AC, Sperber AD, Corsetti M, Camilleri M. Irritable bowel syndrome. Lancet. 2020;396(10263):1675–88. https://doi.org/10.1016/S0140-6736(20)31548-8.
Google Scholar
Sperber AD, Bangdiwala SI, Drossman DA, Ghoshal UC, Simren M, Tack J, Whitehead WE, Dumitrascu DL, Fang X, Fukudo S, et al. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study. Gastroenterology. 2021;160(1):99–114. https://doi.org/10.1053/j.gastro.2020.04.014.
Google Scholar
Black CJ, Ford AC. Global burden of irritable bowel syndrome: trends, predictions and risk factors. Nat Rev Gastroenterol Hepatol. 2020;17(8):473–86. https://doi.org/10.1038/s41575-020-0286-8.
Google Scholar
Camilleri M. Diagnosis and treatment of irritable bowel syndrome: a review. JAMA. 2021;325(9):865–77. https://doi.org/10.1001/jama.2020.22532.
Google Scholar
Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, Harrison SA, Brunt EM, Sanyal AJ. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American association for the study of liver diseases. Hepatology. 2018;67(1):328–57. https://doi.org/10.1002/hep.29367.
Google Scholar
Le MH, Yeo YH, Li X, Li J, Zou B, Wu Y, Ye Q, Huang DQ, Zhao C, Zhang J, et al. Global NAFLD prevalence: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2019;20(12):2809–17. https://doi.org/10.1016/j.cgh.2021.12.002.
Google Scholar
Estes C, Anstee QM, Arias-Loste MT, Bantel H, Bellentani S, Caballeria J, Colombo M, Craxi A, Crespo J, Day CP, et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030. J Hepatol. 2018;69(4):896–904. https://doi.org/10.1016/j.jhep.2018.05.036.
Google Scholar
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023. https://doi.org/10.1016/j.jhep.2023.06.003.
Google Scholar
Wu S, Yuan C, Yang Z, Liu S, Zhang Q, Zhang S, Zhu S. Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study. BMC Med. 2022;20(1):262. https://doi.org/10.1186/s12916-022-02460-8.
Google Scholar
Ng JJJ, Loo WM, Siah KTH. Associations between irritable bowel syndrome and non-alcoholic fatty liver disease: a systematic review. World J Hepatol. 2023;15(7):925–38. https://doi.org/10.4254/wjh.v15.i7.925.
Google Scholar
Lee CG, Lee JK, Kang YS, Shin S, Kim JH, Lim YJ, Koh MS, Lee JH, Kang HW. Visceral abdominal obesity is associated with an increased risk of irritable bowel syndrome. Am J Gastroenterol. 2015;110(2):310–9. https://doi.org/10.1038/ajg.2014.422.
Google Scholar
Zhou Y, Liu S, Zhang Q, Zhang S, Wu S, Zhu S. Bidirectional association between type 2 diabetes and irritable bowel syndrome: a large-scale prospective cohort study. Diabetes Obes Metab. 2024;26(11):5107–15. https://doi.org/10.1111/dom.15852.
Google Scholar
Bhalla D, Dinesh S, Sharma S, Sathisha GJ. Gut-brain axis modulation of metabolic disorders: exploring the intertwined neurohumoral pathways and therapeutic prospects. Neurochem Res. 2024;49(4):847–71. https://doi.org/10.1007/s11064-023-04084-7.
Google Scholar
Scalera A, Di Minno MN, Tarantino G. What does irritable bowel syndrome share with non-alcoholic fatty liver disease? World J Gastroenterol. 2013;19(33):5402–20. https://doi.org/10.3748/wjg.v19.i33.5402.
Google Scholar
Nozu T, Okumura T. Pathophysiological commonality between irritable bowel syndrome and metabolic syndrome: role of corticotropin-releasing factor-toll-like receptor 4-proinflammatory cytokine signaling. J Neurogastroenterol Motil. 2022;28(2):173–84. https://doi.org/10.5056/jnm21002.
Google Scholar
Teratani T, Mikami Y, Nakamoto N, Suzuki T, Harada Y, Okabayashi K, Hagihara Y, Taniki N, Kohno K, Shibata S, et al. The liver-brain-gut neural arc maintains the T(reg) cell niche in the gut. Nature. 2020;585(7826):591–6. https://doi.org/10.1038/s41586-020-2425-3.
Google Scholar
Tilg H, Adolph TE, Trauner M. Gut-liver axis: pathophysiological concepts and clinical implications. Cell Metab. 2022;34(11):1700–18. https://doi.org/10.1016/j.cmet.2022.09.017.
Google Scholar
Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3):e1001779. https://doi.org/10.1371/journal.pmed.1001779.
Google Scholar
Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, Tiribelli C. The fatty liver index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol. 2006;6:33. https://doi.org/10.1186/1471-230X-6-33.
Google Scholar
Garofolo M, Lucchesi D, Giambalvo M, Aragona M, Bertolotto A, Campi F, Bianchi C, Francesconi P, Marchetti P, Del Prato S, et al. Fatty liver index is an independent risk factor for all-cause mortality and major cardiovascular events in type 1 diabetes: an 11-year observational study. Cardiovasc Diabetol. 2024;23(1):85. https://doi.org/10.1186/s12933-024-02171-9.
Google Scholar
Jones GS, Alvarez CS, Graubard BI, McGlynn KA. Agreement between the prevalence of nonalcoholic fatty liver disease determined by transient elastography and fatty liver indices. Clin Gastroenterol Hepatol. 2022;20(1):227–9. https://doi.org/10.1016/j.cgh.2020.11.028.
Google Scholar
Jeon S, Carr R. Alcohol effects on hepatic lipid metabolism. J Lipid Res. 2020;61(4):470–9. https://doi.org/10.1194/jlr.R119000547.
Google Scholar
Frandemark A, Tornblom H, Jakobsson S, Simren M. Work productivity and activity impairment in irritable bowel syndrome (IBS): a multifaceted problem. Am J Gastroenterol. 2018;113(10):1540–9. https://doi.org/10.1038/s41395-018-0262-x.
Google Scholar
Staudacher HM, Black CJ, Teasdale SB, Mikocka-Walus A, Keefer L. Irritable bowel syndrome and mental health comorbidity–approach to multidisciplinary management. Nat Rev Gastroenterol Hepatol. 2023;20(9):582–96. https://doi.org/10.1038/s41575-023-00794-z.
Google Scholar
Thyfault JP, Bergouignan A. Exercise and metabolic health: beyond skeletal muscle. Diabetologia. 2020;63(8):1464–74. https://doi.org/10.1007/s00125-020-05177-6.
Google Scholar
Hyun J, Han J, Lee C, Yoon M, Jung Y. Pathophysiological aspects of alcohol metabolism in the liver. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22115717.
Google Scholar
Marti-Aguado D, Clemente-Sanchez A, Bataller R. Cigarette smoking and liver diseases. J Hepatol. 2022;77(1):191–205. https://doi.org/10.1016/j.jhep.2022.01.016.
Google Scholar
Ho FF, Sun H, Zheng H, Wong DCN, Gao YY, Mao C, Cheung YT, Lam CS, Wang MH, Wu IX, et al. Association of healthy lifestyle behaviours with incident irritable bowel syndrome: a large population-based prospective cohort study. Gut. 2024. https://doi.org/10.1136/gutjnl-2023-331254.
Google Scholar
Blane D, Townsend P, Phillimore P, Beattie A. Health and deprivation: inequality and the North. Br J Sociol. 1987;40:344. https://doi.org/10.2307/590279.
Google Scholar
UK alcohol unit guidance: CMOs’ low risk drinking guidelines. https://www.drinkaware.co.uk/. Accessed 10 Oct 2023.
Mozaffarian D. Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review. Circulation. 2016;133(2):187–225. https://doi.org/10.1161/CIRCULATIONAHA.115.018585.
Google Scholar
Lee JH, Kim D, Kim HJ, Lee CH, Yang JI, Kim W, Kim YJ, Yoon JH, Cho SH, Sung MW, et al. Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis. 2010;42(7):503–8. https://doi.org/10.1016/j.dld.2009.08.002.
Google Scholar
Bedogni G, Kahn HS, Bellentani S, Tiribelli C. A simple index of lipid overaccumulation is a good marker of liver steatosis. BMC Gastroenterol. 2010;10:98. https://doi.org/10.1186/1471-230X-10-98.
Google Scholar
UK Biobank. Digestive health web-based questionnaire. 2019. https://biobank.ndph.ox.ac.uk/ukb/ukb/docs/digestive_health.pdf. Accessed 05 Mar 2024.
Yuan Y, Wang X, Huang S, Wang H, Shen G. Low-level inflammation, immunity, and brain-gut axis in IBS: unraveling the complex relationships. Gut Microbes. 2023;15(2):2263209. https://doi.org/10.1080/19490976.2023.2263209.
Google Scholar
Ghosh SS, Wang J, Yannie PJ, Ghosh S. Intestinal barrier dysfunction, LPS translocation, and disease development. J Endocr Soc. 2020;4(2):039. https://doi.org/10.1210/jendso/bvz039.
Google Scholar
Keivanlou MH, Amini-Salehi E, Hassanipour S, Zare R, Mohammadi-Vajari E, Hashemi M, Salari A, Porteghali P. The value of microbiome-targeted therapy on lipid indices of patients with type 2 diabetes mellitus: an umbrella meta-analysis of randomized controlled trials. Curr Diabetes Rev. 2024;21(1):e180124225761. https://doi.org/10.2174/0115733998284844240102110559.
Google Scholar
Amini-Salehi E, Mahapatro A, Korsapati RR, Korsapati AR, Jain SM, Babaeizad A, Mohammadi S, Rashidian P, Hashemi M, Dave T, et al. Exploring the relationship between gut microbiome modulation and blood pressure in type 2 diabetes: an umbrella review. Nutr Metab Cardiovasc Dis. 2024;34(9):2046–54. https://doi.org/10.1016/j.numecd.2024.05.017.
Google Scholar
Naghipour A, Amini-Salehi E, Orang Gorabzarmakhi M, Shahdkar M, Fouladi B, Alipourfard I, Sanat ZM. Effects of gut microbial therapy on lipid profile in individuals with non-alcoholic fatty liver disease: an umbrella meta-analysis study. Syst Rev. 2023;12(1):144. https://doi.org/10.1186/s13643-023-02299-x.
Google Scholar
Bayrak M. Metabolic syndrome, depression, and fibromyalgia syndrome prevalence in patients with irritable bowel syndrome: a case-control study. Medicine (Baltimore). 2020;99(23):e20577. https://doi.org/10.1097/MD.0000000000020577.
Google Scholar
Guo Y, Niu K, Momma H, Kobayashi Y, Chujo M, Otomo A, Fukudo S, Nagatomi R. Irritable bowel syndrome is positively related to metabolic syndrome: a population-based cross-sectional study. PLoS ONE. 2014;9(11):e112289. https://doi.org/10.1371/journal.pone.0112289.
Google Scholar
Lee SH, Kim KN, Kim KM, Joo NS. Irritable bowel syndrome may be associated with elevated alanine aminotransferase and metabolic syndrome. Yonsei Med J. 2016;57(1):146–52. https://doi.org/10.3349/ymj.2016.57.1.146.
Google Scholar
Chen J, Yuan S, Fu T, Ruan X, Qiao J, Wang X, Li X, Gill D, Burgess S, Giovannucci EL, et al. Gastrointestinal consequences of type 2 diabetes mellitus and impaired glycemic homeostasis: a mendelian randomization study. Diabetes Care. 2023;46(4):828–35. https://doi.org/10.2337/dc22-1385.
Google Scholar
Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, Keilbaugh SA, Hamady M, Chen YY, Knight R, Ahima RS, Bushman F, Wu GD. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology. 2009;137(5):1716–24. https://doi.org/10.1053/j.gastro.2009.08.042.
Google Scholar
Lau WL, Tran T, Rhee CM, Kalantar-Zadeh K, Vaziri ND. Diabetes and the gut microbiome. Semin Nephrol. 2021;41(2):104–13. https://doi.org/10.1016/j.semnephrol.2021.03.005.
Google Scholar
Yang Z, Wang Q, Liu Y, Wang L, Ge Z, Li Z, Feng S, Wu C. Gut microbiota and hypertension: association, mechanisms and treatment. Clin Exp Hypertens. 2023;45(1):2195135. https://doi.org/10.1080/10641963.2023.2195135.
Google Scholar
Yanping W, Gao X, Cheng Y, Liu M, Liao S, Zhou J, Hao J, Jiang G, Lu Y, Qu T, et al. The interaction between obesity and visceral hypersensitivity. J Gastroenterol Hepatol. 2023;38(3):370–7. https://doi.org/10.1111/jgh.16083.
Google Scholar
Aleman RS, Moncada M, Aryana KJ. Leaky gut and the ingredients that help treat it a review. Molecules. 2023. https://doi.org/10.3390/molecules28020619.
Google Scholar
Revelo XS, Luck H, Winer S, Winer DA. Morphological and inflammatory changes in visceral adipose tissue during obesity. Endocr Pathol. 2014;25(1):93–101. https://doi.org/10.1007/s12022-013-9288-1.
Google Scholar
Almeida PP, Valdetaro L, Thomasi BBM, Stockler-Pinto MB, Tavares-Gomes AL. High-fat diets on the enteric nervous system: possible interactions and mechanisms underlying dysmotility. Obes Rev. 2022;23(4):e13404. https://doi.org/10.1111/obr.13404.
Google Scholar
Loomba R, Friedman SL, Shulman GI. Mechanisms and disease consequences of nonalcoholic fatty liver disease. Cell. 2021;184(10):2537–64. https://doi.org/10.1016/j.cell.2021.04.015.
Google Scholar
White BA, Ramos GP, Kane S. The impact of alcohol in inflammatory bowel diseases. Inflamm Bowel Dis. 2022;28(3):466–73. https://doi.org/10.1093/ibd/izab089.
Google Scholar
Camilleri M. Sex as a biological variable in irritable bowel syndrome. Neurogastroenterol Motil. 2020;32(7):e13802. https://doi.org/10.1111/nmo.13802.
Google Scholar
Almeida DM, Rush J, Mogle J, Piazza JR, Cerino E, Charles ST. Longitudinal change in daily stress across 20 years of adulthood: results from the national study of daily experiences. Dev Psychol. 2023;59(3):515–23. https://doi.org/10.1037/dev0001469.
Google Scholar
Hadefi A, Arvanitakis M, Trepo E, Zelber-Sagi S. Dietary strategies in non-alcoholic fatty liver disease patients: from evidence to daily clinical practice, a systematic review. United Eur Gastroenterol J. 2023;11(7):663–89. https://doi.org/10.1002/ueg2.12443.
Google Scholar
Szewczyk-Golec K, Holynska-Iwan I. Dietary interventions in obesity and metabolic syndrome. Nutrients. 2023. https://doi.org/10.3390/nu15112513.
Google Scholar
Fritsch J, Garces L, Quintero MA, Pignac-Kobinger J, Santander AM, Fernandez I, Ban YJ, Kwon D, Phillips MC, Knight K, et al. Low-fat high-fiber diet reduces markers of inflammation and dysbiosis and improves quality of life in patients with ulcerative colitis. Clin Gastroenterol Hepatol. 2021;19(6):1189–99. https://doi.org/10.1016/j.cgh.2020.05.026.
Google Scholar
Fedchuk L, Nascimbeni F, Pais R, Charlotte F, Housset C, Ratziu V, Group LS. Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease. Aliment Pharmacol Ther. 2014;40(10):1209–22. https://doi.org/10.1111/apt.12963.
Google Scholar