Frayne J, Watson S, Snellen M, Nguyen T, Gal Bally M. The association between mental illness, psychotropic medication uses and hypertensive disorders in pregnancy: a multicenter study. Pregnancy Hypertens. 2021;24:22–6.
Google Scholar
National High Blood Pressure Education Program Working Group Report on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 1990;163(5):1691–712.
Thombre Kulkarni M, Holzman C, Wasilevich E, Luo Z, Scheid J, Allswede M. Pregnancy hypertension and its associations with pre-pregnancy depression, anxiety, antidepressants, and anxiolytics. Pregnancy Hypertens. 2019;16:67–74.
Google Scholar
Broekhuijsen K, Ravelli ACJ, Langenveld J, Van Pampus MG, Van Den Berg PP, Mol BWJ, et al. Maternal and neonatal outcomes of pregnancy in women with chronic hypertension: a retrospective analysis of a National register. Acta Obstet Gynecol Scand. 2015;94(12):1337–45.
Google Scholar
Naderi S, Tsai SA, Khandelwal A. Hypertensive disorders of pregnancy. Curr Atheroscler Rep. 2017;19(3):15.
Google Scholar
Tran YH, Huynh HK, Faas MM, De Vos S, Groen H. Antidepressant use during pregnancy and development of preeclampsia: a focus on classes of action and specific transporters/receptors targeted by antidepressants. J Psychiatr Res. 2022;146:92–101.
Google Scholar
Bokslag A, Van Weissenbruch M, Mol BW, De Groot CJM. Preeclampsia; short and long-term consequences for mother and neonate. Early Hum Dev. 2016;102:47–50.
Google Scholar
Leeman L. Hypertensive disorders of pregnancy. Am Fam Physican. 2016;93(2):121–7.
Galbally M, Watson SJ, Spigset O. Depression and antidepressant treatment in the development of hypertensive disorders of pregnancy: results from a prospective cohort study. Aust N Z J Psychiatry. 2023;57(4):520–7.
Google Scholar
Uguz F. Is there any association between use of antidepressants and preeclampsia or gestational hypertension? A systematic review of current studies. J Clin Psychopharmacol. 2017;37(1):72–7.
Google Scholar
Zakiyah N, Ter Heijne LF, Bos JH, Hak E, Postma MJ, Schuiling-Veninga CCM. Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study. BMC Pregnancy Childbirth. 2018;18(1):187.
Google Scholar
Thombre MK, Talge NM, Holzman C. Association between pre-pregnancy depression/anxiety symptoms and hypertensive disorders of pregnancy. J Women’s Health. 2015;24(3):228–36.
Katon WJ, Russo JE, Melville JL, Katon JG, Gavin AR. Depression in pregnancy is associated with preexisting but not pregnancy-induced hypertension. Gen Hosp Psychiatry. 2012;34(1):9–16.
Google Scholar
Huybrechts KF, Bateman BT, Pawar A, Bessette LG, Mogun H, Levin R et al. Maternal and fetal outcomes following exposure to Duloxetine in pregnancy: cohort study. BMJ 2020; 368:m237.
Andrade SE, Raebel MA, Brown J, Lane K, Livingston J, Boudreau D, et al. Use of antidepressant medications during pregnancy: a multisite study. Am J Obstet Gynecol. 2008;198(2):194. e1-194.e5.
Evans J, Heron J, Francomb H, Oke S, Golding J. Cohort study of depressed mood during pregnancy and after childbirth. BMJ. 2001;323(7307):257–60.
Google Scholar
De Vera MA, Bérard A. Antidepressant use during pregnancy and the risk of pregnancy-induced hypertension. Brit J Clin Pharma. 2012;74(2):362–9.
Malm H, Sourander A, Gissler M, Gyllenberg D, Hinkka-Yli-Salomäki S, McKeague IW, et al. Pregnancy complications following prenatal exposure to SSRIs or maternal psychiatric disorders: results from Population-Based National register data. AJP. 2015;172(12):1224–32.
Pearlstein PT. Depression during pregnancy. Best Pract Res Clin Obstet Gynecol. 2015;29(5):754–64.
Reis M, Källén B. Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data. Psychol Med. 2010;40(10):1723–33.
Google Scholar
Petersen I, McCrea RL, Sammon CJ, Osborn DP, Evans SJ, Cowen PJ, et al. Risks and benefits of psychotropic medication in pregnancy: cohort studies based on UK electronic primary care health records. Health Technol Assess. 2016;20(23):1–176.
Google Scholar
Yonkers KA, Gilstad-Hayden K, Forray A, Lipkind HS. Association of panic disorder, generalized anxiety disorder, and benzodiazepine treatment during pregnancy with risk of adverse birth outcomes. JAMA Psychiatry. 2017;74(11):1145.
Google Scholar
Avalos LA, Chen H, Li DK. Antidepressant medication use, depression, and the risk of preeclampsia. CNS Spectr. 2015;20(1):39–47.
Google Scholar
Toh S, Mitchell AA, Louik C, Werler MM, Chambers CD, Hernández-Díaz S. Selective serotonin reuptake inhibitor use and risk of gestational hypertension. AJP. 2009;166(3):320–8.
Benevent J, Araujo M, Karki S, Delarue-Hurault C, Waser J, Lacroix I et al. Risk of hypertensive disorders of pregnancy in women treated with Serotonin-Norepinephrine reuptake inhibitors: A comparative study using the EFEMERIS databaseQuery ID=”Q2″ Text=”Please provide the page number for the reference 25 if possible.” Resolved=”yes”. J Clin Psychiatry. 2023;84(4) :22m14734. https://www.psychiatrist.com/jcp/hypertensive-disorders-with-snris-in-pregnancy-efemeris
Lupattelli A, Wood M, Lapane K, Spigset O, Nordeng H. Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from the Norwegian mother and child cohort study. Pharmacoepidemiology Drug. 2017;26(10):1266–76.
Google Scholar
Bernard N, Forest JC, Tarabulsy GM, Bujold E, Bouvier D, Giguère Y. Use of antidepressants and anxiolytics in early pregnancy and the risk of preeclampsia and gestational hypertension: a prospective study. BMC Pregnancy Childbirth. 2019;19(1):146.
Google Scholar
Guan HB, Wei Y, Wang LL, Qiao C, Liu CX. Prenatal selective serotonin reuptake inhibitor use and associated risk for gestational hypertension and preeclampsia: A Meta-Analysis of cohort studies. J Women’s Health. 2018;27(6):791–800.
Gumusoglu SB, Schickling BM, Vignato JA, Santillan DA, Santillan MK. Selective serotonin reuptake inhibitors and preeclampsia: a quality assessment and meta-analysis. Pregnancy Hypertens. 2022;30:36–43.
Google Scholar
Higgins JPT. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60.
Google Scholar
Lochmann D, Richardson T. Selective serotonin reuptake inhibitors. Springer Int Publishing. 2018;250:135–44. http://link.springer.com/10.1007/164_2018_172.
Wong J, Kurteva S, Motulsky A, Tamblyn R. Association of antidepressant prescription filling with treatment indication and prior prescription filling behaviors and medication experiences. Med Care. 2022;60(1):56–65.
Google Scholar
Palmsten K, Setoguchi S, Margulis AV, Patrick AR, Hernández-Díaz S. Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants?? Am J Epidemiol. 2012;175(10):988–97.
Google Scholar
Latendresse G, Elmore C, Deneris A. Selective serotonin reuptake inhibitors as first-line antidepressant therapy for perinatal depression. J Midwife Womens Health. 2017;62(3):317–28.
Yousif MH, Chandrasekhar B, Kadavil EA, Oriowo MA. Noradrenaline-induced vasoconstriction in the uterine vascular bed of pregnant rats chronically treated with l-NAME: role of prostanoids. J Cardiovasc Pharmacol. 2003;42(3):428–35.
Google Scholar
Ananth CV, Vintzileos AM. Medically indicated preterm birth: recognizing the importance of the problem. Clin Perinatol. 2008;35(1):53–67.
Google Scholar
Finkel MS, Laghrissi-Thode F, Pollock BG, Rong J. Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacol Bull. 1996;32(4):653–8.
Google Scholar
Bolte AC, Van Geijn HP, Dekker GA. Pathophysiology of preeclampsia and the role of serotonin. Eur J Obstet Gynecol Reproductive Biology. 2001;95(1):12–21.
Google Scholar
Palmsten K, Huybrechts KF, Michels KB, Williams PL, Mogun H, Setoguchi S, et al. Antidepressant use risk preeclampsia. Epidemiol. 2013;24(5):682–91.
Kurki T, Hiilesmaa V, Raitasalo R, Mattila H, Ylikorkala O. Depression and anxiety in early pregnancy and risk for preeclampsia. 2000;95(4):487–90.
Qiu C, Williams MA, Calderon-Margalit R, Cripe SM, Sorensen TK. Preeclampsia risk in relation to maternal mood and anxiety disorders diagnosed before or during early pregnancy. Am J Hypertens. 2009;22(4):397–402.
Google Scholar
Qiu C, Sanchez SE, Lam N, Garcia P, Williams MA. Associations of depression and depressive symptoms with preeclampsia: results from a Peruvian case-control study. BMC Women’s Health. 2007;7(1):15.
Google Scholar
Cripe SM, Frederick IO, Qiu C, Williams MA. Risk of preterm delivery and hypertensive disorders of pregnancy in relation to maternal co-morbid mood and migraine disorders during pregnancy. Pediatr Perinat Epid. 2011;25(2):116–23.
Shay M, MacKinnon AL, Metcalfe A, Giesbrecht G, Campbell T, Nerenberg K, et al. Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis. Psychol Med. 2020;50(13):2128–40.
Google Scholar
Sandman CA, Wadhwa PD, Chicz-Demet A, Dunkel-Schetter C, Porto M. Maternal stress , HPA activity, and fetal/infant outcome. Ann N Y Acad Sci.1997;814:266-75.
Newport DJ, Hostetter AL, Juul SH, Porterfield SM, Knight BT, Stowe ZN. Prenatal psychostimulant and antidepressant exposure and risk of hypertensive disorders of pregnancy. J Clin Psychiatry. 2016;77(11):1538–45.
Google Scholar
Stahl SM. Selecting an antidepressant by using mechanism of action to enhance efficacy and avoid side effects. J Clin Psychiatry. 1998;59(Suppl 18):23–9.
Google Scholar
Saydoff JA, Rittenhouse PA, Carnes M, Armstrong J, Van De Kar LD, Brownfield MS. Neuroendocrine and cardiovascular effects of serotonin: selective role of brain angiotensin on vasopressin. Am J Physiology-Endocrinology Metabolism. 1996;270(3):E513–21.
Google Scholar
Ramage AG. Central cardiovascular regulation and 5-hydroxytryptamine receptors. Brain Res Bull. 2001;56(5):425–39.
Google Scholar
Ramage A, Villalon C. 5-Hydroxytryptamine and cardiovascular regulation. Trends Pharmacol Sci. 2008;29(9):472–81.
Google Scholar
Pannu N, Wen X, Kellum JA, Fildes J, Al-Subaie N, Hamilton M, et al. Norepinephrine. Encyclopedia of intensive care medicine. Berlin Heidelberg: Springer; 2012. pp. 1568–73. http://link.springer.com/. https://doi.org/10.1007/978-3-642-00418-6_307.
Foulon P, De Backer D. The hemodynamic effects of norepinephrine: far more than an increase in blood pressure! Ann Transl Med. 2018;6(S1):S25–25.
Google Scholar
Staff AC. The two-stage placental model of preeclampsia: an update. J Reprod Immunol. 2019;134–135:1–10.
Google Scholar
Butler S, Meegan M. Recent developments in the design of anti-depressive therapies: targeting the serotonin transporter. CMC. 2008;15(17):1737–61.
Google Scholar
Eleftheriou G, Zandonella Callegher R, Butera R, De Santis M, Cavaliere AF, Vecchio S, et al. Consensus panel recommendations for the pharmacological management of pregnant women with depressive disorders. IJERPH. 2023;20(16):6565.
Google Scholar
Vigod SN, Frey BN, Clark CT, Grigoriadis S, Barker LC, Brown HK et al. Canadian network for mood and anxiety treatments 2024 clinical practice guideline for the management of perinatal mood, anxiety, and related disorders: guide de pratique 2024 du Canadian network for mood and anxiety treatments pour Le traitement des troubles de l’humeur, des troubles Anxieux et des troubles connexes périnatals. Can J Psychiatry. 2025; 70(6):429-489.
Jarde A, Morais M, Kingston D, Giallo R, MacQueen GM, Giglia L, et al. Neonatal outcomes in women with untreated antenatal depression compared with women without depression: a systematic review and Meta-analysis. JAMA Psychiatry. 2016;73(8):826.
Google Scholar
Mitchell J, Goodman J. Comparative effects of antidepressant medications and untreated major depression on pregnancy outcomes: a systematic review. Arch Womens Ment Health. 2018;21(5):505–16.
Google Scholar
Davalos DB, Yadon CA, Tregellas HC. Untreated prenatal maternal depression and the potential risks to offspring: a review. Arch Womens Ment Health. 2012;15(1):1–14.
Google Scholar
Mesches GA, Wisner KL, Betcher HK. A common clinical conundrum: antidepressant treatment of depression in pregnant women. Semin Perinatol. 2020;44(3):151229.
Google Scholar
Yang LY, Lin FJ, Katz AJ, Wang IT, Wu CH. Prenatal antidepressant use and the implication of hypertensive disorders during pregnancy. Am J Obstet Gynecol. 2021;225(6):672. e1-672.e11.
De Ocampo MPG, Araneta MRG, Macera CA, Alcaraz JE, Moore TR, Chambers CD. Risk of gestational hypertension and preeclampsia in women who discontinued or continued antidepressant medication use during pregnancy. Arch Womens Ment Health. 2016;19(6):1051–61.
Google Scholar
Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019;15(5):275–89.
Google Scholar