Nottingham Forest midfielder Elliot Anderson is set to make his England debut against Andorra.
Anderson, given his first call-up by head coach Thomas Tuchel at the end of last month, gets the nod in the 2026 World Cup qualifier at Villa Park later on Saturday (17:00 BST).
He will partner Arsenal duo Declan Rice and Eberechi Eze in midfield.
Dan Burn is set to play next to Marc Guehi at centre-back, with Reece James and Myles Lewis-Skelly at full-back.
Harry Kane will captain the side as central striker, with Marcus Rashford and Noni Madueke playing out wide.
Jordan Pickford will start in goal.