Researchers from the University College London (UCL) and the University of Oxford have developed a device that can precisely target deep brain structures without the need for surgery, a first in medicine. This — detailed in the journal Nature Communications — breakthrough could transform the treatment of disorders like depression, essential tremors, and Parkinson’s disease.
This technology offers a non-invasive alternative to deep brain stimulation (DBS) — a common treatment for conditions like Parkinson’s that currently requires the implantation of electrodes into the brain. This new system uses transcranial ultrasound stimulation (TUS) technology to deliver mechanical pulses, modifying the activity of neurons.
The system features a helmet with 256 individual ultrasound components that work together to send highly focused beams to specific regions of the brain, modifying neuronal activity as desired. The study shows this new device can accurately focus on brain regions 30 times smaller than previous deep brain ultrasound devices.
In a study involving seven human participants, the team successfully demonstrated the system’s precision. They successfully focused on a small structure deep inside the brain that is involved in vision — the lateral geniculate nucleus (LGN). A real-time fMRI scan was used to confirm the device did accurately hit the intended target.
The ability to precisely modulate deep brain structures without surgery represents a paradigm shift in neuroscience, offering a safe, reversible, and repeatable method for both understanding brain function and developing targeted therapies. — Professor Bradley Treeby of UCL, senior author of the study.
Some members of the research team have now started a UCL spinout company — NeuroHarmonics — aiming to make the device accessible by creating a compact, wearable version of it. If successful, this technology could revolutionize neuroscience.
I have always been fascinated by technology and digital devices my entire life and even got addicted to it. I have always marveled at the intricacy of even the simplest digital devices and systems around us. I have been writing and publishing articles online for about 6 years now, just about a year ago, I found myself lost in the marvel of smartphones and laptops we have in our hands every day. I developed a passion for learning about new devices and technologies that come with them and at some point, I asked myself, “Why not get into writing tech articles?” It is useless to say I followed up the idea — it is evident. I am an open-minded individual who derives an infinite amount of joy from researching and discovering new information, I believe there is so much to learn and such a short life to live, so I put my time to good use — learning new things. I am a ‘bookworm’ of the internet and digital devices. When I am not writing, you will find me on my devices still, I do explore and admire the beauty of nature and creatures. I am a fast learner and quickly adapt to changes, always looking forward to new adventures.