Impact of diabetes mellitus on myocardial function and clinical outcomes in patients with significant aortic regurgitation | Cardiovascular Diabetology

  • Coffey S, Roberts-Thomson R, Brown A, Carapetis J, Chen M, Enriquez-Sarano M, Zühlke L, Prendergast BD. Global epidemiology of valvular heart disease. Nat Rev Cardiol. 2021;18(12):853–64.

    PubMed 

    Google Scholar 

  • Carabello BA. Aortic regurgitation. A lesion with similarities to both aortic stenosis and mitral regurgitation. Circulation. 1990;82(3):1051–3.

    CAS 
    PubMed 

    Google Scholar 

  • Crea F. The burden of cardiovascular risk factors: a global perspective. Eur Heart J. 2022;43(30):2817–20.

    PubMed 

    Google Scholar 

  • Ma CX, Ma XN, Guan CH, Li YD, Mauricio D, Fu SB. Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management. Cardiovasc Diabetol. 2022;21(1):74.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Rawshani A, Sattar N, McGuire DK, Wallström O, Smith U, Borén J, Bergström G, Omerovic E, Rosengren A, Eliasson B, et al. Left-sided degenerative Valvular Heart Disease in type 1 and type 2 diabetes. Circulation. 2022;146(5):398–411.

    CAS 
    PubMed 

    Google Scholar 

  • Barth M, Selig JI, Klose S, Schomakers A, Kiene LS, Raschke S, Boeken U, Akhyari P, Fischer JW, Lichtenberg A. Degenerative aortic valve disease and diabetes: implications for a link between proteoglycans and diabetic disorders in the aortic valve. Diab Vasc Dis Res. 2019;16(3):254–69.

    CAS 
    PubMed 

    Google Scholar 

  • Movahed MR, Hashemzadeh M, Jamal MM. Significant increase in the prevalence of non-rheumatic aortic valve disease in patients with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2007;115(2):105–7.

    CAS 
    PubMed 

    Google Scholar 

  • Kanamori H, Naruse G, Yoshida A, Minatoguchi S, Watanabe T, Kawaguchi T, Tanaka T, Yamada Y, Takasugi H, Mikami A, et al. Morphological characteristics in diabetic cardiomyopathy associated with autophagy. J Cardiol. 2021;77(1):30–40.

    PubMed 

    Google Scholar 

  • Shen LT, Jiang L, Zhu YW, Shen MT, Huang S, Shi R, Li Y, Yang ZG. Additive effect of aortic regurgitation degree on left ventricular strain in patients with type 2 diabetes mellitus evaluated via cardiac magnetic resonance tissue tracking. Cardiovasc Diabetol. 2022;21(1):37.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ranard LS, Bonow RO, Nishimura R, Mack MJ, Thourani VH, Bavaria J, O’Gara PT, Bax JJ, Blanke P, Delgado V, et al. Imaging methods for evaluation of chronic aortic regurgitation in adults: JACC state-of-the-art review. J Am Coll Cardiol. 2023;82(20):1953–66.

    PubMed 

    Google Scholar 

  • Marwick TH, Lam C, Liu Y, Del Prato S, Rosenstock J, Butler J, Ezekowitz J, Ibrahim NE, Tang WHW, Zannad F, et al. Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial. Cardiovasc Diabetol. 2025;24(1):16.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kong WKF, Vollema EM, Prevedello F, Perry R, Ng ACT, Poh KK, Almeida AG, Gonzalez A, Shen M, Yeo TC, et al. Prognostic implications of left ventricular global longitudinal strain in patients with bicuspid aortic valve disease and preserved left ventricular ejection fraction. Eur Heart J Cardiovasc Imaging. 2020;21(7):759–67.

    PubMed 

    Google Scholar 

  • Akintoye E, El Dahdah J, Dabbagh MM, Patel H, Badwan O, Braghieri L, Chedid El Helou M, Kassab J, Jellis CL, Desai MY, et al. Longitudinal assessment of left atrial remodeling in patients with chronic severe aortic regurgitation. JACC Cardiovasc Imaging. 2024;17:1133–45.

    PubMed 

    Google Scholar 

  • Benchea LC, Anghel L, Zăvoi A, Chiuariu T, Birgoan SG, Sascău RA, Stătescu C. Beyond blood sugar: how left atrium strain predicts cardiac outcomes in type 2 diabetes. Biomedicines. 2024;12(8):1690.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tan Y, Li Y, Deng W, Zhang R, Zhao R, Abulipizi A, Zhang J, Ji X, Hou Q, Liu T, et al. Prognostic implications of left atrial strain in bicuspid aortic valve with chronic aortic regurgitation. J Am Heart Assoc. 2024;13(6): e032770.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Alashi A, Mentias A, Abdallah A, Feng K, Gillinov AM, Rodriguez LL, Johnston DR, Svensson LG, Popovic ZB, Griffin BP, et al. Incremental prognostic utility of left ventricular global longitudinal strain in asymptomatic patients with significant chronic aortic regurgitation and preserved left ventricular ejection fraction. JACC Cardiovasc Imaging. 2018;11(5):673–82.

    PubMed 

    Google Scholar 

  • Lancellotti P, Tribouilloy C, Hagendorff A, Popescu BA, Edvardsen T, Pierard LA, Badano L, Zamorano JL. Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2013;14(7):611–44.

    PubMed 

    Google Scholar 

  • Chamberlain JJ, Rhinehart AS, Shaefer CF Jr, Neuman A. Diagnosis and management of diabetes: synopsis of the 2016 American Diabetes Association standards of medical care in diabetes. Ann Intern Med. 2016;164(8):542–52.

    PubMed 

    Google Scholar 

  • Lang RMBL, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of, Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2016;17(4):412.

    Google Scholar 

  • Negishi K, Negishi T, Kurosawa K, Hristova K, Popescu BA, Vinereanu D, Yuda S, Marwick TH. Practical guidance in echocardiographic assessment of global longitudinal strain. JACC Cardiovasc Imaging. 2015;8(4):489–92.

    PubMed 

    Google Scholar 

  • Badano LP, Kolias TJ, Muraru D, Abraham TP, Aurigemma G, Edvardsen T, D’Hooge J, Donal E, Fraser AG, Marwick T, et al. Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. Eur Heart J Cardiovasc Imaging. 2018;19(6):591–600.

    PubMed 

    Google Scholar 

  • Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, Capodanno D, Conradi L, De Bonis M, De Paulis R, et al. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022;43(7):561–632.

    PubMed 

    Google Scholar 

  • Piper C, Schultheiss HP, Akdemir D, Rudolf J, Horstkotte D, Pauschinger M. Remodeling of the cardiac extracellular matrix differs between volume- and pressure-overloaded ventricles and is specific for each heart valve lesion. J Heart Valve Dis. 2003;12(5):592–600.

    PubMed 

    Google Scholar 

  • Yang LT, Takeuchi M, Scott CG, Thapa P, Wang TD, Villarraga HR, Padang R, Enriquez-Sarano M, Michelena HI. Automated global longitudinal strain exhibits a robust association with death in asymptomatic chronic aortic regurgitation. J Am Soc Echocardiogr. 2022;35(7):692-702 e698.

    PubMed 

    Google Scholar 

  • Pearson-Stuttard J, Bennett J, Cheng YJ, Vamos EP, Cross AJ, Ezzati M, Gregg EW. Trends in predominant causes of death in individuals with and without diabetes in England from 2001 to 2018: an epidemiological analysis of linked primary care records. Lancet Diabetes Endocrinol. 2021;9(3):165–73.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183: 109119.

    PubMed 

    Google Scholar 

  • Sattar N, McMurray J, Borén J, Rawshani A, Omerovic E, Berg N, Halminen J, Skoglund K, Eliasson B, Gerstein HC, et al. Twenty years of cardiovascular complications and risk factors in patients with type 2 diabetes: a nationwide Swedish cohort study. Circulation. 2023;147(25):1872–86.

    CAS 
    PubMed 

    Google Scholar 

  • Jia G, DeMarco VG, Sowers JR. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144–53.

    CAS 
    PubMed 

    Google Scholar 

  • Zhang Y, Li Y, Lin Y, Xie M, Zhang L, Sun W, Deng W, Zhao R, Shi J, Li W, et al. Association of glycemic control with right ventricular function assessed by two-dimensional speckle-tracking and three-dimensional echocardiography in type 2 diabetes mellitus. J Am Soc Echocardiogr. 2024;37(12):1156–66.

    PubMed 

    Google Scholar 

  • Shen LT, Shi K, Yang ZG, Guo YK, Shi R, Jiang YN, Yan WF, Li Y. The right ventricular dysfunction and ventricular interdependence in patients with T2DM and aortic regurgitation: an assessment using CMR feature tracking. Cardiovasc Diabetol. 2024;23(1):294.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Liu X, Yang ZG, Gao Y, Xie LJ, Jiang L, Hu BY, Diao KY, Shi K, Xu HY, Shen MT, et al. Left ventricular subclinical myocardial dysfunction in uncomplicated type 2 diabetes mellitus is associated with impaired myocardial perfusion: a contrast-enhanced cardiovascular magnetic resonance study. Cardiovasc Diabetol. 2018;17(1):139.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yoneyama K, Venkatesh BA, Wu CO, Mewton N, Gjesdal O, Kishi S, McClelland RL, Bluemke DA, Lima JAC. Diabetes mellitus and insulin resistance associate with left ventricular shape and torsion by cardiovascular magnetic resonance imaging in asymptomatic individuals from the multi-ethnic study of atherosclerosis. J Cardiovasc Magn Reson. 2018;20(1):53.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kenny HC, Abel ED. Heart failure in type 2 diabetes mellitus. Circ Res. 2019;124(1):121–41.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jia G, Whaley-Connell A, Sowers JR. Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease. Diabetologia. 2018;61(1):21–8.

    CAS 
    PubMed 

    Google Scholar 

  • Kawamura M, Paulsen MJ, Goldstone AB, Shudo Y, Wang H, Steele AN, Stapleton LM, Edwards BB, Eskandari A, Truong VN, et al. Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy. Cardiovasc Diabetol. 2017;16(1):142.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Sharma G, Chaurasia SS, Carlson MA, Mishra PK. Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure. Am J Physiol Heart Circ Physiol. 2024;327(6):H1327-h1342.

    PubMed 

    Google Scholar 

  • Jia G, Hill MA, Sowers JR. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res. 2018;122(4):624–38.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lee MMY, McMurray JJV, Lorenzo-Almorós A, Kristensen SL, Sattar N, Jhund PS, Petrie MC. Diabetic cardiomyopathy. Heart. 2019;105(4):337–45.

    CAS 
    PubMed 

    Google Scholar 

  • Jiang L, Yan WF, Zhang L, Xu HY, Guo YK, Li ZL, Liu KL, Zeng LM, Li Y, Yang ZG. Early left ventricular microvascular dysfunction in diabetic pigs: a longitudinal quantitative myocardial perfusion CMR study. Cardiovasc Diabetol. 2024;23(1):9.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Inoue K, Khan FH, Remme EW, Ohte N, García-Izquierdo E, Chetrit M, Moñivas-Palomero V, Mingo-Santos S, Andersen ØS, Gude E, et al. Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure. Eur Heart J Cardiovasc Imaging. 2021;23(1):61–70.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Singh A, Addetia K, Maffessanti F, Mor-Avi V, Lang RM. LA strain for categorization of LV diastolic dysfunction. JACC Cardiovasc Imaging. 2017;10(7):735–43.

    PubMed 

    Google Scholar 

  • Continue Reading