Nanoemulsion form of vitamin D3 could improve core manifestations of autism

This study investigates the effectiveness of a vitamin D3-loaded nanoemulsion in improving the core symptoms of autism spectrum disorder (ASD) in children. Children with ASD often have low vitamin D3 levels, which are linked to delays in language development, adaptive behavior, and fine motor skills. While traditional vitamin D3 supplementation has shown mixed results in past studies, this research evaluates whether a nanoemulsion form-engineered to enhance absorption and bioavailability-might produce better outcomes.

Eighty children between the ages of 3 and 6 with diagnosed ASD were randomly assigned into two groups: one receiving the vitamin D3 nanoemulsion, and the other receiving a standard marketed vitamin D3 product, both for a duration of 6 months. Their vitamin D3 levels, adaptive behaviors, and language abilities were assessed before and after supplementation using standardized tools such as the Childhood Autism Rating Scale (CARS), Vineland Adaptive Behavior Scale, and Preschool Language Scale. Only the nanoemulsion group showed statistically significant improvements in vitamin D3 levels, autism severity, social IQ, and both receptive and expressive language performance. The conventional supplement, despite raising blood vitamin D3 levels, did not lead to meaningful improvements in behavioral outcomes.

The study concludes that the nanoemulsion form of vitamin D3 is superior to the conventional oral form in terms of increasing vitamin bioavailability and producing clinically relevant improvements in children with ASD. The authors suggest that nanoemulsion technology could offer a valuable strategy for enhancing the effectiveness of nutritional interventions in neurodevelopmental disorders. However, they acknowledge that further studies with larger sample sizes and long-term follow-up are needed to confirm these findings and explore potential gender-related differences in response.