Global, regional, and, national, burden, of, 12, mental, disorders, in, 204, countries, and, territories, 1990–2019:, a, systematic, analysis, for, the, Global, Burden, of, Disease, Study, 2019. Lancet Psychiatry. 2022;92:137–50.
Castaldelli-Maia JM, Bhugra D. Analysis of global prevalence of mental and substance use disorders within countries: focus on sociodemographic characteristics and income levels. Int Rev Psychiatry. 2022;34(1):6–15.
Google Scholar
Haas AD, Ruffieux Y, van den Heuvel LL, Lund C, Boulle A, Euvrard J, et al. Excess mortality associated with mental illness in people living with HIV in cape town, South africa: a cohort study using linked electronic health records. Lancet Glob Health. 2020;8(10):e1326–34.
Google Scholar
Lackner JM, Jaccard J, Krasner SS, Katz LA, Gudleski GD, Blanchard EB. How does cognitive behavior therapy for irritable bowel syndrome work? A mediational analysis of a randomized clinical trial. Gastroenterology. 2007;133(2):433–44.
Google Scholar
Meier SM, Trontti K, Purves KL, Als TD, Grove J, Laine M, et al. Genetic variants associated with anxiety and Stress-Related disorders: A Genome-Wide association study and Mouse-Model study. JAMA Psychiatry. 2019;76(9):924–32.
Google Scholar
Institute of Health Metrics and Evaluation. Global Health Data Exchange (GHDx), (https://vizhub.healthdata.org/gbd-results/, accessed 14 May 2022). Conference Location; 2022 of Conference: Pages.
Chatterjee I. Mean deviation based identification of activated voxels from time-series fMRI data of schizophrenia patients. F1000Res. 2018;7:1615.
Google Scholar
Townsend JD, Torrisi SJ, Lieberman MD, Sugar CA, Bookheimer SY, Altshuler LL. Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry. 2013;73(2):127–35.
Google Scholar
Friedman HS. Neuroticism and health as individuals age. Personal Disord. 2019;10(1):25–32.
Google Scholar
Plana-Ripoll O, Musliner KL, Dalsgaard S, Momen NC, Weye N, Christensen MK, et al. Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population-based cohort study. World Psychiatry. 2020;19(3):339–49.
Google Scholar
Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanzá-Martínez V, Freeman MP, et al. Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry. 2015;2(3):271–4.
Google Scholar
Hassan S, Ross J, Marston L, Osborn D, Walters K. Factors prospectively associated with physical activity and dietary related outcomes in people with severe mental illness: A systematic review of longitudinal studies. Psychiatry Res. 2019;273:181–91.
Google Scholar
Li C, Niu M, Guo Z, Liu P, Zheng Y, Liu D, et al. A mild causal relationship between tea consumption and obesity in general population: A Two-Sample Mendelian randomization study. Front Genet. 2022;13:795049.
Google Scholar
Sanderson E, Davey Smith G, Bowden J, Munafò MR. Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour. Nat Commun. 2019;10(1):2949.
Google Scholar
Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization. JAMA. 2021;326(16).
Meddens SFW, de Vlaming R, Bowers P, Burik CAP, Linnér RK, Lee C, et al. Genomic analysis of diet composition finds novel loci and associations with health and lifestyle. Mol Psychiatry. 2020;26(6):2056–69.
Google Scholar
Subar AFZR, Thompson FE, Johnson CC, Weissfeld JL, Reding D, et al. Is shorter always better? Relative importance of questionnaire length and cognitive ease on response rates and data quality for two dietary questionnaires. Am J Epidemiol. 2001;153:404–9.
Google Scholar
Otowa T, Hek K, Lee M, Byrne EM, Mirza SS, Nivard MG, et al. Meta-analysis of genome-wide association studies of anxiety disorders. Mol Psychiatry. 2016;21(10):1391–9.
Google Scholar
Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51(5):793–803.
Google Scholar
Adams MJ, Streit F, Meng X, Awasthi S, Adey BN, Choi KW, et al. Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies. Cell. 2025;188(3):640–e529.
Google Scholar
Turley P, Walters RK, Maghzian O, Okbay A, Lee JJ, Fontana MA, et al. Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat Genet. 2018;50(2):229–37.
Google Scholar
de Moor MHM, van den Berg SM, Verweij KJH, Krueger RF, Luciano M, Arias Vasquez A et al. Meta-analysis of Genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA Psychiatry. 2015;72(7).
Okbay A, Baselmans BML, De Neve J-E, Turley P, Nivard MG, Fontana MA, et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. 2016;48(6):624–33.
Google Scholar
Trubetskoy V, Pardinas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604(7906):502–8.
Google Scholar
Bigdeli TB, Genovese G, Georgakopoulos P, Meyers JL, Peterson RE, Iyegbe CO, et al. Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry. Mol Psychiatry. 2020;25(10):2455–67.
Google Scholar
Cao S, Zhang Z, Liu L, Li Y, Li W, Li Y, et al. Causal relationships between atopic dermatitis and psychiatric disorders: a bidirectional two-sample Mendelian randomization study. BMC Psychiatry. 2024;24(1):16.
Google Scholar
Yao C, Zhang Y, Lu P, Xiao B, Sun P, Tao J, et al. Exploring the bidirectional relationship between pain and mental disorders: a comprehensive Mendelian randomization study. J Headache Pain. 2023;24(1):82.
Google Scholar
Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent Estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–14.
Google Scholar
Verbanck M, Chen C-Y, Neale B, Do R. Detection of widespread horizontal Pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693–8.
Google Scholar
Guo Y, Li J, Hu R, Luo H, Zhang Z, Tan J, et al. Associations between ADHD and risk of six psychiatric disorders: a Mendelian randomization study. BMC Psychiatry. 2024;24(1):99.
Google Scholar
Chen J, Han Z, Wang Z, Chen L, Wang S, Yao W et al. Identification of immune traits associated with neurodevelopmental disorders by two-sample Mendelian randomization analysis. BMC Psychiatry. 2024;24(1).
Xian W, Wu D, Liu B, Hong S, Huo Z, Xiao H, et al. Graves disease and inflammatory bowel disease: A bidirectional Mendelian randomization. J Clin Endocrinol Metab. 2023;108(5):1075–83.
Google Scholar
Brinkworth GD, Buckley JD, Noakes M, Clifton PM, Wilson CJ. Long-term effects of a very low-carbohydrate diet and a low-fat diet on mood and cognitive function. Arch Intern Med. 2009;169(20):1873–80.
Google Scholar
Zemdegs J, Quesseveur G, Jarriault D, Pénicaud L, Fioramonti X, Guiard BP. High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice. Br J Pharmacol. 2016;173(13):2095–110.
Google Scholar
Derkach KV, Bondareva VM, Chistyakova OV, Berstein LM, Shpakov AO. The effect of Long-Term intranasal serotonin treatment on metabolic parameters and hormonal signaling in rats with High-Fat Diet/Low-Dose Streptozotocin-Induced type 2 diabetes. Int J Endocrinol. 2015;2015:245459.
Google Scholar
Iguacel I, Huybrechts I, Moreno LA, Michels N. Vegetarianism and veganism compared with mental health and cognitive outcomes: a systematic review and meta-analysis. Nutr Rev. 2021;79(4):361–81.
Google Scholar
Beezhold BL, Johnston CS. Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. Nutr J. 2012;11:9.
Google Scholar
Bienenstock J, Forsythe P, Karimi K, Kunze W. Neuroimmune aspects of food intake. Int Dairy J. 2010;20(4):253–8.
Google Scholar
van de Wouw M, Walsh AM, Crispie F, van Leuven L, Lyte JM, Boehme M, et al. Distinct actions of the fermented beverage Kefir on host behaviour, immunity and Microbiome gut-brain modules in the mouse. Microbiome. 2020;8(1):67.
Google Scholar
Obata K. Synaptic Inhibition and gamma-aminobutyric acid in the mammalian central nervous system. Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(4):139–56.
Google Scholar
Daneshzad E, Keshavarz SA, Qorbani M, Larijani B, Azadbakht L. Association between a low-carbohydrate diet and sleep status, depression, anxiety, and stress score. J Sci Food Agric. 2020;100(7):2946–52.
Google Scholar
Lucas M, Chocano-Bedoya P, Shulze MB, Mirzaei F, O’Reilly ÉJ, Okereke OI, et al. Inflammatory dietary pattern and risk of depression among women. Brain Behav Immun. 2014;36:46–53.
Google Scholar
Keck MM, Vivier H, Cassisi JE, Dvorak RD, Dunn ME, Neer SM et al. Examining the role of anxiety and depression in dietary choices among college students. Nutrients. 2020;12(7).
Kroemer NB, Opel N, Teckentrup V, Li M, Grotegerd D, Meinert S, et al. Functional connectivity of the nucleus accumbens and changes in appetite in patients with depression. JAMA Psychiatry. 2022;79(10):993–1003.
Google Scholar
Milaneschi Y, Simmons WK, van Rossum EFC, Penninx BW. Depression and obesity: evidence of shared biological mechanisms. Mol Psychiatry. 2019;24(1):18–33.
Google Scholar
Simmons WK, Burrows K, Avery JA, Kerr KL, Bodurka J, Savage CR, et al. Depression-Related increases and decreases in appetite: dissociable patterns of aberrant activity in reward and interoceptive neurocircuitry. Am J Psychiatry. 2016;173(4):418–28.
Google Scholar
Jacka FNPJ, Mykletun A, et al. Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatry. 2010;167(3):305–11.
Google Scholar
Esposito CM, Ceresa A, Buoli M. The association between personality traits and dietary choices: A systematic review. Adv Nutr. 2021;12(4):1149–59.
Google Scholar
Martyn-Nemeth P, Penckofer S, Gulanick M, Velsor-Friedrich B, Bryant FB. The relationships among self-esteem, stress, coping, eating behavior, and depressive mood in adolescents. Res Nurs Health. 2009;32(1):96–109.
Google Scholar
Keller C, Siegrist M. Does personality influence eating styles and food choices? Direct and indirect effects. Appetite. 2015;84:128–38.
Google Scholar
Esposito CM, Ceresa A, Buoli M. The association between personality traits and dietary choices: a systematic review. Adv Nutrit. 2021;12(4):1149–59.
Macht M. How emotions affect eating: a five-way model. Appetite. 2008;50(1):1–11.
Google Scholar
Penaforte FRO, Minelli MCS, Anastácio LR, Japur CC. Anxiety symptoms and emotional eating are independently associated with sweet craving in young adults. Psychiatry Res. 2019;271:715–20.
Google Scholar
Aucoin M, LaChance L, Naidoo U, Remy D, Shekdar T, Sayar N et al. Diet and anxiety: A scoping review. Nutrients. 2021;13(12).
Kose J, Fezeu LK, Touvier M, Peneau S, Hercberg S, Galan P, et al. Dietary macronutrient intake according to sex and trait anxiety level among non-diabetic adults: a cross-sectional study. Nutr J. 2021;20(1):78.
Google Scholar
Jacques A, Chaaya N, Beecher K, Ali SA, Belmer A, Bartlett S. The impact of sugar consumption on stress driven, emotional and addictive behaviors. Neurosci Biobehav Rev. 2019;103:178–99.
Google Scholar
Stępnicki P, Kondej M, Kaczor AA. Current concepts and treatments of schizophrenia. Molecules. 2018;23(8).
Kim EJ, Lim SY, Lee HJ, Lee JY, Choi S, Kim SY, et al. Low dietary intake of n-3 fatty acids, niacin, folate, and vitamin C in Korean patients with schizophrenia and the development of dietary guidelines for schizophrenia. Nutr Res. 2017;45:10–8.
Google Scholar
Bly MJ, Taylor SF, Dalack G, Pop-Busui R, Burghardt KJ, Evans SJ, et al. Metabolic syndrome in bipolar disorder and schizophrenia: dietary and lifestyle factors compared to the general population. Bipolar Disord. 2014;16(3):277–88.
Google Scholar
Yabut JM, Crane JD, Green AE, Keating DJ, Khan WI, Steinberg GR. Emerging roles for serotonin in regulating metabolism: new implications for an ancient molecule. Endocr Rev. 2019;40(4):1092–107.
Google Scholar
Chen H, Cao Z, Hou Y, Yang H, Wang X, Xu C. The associations of dietary patterns with depressive and anxiety symptoms: a prospective study. BMC Med. 2023;21(1):307.
Google Scholar
Djuricic I, Calder PC. Beneficial outcomes of Omega-6 and Omega-3 polyunsaturated fatty acids on human health: an update for 2021. Nutrients. 2021;13:7.
Google Scholar
Syk M, Isaksson J, Rasmusson AJ, Ekselius L, Cunningham JL. Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults. Sci Rep. 2021;11(1):9690.
Google Scholar
Gilmartin T, Gurvich C, Sharp G. The relationship between disordered eating behaviour and the five factor model personality dimensions: A systematic review. J Clin Psychol. 2022;78(9):1657–70.
Google Scholar