Cicinelli MV, Buchan JC, Nicholson M, Varadaraj V, Khanna RC. Cataracts. Lancet. 2023;401(10374):377–89. https://doi.org/10.1016/s0140-6736(22)01839-6.
Google Scholar
GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9(2):e144–e60. https://doi.org/10.1016/s2214-109x(20)30489-7.
GBD 2019 Blindness and Vision Impairment Collaborators, Vision Loss Expert Group of the Global Burden of Disease Study. Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9(2):e130–e43. https://doi.org/10.1016/s2214-109x(20)30425-3.
Burton MJ, Ramke J, Marques AP, Bourne RRA, Congdon N, Jones I, et al. The Lancet Global Health Commission on Global Eye Health: vision beyond 2020. Lancet Glob Health. 2021;9(4):e489–551. https://doi.org/10.1016/s2214-109x(20)30488-5.
Google Scholar
Assi L, Chamseddine F, Ibrahim P, Sabbagh H, Rosman L, Congdon N, et al. A Global Assessment of Eye Health and Quality of Life: A Systematic Review of Systematic Reviews. JAMA Ophthalmol. 2021;139(5):526–41. https://doi.org/10.1001/jamaophthalmol.2021.0146.
Google Scholar
Javed U, McVeigh K, Scott NW, Azuara-Blanco A. Cataract extraction and patient vision-related quality of life: a cohort study. Eye (Lond). 2015;29(7):921–5. https://doi.org/10.1038/eye.2015.70.
Google Scholar
Asbell PA, Dualan I, Mindel J, Brocks D, Ahmad M, Epstein S. Age-related cataract. Lancet. 2005;365(9459):599–609. https://doi.org/10.1016/s0140-6736(05)17911-2.
Google Scholar
Brilliant LB, Grasset NC, Pokhrel RP, Kolstad A, Lepkowski JM, Brilliant GE, et al. Associations among cataract prevalence, sunlight hours, and altitude in the Himalayas. Am J Epidemiol. 1983;118(2):250–64. https://doi.org/10.1093/oxfordjournals.aje.a113632.
Google Scholar
West SK, Valmadrid CT. Epidemiology of risk factors for age-related cataract. Surv Ophthalmol. 1995;39(4):323–34. https://doi.org/10.1016/s0039-6257(05)80110-9.
Google Scholar
Kanthan GL, Mitchell P, Burlutsky G, Wang JJ. Alcohol consumption and the long-term incidence of cataract and cataract surgery: the Blue Mountains Eye Study. Am J Ophthalmol. 2010;150(3):434-40.e1. https://doi.org/10.1016/j.ajo.2010.04.020.
Google Scholar
Lee HJ, Kim CH, Lee JS, Kim SH. Association between cataract and cotinine-verified smoking status in 11 435 Korean adults using Korea National Health and Nutrition Examination Survey data from 2008 to 2016. J Cataract Refract Surg. 2020;46(1):45–54. https://doi.org/10.1016/j.jcrs.2019.08.035.
Google Scholar
Fukai K, Terauchi R, Furuya Y, Sano K, Nakazawa S, Kojimahara N, et al. Alcohol use patterns and risk of incident cataract surgery: a large scale case-control study in Japan. Sci Rep. 2022;12(1):20142. https://doi.org/10.1038/s41598-022-24465-2.
Google Scholar
Alabdulwahhab KM. Senile Cataract in Patients with Diabetes with and Without Diabetic Retinopathy: A Community-Based Comparative Study. J Epidemiol Glob Health. 2022;12(1):56–63. https://doi.org/10.1007/s44197-021-00020-6.
Google Scholar
Skalka HW, Prchal JT. The effect of diabetes mellitus and diabetic therapy on cataract formation. Ophthalmology. 1981;88(2):117–25. https://doi.org/10.1016/s0161-6420(81)35065-9.
Google Scholar
Liu PK, Chang YC, Wang NK, Ryu J, Tsai RK, Hsu SL, et al. The association between cataract and sleep apnea: a nationwide population-based cohort study. J Clin Sleep Med. 2022;18(3):769–77. https://doi.org/10.5664/jcsm.9714.
Google Scholar
Chen Y, Nondahl DM, Schubert CR, Klein BE, Klein R, Cruickshanks KJ. The Relation between Sleep Disruption and Cataract in a Large Population-Based Study. Ophthalmic Epidemiol. 2017;24(2):111–5. https://doi.org/10.1080/09286586.2016.1259640.
Google Scholar
Jiang H, Wang LN, Liu Y, Li M, Wu M, Yin Y, et al. Physical activity and risk of age-related cataract. Int J Ophthalmol. 2020;13(4):643–9. https://doi.org/10.18240/ijo.2020.04.18.
Google Scholar
Zheng Selin J, Orsini N, Ejdervik Lindblad B, Wolk A. Long-term physical activity and risk of age-related cataract: a population-based prospective study of male and female cohorts. Ophthalmology. 2015;122(2):274–80. https://doi.org/10.1016/j.ophtha.2014.08.023.
Google Scholar
Wang YX, Wei WB, Xu L, Jonas JB. Physical activity and eye diseases. The Beijing Eye Study Acta Ophthalmol. 2019;97(3):325–31. https://doi.org/10.1111/aos.13962.
Google Scholar
Williams PT. Prospective epidemiological cohort study of reduced risk for incident cataract with vigorous physical activity and cardiorespiratory fitness during a 7-year follow-up. Invest Ophthalmol Vis Sci. 2009;50(1):95–100. https://doi.org/10.1167/iovs.08-1797.
Google Scholar
Sano K, Fukai K, Terauchi R, Furuya Y, Nakazawa S, Kojimahara N, et al. Association between ocular diseases and screen time and sedentary time derived from job-exposure matrices. Sci Rep. 2024;14(1):27042. https://doi.org/10.1038/s41598-024-74854-y.
Google Scholar
Saunders TJ, Gray CE, Poitras VJ, Chaput JP, Janssen I, Katzmarzyk PT, et al. Combinations of physical activity, sedentary behaviour and sleep: relationships with health indicators in school-aged children and youth. Appl Physiol Nutr Metab. 2016;41(6 Suppl 3):S283–93. https://doi.org/10.1139/apnm-2015-0626.
Google Scholar
Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 2015;12(3): e1001779. https://doi.org/10.1371/journal.pmed.1001779.
Google Scholar
Huang BH, Duncan MJ, Cistulli PA, Nassar N, Hamer M, Stamatakis E. Sleep and physical activity in relation to all-cause, cardiovascular disease and cancer mortality risk. Br J Sports Med. 2022;56(13):718–24. https://doi.org/10.1136/bjsports-2021-104046.
Google Scholar
Wang M, Zhou T, Li X, Ma H, Liang Z, Fonseca VA, et al. Baseline Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank Study. Diabetes Care. 2020;43(11):2776–84. https://doi.org/10.2337/dc20-1109.
Google Scholar
Kanki M, Nath AP, Xiang R, Yiallourou S, Fuller PJ, Cole TJ, et al. Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants. Nat Commun. 2023;14(1):7096. https://doi.org/10.1038/s41467-023-42758-6.
Google Scholar
Geng T, Li X, Ma H, Heianza Y, Qi L. Adherence to a Healthy Sleep Pattern and Risk of Chronic Kidney Disease: The UK Biobank Study. Mayo Clin Proc. 2022;97(1):68–77. https://doi.org/10.1016/j.mayocp.2021.08.028.
Google Scholar
Lv X, Li Y, Li R, Guan X, Li L, Li J, et al. Relationships of sleep traits with prostate cancer risk: A prospective study of 213,999 UK Biobank participants. Prostate. 2022;82(9):984–92. https://doi.org/10.1002/pros.24345.
Google Scholar
Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381–95. https://doi.org/10.1249/01.Mss.0000078924.61453.Fb.
Google Scholar
Huang SY, Li YZ, Zhang YR, Huang YY, Wu BS, Zhang W, et al. Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants. Mol Psychiatry. 2022;27(10):4343–54. https://doi.org/10.1038/s41380-022-01655-y.
Google Scholar
Chang Q, Zhu Y, Liu Z, Cheng J, Liang H, Lin F, et al. Replacement of sedentary behavior with various physical activities and the risk of all-cause and cause-specific mortality. BMC Med. 2024;22(1):385. https://doi.org/10.1186/s12916-024-03599-2.
Google Scholar
Gao X, Tian S, Huang N, Sun G, Huang T. Associations of daily sedentary behavior, physical activity, and sleep with irritable bowel syndrome: A prospective analysis of 362,193 participants. J Sport Health Sci. 2024;13(1):72–80. https://doi.org/10.1016/j.jshs.2023.02.002.
Google Scholar
Bakrania K, Edwardson CL, Khunti K, Bandelow S, Davies MJ, Yates T. Associations Between Sedentary Behaviors and Cognitive Function: Cross-Sectional and Prospective Findings From the UK Biobank. Am J Epidemiol. 2018;187(3):441–54. https://doi.org/10.1093/aje/kwx273.
Google Scholar
Fan H, Han X, Shang X, Zhu Z, He M, Xu G, et al. Fruit and vegetable intake and the risk of cataract: insights from the UK Biobank study. Eye (Lond). 2023;37(15):3234–42. https://doi.org/10.1038/s41433-023-02498-9.
Google Scholar
Liu YC, Wilkins M, Kim T, Malyugin B, Mehta JS. Cataracts. Lancet. 2017;390(10094):600–12. https://doi.org/10.1016/s0140-6736(17)30544-5.
Google Scholar
Chen C, Wei L, He W, Zhang Y, Xiao J, Lu Y, et al. Associations of severe liver diseases with cataract using data from UK Biobank: a prospective cohort study. EClinicalMedicine. 2024;68: 102424. https://doi.org/10.1016/j.eclinm.2024.102424.
Google Scholar
Mekary RA, Willett WC, Hu FB, Ding EL. Isotemporal substitution paradigm for physical activity epidemiology and weight change. Am J Epidemiol. 2009;170(4):519–27. https://doi.org/10.1093/aje/kwp163.
Google Scholar
Doherty A, Jackson D, Hammerla N, Plötz T, Olivier P, Granat MH, et al. Large Scale Population Assessment of Physical Activity Using Wrist Worn Accelerometers: The UK Biobank Study. PLoS ONE. 2017;12(2):e0169649. https://doi.org/10.1371/journal.pone.0169649.
Google Scholar
Atrooz F, Salim S. Sleep deprivation, oxidative stress and inflammation. Adv Protein Chem Struct Biol. 2020;119:309–36. https://doi.org/10.1016/bs.apcsb.2019.03.001.
Google Scholar
Mattis J, Sehgal A. Circadian Rhythms, Sleep, and Disorders of Aging. Trends Endocrinol Metab. 2016;27(4):192–203. https://doi.org/10.1016/j.tem.2016.02.003.
Google Scholar
Irwin MR, Olmstead R, Carroll JE. Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biol Psychiatry. 2016;80(1):40–52. https://doi.org/10.1016/j.biopsych.2015.05.014.
Google Scholar
López-Sánchez GF, Pardhan S, Trott M, Sánchez-Castillo S, Jackson SE, Tully M, et al. The Association Between Physical Activity and Cataracts Among 17,777 People Aged 15–69 Years Residing in Spain. Ophthalmic Epidemiol. 2020;27(4):272–7. https://doi.org/10.1080/09286586.2020.1730911.
Google Scholar
de Rezende LF, Rodrigues Lopes M, Rey-López JP, Matsudo VK, Luiz OC. Sedentary behavior and health outcomes: an overview of systematic reviews. PLoS ONE. 2014;9(8): e105620. https://doi.org/10.1371/journal.pone.0105620.
Google Scholar
Zhao Q, Chen C, Zhang J, Ye Y, Fan X. Sedentary behavior and health outcomes in patients with heart failure: a systematic review and meta-analysis. Heart Fail Rev. 2022;27(4):1017–28. https://doi.org/10.1007/s10741-021-10132-7.
Google Scholar
Wu J, Fu Y, Chen D, Zhang H, Xue E, Shao J, et al. Sedentary behavior patterns and the risk of non-communicable diseases and all-cause mortality: A systematic review and meta-analysis. Int J Nurs Stud. 2023;146:104563. https://doi.org/10.1016/j.ijnurstu.2023.104563.
Google Scholar
Niklasson J, Fagerström C, Bergman P, Lindberg T, Backåberg S. The meaning of sedentary behavior among older adults: a phenomenological hermeneutic study. BMC Public Health. 2023;23(1):1134. https://doi.org/10.1186/s12889-023-16052-5.
Google Scholar
Sampasa-Kanyinga H, Colman I, Goldfield GS, Janssen I, Wang J, Podinic I, et al. Combinations of physical activity, sedentary time, and sleep duration and their associations with depressive symptoms and other mental health problems in children and adolescents: a systematic review. Int J Behav Nutr Phys Act. 2020;17(1):72. https://doi.org/10.1186/s12966-020-00976-x.
Google Scholar
You Y, Chen Y, Fang W, Li X, Wang R, Liu J, et al. The association between sedentary behavior, exercise, and sleep disturbance: A mediation analysis of inflammatory biomarkers. Front Immunol. 2022;13:1080782. https://doi.org/10.3389/fimmu.2022.1080782.
Google Scholar
German C, Makarem N, Fanning J, Redline S, Elfassy T, McClain A, et al. Sleep, Sedentary Behavior, Physical Activity, and Cardiovascular Health: MESA. Med Sci Sports Exerc. 2021;53(4):724–31. https://doi.org/10.1249/mss.0000000000002534.
Google Scholar
Wei J, Hou R, Xie L, Chandrasekar EK, Lu H, Wang T, et al. Sleep, sedentary activity, physical activity, and cognitive function among older adults: The National Health and Nutrition Examination Survey, 2011–2014. J Sci Med Sport. 2021;24(2):189–94. https://doi.org/10.1016/j.jsams.2020.09.013.
Google Scholar
Carballo-Fazanes A, Rico-Díaz J, Barcala-Furelos R, Rey E, Rodríguez-Fernández JE, Varela-Casal C, et al. Physical Activity Habits and Determinants, Sedentary Behaviour and Lifestyle in University Students. Int J Environ Res Public Health. 2020;17(9). https://doi.org/10.3390/ijerph17093272
De Nys L, Anderson K, Ofosu EF, Ryde GC, Connelly J, Whittaker AC. The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis. Psychoneuroendocrinology. 2022;143:105843. https://doi.org/10.1016/j.psyneuen.2022.105843.
Google Scholar
Janssen X, Martin A, Hughes AR, Hill CM, Kotronoulas G, Hesketh KR. Associations of screen time, sedentary time and physical activity with sleep in under 5s: A systematic review and meta-analysis. Sleep Med Rev. 2020;49:101226. https://doi.org/10.1016/j.smrv.2019.101226.
Google Scholar
Jeong SH, Jang BN, Kim SH, Kim GR, Park EC, Jang SI. Association between sedentary time and sleep quality based on the Pittsburgh Sleep Quality Index among South Korean adults. BMC Public Health. 2021;21(1):2290. https://doi.org/10.1186/s12889-021-12388-y.
Google Scholar
Menezes-Júnior LAA, de Moura SS, Miranda AG, de Souza Andrade AC, Machado-Coelho GLL, Meireles AL. Sedentary behavior is associated with poor sleep quality during the COVID-19 pandemic, and physical activity mitigates its adverse effects. BMC Public Health. 2023;23(1):1116. https://doi.org/10.1186/s12889-023-16041-8.
Google Scholar
Fan M, Sun D, Zhou T, Heianza Y, Lv J, Li L, et al. Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants. Eur Heart J. 2020;41(11):1182–9. https://doi.org/10.1093/eurheartj/ehz849.
Google Scholar
Li X, Xue Q, Wang M, Zhou T, Ma H, Heianza Y, et al. Adherence to a Healthy Sleep Pattern and Incident Heart Failure: A Prospective Study of 408 802 UK Biobank Participants. Circulation. 2021;143(1):97–9. https://doi.org/10.1161/circulationaha.120.050792.
Google Scholar
Gov.UK. Office for Health Improvement & Disparities. Vision profile statistical commentary: July 2025. Published 1 July 2025. Available at: https://www.gov.uk/government/statistics/vision-profile-july-2025/vision-profile-statistical-commentary-july-2025. Accessed 23 Jul 2025.