Professor Fornstedt is internationally recognized for his pioneering contributions to the field of separation science, particularly in advancing our understanding of liquid chromatography theory and its practical applications in complex molecular analysis.
With the growing demand for precision in therapeutic development—especially in the realm of oligonucleotide-based drugs—analytical scientists face mounting challenges in resolving and characterizing structurally similar and high-mass molecules. In Part 1, Professor Fornstedt shared his insights on how modern chromatographic techniques are evolving to address these obstacle of analysing, oligonucleotides.
In part two of this i video interview Torgny answered the following questions:
• How do small interfering ribonucleic acidsd (siRNAs) separations differ from antisense oligonucleotides (ASOs), and what analytical adjustments are typically needed?
• How are digital modeling or machine learning tools helping chromatographers?
Biography
Torgny Fornstedt is a professor at Karlstad University in Sweden. His research combines theory and practice to understand molecular interactions in separation media, focusing on reliable analysis and purification of drug molecules using high-pressure liquid and supercritical fluid systems. Recent work with industry partners tar- gets therapeutic oligonucleotides (ASOs, siRNA) and digital technology applications for quality assurance of next-generation drugs.