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  • FDA Approves First CAR T-Cell Therapy for Marginal Zone Lymphoma In the US – fda.gov

    1. FDA Approves First CAR T-Cell Therapy for Marginal Zone Lymphoma In the US  fda.gov
    2. FDA Approves Liso-Cel for Relapsed/Refractory Marginal Zone Lymphoma  OncLive
    3. FDA Approves Breyanzi in Relapsed/Refractory Marginal Zone Lymphoma  Cure Today
    4. FDA Approves Liso-Cel in Marginal Zone Lymphoma After 2 Lines of Therapy  CancerNetwork
    5. FDA Approves Liso-Cel in Pretreated R/R Marginal Zone Lymphoma  Oncology Nursing News

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  • Apple announces departure of Lisa Jackson and Kate Adams

    Apple announces departure of Lisa Jackson and Kate Adams

    Lisa Jackson, senior vice president of environment, policy and social initiatives at Apple Inc., speaks during the TechCrunch Disrupt 2017 in San Francisco, California, U.S., on Tuesday, Sept. 19, 2017.

    David Paul Morris | Bloomberg | Getty Images

    Apple’s general counsel, Kate Adams, and its vice president for environment, policy, and social initiatives, Lisa Jackson, will retire from Apple, the company announced on Thursday.

    Apple said that Jennifer Newstead would become Apple’s new general counsel in March next year and that Jackson’s government affairs staff would report to her.

    The two executives previously reported to Apple CEO Tim Cook and represent the latest sign that Apple’s senior leadership is seeing a slew of exits.

    In recent weeks, Apple’s head software designer said he was leaving to go to Meta, Apple said that its AI chief was retiring, and Apple’s chief operating officer retired.

    Adams joined Apple and became general counsel in 2017, and oversaw legal matters including litigation, global security, and the company’s privacy initiatives. Under Adams, Apple grappled with rising antitrust scrutiny and regulation around the world, including major lawsuits in the U.S. over the iPhone App Store’s restrictions and fees.

    Jackson joined Apple in 2013, and led the company’s diversity programs as well as much of its policy work in Washington, D.C.

    Prior to joining Apple in 2013, she spent four years as Administrator of the U.S. Environmental Protection Agency, a position she was appointed to by President Barack Obama.

    Jackson is a Democrat, and her retirement shows a shift in Apple’s approach to Washington DC in the second Trump administration. Apple has faced increased tariffs from the Trump administration, and Cook has met with President Trump several times to tout the company’s American manufacturing plans in an effort to limit policy changes that could hurt the company.

    She also led Apple’s environmental initiatives.

    In her role, Jackson “focused on reducing greenhouse gases, protecting air and water quality, preventing exposure to toxic contamination, and expanding outreach to communities on environmental issues,” according to her bio on Apple’s website.

    Jackson was instrumental in Apple’s launch of its Racial Equity and Justice Initiative following the 2020 murder of George Floyd.

    She then helped expand the company’s equity and justice efforts to other countries, including the U.K., Mexico and New Zealand, according to a report on the initiative in 2023.

    “At Apple, we pledge that our resolve will not fade,” Jackson wrote in a section of that report. “We won’t delay action. We will work, each and every day, on the urgent task of advancing equity.”

    Jackson also accompanied Cook to several official functions in Washington, including state dinners.

    Since 2019, Newstead, who will become Apple’s top lawyer, has overseen Meta’s legal and regulatory matters pertaining to its family of apps like Facebook, Instagram, WhatsApp and others.

    Prior to her stint at the social media giant, Newstead served as a Trump-appointed legal advisor at the State Department during the president’s first administration in 2019. 

    Before that, she was a partner at Davis Polk & Wardell and a general counsel of the White House Office of Management and Budget, among other roles in the U.S. government.

    This is breaking news. Please refresh for updates.

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  • STAN WEEKLY NEWS UPDATE

    STAN WEEKLY NEWS UPDATE

    • Prepare for a cinematic, history-bending gladiator drama. New series Spartacus: House of Ashur premieres today, 6PM AEDT.
    • Parts two and three of the Stan Original Revealed – Death Cap Murders premiere this Sunday, December 7.
    • Will Forte and…

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  • October Steel Shipments Down 4.2 Percent From Prior Month

    October Steel Shipments Down 4.2 Percent From Prior Month

    December 4, 2025

    Up 5.1 Percent YTD in 2025 from Same Period in 2024

    WASHINGTON, D.C. – The American Iron and Steel Institute (AISI) reported today that for the month of October 2025, U.S. steel mills shipped 7,692,319 net tons, a 9.2 percent increase from the 7,047,172 net tons shipped in October 2024. Shipments were down 4.2 percent from the 8,032,536 net tons shipped in the previous month, September 2025. Shipments year-to-date in 2025 are 76,425,069 net tons, up 5.1 percent vs. 2024 shipments of 72,731,187 net tons for ten months.

    A comparison of shipments year-to-date in 2025 to the first ten months of 2024 shows the following changes: corrosion resistant sheet and strip, up 4 percent, hot rolled sheet and strip, unchanged and cold rolled sheet and strip, down 3 percent.

    ####

    Contact: Lisa Harrison

    202.452.7115 / lharrison@steel.org

    AISI serves as the voice of the American steel industry in the public policy arena and advances the case for steel in the marketplace as the preferred material of choice. AISI’s membership is comprised of integrated and electric arc furnace (EAF) steelmakers, steel pipe and tube manufacturers and steel processors and fabricators, reflecting the production and distribution of both carbon and stainless steels. These steels are critical to America’s national and economic security, including roads and bridges, buildings, the electrical grid, cars and trucks and all clean energy technologies. AISI also represents associate members who are suppliers to or customers of the steel industry. For more news about steel and its applications, view AISI’s website at www.steel.org. Follow AISI on FacebookLinkedInTwitter (@AISISteel) or Instagram. 


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  • Red Dead Redemption Netflix – How to download, minimum phone specifications, best flagship and budget devices, and more | Esports News

    Red Dead Redemption Netflix – How to download, minimum phone specifications, best flagship and budget devices, and more | Esports News

    Red Dead Redemption Netflix (Image via Rockstar Games)

    Red Dead Redemption Netflix has officially brought Rockstar Games’ legendary open-world Western to mobile, marking one of the platform’s biggest game launches to date. Starting December…

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  • CDC's ACIP pushes back planned vote on newborn hepatitis B vaccines as confusion, debate abound – Fierce Pharma

    1. CDC’s ACIP pushes back planned vote on newborn hepatitis B vaccines as confusion, debate abound  Fierce Pharma
    2. RFK Jr.’s vaccine advisers plan biggest change yet to childhood schedule  The Washington Post
    3. ACIP postpones vote on hepatitis B…

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  • Barriers in Transition to Adult Mental Health Services – European Medical Journal Barriers in Transition to Adult Mental Health Services

    Barriers in Transition to Adult Mental Health Services – European Medical Journal Barriers in Transition to Adult Mental Health Services

    AUTISTIC young people and those with ADHD face barriers when transitioning to adult mental health services.

    Scoping Review of Transition to Adult Mental Health Services

    Using Arksey and O’Malley’s framework and the PRISMA extension for…

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  • AI needs power desperately. Here’s how to invest in companies profiting from the pain.

    AI needs power desperately. Here’s how to invest in companies profiting from the pain.

    By Jurica Dujmovic

    The shortage is a lucrative opportunity – but the window is brief

    AI computing workloads could consume around 500 terawatt-hours annually by 2027 – about twice the U.K.’s total electricity consumption in 2023.

    Rising infrastructure costs and mounting capital constraints are deflating the AI boom. The hyperscalers can’t solve their computing problems fast enough, and that’s creating a rare arbitrage opportunity.

    The solution right now isn’t building data centers. The current investment opportunity lies in the temporary gap between exploding AI demand and the physical constraints of centralized infrastructure expansion. A handful of companies are exploiting this window – which likely will be a 24-to-36- month opportunity. For investors who understand the timing, it’s a compelling hedge against the AI infrastructure bottleneck.

    Physical barriers

    40% of AI data centers will face power constraints by 2027.

    AI’s limiting factor is no longer algorithms or data – it’s the brute-force physics of data-center expansion. Training large models demands tens of thousands of GPUs, dedicated networking and enormous power consumption. Gartner forecasts that 40% of AI data centers will face power constraints by 2027.

    The math is brutally simple: AI computing workloads could consume around 500 terawatt-hours annually by 2027 – about twice the U.K.’s total electricity consumption in 2023. This demand spike is already showing up in the grid.

    Dominion Energy (D), the biggest utility company in Virginia, nearly doubled its data-center power capacity under contract between July and December 2024, and the trend has persisted.

    Even with Microsoft (MSFT), Alphabet (GOOG) (GOOGL), Amazon.com (AMZN) and Meta Platforms (META) spending a combined $370 billion on capex in 2025, they can’t build fast enough. Construction and commissioning typically take 12 to 36 months, but when you include permitting and power-grid build-outs, a full data-center project can stretch to three to six years.

    Time and money

    The economics are compelling during this shortage window

    This time gap is the entire investment thesis.

    When essential resources become expensive and concentrated, parallel markets emerge. We saw this with electricity co-ops in the early 20th century, independent oil producers during OPEC’s reign and broadband resellers in the early internet era.

    With AI, the scarce resource is GPU computing. Several companies are building marketplaces that aggregate idle capacity – consumer GPUs, academic clusters, enterprise overstock – and resell it at a fraction of centralized data-center costs.

    The economics for these companies are compelling during this shortage window:

    Cost structure advantage: Alternative networks don’t finance data centers with debt. They pay participants directly for computing capacity through incentive structures, converting spare capacity into productive assets. The cost of scaling shifts from massive capex to distributed incentives.

    Speed to market: While hyperscalers wait 18 to 36 months for new facilities, these networks can add capacity node by node, with no billion-dollar commitments up front.

    Arbitrage pricing: These companies are capturing demand from the smaller labs, indie studios, emerging markets and others that are priced out of AWS GPU pricing but still need computing.

    The catch? The explosive growth window is finite. These networks will remain viable alternatives even after constraints ease – serving cost-sensitive workloads, emerging markets and indie developers – but the opportunity for substantial investment gains compresses as growth normalizes and hyperscalers’ capacity comes online.

    Read: AI data centers need juice. The next hot stocks give it.

    How to play the computing shortage

    Again, this isn’t a moonshot bet. It’s an infrastructure hedge with a defined window. Here are three approaches, ranked by risk profile:

    Render Network: Aggregates idle GPU capacity from individuals and studios, reselling to the highest bidder for rendering and AI workloads. Think of it as Airbnb for GPUs – idle capacity that would otherwise sit dormant gets monetized, and users get computing at a fraction of data-center pricing. Rather than operating expensive data centers, Render pays a fraction of that cost to harvest capacity from thousands of computers.

    io.net: Focuses on generic GPU computing for AI training and inference. The platform aggregates capacity from data centers, crypto miners and consumer hardware, creating a distributed alternative to centralized cloud providers. Its network is newer and more speculative than Render, but it’s capturing demand from AI startups that can’t afford or access hyperscaler GPU allocations.

    Akash Network: Takes the concept broader, offering a marketplace for general cloud computing and storage beyond just GPUs. This positions it as infrastructure for the full stack, not just AI-specific workloads. Akash is a privately held company but it does have a tradeable crypto token, AKT. This is the highest-risk play in this category, but offers the most diversified exposure if decentralized computing extends beyond AI.

    These are crypto token plays – not stocks

    Before going further, understand what you’re actually buying. All three of these networks operate through native cryptocurrency tokens, not traditional equity. There is no stock ticker, no brokerage-account access and no public-equity wrapper for these businesses.

    Direct exposure requires navigating cryptocurrency exchanges:

    — Render Network (RENDER) trades on Coinbase, Binance and Kraken.

    — is listed on select crypto exchanges such as Binance and Gate.io, with liquidity varying by venue and region.

    — Akash Network (AKT) trades on Coinbase, Kraken and similar venues.

    This means dealing with crypto custody – whether through exchange accounts or self-custody wallets – and accepting the regulatory uncertainty that comes with token investments. If you’re not comfortable with that infrastructure, this thesis won’t work for you.

    For investors who prefer traditional equity exposure, the closest alternatives are second-order beneficiaries of the same capacity constraint:

    — Data-center operators: Equinix EQIX, Digital Realty Trust DLR

    — Power infrastructure: Dominion Energy, Duke Energy DUK, NextEra Energy NEE

    — GPU supply chain: Nvidia NVDA, Broadcom AVGO, Super Micro Computer SMCI

    But here’s the critical distinction: These publicly traded companies benefit from the shortage itself – not from the temporary arbitrage window created by aggregating idle distributed capacity. They’ll do well regardless of whether decentralized computing succeeds. What they won’t give you is direct exposure to the specific dislocation that is going on now.

    Risk factors

    Let’s be clear about what could go wrong with this arbitrage strategy:

    Performance and reliability: Distributed GPU networks face inherent challenges with performance variance, latency and quality control. Enterprise customers paying for AI infrastructure demand reliability. If these networks can’t match centralized performance, the arbitrage doesn’t matter – customers won’t switch.

    Security and compliance: Regulated industries won’t run sensitive workloads on unknown hardware scattered globally. These networks are limited to specific use cases where data sovereignty and compliance aren’t blockers.

    Hyperscaler catch-up timeline: The base case assumes these constraints ease through 2027-’29 as new data centers and power infrastructure come online. If power constraints extend beyond 2029, the high-growth window for these companies stays open.

    Regulatory uncertainty: Several of these networks operate in regulatory gray areas. If governments decide to regulate decentralized computing infrastructure, costs increase and flexibility decreases.

    Crypto market contagion: These tokens trade on crypto exchanges and correlate with broader crypto markets. A bitcoin crash or crypto regulatory crackdown could affect these assets regardless of fundamentals.

    The investment timeline

    The window runs from early 2026 through 2027-’28, which is the core 24-to-36-month period. The broader infrastructure constraint lasts longer, but the outsized arbitrage compresses as hyperscalers come online. This aligns with the infrastructure constraint timeline I’ve been tracking, but extends beyond the initial shortage as power-grid limitations persist.

    Q1 2026: Begin building positions as the 2027 power constraint window becomes consensus view. Dollar-cost average to smooth volatility.

    Q2 2026-Q2 2027: Peak growth opportunity as AI demand continues accelerating while centralized capacity remains severely constrained. These networks capture maximum long-tail demand priced out of hyperscaler infrastructure.

    Q3 2027-Q2 2028: Growth continues, but begins normalizing as new data centers come online and power-grid upgrades progress. Monitor hyperscaler capacity announcements closely – each major facility completion incrementally compresses the arbitrage.

    Q3 2028-Q4 2029: Maturation phase. These networks settle into specialized roles – emerging markets, cost-sensitive workloads, indie developers. They remain viable businesses but growth normalizes.

    It is important to understand that this isn’t a binary “it works until it doesn’t” thesis. It’s a maturation curve where networks transition from high-growth arbitrage plays to steady-state infrastructure alternatives.

    The broader implication

    If GPU aggregation networks prove they can deliver reliable computing at competitive prices during the 2026-’28 constraint period, they will establish legitimacy. Even if hyperscalers eventually recapture market share, these networks will have carved out niches in emerging markets, indie studios and cost-sensitive workloads.

    (MORE TO FOLLOW) Dow Jones Newswires

    12-04-25 1637ET

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • US probes reports Waymo self-driving cars illegally passed school buses 19 times in Texas – Reuters

    1. US probes reports Waymo self-driving cars illegally passed school buses 19 times in Texas  Reuters
    2. Waymo responds to safety concerns amid investigation into incidents caught on school bus cameras  ABC News
    3. AISD asking Waymo to fix safety issues after its cars pass stopped school buses  KVUE
    4. Austin ISD asks Waymo to stop service during drop-off and pickup hours  Spectrum News
    5. Waymo’s Latest Blunder Casts Doubt On Driverless Future  LoneStar 92.3

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