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  • Vigilance state dissociation induced by 5-MeO-DMT in mice

  • Jouvet, M., Michel, F. & Courjon, J. On a stage of rapid cerebral electrical activity in the course of physiological sleep. C. R. Seances Soc. Biol. Fil. 153, 1024–1028 (1959).

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  • Piéron, H. Le…

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  • This Is One of the Best Artificial Intelligence (AI) Stocks to Hold for the Next 10 Years

    This Is One of the Best Artificial Intelligence (AI) Stocks to Hold for the Next 10 Years

    • Iren is well positioned to meet the power shortage for data centers.

    • It signed a $9.7 billion deal with Microsoft recently.

    • Iren has secured 3 gigawatts of power for its data center pipeline.

    • 10 stocks we like better than Iren ›

    Shares of Iren (NASDAQ: IREN) more than tripled in 2025. The Bitcoin miner, founded in 2018, is pursuing a massive opportunity by offering its data centers for artificial intelligence (AI) cloud services.

    Iren has secured thousands of megawatts of clean power to meet the projected energy shortage for AI data centers in the coming years. If it signs more deals as it did with Microsoft recently, this could be just the beginning of the stock’s bull run.

    Image source: Getty Images.

    In October, Iren announced a $9.7 billion contract with Microsoft, which not only verified the value of the company’s data center pipeline, but also, importantly, its ability to build these facilities on schedule.

    Time is of the essence with hyperscalers. Microsoft has the resources to invest in its own data centers, but it still needs companies like Iren as Microsoft has $400 billion in remaining performance obligations with cloud customers and insufficient data center capacity to fulfill them in the immediate future.

    It’s estimated to take several years to secure the land and power to bring a new data center online. Iren has been ahead of the curve, spending the last several years acquiring these assets specifically for this opportunity. It has disclosed 3 gigawatts of secured power for its data center pipeline.

    Long lead times for building new data centers make Iren an increasingly valuable partner for hyperscalers. The stock’s current market cap of $13 billion is a fair price for the company’s current assets and value of the Microsoft contract. This leaves considerable upside as it announces more deals, which could potentially lead to multibagger returns over the next decade.

    Before you buy stock in Iren, consider this:

    The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Iren wasn’t one of them. The 10 stocks that made the cut could produce monster returns in the coming years.

    Consider when Netflix made this list on December 17, 2004… if you invested $1,000 at the time of our recommendation, you’d have $490,703!* Or when Nvidia made this list on April 15, 2005… if you invested $1,000 at the time of our recommendation, you’d have $1,157,689!*

    Now, it’s worth noting Stock Advisor’s total average return is 966% — a market-crushing outperformance compared to 194% for the S&P 500. Don’t miss the latest top 10 list, available with Stock Advisor, and join an investing community built by individual investors for individual investors.

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  • Small Business Sales Edge Up as Consumers Spend More Per Transaction this December, Fiserv Reports :: Fiserv, Inc. (FISV)

    Small Business Sales Edge Up as Consumers Spend More Per Transaction this December, Fiserv Reports :: Fiserv, Inc. (FISV)





    Fiserv Small Business Index rises to 144 as year-over-year sales increase +1.6%

    MILWAUKEE–(BUSINESS WIRE)–
    Fiserv, Inc. (NASDAQ:FISV), a leading global provider of payments and financial services technology, has published the Fiserv Small Business Index for December 2025, indicating small businesses closed out the holiday season with modest gains. The seasonally adjusted Index climbed to 144, while year-over-year sales grew (+1.6%), due to higher average ticket sizes and steady demand for essentials.

    December sales rose month-over-month (+0.8%), while transaction volume remained flat. Compared to 2024, average ticket sizes were up (+2.0%), signaling that consumers spent more per purchase during the holiday period.

    “December’s sales gains show the resilience of small businesses during a competitive holiday season,” said Prasanna Dhore, Chief Data Officer at Fiserv. “Consumers focused on essentials and made selective discretionary purchases, driven by ongoing cost pressures. These patterns, resulting in modest monthly sales growth, highlight how small businesses continue to adjust in a challenging economic climate.”

    Key Takeaways

    Holiday Demand Boosts Retail Sales

    Retail sales among small businesses rose (+0.9%) month-over-month and (+0.3%) year-over-year, with Core Retail (excluding volatile categories) posting stronger (+1.1%) year-over-year growth. Sporting Goods (+5.2%) led annual gains, supported by increased foot traffic (+5.8%).

    Spending on Essentials Outpaces Discretionary Spending

    Essential categories continued to outperform discretionary purchases, growing (+2.8%) year-over-year compared to (+0.7%) for discretionary items. Grocery sales dipped slightly (-0.3%) despite a small uptick in foot traffic (+0.2%).

    Restaurant Sales Remain Flat in December

    Small business restaurants saw minimal change, with sales up (+0.1%) year-over-year and flat month-over-month. Falling year-over-year foot traffic (-1.5%) was the key driver of the low annual growth. Limited-Service Restaurants (+0.5%) outperformed Full-Service Restaurants (-0.6%) year-over-year, while bars saw +1.0% growth, driven entirely by increased foot traffic.

    States Experience Broad Sales Growth

    Compared to November, sales grew in 43 of 50 states during the month of December, a significant increase from the month prior, when only 11 states saw sales increases. Month-over-month increases from high-volume states, including California (+1.6%) and Texas (+1.1%), contributed significantly to this growth. New York (-0.5%), Colorado (-1.5%) and Pennsylvania (-0.2%) were among the few states to experience month-over-month declines.

    To access the full Fiserv Small Business Index, visit fiserv.com/FiservSmallBusinessIndex.

    About the Fiserv Small Business Index®

    The Fiserv Small Business Index is published during the first week of every month and differentiated by its direct aggregation of consumer spending activity within the U.S. small business ecosystem. Rather than relying on survey or sentiment data, the Fiserv Small Business Index is derived from point-of-sale transaction data, including card, cash, and check transactions in-store and online across approximately 2 million U.S. small businesses, including hundreds of thousands leveraging the Clover point-of-sale and business management platform.

    Benchmarked to 2019, the Fiserv Small Business Index provides a numeric value measuring consumer spending, with an accompanying transaction index measuring customer traffic. Through a simple interface, users can access data by region, state, and/or across business types categorized by the North American Industry Classification System (NAICS). Featuring the most detailed classification available, the Fiserv Small Business Index provides visibility into 56 standardized level-6 national industries across 26 subsectors and 13 sectors, allowing users to track sales trends with precision and understand the diverse dynamics shaping the U.S. small business economy.

    About Fiserv

    Fiserv, Inc. (NASDAQ: FISV), a Fortune 500 company, moves more than money. As a global leader in payments and financial technology, the company helps clients achieve best-in-class results through a commitment to innovation and excellence in areas including account processing and digital banking solutions; card issuer processing and network services; payments; e-commerce; merchant acquiring and processing; and Clover®, the world’s smartest point-of-sale system and business management platform. Fiserv is a member of the S&P 500® Index, one of TIME Magazine’s Most Influential Companies™ and one of Fortune® World’s Most Admired Companies™. Visit fiserv.com and follow on social media for more information and the latest company news.

    FISV-G

    For more information contact:

    Media Relations:

    Melissa Moritz

    Vice President, External Communications

    Fiserv, Inc.

    +1 516-410-1188

    melissa.moritz@fiserv.com

    Source: Fiserv, Inc.

    Released January 5, 2026

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  • Sarepta Therapeutics to Present at the 44th Annual J.P. Morgan Healthcare Conference

    Sarepta Therapeutics to Present at the 44th Annual J.P. Morgan Healthcare Conference

    CAMBRIDGE, Mass.–(BUSINESS WIRE)–Jan. 5, 2026–
    Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today announced that senior management will present at the 44th Annual J.P. Morgan Healthcare Conference in San Francisco, Calif. on Monday, Jan. 12, 2026 at 12:00 p.m. E.T. / 9:00 a.m. P.T. Following the presentation there will be a Q&A session starting at 12:20 p.m. E.T. / 9:20 a.m. P.T.

    The presentation will be webcast live under the Events & Presentations section of the investor relations section of Sarepta’s website at https://investorrelations.sarepta.com/events-presentations and will be archived there following the presentation for 90 days. Please connect to Sarepta’s website several minutes prior to the start of the broadcast to ensure adequate time for any software download that may be necessary.

    About Sarepta Therapeutics

    Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold leadership positions in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases.

    Internet Posting of Information

    We routinely post information that may be important to investors in the ‘For Investors’ section of our website at www.sarepta.com. We encourage investors and potential investors to consult our website regularly for important information about us.

    Investor:
    Ian Estepan, 617-274-4052

    iestepan@sarepta.com Ryan Wong, 617-800-4112

    rwong@sarepta.com

    Media:
    Tracy Sorrentino, 617-301-8566

    tsorrentino@sarepta.com

    Source: Sarepta Therapeutics, Inc.

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  • MetaVia Reports Positive Statistically Significant Results from Its Phase 1b Clinical Trial of DA-1726 In Metabolic Disease

    MetaVia Reports Positive Statistically Significant Results from Its Phase 1b Clinical Trial of DA-1726 In Metabolic Disease

    Statistically Significant (p=0.006) Waist Circumference Reduction of 9.8 cm at Day 54

    Significant Direct Hepatic Activity with a 23.7% Reduction in Liver Stiffness (VCTE) by Day 54

    Strong Glycemic Response with a 12.3 mg/dL Fasted Glucose Reduction by Day 54

    Robust Weight Loss with 9.1% Reduction (21.2 lbs) by Day 54

    CAMBRIDGE, Mass., Jan. 5, 2026 /PRNewswire/ — MetaVia Inc. (Nasdaq: MTVA), a clinical-stage biotechnology company focused on transforming cardiometabolic diseases, today announced positive statistically significant results from the 8-week (extended from four weeks) non-titrated 48 mg, multiple ascending dose (MAD) cohort of its Phase 1 clinical trial of DA-1726, a novel, dual oxyntomodulin (OXM) analog agonist that functions as a glucagon-like peptide-1 receptor (GLP1R) and glucagon receptor (GCGR), for the treatment of obesity. The results show robust early weight loss, statistically significant reductions in waist circumference, strong improvements in glucose control, and meaningful reductions in liver stiffness, alongside a favorable safety and tolerability profile.

    In the non-titrated 48 mg cohort, patients experienced no treatment-related discontinuations, and gastrointestinal events were mild to moderate in severity. By Day 26, patients receiving DA-1726 achieved a statistically significant average weight reduction of 6.1% (14.6 lbs.) (p=0.003) and a statistically significant decrease in waist circumference of 5.8 cm (2.3 inches) (p=0.006). These improvements deepened through Day 54, with an average weight loss of 9.1% (21.2 lbs.) and a statistically significant 9.8 cm (3.8 inch) (p=0.022) reduction in waist circumference. Patients also demonstrated a 12.3 mg/dL improvement in fasted glucose from a baseline of 105.3 mg/dL by Day 54. In addition, vibration-controlled transient elastography (VCTE) indicated a 23.7% reduction in liver stiffness from a baseline of 5.9 kPa, suggesting a significant direct hepatic effect from DA-1726.

    “Extending DA-1726 administration to a full eight weeks at the non-titrated 48 mg dose has provided us with extremely encouraging insights,” said Hyung Heon Kim, president and chief executive officer of MetaVia. “Patients in this cohort achieved a statistically significant 6.1% weight loss by Day 26 and 9.1% by Day 54, along with reductions in waist circumference of 5.8 cm and 9.8 cm at those same time points. We believe the statistically significant waist reductions reflect the glucagon component of DA-1726, which may contribute to deeper visceral fat loss than GLP-1 agonists alone. Combined with a favorable tolerability profile with no treatment-related discontinuations, these results highlight DA-1726’s differentiated potential to be a best-in-class treatment option.”

    “We also observed meaningful metabolic improvements, including a 12.3 mg/dL reduction in fasted glucose and early HbA1c benefits, such as a drop from 6.0% to 5.5% by day 54, in a prediabetic subject. These findings are especially important because the vast majority of people with obesity—ranging from 70% to 80%—have diabetes or prediabetes, and diabetic patients typically receive broader insurance coverage for anti-obesity therapies. DA-1726 has the potential to be the most effective GLP-1/glucagon dual agonist in development that has demonstrated glucose lowering without elevations, which may offer both clinical and reimbursement advantages. Because VCTE is the leading noninvasive tool for liver stiffness assessment and is recognized by the FDA as a biomarker in MASH development, seeing a 23.7% reduction in only eight weeks underscores the hepatic potential of DA-1726. Taken together, the data reinforce our view that DA-1726 has best-in-class potential, delivering a compelling balance of weight loss, metabolic improvement, direct hepatic benefit, and tolerability as we advance toward later-stage development.”

    Mr. Kim added, “Looking ahead, our planned 16-week titration studies—to 48 mg in a single step and to 64 mg using a two-step regimen—reflect our confidence in DA-1726’s tolerability and our expectation that it will compare favorably to the slower, more restrictive titration schedules required by today’s GLP-1 drugs. We believe this represents a key competitive advantage. With results expected in the fourth quarter of 2026, we are well positioned to unlock further value creation as we continue advancing DA-1726 toward later-stage development.”

    The Phase 1 trial was a randomized, double-blind, placebo-controlled study designed to evaluate the safety, tolerability, PK, and pharmacodynamics (PD) of single and multiple ascending doses of DA-1726 in obese but otherwise healthy adults with a body mass index (BMI) of 30–45 kg/m². Nine subjects in each cohort were randomized in a 6:3 ratio, with each subject receiving either 4 weekly administrations of DA-1726 or placebo. The extended dosing cohort added 4 weekly administrations of DA-1726 or placebo for a total of 8 weeks of exposure. The primary objective was to assess safety and tolerability based on adverse events (AEs), serious adverse events (SAEs), treatment-emergent events (TAEs), and discontinuations. Secondary endpoints included the PK of DA-1726, assessed via serum concentrations over time and metabolite profiling at the highest doses of DA-1726. Exploratory endpoints included the effect of DA-1726 on metabolic parameters, cardiac parameters, fasting lipid levels, body weight, waist circumference and body mass index (BMI), among others.

    For more information on this clinical trial, please visit: www.clinicaltrials.gov NCT06252220.

    About DA-1726
    DA-1726 is a novel oxyntomodulin (OXM) analogue functioning as a GLP1R/GCGR dual agonist for the treatment of obesity and Metabolic Dysfunction-Associated Steatohepatitis (MASH) that is to be administered once weekly subcutaneously. DA-1726 acts as a dual agonist of GLP-1 receptors (GLP1R) and glucagon receptors (GCGR), leading to weight loss through reduced appetite and increased energy expenditure. DA-1726 has a well understood mechanism and, in pre-clinical mice models, resulted in improved weight loss compared to semaglutide (Wegovy®). Additionally, in pre-clinical mouse models, DA-1726 elicited similar weight reduction, while consuming more food, compared to tirzepatide (Zepbound®) and survodutide (a drug with the same MOA), while also preserving lean body mass and demonstrating improved lipid-lowering effects compared to survodutide. In the Phase 1 multiple ascending dose (MAD) trial in obesity, the 32 mg dose of DA-1726 demonstrated best-in-class potential for weight loss, glucose control, and waist circumference reduction.

    About MetaVia
    MetaVia Inc. is a clinical-stage biotechnology company focused on transforming cardiometabolic diseases. The company is currently developing DA-1726 for the treatment of obesity, and is developing vanoglipel (DA-1241) for the treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH). DA-1726 is a novel oxyntomodulin (OXM) analogue that functions as a glucagon-like peptide-1 receptor (GLP1R) and glucagon receptor (GCGR) dual agonist. OXM is a naturally-occurring gut hormone that activates GLP1R and GCGR, thereby decreasing food intake while increasing energy expenditure, thus potentially resulting in superior body weight loss compared to selective GLP1R agonists. In a Phase 1 multiple ascending dose (MAD) trial in obesity, DA-1726 demonstrated best-in-class potential for weight loss, glucose control, and waist reduction. Vanoglipel is a novel G-protein-coupled receptor 119 (GPR119) agonist that promotes the release of key gut peptides GLP-1, GIP, and PYY. In pre-clinical studies, vanoglipel demonstrated a positive effect on liver inflammation, lipid metabolism, weight loss, and glucose metabolism, reducing hepatic steatosis, hepatic inflammation, and liver fibrosis, while also improving glucose control. In a Phase 2a clinical study, vanoglipel demonstrated direct hepatic action in addition to its glucose lowering effects.

    For more information, please visit www.metaviatx.com.

    Forward Looking Statements

    Certain statements in this press release may be considered forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “believes”, “expects”, “anticipates”, “may”, “will”, “should”, “seeks”, “approximately”, “potential”, “intends”, “projects”, “plans”, “estimates” or the negative of these words or other comparable terminology (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements, which include, among other statements, statements regarding the timing and release of data related to the company’s planned 16-week titration studies. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including, without limitation, those risks associated with MetaVia’s ability to execute on its commercial strategy; MetaVia’s expectations regarding the sufficiency of its existing cash on hand to fund MetaVia’s operations; the timeline for regulatory submissions; the ability to obtain regulatory approval through the development steps of MetaVia’s current and future product candidates; the ability to realize the benefits of the license agreement with Dong-A ST Co. Ltd., including the impact on future financial and operating results of MetaVia; the cooperation of MetaVia’s contract manufacturers, clinical study partners and others involved in the development of MetaVia’s current and future product candidates; potential negative interactions between MetaVia’s product candidates and any other products with which they are combined for treatment; MetaVia’s ability to initiate and complete clinical trials on a timely basis; MetaVia’s ability to recruit subjects for its clinical trials; whether MetaVia receives results from MetaVia’s clinical trials that are consistent with the results of pre-clinical and previous clinical trials; impact of costs related to the license agreement, known and unknown, including costs of any litigation or regulatory actions relating to the license agreement; the effects of changes in applicable laws or regulations; the effects of changes to MetaVia’s stock price on the terms of the license agreement and any future fundraising; and other risks and uncertainties described in MetaVia’s filings with the Securities and Exchange Commission, including MetaVia’s most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q. Forward-looking statements speak only as of the date when made. MetaVia does not assume any obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

    Contacts:

    MetaVia
    Marshall H. Woodworth
    Chief Financial Officer
    +1-857-299-1033
    [email protected]

    Rx Communications Group
    Michael Miller
    +1-917-633-6086
    [email protected]

    SOURCE MetaVia Inc.

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  • Mobilizing Capital for Regenerative Agriculture and Nature: From Metrics to Investment Decisions

    Mobilizing Capital for Regenerative Agriculture and Nature: From Metrics to Investment Decisions

    Sustainability is increasingly proving to be a driver of corporate financial performance. Recent analysis from WBCSD shows positive financial returns, with reported ROI ranging from 2x to 14x, especially in sectors like food and beverage. Companies with strong sustainability practices often benefit from a lower cost of capital, while those that fail to act face tangible financial penalties, including EBITDA reductions of 5% to 25%. In agrifood value chains, there is growing evidence of the linkage between climate, nature, and equity outcomes and management of material risks and opportunities that shape long-term value and resilience. In October 2025, WBCSD and Principles for Responsible Investment brought together a group of agrifood companies and investors to discuss how shared metrics can better support decision-making for both corporates and investors and drive more coordinated action across the sector. The article highlights the main insights fromthe dialogue.

    WBCSD Drives Convergence on Environmental and Socioeconomic Metrics for Decision-Making 

    Through WBCSD and OP2B, 52 companies and 33 partner organizations representing over 1,100 businesses have converged on core outcomes and indicators for regenerative agriculture and sustainable land use. This is a holistic set of environmental, social, and economic outcomes and indicators, in alignment with leading standards and areas of convergence. This links corporate, policy and investor decision-making with actions at the farm and landscape levels, for instance through the SAI Platform.   

    WBCSD supports the recognition of sustainable corporate performance by financial markets to ensure that companies demonstrating strong sustainability outcomes are financially rewarded. An effective corporate performance and accountability system is key to this; harmonized standards, metrics and measurement approaches that companies and investors can use for decision-making. By translating these outcomes into comparable data, metrics empower financial market actors to make informed decisions that align financial performance with sustainability goals. The growing momentum behind mandatory reporting further accelerates the adoption of standardized disclosures, ensuring transparency and consistency across markets.

    Investors are Increasingly Using and Interpreting Sustainability Metrics Through a Financial and Strategic Lens

    Regenerative agriculture is emerging as a key focus area for investors as a means to enhance supply chain resilience, protect land value, and monetize ecosystem services. Investors are therefore seeking metrics that are consistent, comparable, and outcome-focused and that help them translate sustainability performance into measurable financial terms, such as improved returns, lower risk, and more stable long-term supply chains. Beyond indicators like soil health and carbon sequestration, investors are also looking for metrics that capture broader biodiversity and social benefits to better understand the full scope of value creation.  

    Currently, there’s a lack of recognized sector pathways or benchmarks, making it premature for investors to set performance thresholds. Instead, they’re assessing whether companies use comprehensive metrics aligned with recognized initiatives like those from WBCSD.

    – Bethany Davies, Principles for Responsible Investment 

    Tikehau Capital shared a practical example of an impact measurement framework to evaluate corporate performance on regenerative agriculture. In partnership with AXA and Unilever, the fund integrates cross-sector expertise to identify investable opportunities. Its framework measures both environmental and social outcomes, including biodiversity, water, carbon, nutrition, and health, using outcome-based indicators such as the number of hectares managed under regenerative practices. 

    Overcoming Key Bottlenecks to Investor Action 

    Although investors recognized the value of the WBCSD outcomes in driving consistent, scalable, and outcome-based assessment, several barriers continue to limit their broader integration into investment practice. 

    Low corporate reporting rates and fragmented disclosure frameworks limit investor benchmarking. 

    Inconsistent reporting frameworks and limited disclosure from companies limit investors’ ability to assess performance and allocate capital effectively. Greater harmonization and broader participation in reporting are needed to ensure interoperability, reduce duplication, and enhance comparability. Continued corporate engagement in metric development should be leveraged to accelerate adoption and build more robust datasets for benchmarking. 

    From an investor standpoint, disclosures are important because they show how a company is adopting its strategy on regenerative agriculture, or any other solution for that matter.

    – Sajeev Mohankumar, FAIRR Initiative 

    Lack of recognized sectoral pathways or benchmarks. 

    Without agreed definitions of what good looks like in regenerative agriculture, investors rely heavily on qualitative indicators, such as alignment with outcomes through WBCSD. There is a need to establish clear, sector-specific benchmarks and combine metric evaluation with company engagement to validate results, strengthen data reliability, and encourage consistent disclosure. 

    Disconnect between sustainability goals and executive incentives. 

    Senior leaders are often rewarded based on short-term financial performance rather than long-term sustainability outcomes. To shift this dynamic, stronger evidence linking regenerative outcomes to tangible business outcomes such as resilience, risk mitigation, supply chain security, and long-term productivity is needed. Embedding these outcomes into incentive structures can help align corporate priorities with sustainability objectives. 

    Limited guidance on applying and interpreting metrics. 

    Clear, science-based guidance is needed to support consistent use of metrics and interpretation of results. This includes defining robust baselines and sector-specific thresholds to improve the credibility and usability of reported data for both companies and investors. 

    Call to Action 

    Overcoming these barriers will be key to scaling investment in regenerative agriculture and turning ambition into a measurable impact. WBCSD continues to work with investors, companies, and standard-setting bodies to build alignment across frameworks, and support the adoption and implementation of consistent, comparable, and decision-useful metrics.  

    For more information about the agriculture and food metrics we will take into 2025, please reach out to Kate Newbury-Hyde (newbury@wbcsd.org) or Ludmila Cmarkova (cmarkova@wbcsd.org). To engage in the work, ensure you are part of WBCSD’s Agriculture and Food Pathway.

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