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  • New Brain Disease Database Could Aid Research

    New Brain Disease Database Could Aid Research

    Some of the biggest recent advances in diagnosing and treating neurodegenerative diseases center on biomarkers, the proteins found in blood and cerebrospinal fluid that can reveal when a certain disease exists, sometimes even before symptoms occur.

    A new database — the largest-ever collection of data on proteins linked to brain diseases like Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS) — is expected to help scientists speed up the search for effective treatments. 

    “The scale and depth of the dataset … make it an extraordinary resource with the potential to transform how we study, detect and treat neurodegenerative diseases,” said Simon Lovestone, global head of discovery and translational research for Janssen Neuroscience at Johnson & Johnson, in a news release.

    Backed by Gates Ventures and Johnson & Johnson, the Global Neurodegeneration Proteomics Consortium (GNPC) consists of 23 institutions that have contributed neurodegenerative disease data on biomarkers from 35,000 blood and cerebrospinal fluid samples from across the world. The information will be available to researchers for free.

    The GNPC is a perfect example of what is possible when scientists around the world work together, says Bill Gates, the founder of Gates Ventures, who teamed up with Johnson & Johnson to form the consortium in 2023.

    “The results have exceeded even our wildest expectations,” Gates wrote in an editorial published July 15 in Nature Medicine, noting that consortium members studied 250 million protein measurements from blood and spinal fluid in its first year.

    The value of the data

    Around 2007, researchers showed that they could see protein changes in blood that reflect disease. But there’s been a lack of access to large amounts of high-quality, standardized data for scientists to use, says Carlos Cruchaga, a genomicist and director of the NeuroGenomics and Informatics Center at Washington University in St. Louis, who used GNPC data in his research.

    The GNPC gives access to protein data spanning multiple neurodegenerative diseases, Cruchaga says. This can be especially helpful to understand similarities and patterns of neurodegeneration, which is still not fully understood.

    Another advantage of the GNPC data is that researchers won’t have to start studies from scratch, collecting their own samples to conduct those studies. “That is going to open the door for new biomarkers and diagnostic tools,” Cruchaga says.

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  • Retail investors turn from AI and put stocks at risk, trading desk says

    Retail investors turn from AI and put stocks at risk, trading desk says

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  • Sarepta Therapeutics Announces Strategic Restructuring and Pipeline Prioritization Plan to Maintain Long-term, Sustainable Growth and Provides Update on ELEVIDYS Label – Sarepta Therapeutics

    1. Sarepta Therapeutics Announces Strategic Restructuring and Pipeline Prioritization Plan to Maintain Long-term, Sustainable Growth and Provides Update on ELEVIDYS Label  Sarepta Therapeutics
    2. Sarepta to cut 500 jobs after gene therapy setback  TradingView
    3. Sarepta Therapeutics Halts ELEVIDYS Shipments for Non-Ambulatory DMD Patients  Yahoo Finance
    4. Sarepta to cut 36% of workforce amid strategic restructuring  Investing.com
    5. Sarepta Therapeutics makes layoffs after gene therapy setback  The Business Journals

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  • Largest piece of Mars on Earth sells for over $5m at New York auction | Mars

    Largest piece of Mars on Earth sells for over $5m at New York auction | Mars

    The largest piece of Mars ever found on Earth was sold for just over $5m at an auction of rare geological and archaeological objects in New York on Wednesday, while a juvenile dinosaur skeleton went for more than $30m.

    The 54-pound (25kg) rock named NWA 16788 was discovered in the Sahara desert in Niger by a meteorite hunter in November 2023, after having been blown off the surface of Mars by a massive asteroid strike and traveling 140m miles (225m km) to Earth, according to Sotheby’s. The estimated sale price before the auction was $2m to $4m.

    The identity of the buyer was not immediately disclosed. The final bid was $4.3m. Adding various fees and costs, the official bid price was about $5.3m.

    Two advance bids of $1.9m and $2m were submitted. The live bidding went slower than for many other objects that were sold, with the auctioneer trying to coax more offers and decreasing the $200,000 to $300,000 bid intervals to $100,000 after the proposals hit $4m.

    The red, brown and gray meteorite is about 70% larger than the next largest piece of Mars found on Earth and represents nearly 7% of all the Martian material currently on this planet, Sotheby’s says. It measures nearly 15in by 11in by 6in (375mm by 279mm by 152mm).

    It was also a rare find. There are only 400 Martian meteorites out of the more than 77,000 officially recognized meteorites found on Earth, the auction house says.

    “This Martian meteorite is the largest piece of Mars we have ever found by a long shot,” Cassandra Hatton, vice-chairman for science and natural history at Sotheby’s, said in an interview before the auction. “So it’s more than double the size of what we previously thought was the largest piece of Mars.”

    It is not clear exactly when the meteorite was blasted off the surface of Mars, but testing showed it probably happened in recent years, Sotheby’s says.

    Hatton said a specialized lab examined a small piece of the red planet remnant and confirmed it was from Mars. It was compared with the distinct chemical composition of Martian meteorites discovered during the Viking spacecraft that landed on Mars in 1976, she said.

    The examination found that it was an “olivine-microgabbroic shergottite”, a type of Martian rock formed from the slow cooling of Martian magma. It has a coarse-grained texture and contains the minerals pyroxene and olivine, Sotheby’s says.

    It also has a glassy surface, probably due to the high heat that burned it when it fell through Earth’s atmosphere, Hatton said. “So that was their first clue that this wasn’t just some big rock on the ground,” she said.

    The meteorite previously was on display at the Italian Space Agency in Rome. Sotheby’s did not disclose the owner.

    The juvenile Ceratosaurus nasicornis skeleton is displayed at Sotheby’s in New York. Photograph: Eduardo Muñoz/Reuters

    Bidding for the juvenile Ceratosaurus nasicornis dinosaur skeleton started with a high advance bid of $6m, then escalated with offers $500,000 higher than the last and later $1m higher than the last before ending at $26m. The official sale price was $30.5m with fees and costs. The original estimate was $4m to $6m.

    Parts of the skeleton were found in 1996 near Laramie, Wyoming, at Bone Cabin Quarry, a goldmine for dinosaur bones. It is more than 6ft (2 meters) tall and nearly 11ft long.

    Specialists assembled nearly 140 fossil bones with some sculpted materials to recreate the skeleton and mounted it so it is ready to exhibit, Sotheby’s says.

    The skeleton is believed to be from the late Jurassic period, about 150m years ago, Sotheby’s says.

    Ceratosaurus dinosaurs were bipeds with short arms that appear similar to the Tyrannosaurus rex, but smaller. Ceratosaurus dinosaurs could grow up to 25ft long, while the Tyrannosaurs rex could be 40ft long.

    The skeleton was acquired last year by Fossilogic, a Utah-based fossil preparation and mounting company.

    Wednesday’s auction was part of Sotheby’s Geek Week 2025 and featured 122 items, including other meteorites, fossils and gem-quality minerals.

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  • Virtuos, the studio behind Oblivion Remastered, is reportedly laying off staff

    Virtuos, the studio behind Oblivion Remastered, is reportedly laying off staff

    Virtuos, the studio that developed The Elder Scrolls 4: Oblivion Remastered, is reportedly laying off seven percent of its staff, or around 300 employees, according to Gauthier Andres, a reporter and co-founder at Origami. The studio has provided support on a number of large game projects — including a recent patch for Cyberpunk 2077 — and employs over 4,200 people across the US, Europe and Asia.

    The brunt of the layoffs are happening to Virtuos employees in China, where Andres reports that around 200 positions are being eliminated. Virtuos’ teams in France, who were primarily responsible for the surprise release of Oblivion Remastered back in April, are also expected to be impacted.

    Besides reviving Bethesda classics, Virtuos has contributed work to the upcoming Metal Gear Solid Delta: Snake Eater and several ongoing live service games, like Dune: Awakening and Sea of Thieves. Nothing about the company’s output or the critical reception of its games would suggest it needs to conduct layoffs, but that reflects the current precarious state of the games industry. Even having theoretically steady work doing post-release support and game remasters isn’t enough.

    Virtuos’ layoffs follows the sweeping cuts Microsoft made to its Xbox division in early July. Microsoft reportedly cancelled games, like Rare’s long-in-development Everwild, and shutdown whole studios, like The Initiative. Romero Games, which had an unannounced funding deal with Microsoft, was also forced to cancel its current project, though it hopes to find a new publishing partner.

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  • Trial begins as Meta investors, Zuckerberg square off over alleged privacy violations – Reuters

    1. Trial begins as Meta investors, Zuckerberg square off over alleged privacy violations  Reuters
    2. Meta Investors File $8B Caremark Lawsuit Against Zuckerberg Over Facebook Privacy Violations  techi.com
    3. Canada Approves Major Oilfield Merger with Conditions to Protect Competition  PYMNTS.com
    4. Meta CEO Mark Zuckerberg expected to testify in $8 billion Facebook privacy lawsuit  WDHN
    5. Zuckerberg Faces Meta Shareholder Data Scandal Trial  MarketScreener

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  • In cosmic first, scientists see planets take shape around a star to form solar system – France 24

    1. In cosmic first, scientists see planets take shape around a star to form solar system  France 24
    2. Astronomers observe birth of a solar system for first time  Dawn
    3. Refractory solid condensation detected in an embedded protoplanetary disk  Nature
    4. Astronomers capture rocky planet birth around young Sun-like star in unprecedented detail  India TV News
    5. Astronomers capture the birth of planets around a baby sun outside our solar system  Longview Daily News

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  • Elsa Pataky sets record straight on marriage troubles with Chris Hemsworth

    Elsa Pataky sets record straight on marriage troubles with Chris Hemsworth



    Elsa Pataky sets record straight on marriage troubles with Chris Hemsworth

    Elsa Pataky put rumours of marital troubles to rest with a candid move during her separation from husband Chris Hemsworth.

    On Wednesday, July 15, the Fast & Furious star shared behind-the-scenes moments from the set of her upcoming Spanish TV series, Matices, on Instagram.

    “Working in Spain again with my favourites! [red heart emoji]” she captioned the post, which featured her enjoying her time on the set with her colleagues.

    It appears that Pataky’s time away from Hemsworth is simply the result of work obligations.

    The actress, 48, is currently filming in her native Spain, where the series is expected to premiere in May.

    Meanwhile, Hemsworth, 41, made a solo appearance at Wimbledon over the weekend, attending Evian’s VIP suite on the final day of the tournament.

    The Thor star was seen smiling in photos with Dame Helen Mirren and rapper Stormzy.

    Marriage trouble rumours started to swirl, as the couple, married for over a decade, haven’t been photographed together recently and have taken separate trips.

    The Avengers actor travel to Hossegor, France, with longtime friend and personal trainer Luke Zocchi, and Elsa stays back in Spain for both work and downtime.

    While the pair has yet to directly address the rumours, Elsa’s latest post appeared to be sending a subtle message: the distance is professional, not personal.

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  • Maximizing Emerging Trends in Locally Led AI Solutions for Climate Action – SDG Knowledge Hub

    1. Maximizing Emerging Trends in Locally Led AI Solutions for Climate Action  SDG Knowledge Hub
    2. AI in Environmental Sustainability Market Thrives with  openPR.com
    3. Study Shows How AI Can Cut Over 5 Billion Tons of Carbon Emissions in 3 Key Sectors  CarbonCredits.com
    4. AI Innovation Meets Climate Action — Where Technology Powers Grassroots Solutions  CSRwire

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  • Gwyneth Paltrow confesses enjoying intimacy with Jennifer Lopez’s ex Ben Affleck

    Gwyneth Paltrow confesses enjoying intimacy with Jennifer Lopez’s ex Ben Affleck

    Photo: Gwyneth Paltrow on passionate romance with Jennifer Lopez’s ex Ben Affleck

    Gwyneth Paltrow was reportedly charmed by Ben Affleck’s intelligence.

    As fans will be aware, the actress called off her engagement with Brad Pitt and started dating Jennifer Lopez’s ex in 1997.

    In her bombshell book titled Gwyneth: The Biography by Amy Odell, the acting sensation weighed in on her time with the father of three, who was then struggling with alcoholism.

    The memoir addressed the time spent by Gwyneth with Ben as a journey of desire and passion.

    An excerpt from the book revealed, “Affleck was struggling with alcoholism and a gambling habit around the time he met Gwyneth, who was attracted to his intellect.”

    It also mentioned that not everyone was a fan of the chemistry between the two, specially Gwyneth’s pals were concerned for her.

    “ Her friends had reservations about him, because he didn’t always reciprocate her affection,” it continued.

    Reportedly, it was because Ben “at times seemed more interested in playing video games with the guys at his house than being with Gwyneth.”

    “ She spoke openly about how much she enjoyed their (intimate) life. She told Aucoin one day that she loved when Affleck [engaged in a certain (intimate) act],” the book containing many bombshells continued.  


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