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  • BBC chief faces questions over failure to pull live stream of Bob Vylan IDF chant | BBC

    BBC chief faces questions over failure to pull live stream of Bob Vylan IDF chant | BBC

    The BBC’s director general is facing questions over why he did not pull the live-stream footage of Bob Vylan after being informed during a visit to Glastonbury of the chants calling for the death of Israeli soldiers.

    Tim Davie, who has led the BBC for nearly five years, was told of the chanting of “death, death to the IDF [Israel Defense Forces]” by Bob Vylan’s vocalist after it had been broadcast live on the BBC on Saturday afternoon.

    He was at the festival in Somerset on a visit to meet presenters and production staff when he was told that the chanting had been aired.

    “At that point he was clear it should not feature in any other Glastonbury coverage,” a BBC spokesperson said. The decision was taken that the footage of Bob Vylan would not be made available on the broadcaster’s on-demand service.

    But the live stream of the West Holts stage where Bob Vylan performed continued to be aired for a number of hours after the incident, allowing anyone watching the broadcast live to rewind it.

    The band put out a statement on Tuesday saying they were “not for the death of Jews, Arabs or any other race or group”. In an Instagram post they said: “Today a good many people would have you believe a punk band is the number one threat to world peace. Last week it was a Palestine pressure group, the week before that it was another band.

    “We are not for the death of Jews, Arabs or any other race or group of people. We are for the dismantling of a violent military machine. A machine whose own soldiers were told to use unnecessary lethal force against innocent civilians waiting for aid. A machine that has destroyed much of Gaza.

    “We, like those in the spotlight before us, are not the story. We are a distraction from the story and whatever sanctions we receive will be a distraction.”

    The Irish rap trio Kneecap, including the member Liam Óg Ó hAnnaidh, who appeared in court earlier this month charged with a terror offence, took to the stage directly after Bob Vylan and led chants of “Free Palestine”. Their performance was not livestreamed.

    The BBC did not offer any explanation for the decision made after consultation with Davie.

    The broadcaster has already issued an apology on behalf of its staff running the live operations for failing to pull away from the performance of Bob Vylan during the chanting, describing the scenes as “utterly unacceptable”.

    A BBC spokesperson said: “The director general was informed of the incident after the performance and at that point he was clear it should not feature in any other Glastonbury coverage.”

    Sir Ephraim Mirvis, the chief rabbi, said the incident was a “national shame”.

    He wrote on X: “The airing of vile Jew-hatred at Glastonbury and the BBC’s belated and mishandled response, brings confidence in our national broadcaster’s ability to treat antisemitism seriously to a new low.

    “It should trouble all decent people that now, one need only couch their outright incitement to violence and hatred as edgy political commentary, for ordinary people to not only fail to see it for what it is, but also to cheer it, chant it and celebrate it. Toxic Jew-hatred is a threat to our entire society.”

    Avon and Somerset police said on Monday they had launched an investigation into both performances after reviewing video footage and audio recordings. A senior detective has been appointed to lead the investigation.

    A police spokesperson said: “This has been recorded as a public order incident at this time while our inquiries are at an early stage.

    “The investigation will be evidence-led and will closely consider all appropriate legislation, including relating to hate crimes.”

    Jonathan Reynolds, the business secretary, said he had been shocked by the behaviour of some at the festival.

    He told BBC Radio 4’s Today: “There are some lessons, I think, for broadcasters from this, but let’s also not shy away from the issue, which is people in a crowd glorifying violence.

    “I don’t think it’s something we’d associate with any music festival, but it’s a wider societal problem.

    “It’s possible, I think, to be completely concerned by the scenes in Gaza and not stray into the kind of behaviour and endorsement that we saw with that performance.

    “And I’m deeply shocked to be honest, that people would even not realise what I think they’re participating in when they do that.”

    Writing on Instagram, Pascal Robinson-Foster, who performs under the name Bob Vylan, wrote: “Teaching our children to speak up for the change they want and need is the only way that we make this world a better place …

    “Let us display to them loudly and visibly the right thing to when we want and need change. Let them see us marching in the streets, campaigning on ground level, organising online and shouting about it on any and every stage that we are offered.”

    The band is due to perform on 5 and 6 July at Victoria Warehouse in Manchester. The Jewish Representative Council of Greater Manchester & Region has urged the venue to call off the show.

    A Greater Manchester police spokesperson said: “We are aware that Bob Vylan will be performing in Manchester at the weekend.

    “Greater Manchester is famous for promoting music of all genres and we welcome all artists to our region. However, we will act immediately on any reports of commentary or actions that could be breaking the law.”

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  • SAS places record order for 55 E195-E2 to power growth and regional connectivity

    SAS places record order for 55 E195-E2 to power growth and regional connectivity

    Scandinavian Airlines (SAS) has entered into an agreement to acquire 45 Embraer (NYSE: ERJ; B3: EMBR3) E195-E2 aircraft, with purchase rights for an additional 10 aircraft — the largest SAS jet order direct from a manufacturer since 1996. This milestone agreement supports SAS’ long-term fleet renewal strategy, which is focused on increasing efficiency, reducing emissions, and unlocking future growth opportunities from its global hub in Copenhagen as well as across its Scandinavian and international network.

    The first aircraft deliveries from Embraer are scheduled to begin in late 2027, with further deliveries extending over approximately four years. Excluding purchase rights, the value for the order is approximately US$4 billion.

    “This is a defining moment for SAS,” says Anko van der Werff, President & CEO, SAS. “The Embraer E195-E2 is a world-class aircraft, combining outstanding performance with excellent fuel efficiency and comfort. This aircraft is key to enabling future growth and improved connectivity across Scandinavia and beyond. We’ve taken the time to make the right decision — and this major investment reflects our confidence in the future and the strength of the agreement we’ve secured.”

    The E195-E2 will play a vital role in optimizing SAS’ operations and enhancing connectivity across Scandinavia and Europe. Its size and range are ideally suited to complement SAS’ existing fleet and route structure, allowing for more frequencies, better network flexibility, and lower trip costs.

    Built for the future of sustainable aviation
    “The E2 is central to our strategy to build a modern, efficient fleet with strong performance. It enables us to serve more routes with lower emissions, better economics, and a premium experience for our passengers,” adds Van der Werff. “Together with Embraer, we are setting the course for the next chapter of SAS.”

    The E2 family of aircraft has already been tested with 100% sustainable aviation fuel (SAF) and is in the process of being fully certified to fly on 100% SAF in the foreseeable future. Today blends of up to 50% SAF are already achievable.

    Arjan Meijer, President and CEO Embraer Commercial Aviation, says: “We are thrilled to deepen our partnership with SAS through this landmark deal. The E2 is the quietest single aisle jet available today – 29% more fuel efficient and with a 62% reduction in noise footprint over the previous generation jet, the E195-E2 is a game-changer in terms of efficiency, performance, and passenger comfort. We are confident that these aircraft will play a crucial role in SAS’ fleet renewal and expansion strategy, supporting their ambitious growth plans and enhancing their operational capabilities.”

    Powered by Pratt & Whitney’s advanced PW1900G GTF engines, the E195-E2 delivers double-digit reductions in fuel burn, emissions, and noise compared to previous-generation aircraft. The new fleet will help lower SAS’ environmental footprint and reinforce its position as a driving force in reducing aviation’s climate impact.

    This order marks another step in SAS’ future-focused transformation, supporting a modernized fleet and improved travel experience. SAS continues to strengthen its overall network and international reach while enhancing connectivity between regional cities and global destinations through more seamless and sustainable operations.

    This order was facilitated by the support of Skyworks Holding.

    SAS was recently ranked as the world’s most punctual airline*, a testament to the company’s commitment to operational excellence and reliability.

    *SAS ranked No. 1 out of 660 airlines globally for on-time performance in April and May 2025 (source: Cirium).


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  • Why is Musk calling for a new America Party over Trump’s Beautiful Bill? | Donald Trump News

    Why is Musk calling for a new America Party over Trump’s Beautiful Bill? | Donald Trump News

    Billionaire Elon Musk said on Monday that he would form a new political party in the United States if a Republican-leaning Congress passes President Donald Trump’s “One Big Beautiful Bill”, which proposes tax breaks and funding cuts for healthcare and food programmes.

    Musk has voiced criticism of the bill on multiple occasions over the past month and began suggesting the idea of the new party on social media starting early June.

    Here is more about Musk’s reservations about the bill, and about his new proposed party.

    What has Musk said about the America Party?

    Musk has been saying that if the bill is passed, Republicans are no different from Democrats, who are often accused by conservatives of being profligate with spending taxpayers’ dollars.

    The version of the bill that the Senate is discussing at the moment, if passed by both chambers of Congress, would expand the national debt by $3.3 trillion between 2025 and 2034. The current US national debt stands at more than $36 trillion.

    “If this insane spending bill passes, the America Party will be formed the next day,” Musk posted on his social media platform, X, on Monday.

    “Our country needs an alternative to the Democrat-Republican uniparty so that the people actually have a VOICE.”

    In an earlier post, Musk wrote: “It is obvious with the insane spending of this bill, which increases the debt ceiling by a record FIVE TRILLION DOLLARS that we live in a one-party country – the PORKY PIG PARTY!!”

    The debt ceiling, set by the US Congress, determines the upper limit to the amount of money that the US Treasury can borrow. The current debt limit is $36.1 trillion.

    Why does Musk oppose the bill?

    Once a key aide and major campaign donor for Trump, Musk had a public online falling out with the president in June over his criticism of the bill.

    On June 3, Musk wrote on X: “I’m sorry, but I just can’t stand it anymore. This massive, outrageous, pork-filled Congressional spending bill is a disgusting abomination.”

    Musk alleged that Trump was linked to disgraced financier Jeffrey Epstein in a now-deleted post on X. However, Trump and Musk seemed to have reached a detente when Trump told reporters that he wished Musk well while the latter wrote on X on June 11 that he had gone “too far” in his criticism of the US president.

    However, since then, Musk has argued in a series of online posts that the bill would increase the debt ceiling, “bankrupt America”, and “destroy millions of jobs in America”.

    Musk owns the electric vehicle (EV) manufacturer Tesla. The current version of the bill, with amendments made by the Senate, seeks to end the tax credit for purchases of EVs worth up to $7,500, starting on September 30. This could reduce the consumer demand for EVs in the US.

    What is the America Party that Musk proposed?

    On June 5, Musk posted a poll on his X account, asking his followers: “Is it time to create a new political party in America that actually represents the 80 percent in the middle?”

    While social media polls are known to be nonrepresentative of broader public sentiment, 5.6 million people voted on the poll, and 80.4 percent responded with “yes”. Since then, Musk has repeatedly reposted the poll result, citing it as evidence that most Americans want a new party to be formed.

    “Musk believes that 80 percent of Americans are unhappy with the two major parties and are not being represented,” Natasha Lindstaedt, a professor at the Department of Government, the University of Essex, told Al Jazeera.

    While that number might not reflect the wider American public, it does point to a trend in the electorate; according to a Gallup poll from 2024, 43 percent of Americans identified as independent, 28 percent identified as Republican and 28 percent identified as Democrat. In other words, more Americans identify as independent than as either Democrat or Republican.

    One of Musk’s followers replied to a post on X with an image with the text “America Party”. The world’s richest man responded: “‘America Party’ has a nice ring to it. The party that actually represents America!”

    How real is Musk’s threat?

    Experts say Musk, whose net worth is $363bn as of Monday according to the Bloomberg Billionaires Index, would realistically be able to fund a third party in the US. However, it is still unclear whether he would go ahead with his plan or whether his party would have a significant effect on US elections.

    “Musk certainly has the financial power to back a third party that could be very disruptive to the Republican Party, but it’s not certain if Musk will take on this risk,” Lindstaedt said.

    Lindstaedt recalled how earlier this month, Musk backed down from his criticism of Trump on X. “If we take him at his word, he could spend hundreds of millions on this project,” she added.

    “Musk has been ramping up his criticism of the bill lately, and he may find specific legislators [particularly from the House] would be willing to defect if their constituencies are more negatively affected by Trump’s policies,” Lindstaedt said, referring to the House of Representatives. “He will also have the attention of fiscal hawks in particular.”

    Lindstaedt added that among American voters, there is a “huge appetite” for a third party.

    “The bill will leave the US spending hundreds of billions just in the interest, and the more Americans understand this, the more they may want to flock to something different. US public frustration with the traditional parties is at an all-time high, and Musk may be able to capitalise on this.”

    However, Thomas Gift, an associate professor of political science in the UCL School of Public Policy in London, said it was unclear whether Musk is serious and suggested that the barriers to breaking the Republican-Democrat duopoly are hard to scale for anyone.

    “This is Elon Musk bluffing,” he told Al Jazeera. “He knows as well as anyone that the power of party machines behind Democrats and Republicans is too much to surmount.”

    Gift added that while forming a party is possible, “winning seats in Congress or the White House is another matter entirely”.

    “At best, a third party will have little impact on US elections; at worst, it will play ‘spoiler’, taking votes from one of the two parties and de facto giving it to another.”

    What has Trump said about Musk?

    On Monday, Trump posted on his Truth Social platform, saying: “Elon Musk knew, long before he so strongly Endorsed me for President, that I was strongly against the EV Mandate. Electric cars are fine, but not everyone should be forced to own one.”

    Trump added: “Without subsidies, Elon would probably have to close up shop and head back home to South Africa. No more Rocket launches, Satellites, or Electric Car Production, and our Country would save a FORTUNE.”

    “Perhaps we should have DOGE take a good, hard, look at this? BIG MONEY TO BE SAVED!!!” Trump wrote, referring to the Department of Government Efficiency, an advisory body aimed at boosting government efficiency and upgrading Information Technology, that Musk formed and led at the start of Trump’s second administration, before leaving on May 30.

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  • Successful Conservative Management of Aplasia Cutis Congenita in a Preterm Neonate

    Successful Conservative Management of Aplasia Cutis Congenita in a Preterm Neonate


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  • Aftermath of an Israeli air attack on a Gaza cafe | Israel-Palestine conflict News

    Aftermath of an Israeli air attack on a Gaza cafe | Israel-Palestine conflict News

    Israeli forces killed at least 95 people in Gaza on Monday with air raids that left 39 dead at a seaside cafe and gunfire that killed Palestinians trying to get desperately needed food aid, witnesses and health officials said.

    One air raid hit al-Baqa Cafe in Gaza City when it was crowded with women and children, said Ali Abu Ateila, who was inside at the time.

    “Without warning, all of a sudden, a warplane hit the place, shaking it like an earthquake,” he said.

    At least 39 people were killed and dozens were wounded, many critically.

    Among the dead was journalist Ismail Abu Hatab, as well as women and children who had gathered at the cafe.

    The Palestinian Journalists Syndicate said more than 220 journalists had been killed in Gaza since the war began in October 2023.

    The cafe, one of the few businesses to continue operating during the 20-month war, was a gathering spot for residents seeking internet access and a place to charge their phones.

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  • Over 5,000 unaccompanied Afghan children return from Iran: UNICEF – ANI News

    1. Over 5,000 unaccompanied Afghan children return from Iran: UNICEF  ANI News
    2. Over 230,000 Afghans left Iran in June ahead of deadline  Dawn
    3. Nowhere to run: The Afghan refugees caught in Israel’s war on Iran  Al Jazeera
    4. No Safe Return: The Case Against Deporting Afghan Refugees  The Diplomat – Asia-Pacific Current Affairs Magazine
    5. TAWDIKHABARI – Deportation of Afghan Refugees from Iran, Pakistan Discussed  TOLOnews

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  • Shefali Jariwala’s last hour: A deadly price for eternal beauty

    Shefali Jariwala’s last hour: A deadly price for eternal beauty





    Shefali Jariwala’s last hour: A deadly price for eternal beauty – Daily Times


































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  • Spain and Portugal record hottest June ever

    Spain and Portugal record hottest June ever

    Thomas Mackintosh

    BBC News

    Getty Images A woman fans herself during the June heatwave in MadridGetty Images

    A woman fans herself during the June heatwave in Madrid

    Both Portugal and Spain recorded their hottest June ever as scorching temperatures continue to grip Europe.

    Spain’s national weather service Aemet said the country’s “extremely hot” June 2025 “has pulverised records”, surpassing the normal average for July and August.

    The Portuguese meteorological service said 46.6C was the highest temperature recorded in June.

    Elsewhere on the continent on Tuesday, tens of thousands of people have been evacuated because of wildfires in western Turkey, while two people died in Italy following separate heat-related deaths.

    Overnight, the Aemet meteorological agency said that several places across the Iberian peninsula had topped 43C, but added that a respite in temperatures was on its way from Thursday.

    Night-time temperatures recorded overnight into Tuesday hit 28C in Seville and 27C in Barcelona.

    In Turkey, rescuers evacuated more than 50,000 people – mostly from the western province of Izmir – as firefighters continued to put out hundreds of wildfires that had broken out in recent days.

    Fires have also swept through parts of Bilecik, Hatay, Sakarya, and Manisa provinces.

    Forestry Minister Ibrahim Yumakli said over the past three days, emergency teams had responded to 263 wildfires nationwide.

    Getty Images Flames can be seen through smoke on a hillside in the Seferihisar district of Izmir
Getty Images

    Residents have been evacuated near the resort city of Izmir in Turkey as wildfires rage

    In France, many cities experienced their hottest night and day on record for June on Monday, but forecasters have said the heatwave should expect to peak on Tuesday.

    The top of the Eiffel Tower in Paris has been closed because of the intense European heatwave; while Climate Minister Agnès Pannier-Runacher called an “unprecedented” situation.

    For first time in five years the Paris region has activated a red alert, along with 15 other French regions. The Ministry of Education has said 1,350 public schools will either be partially or completely closed on Tuesday.

    A reading of 46.6 C (115.9F) was registered in Mora, Portugal, about 60 miles east of Lisbon on Sunday. Portuguese weather officials were working to confirm whether that marked a new record for June.

    Getty Images The sun rises by the Eiffel Tower in Paris as the city is on red alert for high temperatures, with the top of the Eiffel Tower shut
Getty Images

    The summit of the Eiffel Tower will be closed all day on 1 July and 2 July, officials said

    In Italy, the Tuscany region has seen hospital admissions rise by 20%, according to local reports.

    Italians in 21 out of the 27 cities have been subjected to the highest heat alert and 13 regions, including Lombardy and Emilia, have been advised not to venture outside during the hottest periods of the day.

    In Lombardy, working outdoors has been banned from 12:30 to 16:00 on hot days on building sites, roads and farms until September.

    Temperatures in Greece have been approaching 40C for several days and wildfires hit several coastal towns near the capital Athens destroying homes and forcing people to evacuate.

    Parts of the UK were just shy of being one of the hottest June days ever on Monday.

    The highest UK temperature of the day was recorded at Heathrow Airport in London at 33.1C. Meanwhile, Wimbledon recorded a temperature of 32.9C, the tennis tournament’s hottest opening day on record.

    In Germany, the country’s meteorological service warned that temperatures could reach almost 38C on Tuesday and Wednesday – further potentially record-breaking temperatures.

    The heatwave lowered levels in the Rhine River – a major shipping route – limiting the amount cargo ships can transport and raising freighting costs.

    Countries in and around the Balkans have also been struggling with the intense heat, although temperatures have begun to cool. Wildfires have also been reported in Montenegro.

    While the heatwave is a potential health issue, it is also impacting the environment. Higher temperatures in the Adriatic Sea are encouraging invasive species such as the poisonous lionfish, while also causing further stress on alpine glaciers that are already shrinking at record rates.

    The UN’s human rights chief, Volker Turk, warned on Monday that the heatwave highlighted the need for climate adaptation – moving away from practices and energy sources, such as fossil fuels, which are the main cause of climate change.

    “Rising temperatures, rising seas, floods, droughts, and wildfires threaten our rights to life, to health, to a clean, healthy and sustainable environment, and much more,” he told the UN’s Human Rights Council.

    Heatwaves are becoming more common due to human-caused climate change, according to the UN’s Intergovernmental Panel on Climate Change.

    Extreme hot weather will happen more often – and become even more intense – as the planet continues to warm, it has said.

    Richard Allan, Professor of Climate Science at the University of Reading in the UK, explained that rising greenhouse gas levels are making it harder for the planet to lose excess heat.

    “The warmer, thirstier atmosphere is more effective at drying soils, meaning heatwaves are intensifying, with moderate heat events now becoming extreme.”

    Thin, green banner promoting the Future Earth newsletter with text saying, “The world’s biggest climate news in your inbox every week”. There is also a graphic of an iceberg overlaid with a green circular pattern.

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  • Bocodepsin/Binimetinib Is Tolerable, Shows Combinatorial Activity in NRAS-Mutant Metastatic Melanoma

    Bocodepsin/Binimetinib Is Tolerable, Shows Combinatorial Activity in NRAS-Mutant Metastatic Melanoma

    NRAS-Mutant Metastatic Melanoma |

    Image credit: © Artur – stock.adobe.com

    The combination of the oral histone deacetylase (HDAC) inhibitor bocodepsin (OKI-179) and binimetinib (Mektovi) had a manageable safety profile and produced initial responses in patients with NRAS-mutant metastatic melanoma, according to data from the phase 2 portion of the phase 1b/2 NAUTILUS trial (NCT05340621) presented during the 2025 ASCO Annual Meeting.1

    Findings from the primary analysis showed that patients treated with the combination achieved a median progression-free survival (PFS) of 6.7 months. Among 20 evaluable patients, the overall response rate was 30%.

    Regarding safety, the combination was found to be tolerable. The most common toxicities occurring in more than 10% of patients were dermatitis acneiform (21%), anemia (17%), and thrombocytopenia (17%). No grade 3/4 toxicities were seen in more than 10% of patients, including no high-grade rash.

    “Initial response data in patients with NRAS-mutant melanoma are supportive of potential combinatorial activity of a MEK inhibitor and HDAC inhibitor bocodepsin with longer PFS than what is typically seen with MEK inhibition alone,” lead study author Rodabe N. Amaria, MD, and colleagues wrote in a poster presentation of the data. “MEK inhibition and HDAC inhibition warrant further study in a larger patient cohort.”

    Amaria is an assistant professor in the Department of Melanoma Medical Oncology, Division of Cancer Medicine, at The University of Texas MD Anderson Cancer Center in Houston, Texas.

    Dive Into the Background and Design of the NAUTILUS Trial

    Activating NRAS mutations occur in 15% to 20% of metastatic melanoma cases. The MEK inhibitor binimetinib has demonstrated modest single-agent activity in this setting, with an ORR of 15% and a median PFS of 2.8 months. Preclinical studies have shown that HDAC inhibitors can potentiate the efficacy of MEK inhibitors in RAS pathway–driven melanomas by concurrently suppressing 2 DNA repair pathways. Bocodepsin, a novel, oral, Class I–selective HDAC inhibitor, has been associated with low-grade toxicities and demonstrated synergistic activity with binimetinib in NRAS-mutant melanoma models, supporting the inception of the NAUTILUS trial.

    NAUTILUS was comprised of a phase 1b dose-escalation and a phase 2 single-arm study.2 The phase 1 portion enrolled patients with advanced solid tumors without activating RAS pathway alterations; phase 2 included patients with NRAS-mutant metastatic melanoma who previously received or were ineligible for immune checkpoint inhibitor therapy.

    In the dose-escalation study, patients received either 200 mg (cohort 1; n = 8) or 300 mg (cohort 2; n = 6) of bocodepsin administered on a 4-days-on/3-days-off schedule, in combination with binimetinib at 45 mg twice daily.1 The 300 mg dose of bocodepsin was established as the recommended phase 2 dose (RP2D) and was subsequently used in all 22 patients enrolled in the single-arm phase 2 portion.

    In phase 1b, the primary end points were identification of the maximum tolerated dose and the RP2D.2 In phase 2, the primary end point was objective response rate (ORR), with secondary end points including safety and pharmacokinetics.1,2

    The median age of patients in the phase 2 portion of NAUTILUS (n = 24) was 69 (range, 39-82).1 The majority of patients were female (53%) and had an ECOG performance status of 1 (71%). The median number of prior lines of therapy was 3 (range, 1-9), and lactate dehydrogenase levels were elevated in 41% of patients.

    Interim data from NAUTILUS showed that, as of the safety data cutoff of July 6, 2023, no dose-limiting toxicities were observed with the combination in either cohort 1 or cohort 2, and adverse effects (AEs) were generally manageable with supportive care or dose interruptions/ reductions.2 The most common treatment-related AEs were as expected based on the agents’ individual safety profiles, and no grade 4/5 TRAEs were observed.

    At an efficacy data cutoff of September 26, 2023, the ORR per RECIST 1.1 criteria among all response-evaluable patients with NRAS-mutant metastatic melanoma in phase 1 and phase 2 (n=16) was 38%; this was comprised entirely of partial responses. Stable disease was also achieved by 38% of patients, and 25% experienced disease progression.

    References

    1. Amaria R, Duvivier H, Tsa K, et al. Nautilus, a phase 1b/2 trial of combining oral HDAC inhibitor (HDACi) with MEK inhibitor (MEKi) in patients with NRAS-mutated metastatic melanoma (MM): Results from the phase 3 ECHELON-3 study. J Clin Oncol. 2025, 43(suppl 16):9552.doi:10.1200/JCO.2025.43.16_suppl.9552
    2. Amaria R, Duvivier H, Tsa K, et al. Novel strategy for RAS-pathway targeting: Initial results from a phase 1b/2 clinical trial of the oral HDAC inhibitor bocodepsin (OKI-179) combined with binimetinib in patients with RAS-pathway mutated solid tumors and NRAS mutated melanoma. Mol Cancer Ther. 2023; 22(suppl 12):PR012. doi:10.1158/1535-7163.TARG-23-PR012

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  • Pakistan to expand Gwadar Port to boost maritime trade, regional connectivity-Xinhua

    ISLAMABAD, July 1 (Xinhua) — Pakistan’s Ministry of Maritime Affairs on Tuesday announced a comprehensive plan to expand operations at Gwadar Port by establishing new shipping lines and introducing a ferry service to Gulf Cooperation Council (GCC) countries, the ministry said in a statement.

    Chairing a meeting here, Minister for Maritime Affairs Muhammad Junaid Anwar Chaudhry said the initiative is part of a broader strategy to boost regional connectivity, enhance Pakistan’s maritime trade, and develop Gwadar into a major transshipment and logistics hub in the Arabian Sea.

    The federal minister added that the expansion would support growing trade with Central Asia and the Middle East, while positioning Gwadar as a central node in regional supply chains.

    As part of the initiative, the ministry also plans to launch a ferry service from Gwadar to GCC countries to provide affordable and direct maritime transport for passengers and cargo.

    Located in the county’s southwest Balochistan province, the port is a key component of the China-Pakistan Economic Corridor.

    Launched in 2013, the flagship project of the China-proposed Belt and Road Initiative connects Gwadar port with Kashgar in northwest China’s Xinjiang Uygur Autonomous Region.

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