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  • ENDO: Older Age, Female Sex Tied to Greater Muscle Loss With Semaglutide

    ENDO: Older Age, Female Sex Tied to Greater Muscle Loss With Semaglutide

    THURSDAY, July 17, 2025 (HealthDay News) — Older age and female sex may be associated with greater muscle loss in adults with obesity prescribed semaglutide, and greater muscle loss is independently associated with less improvement in glucose homeostasis, according to a study presented at ENDO 2025, the annual meeting of the Endocrine Society, held from July 12 to 15 in San Francisco.

    Melanie S. Haines, M.D., from Massachusetts General Hospital in Boston, and colleagues conducted an observational prospective study to identify risk factors for and factors that protect against loss of muscle mass due to weight loss with semaglutide. The analysis included 40 adults with obesity who were prescribed either semaglutide (23 individuals) or a diet and lifestyle intervention for weight loss (Healthy Habits for Life [HHL]; 17 individuals) for three months.

    The researchers found that mean weight loss was 6.3 percent with semaglutide versus 2.5 percent with HHL. Nearly half of the weight loss (47.5 percent) was lean mass in the semaglutide group versus 35.7 percent in the HHL group. At three months, lower protein intake in the semaglutide group (R = 0.52) and older age in the HHL group (R = −0.53) were associated with a greater decrease in lean mass. Older age, female sex, and lower protein intake at three months were associated with a greater decrease in lean mass in the semaglutide group but not the HHL group when adjusting for change in weight. A greater decrease in lean mass was associated with less improvement in glycated hemoglobin in an adjusted analysis in the semaglutide group only. In the semaglutide group only, the bone resorption marker C-terminal telopeptide (15 percent) and total body bone mineral density (1.8 percent) increased.

    “Older adults and women may be more likely to lose muscle on semaglutide, but eating more protein may help protect against this,” Haines said in a statement. “Losing too much muscle may reduce the benefits of semaglutide on blood sugar control. This means preserving muscle during weight loss with semaglutide may be important to reduce insulin resistance and prevent frailty in people with obesity.”

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  • NHG Health expands access to diabetic foot and eye screenings

    NHG Health expands access to diabetic foot and eye screenings

    This fuels efforts to enhance early detection and management.

    NHG Health has expanded its existing programme to allow patients with diabetes to access Diabetic Foot Screening (DFS) and Diabetic Retinal Photography (DRP) services at locations in their neighbourhoods.

    In a statement, NHG Health said that this was implemented through its Population Health campus, which teamed up with GPs in its Central-North Primary Care Network (CN-PCN) and community partners.

    “This initiative is part of NHG Health’s wider efforts as the Regional Health Manager for Central and North Singapore to build healthier communities,” it added.

    There are about 1,500 diabetes-related lower extremity amputations in Singapore, which averages four per day . Diabetes is also a leading cause of blindness in the city-state, and amongst patients with diabetes, there is a 33.9% prevalence of diabetic retinopathy.

    “Early screening for diabetic foot and eye complications is key to timely intervention and preventing serious issues such as lower limb extremity amputations and diabetic retinopathy,” said associate professor Karen Ng, director of Central-North Primary Care Network, chief of primary care, Population Health, NHG Health, and CEO of NHG Polyclinics.

    “By partnering with GPs in our Central-North Primary Care Network and Active Ageing Centres, we have brought such screenings much closer to the community, at patients’ convenience,” Ng added.

    Launched in November 2023, the programme aims to improve access for patients and operational efficiency for GPs, enabling them to provide preventive care and interventions for patients.

    There are over 700 patients with diabetes who have benefited from the one-stop screening services, with 92 CN-PCN GP clinics referring patients to 12 screening locations, including Active Ageing Centres (AAC), Community Centres (CC), and Resident Networks (RN). 
     


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  • Conor McGregor next fight confirmed? The Notorious confirms he’s joined UFC anti-doping pool for UFC White House

    Conor McGregor next fight confirmed? The Notorious confirms he’s joined UFC anti-doping pool for UFC White House

    Conor McGregor is signalling his intentions to make a UFC return after a four-year hiatus.

    The former two-division champion, who last fought in 2021, has announced he is back in the UFC’s anti-doping program to prepare for a potential appearance on a historic fight card at the White House in 2026.

    In an interview with The Schmo following a BKFC press conference in Florida, McGregor confirmed his re-entry into the program, stating, “They’re testing me. I’m in the pool. I thought that’s what the pools were for, jumping in and out, but I’m back in the pool. So get ready and stay ready because damage will be done. Oval office. White House card.”

    The event, planned to coincide with the America 250 celebrations, was proposed by President Donald Trump, who expressed interest in hosting a UFC card at the White House.

    UFC president Dana White later confirmed that discussions for the event were already underway, with fighters lining up to participate.

    McGregor’s return to the anti-doping program comes after a series of setbacks in recent years.

    After suffering a severe leg injury in 2021, McGregor temporarily withdrew from the UFC’s drug testing pool. He re-entered the program in 2023 while preparing for a bout against Michael Chandler, a fight that was later cancelled due to a broken pinky toe.

    Though McGregor has been tested multiple times in 2024, UFC anti-doping records indicate he has not undergone testing in 2025. This gap suggests he may have once again opted out of the program earlier this year.

    However, with the White House card not scheduled until at least July 2026, McGregor has ample time to comply with the necessary six months of drug testing required for a return to competition.

    While McGregor’s participation in the event is far from guaranteed, his latest announcement adds fuel to the speculation surrounding his UFC comeback. Fans now await further developments on whether McGregor will indeed fight on this landmark card.

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  • UN Women launches digital startup roundtable to uplift young women in tech with KOICA’s support

    UN Women launches digital startup roundtable to uplift young women in tech with KOICA’s support

    ISLAMABAD  –  UN Women Pakistan yesterday launched the first event of its Digital Startup Roundtable Series in Islamabad with the support of the Korea International Cooperation Agency (KOICA).

    The event convened thought leaders, innovators, policy experts, development partners, and aspiring young women entrepreneurs to explore the transformative power of digital skills in driving women’s economic empowerment.

    Under the Digitalization for Women’s Economic Empowerment (D4WEE) project, the roundtable served as a dynamic platform for collaboration, dialogue, and innovation.

    The event aligned with the shared vision of UN Women and KOICA to promote gender equality and inclusive development through technology and entrepreneurship. It focused on the unique challenges and opportunities faced by young women in Pakistan’s digital ecosystem and emphasized the importance of fostering an enabling environment for their participation and leadership in the tech sector.

    “In today’s rapidly evolving digital economy, leaving women behind is not an option,” said Jacqui Ketunuti, Deputy Country Representative, UN Women Pakistan. “We are working towards a future where young women shape the tech landscape, lead innovations, and take their ideas from local to global. But vision alone is not enough — we call on all partners to step up, invest in women, open doors to mentorship, and amplify every voice. Only then can we unlock the full potential of Pakistan’s digital future.”

    Echoing this sentiment, the Sodam Baek, Deputy Country Director, KOICA Pakistan emphasized KOICA’s long-term commitment to promoting sustainable development through inclusive innovation in these words, “KOICA is committed to investing in projects that empower women and promote sustainable development. Our collaboration with UN Women is rooted in our belief that technology, when made accessible and inclusive, can be a powerful equalizer. Through this partnership, we aim to equip young women with the tools they need to succeed in the digital economy.”

    Adding a national perspective, Sayyed Ahmad Masud, National Incubation Centre Islamabad highlighted the importance of women’s participation in shaping the country’s digital future.

    “Digital skills are the cornerstone of progress in today’s world. By empowering women to embrace technology, we are not only enabling individual success but also fostering national growth. Women’s participation in the digital sector is vital to Pakistan’s future,” he stated.

    The event featured two key thematic sessions addressing barriers and opportunities for women in the digital economy. 

    The first session focused on policy and infrastructure, bringing together policymakers, digital experts, and development practitioners to discuss the structural challenges that limit women’s access to technology. Participants explored ways to strengthen digital infrastructure, integrate gender-responsive indicators into national e-governance reforms, and expand access in underserved regions.

    The second session centered on mentorship and market access, offering a collaborative space to brainstorm strategies for supporting women-led startups. Discussions emphasized the importance of mentorship, business development services, access to finance, and procurement opportunities. Speakers shared practical insights on how to connect women entrepreneurs with both local and international markets and called for ecosystem stakeholders to actively support underrepresented women in tech.

    The Digital Startup Roundtable Series is organized as part of the KOICA-funded Digitalization for Women’s Economic Empowerment (D4WEE) project, which aims to enhance the participation of women aged 18 to 35 in the technology sector through digital skills training, mentorship, and private sector engagement. Implemented across Lahore, Faisalabad, Multan, Mardan, Peshawar, and Swabi, the project seeks to bridge the digital divide in Pakistan and ensure women have equal access to opportunities in the country’s evolving digital landscape.


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  • Russia says it shot down 73 Ukrainian drones aimed at Moscow

    Russia says it shot down 73 Ukrainian drones aimed at Moscow

    Russian air defences destroyed 73 Ukrainian drones overnight, including three heading for Moscow, Russia’s defence ministry said on Friday.

    Most of the drones were downed over Russia’s southwestern regions, including 31 over the Bryansk region that borders Ukraine, the ministry said on the Telegram messaging app.

    Moscow Mayor Sergei Sobyanin, writing on Telegram, made no mention of casualties or damage, but said emergency services were examining the area where drone fragments fell to the ground.

    The federal aviation agency, Rosaviatsia, briefly ordered the suspension of operations at two airports near the capital, Domodedovo and Zhukovsky, but services were later resumed.

    Operations were halted well after midnight at a third Moscow airport, Vnukovo, before being reinstated by the morning.

    There was no immediate comment from Ukraine about the attacks. Kyiv says that its strikes inside Russia are necessary to destroy infrastructure key to Moscow’s efforts in its war against Ukraine, now in its fourth year.

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  • The OMEGA Seamaster Diver 300M in Orange

    Throughout the past 20 years, the colour orange has become a signature part of OMEGA’s dive watch designs, helping to improve visibility and safety underwater.

    The emblematic orange shade has added vibrancy and unique aesthetic appeal across multiple Seamaster collections, and this year, it is introduced into the iconic Diver 300M range, giving customers the choice between two distinctive models in stainless steel. 

    The entire Seamaster Diver 300M collection recently underwent a comprehensive revamp, with new mesh bracelets, domed sapphire crystals, and oxalic anodised aluminium bezels. These latest models continue that same design theme, while establishing their own identity through a black and orange colourway. 

    The OMEGA Seamaster Diver 300M © OMEGA

    Each 42 mm timepiece is distinguished by its black aluminium dial, with rhodium plated skeletonized hands and indexes that are filled with white Super-LumiNova for a blue glow in dark conditions. Most notably, the central seconds hand is coated with an orange varnish, along with the indexes at the four quarter positions. There is also an orange Seamaster name, located beneath an OMEGA logo that is transferred in white. 

    The OMEGA Seamaster Diver 300M © OMEGA

    Importantly, OMEGA has retained all of the Diver 300M’s legendary features, which have remained a defining part of the collection’s design heritage since 1993. These include the helium escape valve at 10 o’clock, the scalloped bezel and protruding crown guards, as well as the diving scale on the bezel – added in white Super-LumiNova for these editions. 

    This new orange style has been delivered in two different expressions. Either on a brushed mesh bracelet with clasp, or with an integrated orange rubber strap with foldover clasp. 

    The OMEGA Seamaster Diver 300M © OMEGA

    Inside, each watch is driven by the OMEGA Co-Axial Master Chronometer Calibre 8806, visible through the caseback’s sapphire crystal. Excellence in precision, performance and magnetic resistance is guaranteed by the Master Chronometer certification, with tests certified by the Swiss Federal Institute of Metrology (METAS). 

    The OMEGA Seamaster Diver 300M © OMEGA

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  • England v India: Balls to be examined by Dukes after ‘soft’ issues

    England v India: Balls to be examined by Dukes after ‘soft’ issues

    The process for making the Dukes remains a traditional one.

    They are still produced from cork, wound in string, cased in leather and held together by a hand-stitched seam. The cow hides that provide the leather are also dipped in dye, providing further variation.

    Jajodia says there could be a number of factors at play.

    “One is the raw materials which are natural and then has to be moulded and put together by a human being,” he said.

    “Obviously the major aspect of a cricket ball is the leather that holds the whole thing together, and if the fibres that form the animal skin has got some sort of weakness or inherent problem that’s something we can only find if it fails by further inspection and investigation.”

    He added: “Covid did have a very serious effect on all sorts of businesses.

    “In the whole process of tanning leather I would expect changes in personnel, whether either they passed away or decided that it was all too difficult.

    “Also it may be some of the chemicals are not available any more because companies are going out of business. It could be the cattle themselves or it could be the processes.

    “There is literally almost one tanner left that does cricket ball leather so there’s not a choice. You have to work with the tannery to make sure that they produce what you want and by and large they do.”

    Jajodia also believes the modern game, with bigger bats, more sixes and harder playing surfaces may also be a factor.

    “The unique nature of cricket is that you can’t test that ball before it goes into play so therefore, if it fails, it fails in use and at the very highest level it’s in the glare of publicity,” he said.

    “All we can do to check everything as thoroughly as we can during the whole process of making the ball.”

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  • China calls for strengthening SCO economic, trade cooperation

    China calls for strengthening SCO economic, trade cooperation

    Gao Yunlong, vice-chairman of the National Committee of the Chinese People’s Political Consultative Conference and chairman of the All-China Federation of Industry and Commerce, addresses the opening of the Shanghai Cooperation Organization (SCO) business forum in Beijing, capital of China, July 17, 2025. [Xinhua/Jin Liangkuai]

    BEIJING — Gao Yunlong, chairman of the All-China Federation of Industry and Commerce, called for bolstering economic and trade cooperation within the Shanghai Cooperation Organization (SCO) when speaking at the opening of the SCO business forum in Beijing on Thursday.

    Economic and trade cooperation is a powerful engine driving the SCO’s dynamic development, said Gao, also vice-chairman of the National Committee of the Chinese People’s Political Consultative Conference.

    Gao said China is ready to work with other parties to further align regional development strategies, enhance the quality and level of SCO economic and trade cooperation, and ensure the stability and efficiency of industrial and supply chains.

    He stressed that these efforts will promote the building of an SCO community with a shared future and contribute to lasting global peace and shared prosperity.

    Hosted by the China Council for the Promotion of International Trade, the forum attracted nearly 400 participants from government institutions and the business community both at home and abroad.

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  • Asian shares mostly advance after Wall Street cruises to more records

    Asian shares mostly advance after Wall Street cruises to more records

    MANILA, Philippines — Asian shares were mostly higher on Friday after Wall Street rose to records following better-than-expected updates on the economy and a mixed set of profit reports from big U.S. companies.

    Japan’s Nikkei 225 edged 0.1% lower to 39,854.28 as traders stayed on the sidelines ahead of an election for the upper house of parliament on Sunday that could wipe out the ruling coalition’s upper house majority.

    The government reported that core inflation excluding volatile food and energy prices rose to 3.3% in June from a year earlier, slowing from 3.7% in May but still above the central bank’s 2% target.

    Hong Kong’s Hang Seng index added 0.7% to 24,676.64, while the Shanghai Composite index advanced 0.3% to 3,528.90.

    Taiwan’s Taiex climbed 0.9%, helped by a 2.2% gain for Taiwan Semiconductor Manufacturing Co. On Thursday, TSMC reported its net income soared nearly 61% in the last quarter from a year earlier. The world’s largest contract chip maker said it’s seeing strong demand from artificial-intelligence and other customers. On Thursday, TSMC’s stock that trades in the United States rose 3.4%.

    Australia’s S&P/ASX 200 rose 1.5% to 8,765.00, and the Kospi in South Korea shed 0.6% to 3,173.69. India’s Sensex shed 0.3%.

    “Asia’s riding the global rally wave, AI fever refuses to break, and even the Fed is making soothing noises,” Stephen Innes of SPI Asset Management wrote in a commentary. “But underneath all the sunshine is a market running hot, with volatility on sale and positioning still cautious.”

    On Thursday, the S&P 500 climbed 0.5% to top its all-time high set a week ago, closing at 6,297.36. The Dow Jones Industrial Average rose 0.5% to 44,484.49, and the Nasdaq composite added 0.7% to its own record set the day before, climbing to 20,885.65.

    Trading was calmer than on Wednesday, when President Donald Trump rocked financial markets by saying he had discussed the “concept” of firing the chair of the Federal Reserve, though he said he was unlikely to do so. Such a move could help Wall Street get the lower interest rates investors love, but would also risk a weakened Fed unable to make the unpopular moves needed to keep inflation under control.

    Apart from TSMC, other stocks involved in AI also climbed. A 1% gain for Nvidia was one of the strongest forces pushing upward on the S&P 500.

    PepsiCo jumped 7.5% after delivering revenue and profit that topped Wall Street’s expectations.

    Treasury yields were mixed following several better-than-expected reports on the economy.

    One said that shoppers upped their spending at U.S. retailers by more last month than economists expected. Such spending, along with a relatively solid jobs market, has helped keep the U.S. economy out of a recession.

    A separate report said that fewer U.S. workers applied for unemployment benefits last week, which could be a signal of limited layoffs. A third suggested unexpectedly strong growth in manufacturing in the mid-Atlantic region.

    Such solid data could keep the Federal Reserve on pause when it comes to interest rates. The Fed has been keeping rates steady this year, after cutting them at the end of last year. The Fed’s chair, Jerome Powell, has been insisting that he wants to wait for more data about how Trump’s tariffs will affect the economy and inflation before the Fed makes its next move.

    That’s because while lower interest rates could boost the economy and prices for investments, they would also give inflation more fuel. Prices may already be starting to feel the upward effects of tariffs, based on the latest data. In other dealings on Friday, U.S. benchmark crude oil rose 33 cents to $66.56 per barrel. Brent crude, the international standard, also was up 33 cents, at $69.85 per barrel. The U.S. dollar edged slightly higher to 148.67 against the Japanese yen from 148.61. The euro rose to $1.1623 from $1.1596. ___ AP Business Writer Stan Choe contributed.

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  • Syria’s Druze find bodies in the streets while searching for loved ones after clashes

    Syria’s Druze find bodies in the streets while searching for loved ones after clashes

    JARAMANA, Syria — A Syrian Druze woman living in the United Arab Emirates frantically tried to keep in touch with her family in her hometown in southern Syria as clashes raged there over the past days.

    Her mother, father and sister sent videos of their neighbors fleeing as fighters moved in. The explosions from shelling were non-stop, hitting near their house. Her family took shelter in the basement. When she reached them later in a video call, they said her father was missing. He had gone out during a lull to check the situation and never returned.

    “Now I only pray. That’s all I can do,” she told The Associated Press at the time.

    Hours later, they learned he had been shot and killed by a sniper. The woman spoke on condition of anonymity fearing that using her name would put her surviving family and friends at risk.

    A ceasefire went into effect late Wednesday, easing days of brutal clashes in Sweida. Now, members of its Druze community who fled or went into hiding are returning to search for loved ones and count their losses. They are finding homes looted and bloodied bodies of civilians in the streets.

    The fighting began with tit-for-tat kidnappings and attacks between local Sunni Bedouin tribes and Druze militias in the majority-Druze Sweida province. Government forces that intervened to restore order clashed with the Druze militias, but also in some cases attacked civilians.

    At least 600 people — combatants and civilians on both sides — were killed in four days of clashes, according to the Syrian Observatory for Human Rights, a Britain-based war monitor. It said the dead included more than 80 civilians, mostly Druze, who were rounded up by fighters and collectively shot to death in what the monitor called “field executions.”

    “These are not individual acts but systemic,” the Observatory’s director Rami Abdul-Rahman told the AP. “All the violations are there. You can see from the bodies that are all over the streets in Sweida clearly show they’re shot in the head.”

    In response, Druze militias have targeted Bedouin families in revenge attacks since the ceasefire was reached. Footage shared on Syrian state media shows Bedouin families putting their belongings in trucks and fleeing with reports of renewed skirmishes in those areas. There was no word on casualties in those attacks.

    Most of the Syrian Druze who spoke to the AP requested anonymity, fearing they and their families could be targeted.

    The Druze religious sect is an offshoot of Ismailism, a branch of Shiite Islam. More than half of the roughly 1 million Druze worldwide live in Syria. The others live in Lebanon and Israel, including in the Golan Heights, which Israel captured from Syria in the 1967 Mideast War and annexed in 1981.

    They largely celebrated the downfall in December of Syrian autocrat Bashar Assad but were divided over interim President Ahmad al-Sharaa’s Sunni Islamist rule. The latest violence has left the community more skeptical of Syria’s new leadership and doubtful of peaceful coexistence.

    One Syrian-American Druze told the AP of his fear as he watched the clashes from the United States and tried to account for his family and friends whom he had seen in a recent trip to his native city Sweida.

    Despite internet and communications breakdowns, he tracked down his family. His mother and brother fled because their home was shelled and raided, he said. Their belongings were stole, windows shattered. Their neighbors’ house was burned down. Two other neighbors were killed, one by shelling, another by stray bullets, he said.

    He also pored over online videos of the fighting, finding a harrowing footage.

    It showed gunmen in military uniform forcing a number of men in civilian clothes to kneel in the street in a well-known roundabout in Sweida. The gunmen then spray the men with automatic fire, their bodies dropping to the ground. The footage was seen by the AP.

    To his horror, he recognized the men. One was a close family friend — another Syrian American on a visit to Sweida from the U.S. The others were the friend’s brother, father, three uncles and a cousin. Friends he reached told him that government forces had raided the house where they were all staying and took them outside and shot them.

    “We affirm that protecting your rights and freedoms is among our top priorities,” al-Sharaa said in a speech broadcast Thursday, where he addressed the Druze people in Syria, promising to hold perpetrators of civilian killings to account.

    But some rights groups accused Syria’s interim government of systematic sectarian violence, similar to that inflicted on the Alawite religious minority in the coastal province of Latakia in the aftermath of Assad’s fall as the new government tried to quell a counterinsurgency there.

    Footage widely circulated on social media showed some of the carnage. One video shows a living room with several bodies on the floor and bullet holes in the walls and sofa.

    In another, there are at least nine bloodied bodies in one room of the home of a family that took in people fleeing the fighting. Portraits of Druze notables are visible, smashed on the floor.

    Evelyn Azzam, a Druze woman, is searching the Damascus suburb of Jaramana, trying to find out what happened to her husband, Robert Kiwan.

    Last week, the 23-year-old Kiwan left home in Jaramana early as he does every day to commute to his job in Sweida.

    He got caught up in the chaos when the clashes erupted. Azzam was on the phone with him as government forces questioned him and his coworkers. She heard a gunshot when one of the coworkers raised his voice. She heard her husband trying to appeal to the soldiers.

    “He was telling them that they are from the Druze of Sweida, but have nothing to do with the armed groups,” the 20-year-old Azzam said.

    Then she heard another gunshot; her husband was shot in the hip. An ambulance took him to a hospital, where she later learned he underwent an operation. But she hasn’t heard anything since and doesn’t know if he survived.

    Back in the U.S., the Syrian-American said he was relieved that his family is safe but the video of his friend’s family being gunned down in the street filled him with “disbelief, betrayal, rage.”

    He said his family and friends protested against Assad, celebrated his downfall and wanted to give al-Sharaa’s rule a chance. He said he hadn’t wanted to believe that the new Syrian army — which emerged from al-Sharaa’s insurgent forces — was made up of Islamic militants.

    But after the violence in Latakia and now in Sweida, he sees the new army as a “bunch of militias … with a huge majority being radicals.”

    “I can’t imagine a world where I would be able to go back and integrate with these monsters,” he said.

    ___

    Chehayeb reported from Beirut.

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