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  • Fortnite fans get banned for life, are forced to publicly apologize

    Fortnite fans get banned for life, are forced to publicly apologize

    Bring out the world’s smallest violins, because Fortnite ne’er-do-wells are having a tough time out there. The last couple of years have seen Epic Games ramp up efforts against players who break their rules, often in extremely public ways. This time, both a cheater and a hacker have both issued public statements as a part of their punishment in larger legal proceedings.

    In a social media post, Epic Games says that it has taken legal action against two parties: one who sold cheats, and another who digitally attacked live streamers as they were playing Fortnite. Beyond being banned forever from the plucky battle royale game, both of these players have had to issue public statements on YouTube that acknowledge their transgressions.

    The ex-Fortnite player responsible for the denial of service attacks, which overwhelm a target with internet traffic until they are incapable of moving freely, goes under the handle Zebsi. Though Zebsi only has a little over 2,000 followers on the platform as of this writing, they still published a text-heavy video where they say that they “regret my actions.” The video is a minute long but it only contains a couple of sentences.

    In the other YouTube upload from an account with around 200 followers, a fan known as Mirrored admits that they not only used cheats during Fortnite tournaments, they also distributed cheats to other players. “I would like to apologize to the Fortnite community,” Mirrored writes before mentioning that they are banned for life from the game and will face legal action if they ever sell cheats again.

    “If you break the rules there are consequences,” Epic states in the X post detailing the castigation of both players. This is the latest in a series of highly aggressive tactics against cheaters, including one settlement from a cheating lawsuit involving players who won $20,000 during a tournament that was donated to charity. So far, Epic Games has been involved in over a dozen lawsuits of a similar nature, though most of them have involved people who profit from illicit actions in Fortnite and not necessarily situations where someone disrupts the experience of other players.

    Not all cases are nearly this serious, however. Sometimes, developers will find an in-game way to teach cheaters a lesson, as Rockstar did when it blew up GTA Online fans who used an exploit to drive a digital car. Though the Fortnite players who issued statements in July may not ever see a Victory Royale again, this likely won’t be the last time we hear about cheaters facing pressure from the companies who make games.

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  • These lizards survived the asteroid that killed the dinosaurs

    These lizards survived the asteroid that killed the dinosaurs



    A new study has found that night lizards, small reptiles that inhabit North and Central America, survived the extinction event that wiped out most life on Earth—despite living near ground zero.

    The asteroid strike 66 million years ago caused a mass extinction that wiped out 75% of Earth’s animal species, including all non-avian dinosaurs.

    The new study has found that the oldest common ancestor of today’s xantusiid night lizards—small lizards that, despite their name, are most active during the day—predates the Cretaceous–Paleogene (K-Pg) extinction event. And they endured despite living in ecosystems within and near the Yucatan Peninsula, the site of the asteroid impact.

    The study challenges prevailing hypotheses concerning the life history traits associated with surviving mass extinctions, the researchers say.

    “We show that xantusiid night lizards are the only living family of terrestrial vertebrates known to survive of the K–Pg mass extinction in proximity to where the asteroid struck,” says Chase Brownstein, a student in Yale’s Graduate School of Arts and Sciences, in the ecology and evolutionary biology department, and the study’s lead author.

    “This is especially interesting because night lizards don’t fit neatly into the conventional understanding of how to survive a mass extinction. For example, they have small litter sizes of one or two individuals when it’s widely believed that having a lot of offspring enhances the chances of survival.”

    The study in the journal Biology Letters originated in a seminar co-taught by Yale professors Thomas Near and Martha Muñoz that focused on large-scale evolutionary changes to squamates, the order of reptiles that includes lizards and snakes.

    “This paper demonstrates that when faculty members collaborate on teaching a class, exciting research can result,” says Near, professor of ecology and evolutionary biology in Yale’s Faculty of Arts and Sciences (FAS), and a coauthor of the study.

    “In this case, it gave students like Chase an opportunity to pursue interesting research and also brought together two labs that don’t always have the chance to work together.”

    Muñoz, associate professor of ecology and evolutionary biology in FAS, also coauthored the study.

    Xantusiid night lizards are a species-poor lineage (an evolutionary lineage with relatively few living species) with conserved anatomy, meaning their anatomical features have remained relatively unchanged over evolutionary time across species. Despite their name, night lizards are most active during the day and at twilight. They live in microhabitats—small-scale environments, such as rock crevices or decaying logs, with unique properties from the surrounding ecosystem.

    For their analysis, the researchers created a time-calibrated evolutionary tree using a technique called Bayesian tip-dating, which combines molecular genetic data with fossil specimens. They used DNA data for seven nuclear genes stored in GenBank, a database of all publicly available DNA sequences maintained by the US National Institutes of Health.

    The researchers placed fossils at the tips of the tree’s branches, which helped to calibrate time. They restricted the analysis to nuclear genetic data (which is extracted from the nucleus of cells) as opposed to mitochondrial data (genetic information contained in the “powerhouse” of the cells), which prior research has shown artificially inflates estimates of when species diverged, the researchers note.

    Night lizards have been endemic to North and Central America since the early stages of the Late Cretaceous, about 92 million years ago, according to the analysis. The results support the hypothesis that at least two lineages of night lizards persisted through the K–Pg extinction event, the researchers say.

    By integrating life history data from living night lizard species, the researchers showed that the night lizard ancestors that witnessed the asteroid impact likely produced litter or clutch sizes of one or two babies.

    The researchers don’t speculate on how the night lizards managed to survive the asteroid impact, but their findings suggest that the factors that facilitated survival are more complicated than previously thought.

    “They were literally living within blast radius,” Brownstein says. “It’s interesting to consider how they survived. I think our findings suggest that no particular set of traits is necessarily the ‘best’ for surviving extinction. Certainly, some traits must be advantageous, it’s just difficult to know which and why.”

    The study underscores the importance of GenBank and other federally maintained databases in supporting scientific inquiry, says Near, who is also the Bingham Oceanographic Curator of Ichthyology at the Yale Peabody Museum.

    “GenBank and other federal repositories fuel curiosity-based science,” he says. “They are public libraries of vast amounts of information that allow scientists to perform research without needing to obtain large grants. They’re invaluable to improving our understanding of the world.”

    Additional coauthors are from Yale and Ciudad Universitaria in Coyoacán, Mexico.

    Source: Yale

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  • Agreement with Mallorca for the transfer of Pablo Torre

    Agreement with Mallorca for the transfer of Pablo Torre

    FC Barcelona and RCD Mallorca have reached an agreement for the transfer of the player Pablo Torre. The blaugranes retain a buy back option and percentage of any future sale of the midfielder. 

    The Club wishes him all the best for the future on and off the field. 

    As such the player from Cantabria brings an end to his three year spell as a blaugrana after arriving from Racing Santander in the summer of 2022. Torre spent the 2023/24 season on loan at Girona and in his two campaigns with Barça he made 27 appearances, scored five goals and provided four assists, showing evidence of his undoubted talent. 

    Beginnings at Racing Santander

    Son of former Racing Santander player Esteban Torre, Pablo began his career at the Cantabrian club at the age of 12. During the 2020/21 season, at the age of just 17, Pablo Torre made his debut for the Racing first team in the old Second Division B and as the season continued he became a regular in the side. The following season he was one of the top performers in the newly formed Primera RFEF Division and helped Racing win promotion back to the Second Division before joining FC Barcelona. 

    Despite the leap up two division and being in theory a Barça Atlètic player, Torre spent most of the season with the first team gaining valuable experience in La Liga, the Copa del Rey and the Champions League. 

    Loan to Girona and return to Barça

    After his first season as a blaugrana, the midfielder went out on loan to Girona in search of more playing time. In Míchel’s side he figured regularly making 29 appearances before returning to FC Barcelona at the end of the 2023/24 season. 

    Limited playing time but well exploited

    Under coach Hansi Flick competition in midfield was fierce with the likes of Pedri, Gavi, Dani Olmo and Fermín in the squad. Minutes were hard to come by but when he did feature he showed his class. Now, he has the opportunity to do so as a Mallorca player. 

     

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  • Elmo’s X account ‘compromised by unknown hacker’ with racist and antisemitic posts | Technology

    Elmo’s X account ‘compromised by unknown hacker’ with racist and antisemitic posts | Technology

    Hackers gained access to the X account of the puppet Elmo over the weekend and used it to post racist and antisemitic threats as well as make profane references to Jeffrey Epstein. Sesame Workshop was still trying to regain full control Monday over the iconic red character’s account.

    “Elmo’s X account was compromised by an unknown hacker who posted disgusting messages, including antisemitic and racist posts. We are working to restore full control of the account,” a Sesame Workshop spokesperson said Monday. Sesame Workshop is the nonprofit behind Sesame Street and Elmo.

    The account was compromised over the weekend and instead of the usual posts of encouragement and kindness, Elmo’s 650,000 followers were given antisemitic threats and racist messages. The account also made a profane reference to convicted sex trafficker Epstein and demanded the US government release more information on him, adding to the controversy over the FBI’s confirmation that Epstein killed himself. Those tweets were soon deleted, though Elmo’s account retains a link to a Telegram channel from a user who takes credit for the hack.

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    X, owned by billionaire Elon Musk, did not immediately respond to a request for comment.

    Elmo’s social media account has lately become a place for mental health awareness. Last year, the red fuzzy monster, eternally age three and a half , caused a sensation when he asked: “Elmo is just checking in! How is everybody doing?” It prompted responses from Joe Biden and Chance the Rapper.

    X has long struggled with protecting high-profile accounts that can cause major damage with a single tweet. Last year, multiple British MPs and international organizations saw their accounts breached and used to hawk cryptocurrency.

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  • Runners ‘frustrated’ as Dundee half marathon cut a mile short

    Runners ‘frustrated’ as Dundee half marathon cut a mile short

    Katy Scott

    BBC Scotland News

    Thomas Mills Thomas Mills wears a blue top with a blue ribbon of a medal around his neck. The ribbon says "HALF DRAM 2025 FINISHER". He smiles and stands in front of a tree with lots of green leaves.Thomas Mills

    Thomas Mills had entered the half marathon as his first official running event

    Runners have been left “frustrated” after a half marathon event in Dundee was cut more than a mile short.

    The Half DRAM on Sunday began at Camperdown Park in the city and finished at the Barnhill Rock Gardens in Broughty Ferry.

    Organisers Eventfull Management apologised and said two stewards had misdirected the runners.

    As a result 1.1 miles (1.8km) were cut from the half marathon distance of 13.1 miles (21.1km).

    Runners told BBC Scotland News that the mistake happened early on in the race, with some people running beyond the finish line to make up for the lost distance.

    Organiser Nicholas Kydd said about 700 people took part in the race across the city.

    Scotland experienced temperatures as high as 30C (86F) on Sunday while Dundee peaked at just over 23C (73.4).

    Thomas Mills Thomas Mills runs along the still River Tay wearing a blue top, black shorts, white trainers and an orange knee brace. He smiles at the camera.Thomas Mills

    Thomas Mills noticed the route was slightly different to the one he was expecting

    Thomas Mills entered the Half DRAM as his first official running event.

    He had walked the route in the days leading up to the event and noticed it was different when he checked the path afterwards.

    Thomas said he initially thought that stewards had misdirected the runners or the front runners had ran the wrong way by mistake.

    He said: “When we saw the signs saying we had run one mile and then two miles, everyone around me said it didn’t sound right because we’d only ran a few hundred metres.

    “People have been training for months to run that distance, so to find that it wasn’t quite long enough was frustrating.

    “People were running lengths of Broughty Ferry to make up the distance which wasn’t good.”

    But despite the mistake, he said the event was still a “really good day out” and he would be signing up for it next year.

    Ryan Cruikshanks Ryan Cruikshanks has short brown hair and a short brown beard. He stands in front of the blue sky with a cloud across it. He wears a white top with a "Half DRAM 2025" label and holds a bottle of Lucozade.Ryan Cruikshanks

    Ryan Cruikshanks was on track for a record time at the half marathon

    Ryan Cruikshanks told BBC Scotland News that the error was “slightly frustrating” as he was on track for a personal best time for the half marathon.

    He said: “I think most realised it was going to be short once we hit Broughty Ferry.

    “I know some had it in them to run back to complete the full distance but I wasn’t one of those.

    “Everything else was amazing considering the conditions.”

    Eventfull Management runs other events, including the Monikie Triathlon on Saturday and the Arbroath Half Marathon in September.

    ‘Human errors’

    Organiser Nicholas Kydd said runners – who had paid £22 to enter – had been misdirected by stewards within the first 300m of the course.

    He added: “As it only became apparent to myself what had actually happened a few miles into the course, it was then impossible to rectify the situation.

    “I would like to clarify that the official Half DRAM 2025 route was accurately measured, shared with all runners in advance and fully signposted and stewarded on race day.

    “Unfortunately isolated human errors by two stewards at a key point on the course meant all runners were inadvertently directed off the intended path.”

    He said affected runners would be offered a 50% discount to take part in the Half BraemarAthon in September, as well as discounted entry to Dundee’s Half DRAM in 2026.

    The Great Scottish Run in Glasgow, the country’s biggest mass participation race, experienced course measurement issues in 2016 and, again, in 2022 when it was about 150m short.

    The most recent error meant Commonwealth 10,000m champion Eilish McColgan’s 10k course record was invalidated.

    Organisers apologised and the course was re-measured in 2023 to ensure it was correct.

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  • ‘They digest externally’: the artist who creates paintings with live flies | Art

    ‘They digest externally’: the artist who creates paintings with live flies | Art

    One morning in Denver as artist John Knuth was getting his exhibition ready at the David B Smith Gallery, the police knocked on the door to check he wasn’t housing a dead body. “They said, ‘We’ve got a report of a lot of flies in here. Is there a dead body or anything rotting?’” Knuth recalls to the Guardian over Zoom.

    The hundreds of flies emerging from Knuth’s gallery were actually his collaborators. For over a decade, Knuth has been creating paintings using the regurgitation of tens of thousands of flies. “When flies eat they digest externally,” explains Knuth. “They’re in a constant state of regurgitation. They land on a surface, puke up, suck it back in. Puke up, suck it back in.” After feeding the insects a mixture of acrylic colored paint and sugar water, the flies spend several weeks expelling the mixtures on to his canvases. “From that I get these really transcendent color connections.”

    While that might sound like a rather odd and disgusting approach, Knuth has been praised for pushing the boundaries of nature, beauty and process with his abstract pointillist paintings, which have been described as “vibrant and seemingly luminescent” and “incandescent [and] shimmering”.

    As well as being sticky work, it occasionally leads to run-ins with the law. After inviting the investigating Denver police officers inside the gallery, the effortlessly effervescent and excitable Knuth charmingly explained that rather than concealing a corpse, the flies were busy at work. “I told them, ‘I’m an artist. Hundreds of thousands of flies are making paintings for me. Some are escaping.” The cops quickly echoed the usual response Knuth gets for his work from critics and gallery visitors alike. “They were so intrigued. They were like, ‘This is amazing.’ They invited the people at the bank who reported the flies over and 20 minutes later they were all on board with it and apologizing for raising a fuss.”

    John Knuth. Photograph: Ian Byers-Gamber

    Knuth is currently showcasing his latest array of fly paintings at the Hollis Taggart gallery in New York as part of his exhibition, The Hot Garden. This showcase has been particularly resonant for Knuth. It’s his first major exhibition since he lost the Los Angeles home he shared with his wife and child, as well as his entire archive, in January’s Eaton fire. After the tragedy, Knuth returned to fly paintings as “they helped pay for my house that burned down. I wanted to get back to the beginning point.”

    It was almost inevitable that Knuth’s art would intersect with nature. Growing up in the suburbs of Minneapolis and St Paul, Knuth spent all of his time catching snakes, frogs, turtles, and fishing. Knuth’s fascination with animals and insects continued when he became an artist. He would mix rattlesnake venom with paint, he painted coyote penis bones gold, and created gold leaf horseshoe crabs. Even he recognizes that he’s chosen quite an unusual path. “I remember thinking at one point, ‘What the fuck am I doing? Why didn’t I start painting nudes or get a muse?’”

    While struggling in high school, Knuth found his salvation in several art books at the library. Intrigued by the work of Andy Warhol and Jasper Johns in particular, Knuth started to regularly visit the variety of art museums across Minneapolis. “There’s a tremendous art community there that fed my curiosity. That’s really where I discovered art.” Knuth then attended the University Of Minnesota, where he got a BFA in art, and worked under Mark Dion – a conceptual artist renowned for mixing art and science. “He was my mentor. He showed me you can be really smart and an intellectual troublemaker, plus go out and drink beer and make a living as an international artist.”

    John Knuth – Daybreak. Photograph: John Knuth / Evan Walsh

    Knuth was first struck by the idea to work with flies in the buildup to the 2003 Iraq war. After reading that flies had been responsible for more human suffering than all wars, because of how they have spread malaria and numerous other diseases, Knuth initially wanted to create an anti-war piece by tying paper airplanes on to house flies to make his “own little biological warfare air force”. As he explored this option, he noticed that flyspeck looked like little spots of paint.

    In 2005, Knuth continued his experimentation by feeding flies McDonald’s and Taco Bell. But the results were just brown paintings. “They were cool conceptual objects. But not beautiful artworks.” He also didn’t have enough money to buy the number of flies he required to fulfill his vision. Then in 2013, Knuth was approached by the Museum Of Contemporary Art in Los Angeles to do a “big production” of his fly paintings. The resulting video went viral. “That moment made my career. Since then I’ve had shows around the world.” Knuth’s fly paintings have been bought by multiple private art collectors and are also in the permanent collection at the Asheville Art Museum, North Carolina.

    The Hollis Taggart show marks Knuth’s third solo exhibition in New York. After being approached by director Paul Efstathiou in February, Knuth devised the concept of the Hot Garden because he wanted to reflect what he and numerous artists had gone through with the Los Angeles fires. “This was a generation changing event for my generation of artists. I literally know hundreds of artists that got hit by this. Five artists on my block alone lost their houses.” Since his work had always engaged with climate, bugs and life, it felt like a natural continuation to bring the fire into his paintings. For the titular piece of the exhibition, Knuth wanted to create “distorted or distressed landscapes by pulling paint across the canvas to make fire motifs”. For the piece January 7, the day that Knuth watched his home burn down, he mixed red, lavender and green flyspeck to produce a “dark and ominous” tone and visuals reminiscent of fire and smoke. While constructing his paintings, Knuth looked at Monet’s use of color compositions in his lily paintings, while turning to warm colors, like oranges and yellows, because they represented heat.

    Knuth isn’t just presenting his fly paintings at The Hot Garden. He’s also exhibiting a sculptural installation, entitled The Sculpture Garden. It includes fragments of artworks recovered from his destroyed home, as well as pieces from other artists affected by the fire. Glenn Phillips, the director of the Getty Research Center, was so impressed that he’s already bought two pieces for the Getty Museum. Including, This Is Our Pompeii, a New York Times article on the impact of the LA fires on local artists, covered in red flyspeck.

    John Knuth – Untitled. Photograph: John Knuth / Evan Walsh

    While Knuth is delighted that the fly paintings have connected with art lovers and critics yet again, he can’t help but get a little somber when asked if the exhibition has helped him process his trauma. “Being busy helps. Having a reason to keep doing this helps. But all of my archive and retrospective is gone. That’s the first 25 years of my career. My work was a way to engage in the world. Unfortunately the world engaged with me pretty intensely six months ago. There’s just so much tragedy in the world that the news cycle moves on.”

    But as Knuth picks up the pieces for the next phase of his career, he’s not straying too far away from the formula that has garnered him so much success. His new Pasadena studio is full of dead flies caught in fly traps hanging from the globe, giant fishhook sculptures, dead stuffed rattlesnakes painted red, and hundreds of black sea urchins in gold foil painted black. “I’m 46 now, so hopefully I have another 25 years left to make up for what I lost.”


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  • Olivia Culpo, Christian McCaffrey welcome baby girl

    Olivia Culpo, Christian McCaffrey welcome baby girl

    Olivia Culpo and Christian McCaffrey are now parents, and the arrival of their baby girl has them both feeling lucky.

    Model-actor Culpo revealed Sunday that she and her NFL star husband welcomed their daughter earlier this month. She marked the beginning of her journey into motherhood on Instagram, sharing several pictures from her newborn’s first moments in the world. A carousel of black-and-white photos document tender moments between Culpo, McCaffrey and their baby at Cedars-Sinai.

    Culpo’s Instagram post also included a name reveal. “Colette Annalise McCaffrey,” she captioned her photos, adding a white heart emoji.

    Additionally, Culpo shared photos from baby Colette’s arrival to her Instagram stories, where she praised her San Francisco 49ers running back husband. “Colette is so lucky to have the best daddy in the world,” she wrote in an Instagram photo of McCaffrey tending to their newborn. “A love like no other.”

    In another Instagram story on Sunday, Culpo recalled her labor as the “scariest and most rewarding of all experiences” and her husband’s calming effect. She shared a photo of McCaffrey holding her head during her delivery. In his Instagram story, McCaffrey reciprocated the sentiment, posting a photo of himself holding his baby girl.

    “Luckiest man on the planet,” he captioned the photo. “I love you @OliviaCulpo.”

    Culpo, 33, and McCaffrey, 29, were rumored to be dating as early as May 2019 and got engaged in April 2023. They married in June 2024 in Culpo’s native Rhode Island. Culpo, a former Miss Universe, announced in March that she and her husband were expecting their first child together.

    “Next chapter, motherhood,” she captioned photos from her maternity photo shoot.

    A representative for Culpo did not immediately respond on Monday to The Times’ request for additional information.


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  • England beat Jadeja, India in third Test at Lord’s | Cricket News

    England beat Jadeja, India in third Test at Lord’s | Cricket News

    England survived a courageous second innings fightback by India’s Ravindra Jadeja on the final day of the third Test at Lord’s Cricket Ground in London.

    England beat India by 22 runs on a final day of simmering tension and high drama in the third Test at Lord’s to move 2-1 up in the best-of-five series.

    Shoaib Bashir bowled Mohammed Siraj for four to seal victory, India’s number 11 playing a defensive stroke before the ball trickled down the face of his bat and rolled on to the stumps as he watched on in disbelief.

    As the England players celebrated wildly late on Monday, Ravindra Jadeja trudged off the field after making a valiant unbeaten 61 to take India to the brink of an extraordinary win.

    The hosts had looked on course for a far more comfortable victory when they reduced India to 112-8 at lunch, but Jadeja and Jasprit Bumrah battled for nearly two hours to inch their team towards a target of 193.

    Jadeja was given out leg before wicket to Chris Woakes by the umpire. But the decision was overturned on review, and the left-hander heaved the next delivery over mid-wicket for six, prompting loud cheers from the Indian fans.

    England finally made the breakthrough when Bumrah, on five, skied an attempted pull off Ben Stokes and was caught by substitute fielder Sam Cook.

    The majority of the crowd erupted with a mixture of joy and relief, but Jadeja continued to frustrate England, reaching his 50, off 150 balls, by edging Stokes over the slips for four.

    Siraj survived 30 deliveries for his four runs as Jadeja farmed the bowling and took a succession of singles off the fourth ball of the over to dominate the strike.

    Siraj suffered a painful blow to his shoulder after being struck by a Jofra Archer delivery and shortly afterwards his resistance was finally broken.

    Ravindra Jadeja top-scored for India in the second innings with a patient 61 runs and was not out at the end of play [Peter Cziborra/Action Images via Reuters]

    A good morning for England

    England had claimed four wickets in the morning to take charge of the match after India resumed on 58-4.

    Rishabh Pant played an extraordinary one-handed straight drive for four off Archer to move to nine, but the fast bowler responded two balls later with an excellent delivery which uprooted his off stump.

    Stokes snared KL Rahul lbw for 39, the England captain dropping to his knees and imploring the umpire to give him out.

    He refused to do so, but England called for a review and the decision was overturned to huge cheers from the crowd.

    Washington Sundar was next to fall for a duck, Archer leaping to his right to take a superb one-handed catch off his own bowling.

    Jadeja and Nitish Kumar Reddy frustrated England with solid defence in a partnership of 30 until Woakes found the edge of Reddy’s bat just before lunch to give the hosts a huge lift as they left the field to warm applause from a packed crowd.

    The fourth Test will begin on July 23 at Old Trafford in Manchester.

    England players react.
    England’s Jamie Smith and Ollie Pope celebrate after Shoaib Bashir takes the last wicket of India’s Mohammed Siraj, centre, to win the third Test [Peter Cziborra/Action Images via Reuters]

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  • Pre-season enters its second week

    Aston Villa commenced the second week of pre-season training at Bodymoor Heath on Monday, as more of Unai Emery’s first team stars returned to action. Preparations for 2025/26 got underway last week, with a number of Villans back in the building for the first time in six weeks, as many players who spent the summer break on international duty returned a week later. The likes of Ollie Watkins, Lucas Digne, Youri Tielemans and captain John McGinn set foot in Bodymoor and got back to work, as Emery prepares his men for their first friendly outing at Walsall this Wednesday (ko 7.30pm). Here’s how the day unfolded… Checking in The Villans touched down at Bodymoor bright and early and got straight to work, with Emery’s charges all smiles in the July sunshine… Getting started in the gym First off was an indoor session in the gym for the Villans, who were put through their paces before heading outside… Grinding on the grass Then came an intense session outside for those back in training, as the Villans worked up a sweat by getting their legs moving on the grass… Villa’s all-new training range, as sported by Emery’s men above, is also now available to shop – both online and in person, from the Villa Store and AVFC Sport and Leisure store in the Bullring. 2025/26 Training Range On sale now Shop Here

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  • FDA’s Oncologic Drugs Advisory Committee Casts Interesting Votes

    FDA’s Oncologic Drugs Advisory Committee Casts Interesting Votes

    John M. Burke, MD

    Hematologist and Medical Oncologist Rocky Mountain Cancer Centers Associate Chair US Oncology Hematology Research Program

    Aurora, CO

    On May 20, 2025, the FDA convened a meeting of the Oncologic Drugs Advisory Committee (ODAC) to consider 2 important questions. The first addressed the application for full approval of glofitamab-gxbm (Columvi) for patients with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL). The second addressed the application for the monoclonal antibody daratumumab (Darzalex) for adult patients with high-risk smoldering myeloma (SM). The FDA granted accelerated approval in 2023 to glofitamab for treatment of R/R DLBCL based on a single-arm trial that demonstrated an overall response rate of 56%. STARGLO (NCT04408638) was the confirmatory trial that, if positive, would lead to a full approval of glofitamab. In the phase 3 STARGLO trial, patients with R/R DLBCL were assigned to receive glofitamab plus gemcitabine and oxaliplatin (GemOx) or rituximab (Rituxan; Genentech) plus GemOx. The results favored glofitamab-GemOx, which demonstrated improved overall survival (OS), progression-free survival (PFS), complete response rates, and overall response rate. Although these results suggest glofitamab should be a slam dunk for full FDA approval, there is, of course, a rub. The rub is that only 25 of the 274 patients in STARGLO were from North America, whereas 131 patients, or 48%, were from Asia. Furthermore, on subset analysis, the North American patients did not benefit from glofitamab-GemOx. The FDA convened the ODAC meeting to answer the question of whether the STARGLO population and trial results are applicable to the proposed US patient population. The ODAC voted 8-to-1 that the answer is no. The FDA’s message is loud and clear: A drug may not get approved if the trial does not include enough patients from the US. Pharma, take note. T he second question addressed by ODAC was more straightforward: “Should we approve this drug?” They considered whether the results of the phase 3 AQUILA (NCT03301220) trial support a favorable benefit-risk profile for daratumumab in high-risk SM. Patients treated with daratumumab had improved PFS and OS; however, OS results were immature. The ODAC voted 6-to-2 in favor of daratumumab’s benefit/risk profile in SM. I find this a bit surprising. What really matters clinically is whether such a treatment can prevent morbidity and/or prolong OS. It will be interesting to see what the FDA decides—and what our patients prefer.

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